ライフサイエンスコーパス: anilino

1 The fluorescent, hydrophobic compound 8-anilino 1-naphthalene sulphonate (ANS) was used to quant

2 we report a new iridium system comprising 2-anilino-1,10-phenanthroline as the ligand that catalyzes

3 Competition experiments between 8-anilino-1-naphtalene sulfonic acid, which has fluorescen

4 one binding site and allows the binding of 8-anilino-1-naphtalene sulfonic acid.

5 Furthermore, 8-anilino-1-naphthalene sulfonate (ANS) binding to cCSQ cl

6 S-Methylglutathione and 8-anilino-1-naphthalene sulfonate (ANS) each yield partial

7 nium hydrochloride (GuHCl), tryptophan and 8-anilino-1-naphthalene sulfonate (ANS) fluorescence detec

8 nastellin binding to III3 was monitored by 8-anilino-1-naphthalene sulfonate (ANS) fluorescence.

9 The extrinsic fluorescence dye 8-anilino-1-naphthalene sulfonate (ANS) is widely used for

10 nilino)naphthalenesulfonic acid (bis-ANS), 8-anilino-1-naphthalene sulfonate (ANS), and 1-azidonaphth

11 8-Anilino-1-naphthalene sulfonate fluorescence enhancement

12 , fluorescent dye binding experiments with 8-anilino-1-naphthalene sulfonate revealed increased expos

13 ophan spectral properties was evaluated by 8-anilino-1-naphthalene sulfonic acid (ANS) fluorescence a

14 s display much stronger signal compared to 8-anilino-1-naphthalene sulfonic acid (ANS), a commonly us

15 t for the binding of the hydrophobic probe 8-anilino-1-naphthalene sulfonic acid (ANS), suggesting po

16 uorescence spectroscopy in the presence of 8-anilino-1-naphthalene sulfonic acid (ANS), we show that

17 LDH was noncovalently labeled with 8-anilino-1-naphthalene sulfonic acid (ANS).

18 Mechanistic studies using bis-8-anilino-1-naphthalene sulfonic acid as a proxy drug show

19 8-Anilino-1-naphthalene sulfonic acid binding data showed

20 nd hydrophobic pocket-binding molecule bis-8-anilino-1-naphthalene sulfonic acid revealed static bind

21 sed binding of the fluorophore bis-(5, 5')-8-anilino-1-naphthalene sulfonic acid to the chaperonin.

22 NP) synthesized by a green method and poly(8-anilino-1-naphthalene sulphonic acid) modified glassy ca

23 bitors but were reduced in the presence of 8-anilino-1-naphthalene-sulfonic acid (ANS) or Congo Red (

24 luorescence associated with the binding of 8-anilino-1-naphthalene-sulfonic acid to hydrophobic regio

25 vironment-sensitive fluorescent probe ANS (8-anilino-1-naphthalene-sulfonic acid) provided further ev

26 dendrimers to bind the fluorescent probe, 8-anilino-1-naphthalene-sulfonic acid.

27 0 K using circular dichroism spectroscopy, 8-anilino-1-naphthalene-sulphonate binding, and Trp solvat

28 Similarly, the ANS (8-anilino-1-naphthalenesulfate) binding showed generally i

29 Trp fluorescence and fluorescence-detected 8-anilino-1-naphthalenesulfonate (ANS) binding.

30 Fluorescence behavior of 8-anilino-1-naphthalenesulfonate (ANS) reflects a blue-shi

31 ular dichroism, chemical denaturation, and 8-anilino-1-naphthalenesulfonate binding.

32 d a decrease in alpha-helical content, and 8-anilino-1-naphthalenesulfonate fluorescence revealed the

33 However, the hydrophobic probe 5, 5'-bis-(8-anilino-1-naphthalenesulfonate) (bis-ANS) inhibited FtsZ

34 ANS (8-anilino-1-naphthalenesulfonate), a hydrophobic probe sim

35 cally distinct region, characterized by an 8-anilino-1-naphthalenesulfonate-positive hydrophobic sign

36 hroism (CD), one-dimensional (1)H NMR, and 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence ex

37 highest surface hydrophobicity measured by 8-anilino-1-naphthalenesulfonic acid (ANS) probe (p<0.05).

38 dissociation of CF1 during cold treatment, 8-anilino-1-naphthalenesulfonic acid (ANS) was employed.

