ライフサイエンスコーパス: animal study

1 mouse glioblastoma cell line and in a whole-animal study.

2 Experimental animal study.

3 Interventional controlled experimental animal study.

4 Randomized animal study.

5 Prospective randomized ex vivo animal study.

6 essed this issue with a large interventional animal study.

7 supported by a dedicated experimental large animal study.

8 s review is largely comprised of preclinical animal studies.

9 velopment, potentially reducing the need for animal studies.

10 ovide a suitable primary model for follow-up animal studies.

11 re tested under in vitro conditions prior to animal studies.

12 might potentially be a better candidate for animal studies.

13 licate the efficacy observed in pre-clinical animal studies.

14 s have shown promising results in orthotopic animal studies.

15 ort findings from previous observational and animal studies.

16 nitoring of tumor progression in preclinical animal studies.

17 microscopy, competitive binding assays, and animal studies.

18 0.8 V/m, the lower limit of effectiveness in animal studies.

19 comes has recently emerged from clinical and animal studies.

20 ed only after brain injury, causing edema in animal studies.

21 of experimental design and interpretation in animal studies.

22 issue inflammation and insulin resistance in animal studies.

23 and exceeding protective thresholds seen in animal studies.

24 onditioning and extinction in both human and animal studies.

25 its promising applications for live cell and animal studies.

26 g an experimentally tractable alternative to animal studies.

27 suggested to be embryotoxic and fetotoxic in animal studies.

28 in C-terminus are often used in cellular and animal studies.

29 l understood and rely mainly on experimental animal studies.

30 proven effective at reducing fat storage in animal studies.

31 ficant difference in their effect in post-MI animal studies.

32 there is a lack of supporting evidence from animal studies.

33 t host environments can be better modeled in animal studies.

34 o ensure reproducibility in experimental and animal studies.

35 facilitate comparability of future human and animal studies.

36 Minor publication bias was observed in small animal studies.

37 nd optimization of stimulation parameters in animal studies.

38 sphingolipid synthases prevented diabetes in animal studies.

39 SZ by gene association, postmortem brain and animal studies.

40 amplitude (p < 0.001), consistent with prior animal studies.

41 istries with the related outcome in cell and animal studies.

42 ational potential of findings in preclinical animal studies.

43 excitation (2PE) in tissue culture and whole-animal studies.

44 understanding disease mechanics are based on animal studies.

45 mia-reperfusion (IR) have been recognized in animal studies.

46 shown to cause depression-like phenotypes in animal studies.

47 a valuable framework for relating human and animal studies.

48 ack of cerebrocortical atrophy in the oldest animals studied.

49 Confirming previous animal studies, 1B6 was poor at reversing glycemia in a

50 l of 44 studies (three in vitro studies, two animal studies, 28 patient reports or patient series, an

51 the hemagglutinin stalk confer protection in animal studies(4-6).

52 When advanced to animal studies, 4 (V2a) significantly prevented acute mo

53 In both animals studied, across an unbiased sample of neurons, t

54 al research, both the sex and the age of the animals studied affect disease phenotypes by modifying t

55 The in vivo animal studies also showed that all the drug-loaded PLGA

56 Animal studies also suggest that hyperactivation of Src,

57 model of glioma.Materials and MethodsIn this animal study, anatomic MRI and dynamic (13)C MR spectros

58 Data from animal studies and a ring vaccination clinical trial con

59 However, animal studies and a study in immunocompromised children

60 s limited because it is derived largely from animal studies and analysis of human mononuclear phagocy

61 the quantification of pancreatic disease in animal studies and become a unifying quantification tool

62 lysis tools can further push the boundary of animal studies and bridge the gap with human studies, to

63 erception that fibrotic tissue is permanent, animal studies and clinical data now demonstrate the hig

64 za vaccine candidates are being evaluated in animal studies and clinical human trials.