39 Fluorescence intensity measurements of 8-anilino-1-naphthalenesulfonic acid (ANS) were monitored

40 hydrophobic and hydrophilic properties of 8-anilino-1-naphthalenesulfonic acid (ANS).

41 ic spectra and extrinsic fluorescence with 8-anilino-1-naphthalenesulfonic acid and tetramethylrhodam

42 induced a relatively small enhancement in 8-anilino-1-naphthalenesulfonic acid fluorescence intensit

43 scopy and reactivity with thioflavin S and 8-anilino-1-naphthalenesulfonic acid fluorescent probes, t

44 16-(9-anthroyloxy)palmitic acid (16AP) and 8-anilino-1-naphthalenesulfonic acid is reduced.

45 Binding studies using 8-anilino-1-naphthalenesulfonic acid suggest that the E175

46 h a substantial increase in the binding of 8-anilino-1-naphthalenesulfonic acid with only modest chan

47 opthan synthase catalysis, the fluorophore 8-anilino-1-naphthalensulfonate (ANS) is used to identify

48 probe [the product of modification with N-(4-anilino-1-naphthyl)maleimide] on the alpha subunit durin

49 ANS (8-anilino-1-napthalene sulfonic acid) was used to probe th

50 reduces exposure of hydrophobic sites for 8-anilino-1-napthalenesulfonic acid binding and beta-struc

51 t expose hydrophobic surfaces that support 8-anilino-1-napthalenesulfonic acid binding.

52 A series of anilino 2-norbornyl alcohols have been prepared and reac

53 Chalaniline B [1-anilino-2,8-dihydroxy-3-(hydroxymethyl)xanthone], an ant

54 aluation of deshydroxymethylchalaniline B (1-anilino-2,8-dihydroxyxanthone) revealed MIC values of 8

55 Fluoropodophyllotoxin (11) and several 4beta-anilino-2-fluoro-4'-O-demethyl analogues were synthesize

56 A new class of 2-anilino-3-cyanobenzo[b]thiophenes (2,3-ACBTs) was studie

57 This 4-anilino-3-quinolinecarbonitrile (SKI-606) ablates tyrosi

58 the binding of a fluorescent probe 1,1'-bis(anilino)-4-,4'-bis(naphthalene)-8,8'-disulfonate (bis-AN

59 , 4'-O-demethyl-4beta-(-)-(4' '-camphanamido-anilino)-4-desoxypodophyllotoxin (25), 4-beta-disubstitu

60 llotoxins (18-20, 26), 4-alpha-disubstituted-anilino-4'-demethyl-4-desoxypodophyllotoxin (27), 4-beta

61 xypodophyllotoxin (25), 4-beta-disubstituted-anilino-4'-demethyl-4-desoxypodophyllotoxins (18-20, 26)

62 ypodophyllotoxin (27), 4-beta-trisubstituted-anilino-4'-demethyl-desoxypodophyllotoxin (22, 23), and

63 e attachment of a single water molecule to 4-anilino-4'-nitro azobenzene on the same inert surface, t

64 )(1), where H2tBAFPh is 2-(2-trifluoromethyl)anilino-4,6-di-tert-butylphenol, were found to activate

65 nships (SARs) that led to the discovery of 2-anilino-4-(thiazol-5-yl)pyrimidine ATP-antagonistic CDK2

66 ng the recent discovery and development of 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin dependent kina

67 We identified a series of 3-anilino-4-arylmaleimides as dual inhibitors of SLK and S

68 -demethyl-4beta-[(4' '-(benzimidazol-2' '-yl)anilino]-4-desoxypodophyllotoxin (21), 4'-O-demethyl-4be

69 evented by the guanylyl cyclase inhibitors 6-anilino-5,8-quinolinedione (5 mumol/L, n = 6) or 1H-(1,2

70 O-induced activation of PAL was blocked by 6-anilino-5,8-quinolinedione and 1H-(1,2,4)-oxadiazole[4,3

71 imilarly, the guanylate cyclase inhibitors 6-anilino-5,8-quinolinedione and 1H-[1,2,4]oxadiazolo[4,3-

72 Although 6-anilino-5,8-quinolinedione fully blocked PAL activation,

73 cGMP production was inhibited by LY 83583 (6-anilino-5,8-quinolinedione), a specific inhibitor of gua

74 Two inhibitors of sGC, 6-anilino-5,8-quinolinequinone (LY83583) and 1H-[1,2,4]oxa

75 e-2 (MetAP2), identified a potent class of 3-anilino-5-benzylthio-1,2,4-triazole compounds.