65 cs shifted from one driven by discoveries in animal studies and clinical observations (eg, oestrogen,

66 on-a-Chip platform to bridge the gap between animal studies and clinical trials for the pharmaceutica

67 Biomedical research has relied on animal studies and conventional cell cultures for decade

68 Several EDC effects have been reported in animal studies and extrapolated to human studies.

69 xample, there is growing evidence, both from animal studies and from human neuroimaging, that activit

70 Larger animal studies and human studies are necessary to confir

71 Animal studies and human trials have evaluated strategie

72 en, MeDALL included mechanistic experimental animal studies and in vitro studies in humans.

73 Animal studies and nonpivotal trials were excluded.

74 has been found to improve sepsis outcomes in animal studies and one clinical study.

75 sphenol A (BPA) show reproductive effects in animal studies and potentially affect human ovulation, c

76 Animal studies and recent clinical research suggests tha

77 ults underline the importance of comparative animal studies and show that optimal models must be view

78 SEA have been shown to provide protection in animal studies and to reduce clinical severity in bacter

79 We excluded animal studies and trials in pediatric populations (age

80 plications ranging from single-cell to whole-animal studies and with live mapping of neuronal activit

81 lation in conditions of parental stress (one animal study and seven human studies) also reported incr

82 nociceptive processes (in line with previous animal studies); and the LC showing lateralized activity

83 associated with reduced histology damage in animal studies, and improvements in clinical remission i

84 ystem theory, including cross-modal studies, animal studies, and so forth.

85 view, we examine data from in vitro studies, animal studies, and the existing human sepsis studies in

86 Animal studies are a foundation for defining mechanisms

87 the pathophysiological literature, including animal studies, as well as experimental psychology and c

88 In animal studies, both seizures and interictal spikes indu

89 limus-coated balloons has been shown in few animal studies, but data from randomized clinical trials

90 -inflammatory functions in some clinical and animal studies, but the direct mechanism is not fully un

91 otect against Abeta toxicity in cellular and animal studies, but the molecular mechanism of this prot

92 ics has been employed in a growing number of animal studies, but the technique has yet to be widely u

93 Although animal studies can emulate the complexity of an organism

94 ng and executive functions, and (4) show how animal studies can reveal population and network phenome

95 In animal studies, central and blood borne inflammatory cyt

96 rious phenomena that are well established in animal studies: changes in local ionic concentration, ch

97 y 2015 under protocols approved by the local animal studies committee and institutional review board.

98 In animal studies, compared with the control diet, consumpt

99 there is conflicting evidence from human and animal studies concerning the effects of THC on the dopa

100 A prospective comparative case - control animal study conducted on 56 eyes of 28 healthy new born

101 of local recruitment.SIGNIFICANCE STATEMENT Animal studies consistently show marked changes in actio

102 Thus, these cell culture and whole animal studies demonstrate a role for the retrograde dyn

103 In vitro laboratory and animal studies demonstrate a synergistic role for the co

104 Clinical and animal studies demonstrate that alcohol intoxication at

105 Animal studies demonstrate that hyperactive neurons faci

106 Data from human and animal studies demonstrate that nutrition strongly affec

107 Animal studies demonstrate that this may be mediated by

108 In all cases, the large animal studies demonstrated improvement in conduction ve

109 Animal studies demonstrated that early postnatal ablatio

110 Animal studies demonstrated that the most potent cross-r

111 The xenograft animal study demonstrated MART-10 could effectively repr

112 arize data from a diverse array of human and animal studies demonstrating that the vmPFC is a key nod

113 In animal studies, dietary choline or TMAO significantly ac

114 While this animal study does not demonstrate any advantages for ear

115 bility of carbamoylguanidine-type ligands in animal studies elucidating the role of the H(2)R in the

116 Recently, the first animal studies emerged that present examples of early-li

117 If further animal studies establish that a marked reduction in B. m

118 However, these same animal studies failed to accurately predict many of the

119 Our pharmacological and transgenic animal studies find that reducing polyamines enhances co

120 Here we synthesize findings from human and animal studies focusing on sensitive periods and their r

121 continued basic science, translational, and animal studies for providing mechanisms to explain causa

122 However, our recent small animal studies found large numbers of recipient stem cel

123 common to see contradictions of outcomes in animal studies from different research groups, leading t