76 We report that bis-ANS (1,1'-bis(4-anilino-5-napthalenesulfonic acid), an environment sensi

77 nment-sensitive fluorescent probe 1,1'-bis(4-anilino-5-napththalenesulfonic acid (bis-ANS).

78 ost potent and selective validated hits, a 2-anilino-5-phenyl-1,3,4-oxadiazole (24) and a phenylmethy

79 A series of derivatives of 2-anilino-5-phenyloxazole (5) has been identified as inhib

80 on with substituted anilines furnished the 4-anilino-6, 7-dialkoxyquinoline-3-carbonitrile inhibitors

81 The synthesis and SAR of a series of 4-anilino-6, 7-dialkoxyquinoline-3-carbonitrile inhibitors

82 o prepared for comparison, as were several 1-anilino-6,7-dimethoxyisoquinoline-4-carbonitriles.

83 Initial 4-anilino-6-aminoquinoline-3-carbonitrile leads showed poo

84 by substitution at the C-8 position of our 4-anilino-6-aminoquinoline-3-carbonitrile leads.

85 The 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles were prepared f

86 n experiments using circular dichroism and 2-anilino-6-napthaline-sulfonate (ANS) fluorescence show t

87 structure-activity relationships of these 4-anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles ar

88 Bovine serum albumin (BSA) and 1-anilino 8-naphthalene sulfonic acid (ANS) were used for

89 Here we report that both 1-anilino-8 naphthalene sulfonate (ANS) and the covalent a

90 ns, including cooperative folding, lack of 1-anilino-8-naphthalene sulfonate binding, and limited deu

91 proach, the rotational correlation time of 1-anilino-8-naphthalene sulfonate bound to nonpolar surfac

92 Using tubulin-1-anilino-8-naphthalene sulfonate complex fluorescence, we

93 1-Anilino-8-naphthalene sulfonate fluorescence indicates t

94 The ANS- (1-anilino-8-naphthalene sulfonate) anion is strongly, domi

95 measurements with earlier measurements on 1-anilino-8-naphthalene sulfonate, thioflavin T, and dynam

96 1H-NMR features and fluorescent binding of 1-anilino-8-naphthalene sulfonate.

97 nd interactions with the hydrophobic probe 1-anilino-8-naphthalene-sulfonic acid (ANS).

98 graphy, intrinsic tryptophan fluorescence, 1-anilino-8-naphthalenesulfonate (ANS) binding, circular d

99 Further, during binding experiments with 1-anilino-8-naphthalenesulfonate (ANS), the WT and N78D mu

100 es, and proteins and the hydrophobic probe 1-anilino-8-naphthalenesulfonate (ANS).

101 g within the ECD1 as determined by NMR and 1-anilino-8-naphthalenesulfonate binding but did not preve

102 ioning, liposome floatation assay, and bis-1-anilino-8-naphthalenesulfonate binding revealed that two

103 Fluorescence assays with 1-anilino-8-naphthalenesulfonate demonstrate that a hydrop

104 Interestingly, 1-anilino-8-naphthalenesulfonate fluorescence is at a mini

105 1-Anilino-8-naphthalenesulfonate monitored the involvement

106 noncovalent labeling with thioflavin T and 1-anilino-8-naphthalenesulfonate to follow the conformatio

107 3 and room temperature, measured by using 1-anilino-8-naphthalenesulfonate, were 9.4 x 10(-5) and 3.

108 dged by its binding to a fluorescent probe 1-anilino-8-naphthalenesulfonate.

109 cU by near-ultraviolet circular dichroism, 1-anilino-8-naphthalenesulfonic acid binding, free energy

110 e C-terminal domain have been evaluated by 1-anilino-8-naphthalenesulfonic acid binding, the kinetics

111 bserved previously for the GroEL 4, 4'-bis(1-anilino-8-naphthalenesulfonic acid) complex.

112 The binding of 4, 4'-bis(1-anilino-8-naphthalenesulfonic acid) to GroEL in the pres

113 he fluorescent, hydrophobic probe 4,4'-bis(1-anilino-8-naphthalenesulfonic acid), while the fluoresce

114 its reduced binding of the fluorescent dye 1-anilino-8-naphthalenesulfonic acid.

115 ve-like secondary structure and shows strong anilino-8-naphthalenesulphonate binding due to increased

116 residual secondary structure, and shows weak anilino-8-naphthalenesulphonate binding.