124 Within the limitations of this DM animal study, gaseous ozone application accelerates xeno

125 Animal studies have been excluded.

126 f TRAP on the cardiopulmonary system in most animal studies have been tested using acute exposure to

127 Animal studies have demonstrated beneficial effects of t

128 lstilbestrol (DES), for which both human and animal studies have demonstrated female reproductive tox

129 Animal studies have demonstrated that adolescent nicotin

130 Animal studies have demonstrated that catecholamines reg

131 Human and animal studies have demonstrated that helminth infection

132 In vitro and animal studies have demonstrated that topical applicatio

133 Although animal studies have demonstrated that WE thrombin acts a

134 Animal studies have demonstrated that ZIKV virus can inf

135 Whereas animal studies have demonstrated the importance of the l

136 ney and cardiovascular injury in humans, and animal studies have described a causative link.

137 Recently, several human and animal studies have emphasized the involvement of senesc

138 Several animal studies have emphasized the role of gut microbiot

139 No clinical or animal studies have evaluated mild carotid occlusion, an

140 Leveraging a large repertoire of techniques, animal studies have examined roles of specific cell type

141 estinal disorders (FGIDs), and independently animal studies have explored microbiome-driven mechanism

142 Recent in vitro and animal studies have found the proton pump inhibitor (PPI

143 Animal studies have further shown the importance of TREM

144 Animal studies have identified both neural and endocrine

145 Animal studies have identified therefore that e-cigarett

146 Animal studies have implicated glucocorticoid mechanisms

147 Although both human and animal studies have implicated striatal D(2)-like and D(

148 icacy results from both in-vitro and in-vivo animal studies have led to their steady progression thro

149 Animal studies have provided compelling evidence demonst

150 Animal studies have provided targets for interventions t

151 Comparative animal studies have revealed the existence of inter-grou

152 Nonhuman animal studies have robustly demonstrated that mothers p

153 patients with differing outcomes and use of animal studies have shed some light on this issue, but m

154 Previous histopathologic and animal studies have shown axonal impairment and loss of

155 G toxicity have not been published, however, animal studies have shown FG or Geniposide can cause hep

156 Multiple animal studies have shown PBDEs to be thyroid hormone (T

157 Animal studies have shown that a high intake of galactos

158 Preclinical animal studies have shown that choline, which is an esse

159 e past several years, a variety of human and animal studies have shown that circadian clocks regulate

160 Although animal studies have shown that exposure to glyphosate (a

161 Previous animal studies have shown that knockout of the serotonin

162 In vivo animal studies have shown that MWCNT cause biomechanical

163 Animal studies have shown that the striatal cholinergic

164 While animal studies have suggested causal involvement of the

165 Animal studies have suggested that transient receptor po

166 In vitro and animal studies have suggested that trazodone, a licensed

167 of the post-translational modifications, and animal studies have suggested the involvement of IgG gly

168 in support of immune-escape mechanisms into animal studies, human laboratory studies, and human clin

169 im of making remaining material derived from animal studies in biomedical research more visible and a

170 preclinical cell culture methods and in vivo animal studies in the near term, and in some cases repla

171 s orchestrate such timing as demonstrated by animal studies in vitro [3, 4] and in vivo [5, 6], sugge

172 s appear to be borne out in both patient and animal studies in which expiration is terminated before

173 threshold values have been obtained through animal studies in which nickel was dosed at 100% accessi

174 enesis score of 19.8 +/- 3.8 obtained in the animal studies indicate a proper wound healing.

175 Both human and animal studies indicate a role for ANP as a regulator of

176 Recent data from animal studies indicate that anthracyclines cause cardia

177 Animal studies indicate that early life vitamin D is cru

178 However, emerging evidence from human and animal studies indicate that insulin influences cerebral

179 However, animal studies indicate that PAG analgesia is mediated l

180 Animal studies indicate that the kappa-opioid receptor/d

181 Our animal study indicated that 33% of vaccinated mice remai

182 6 levels: in vitro characterization, in vivo animal studies, initial human studies, impact on clinica

183 translatability of findings from preclinical animal studies into the clinic.