117 1-Anilino-8-napthalene sulfonate (ANS) binding and size-ex

118 l characterisation of these variants using 1-anilino-8-napthalene sulphonic acid (ANS) binding, near-

119 nthryl (BAET), and 10,10'-bis(N,N-diphenyl-4-anilino)-9,9'-bianthryl (BATA) in detail, we probed thei

120 ilino azatoxin class follows the SAR of the (anilino)acridine family.

121 e subsequent conversion to an axially chiral anilino alcohol is also reported.

122 The 2-anilino and 2-(dialkylamino)alkylamino substituents as w

123 that although both the 3-(morpholinosulfonyl)anilino and benzenesulfonamide moieties in these compoun

124 ydrophobic interactions with the piperazine, anilino, and phenyl groups of nintedanib, providing a st

125 ip (SAR) profile of the nonintercalating C11 anilino azatoxin class follows the SAR of the (anilino)a

126 attractive strategy to prepare diverse gamma-anilino-beta-ketoesters in one step.

127 oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic ac

128 carbonyl ]am ino]ethyl]amino]carbonyl]methyl]anilino]carbonyl]methyl]phenyl] adenosine (p- and m-DITC

129 Reaction of resin-bound o-anilino derivative with arylisothiocyanates yielded resi

130 with tin chloride, generated a resin-bound o-anilino derivative.

131 On the basis of an anilino diaryl sulfide screening lead 1, in combination

132 series of conformationally constrained ortho-anilino diaryl ureas.

133 aluated the antinociceptive activity of five anilino enaminones E139, ethyl 4-(4'-chlorophenyl)amino-

134 scovery and optimization of a series of 8-(1-anilino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxam

135 classes of agonists in which the bridgehead anilino group from our first series was replaced with an

136 Optimization of the C-4 anilino group of 1a led to 1c, which contains a 2,4-dich

137 The anilino group of the CDK2-bound compound was essentially

138 oelectronic effect involving twisting of the anilino group out of the plane of the benzene ring that

139 the nanoparticle chemically and contains an anilino group that is located on the end of the linker m

140 For the p38-bound inhibitor, the anilino group was angled out of plane and was positioned

141 with a bulky group at the 4'-position of the anilino group were shown to be competitive with both ATP

142 2-Anilino groups with small hydrophobic groups in the meta

143 in the 2, 4-diamino-5-methyl-6-[(substituted anilino)methyl]pyrido[2, 3-d]pyrimidine series generally

144 een 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyrido[2,3-d]pyrimidines 5-17 were synthe

145 yielded 2,4-diamino-6-bromo-5-[(substituted anilino)methyl]thieno[2,3-d]pyrimidines.

146 dependent rhodamine analogues possessing an anilino-methyl moiety was developed and shown to exhibit

147 2,4-Diamino-5-[3,5-dichloro-4-(1-pyrrolo)anilino]methyl]- 6-bromothieno[2,3-d]pyrimidine was the

148 rious substituents on the phenyl ring of the anilino moiety at the C-3 position of the 1,2,4-triazole

149 hydroxylation at C8), installation of the C1-anilino moiety by a regioselective Buchwald-Hartwig amin

150 light on substituent effects in the pendant anilino moiety of 4-anilinoquinazolines and 4-anilinoqui

151 Fluorescence binding assays with 1-anilino naphthalene-8-sulfonic acid (ANS) confirm that t

152 SVNLDVK were identified earlier as 1,1'-bi(4-anilino) naphthalene-5,5'-disulfonic acid (bis-ANS)-bind

153 rystallin chaperone interacts with 1,1'-bi(4-anilino) naphthalene-5,5'-disulphonic acid (bis-ANS) and

154 oup transformation gave 1,8-bis(3'-methyl-4'-anilino)naphthalene, 16, and 1,8-bis(4'-anilino)naphthal

155 l-4'-anilino)naphthalene, 16, and 1,8-bis(4'-anilino)naphthalene, 21, in 65% and 90% overall yield, r

156 mutant showed a 2-fold increase in 1,1'-bi(4-anilino)naphthalene-5,5'-disulfonic acid (bis-ANS) bindi

157 rporation of the hydrophobic probe 1,1'-bi(4-anilino)naphthalene-5,5'-disulfonic acid (bis-ANS) into