184 ue in depth by conducting a meta-analysis of animal studies investigating the efficacy of the clinica

185 Integrated information from human and animal studies is beginning to expand insights regarding

186 , evidence from recent human and preclinical animal studies is reviewed, indicating that SPMs are phy

187 The aim of this animal study is to analyze bone remodeling around platfo

188 In contrast to data from animal studies, leptin treatment does not affect energy

189 and control patients confirmed results from animal studies (mean CNR for NASH vs control patients, 2

190 risk factor for hearing impairment, and, in animal studies, molecular evidence suggests a role for I

191 To make animal studies more relevant to human health, research a

192 is characteristic in humans, relying also on animal studies of analogous skills.

193 Some animal studies of auditory cortical processing have sugg

194 in rats, and 89% of human studies and 70% of animal studies of early-life adversity reported increase

195 We assess animal studies of genetic and environmental models for N

196 trophil accumulation across murine and large animal studies of influenza infection.

197 Systematic consideration of experimental animal studies of oral biphenyl exposure took into accou

198 As a scientific case study, preclinical animal studies of these nutrients definitively influence

199 ctively demonstrated in a longitudinal (same-animal) study of rapidly-changing phenomena such as ultr

200 ten less morphologically conspicuous than in animals, studies of sex-biased gene expression may provi

201 Despite the extensive animal studies on how amblyopia emerges, we know surpris

202 cupational and accidental exposure, only few animal studies on the genotoxic effects of chronic LDR r

203 rity, thereby providing clinical validity to animal studies on the role of platelets in severe infect

204 as Transwells) represents an alternative to animal studies or use of colon cancer-derived cell lines

205 Animal studies provide evidence that these functions are

206 Although animal studies provided significant insights in understa

207 Here we review human and animal studies published to date and summarize the cardi

208 Some animal studies raise the possibility that a subcortical

209 number of clinical reports and some critical animal studies regarding pre-existing and treatment-indu

210 However, the sample size necessary for animal studies requires increased sample preparation and

211 Our observations derived from animal studies resembling conditions in diabetic patient

212 Animal studies reveal networks of microvessels linking b

213 In vivo animal studies reveal that protoporphyrin IX fluorescenc

214 Animal studies reveal that the cancer-induced bone pheno

215 ologies are becoming clearer, several recent animal studies revealed that short-term administration o

216 Previous animal studies revealed that vaccination with siderophor

217 Animal study revealed that TTT-28 enhanced the intratumo

218 entally relevant levels of DE-71, additional animal studies should be conducted that further characte

219 Epidemiological and animal studies show that deleterious maternal environmen

220 mitochondrial function.IMPORTANCE Human and animal studies show that HIV infection, combined with th

221 Animal studies showed COL13A1, a synaptic extracellular-

222 Recent animal studies showed physiologically tight disynaptic c

223 In contrast with clinical results, animal studies showed significantly increased survival i

224 Based on animal studies showing a role of complement in APS-relat

225 These observations were confirmed by in vivo animal studies showing preferential recruitment of APCs

226 These results are consistent with those from animal studies showing that exposure to PBDEs is associa

227 In animal studies, sirtuin 1 (SIRT1) was associated with pr

228 In nearly all animals studied so far, the circadian system has been im

229 ntrol gene for eye development in all seeing animals studied so far.

230 Animal studies suggest an anti-fibrillatory action of th

231 Animal studies suggest that Abeta and tau lead to blood

232 Human epidemiological and animal studies suggest that developmental exposure to co

233 Animal studies suggest that exposure to artificial sweet

234 Evidence from recent animal studies suggest that minocycline, a broad-spectru

235 Animal studies suggest that one strategy for treating Al

236 Animal studies suggest that pancreatitis-induced acinar-

237 Previous human and animal studies suggest that patients with a susceptible

238 Animal studies suggest that retinal dopamine deficiency

239 Clinical and animal studies suggest that sleep disturbance is signifi

240 well as propagation phase, and insights from animal studies suggest that targeting the IL-1 pathway c

241 Animal studies suggest that the alERC may support the sp

242 Animal studies suggest that the ECS stimulates the senso

243 Recent animal studies suggest that the pedunculopontine nucleus

244 Animal studies suggest that these differences are in par

245 Animal studies suggest that while neutralizing antibodie

246 Animal studies suggest the anti-fibrillatory effect may

247 Animal studies suggest vital roles of sphingolipids, esp

248 D, recent evidence from human postmortem and animal studies suggests a selective vulnerability of GAB

249 Evidence from animal studies suggests maternal caffeine intake during

250 Evidence from animal studies suggests that exposure to organophosphate

251 Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related

252 This, along with results in animal studies, suggests that RFFL may have effects on c

253 Animal studies support the hypothesis that in slow-wave

254 The results of in vitro and in vivo animal studies support the observations made in phase II

255 Both human and animal studies support the relationship between depressi

256 Most preclinical animal studies test influenza vaccines in immunologicall

257 traditional 2D cell cultures and preclinical animal studies that have historically been the standard

258 Despite numerous animal studies that have illustrated the impact of addit

259 fe exposure to these compounds and summarize animal studies that help explain human correlative data.

260 everal decades have seen a surge in nonhuman animal studies that inform us about human spoken languag

261 oral, and electrophysiological findings from animal studies that provide a new understanding on how M

262 or these cell therapy trials is derived from animal studies that show a modest but reproducible impro

263 or the theory is largely drawn from nonhuman animal studies that use invasive pharmacological or elec

264 ustry did not disclose evidence of harm from animal studies that would have (1) strengthened the case

265 In confirmatory animal studies, the protective effect of [Nle(4), D-Phe(

266 Through human genetic and animal studies, there are now hundreds of known genetic

267 In cell culture and animal studies, these effects alter the expression of en

268 ghlighting the differences between human and animal studies throughout.

269 tter comparison of results from in vitro and animal studies to accelerate progress.

270 o moving vaccine candidates from preclinical animal studies to clinical trials.

271 Most animal studies to date have injected viral suspensions i

272 es and mood, emotion, cognition, and memory; animal studies to determine epigenetic changes that repr

273 This review coalesces human and animal studies to link PAG neuropathways to specific ele

274 take this into account when designing large animal studies to most closely mimic the clinical course

275 of microbial-immune wiring while focusing on animal studies to probe a prioritized subset of interact

276 d best practice in the design and conduct of animal studies to support researchers in improving stand

277 regarding the generalizability of controlled animal studies to the more multifaceted pattern of human

278 All animals studied to date are associated with symbiotic co

279 ss of ADARs affects neuronal function in all animals studied to date.

280 Animal studies using chronic social defeat stress (CSDS)

281 Animal studies using mice carrying orthotopic breast MDA

282 improves absorption of calcium; however, in animal studies vitamin D also increases the absorption o

283 In agreement with anatomical data from animal studies, we found evidence for somatosensory and

284 Consistent with animal studies, we found that in human BCa bone metastat

285 In animal studies, we found that the SaeR-binding mutation

286 Motivated by results from animal studies, we hypothesized higher than expected rat

287 In contrast to previous animal studies, we relied on blind analytical procedures

288 Non-VCA studies and animal studies were excluded.

289 Animal studies were included only to support pertinent d

290 Materials and Methods Animal studies were performed according to institutional

291 Two main aims of this animal study were to inspect the possible effects of per

292 For reconfirming the findings of the animal studies when administering 1 to healthy human vol

293 ce for such "metagenomic" effects comes from animal studies, where the socio-genetic environment can

294 here is often a disconnect between human and animal studies, which hampers translation of microbiome

295 for validation of mechanistic insights from animal studies while also allowing new discovery.

296 ses cell proliferation, both in-vitro and in animal studies, while also demonstrates additive efficac

297 rting this hypothesis from human imaging and animal studies will be discussed, and combinatorial drug

298 significance, and pathobiology derived from animal studies will likely provide precision therapies t

299 a promise as a myelin biomarker in human and animal studies with a particular advantage of sensitivit

300 ive stress and angiogenesis, are reported in animal studies with nicotine-containing devices.