158 1,1'-Bis(4-anilino)naphthalene-5,5'-disulfonic acid binding, an ind

159 1,1'-Bis(4-anilino)naphthalene-5,5'-disulfonic acid cross-linking t

160 The 1,1'-bi(4-anilino)naphthalene-5,5'-disulfonic acid fluorescence in

161 However, 1,1'-bi(4-anilino)naphthalene-5,5'-disulfonic acid interaction ind

162 ATP hydrolysis was analyzed using 1,1'-bis(4-anilino)naphthalene-5,5'disulfonic acid (bisANS), a hydr

163 ic and static light scattering and 1,1-bis(4-anilino)naphthalene-5,5-disulfonic acid (bis-ANS) fluore

164 ission of acrylodan and 2-(4'-(iodoacetamido)anilino)naphthalene-6-sulfonic acid (IAANS) attached to

165 tive fluorescent probe, 2-(4'-(iodoacetamido)anilino)naphthalene-6-sulfonic acid (IAANS), to yield a

166 ents that showed IAANS (2-(4'-(iodoacetamido)anilino)naphthalene-6-sulfonic acid) coupled to Cys 35 c

167 the fluorescence probe, 2-((4'-iodoacetamido)anilino)naphthalene-6-sulfonic acid; and the labeled Pg

168 rescence of the hydrophobic probe 1,1'-bis(4-anilino)-naphthalene-5,5'-disulfonic acid.

169 methods (circular dichroism, aromatic and 8-anilino-naphthalene-1-sulfonic acid fluorescence, visibl

170 negligible binding of the hydrophobic dye 1-anilino-naphthalene-8-sulfonate (ANS) between pH 7 to 5.

171 on of a hydrophobic core as detected using 1-anilino-naphthalene-8-sulfonate fluorescence.

172 c pH levels, IEk binds the fluorescent dye 1-anilino-naphthalene-8-sulfonic acid (ANS), a probe for e

173 the fluorescent probe 2-[(4'-(iodoacetamido)anilino]naphthalene-6-sulfonic acid (IAANS) at Cys-35.

174 the fluorescent probe 2(-)[4'-(iodoacetamido)anilino]naphthalene-6-sulfonic acid.

175 evaluated using fluorescent probes 1,1'-bi(4-anilino)naphthalenesulfonic acid (bis-ANS), 8-anilino-1-

176 valuated using a fluorescent probe 1,1'-bi(4-anilino)naphthalenesulfonic acid (bis-ANS).

177 The peptides contained either the acetamido-anilino-naphthyl sulfonic acid (AANS), acrylodan, or dan

178 eptides was detected by measuring 1,1'-bis(4-anilino)napthalene-5,5'-disulfonic acid (bisANS) fluores

179 Hydrophilic substituents on the anilino nitrogen abolish agonist activity or produce ant

180 ant removal of the benzyl ether yields the o-anilino, o-phenolic polyaryls.

181 al database screening strategy has led to 7-[anilino(phenyl)methyl]-2-methyl-8-quinolinol (4, NSC 668

182 strong intramolecular hydrogen bonds between anilino protons and pyridyl and azo nitrogen atoms are r

183 recalculated with methyl groups in place of anilino protons, the barrier to isomerization disappears

184 lic ligand efficiency (LLE) in a series of 2-anilino-pyrimidine IGF-1R kinase inhibitors led to the i

185 Here, we describe the optimization of the 2-anilino quinazoline class as antimalarial agents.

186 Here, we show that BIBW2992, an anilino-quinazoline designed to irreversibly bind EGFR a

187 -donating groups at the para-position of the anilino ring enhance or maintain in vitro and in vivo ag

188 communicated that an ortho acyl group on the anilino ring enhanced oral absorption in this category o

189 itional substituent at the 6-position of the anilino ring further increases the potency of this serie

190 roduction of a meta hydroxyl group on the C4 anilino ring was computed to be particularly favorable.

191 is less electrophilic than the extended bis(anilino)squaraine analogue, but it is still susceptible

192 l encapsulation of fluorescent, deep-red bis(anilino)squaraine dyes inside Leigh-type tetralactam mac

193 In the closed form, the anilino substituent preferred equatorial orientation, wh

194 the two domains of the protein and with the anilino substituent projecting into a hydrophobic pocket

195 yrylium dyes were prepared with one or two 4-anilino substituents at the 2- and 6-positions and with

196 In an attempt to find optimal anilino substituents for pol IIIC binding and optimal 3-

197 nificant drawback of our original bridgehead anilino-substituted series.

198 The influence of 4-anilino substitution on pan-erbB inhibitory potency was

199 s on inhibitor potency by methylation of the anilino-triazole nitrogens, as well as the X-ray crystal