ライフサイエンスコーパス: anion exchanger

1 ed between the same anion and the lipophilic anion exchanger.

2 cation exchanger and the other containing an anion exchanger.

3 rnary ammonium groups to form a "tentacular" anion exchanger.

4 as well as the surface delivery of the AE1-4 anion exchanger.

5 ssigned to the cytoplasmic surface of native anion exchanger.

6 to the cytoplasmic domain of band 3, the RBC anion exchanger.

7 r induce a cation leak in a still functional anion exchanger.

8 ncentrated on a narrow bore (2 mm) aliphatic anion exchanger.

9 minantly by CFTR or by an electrogenic SLC26 anion exchanger.

10 lectrogenic NBCs and 33-43% identical to the anion exchangers.

11 solute carrier family 26 member A6 (SLC26A6) anion exchangers.

12 detergent insolubility by newly synthesized anion exchangers.

13 amics remain underexplored compared to other anion exchangers.

14 y extracted from aqueous solutions by liquid anion exchangers.

15 be important in other cell types expressing anion exchangers.

16 ly of bicarbonate transporters that includes anion exchangers.

17 extraction of synthetic dyes using a liquid anion exchanger (0.01 M solution of trioctylmethylammoni

18 lls that express the H(+)-ATPase but not the anion exchanger 1 (AE1) and that are thought to mediate

19 Anion Exchanger 1 (AE1) is an elevator-type transporter

20 Anion exchanger 1 (AE1) is responsible for the exchange

21 Anion exchanger 1 (AE1) mediates Cl(-)/HCO3(-) exchange

22 The anion exchanger 1 (AE1), a member of bicarbonate transpo

23 Anion exchanger 1 (AE1), also known as band 3 or SLC4A1,

24 ainst the carboxy-terminal 12 amino acids of anion exchanger 1 (AE1), revealed a distribution of immu

25 reaction inside red blood cells, and band 3 [anion exchanger 1 (AE1)] provides a passage for HCO3(-)

26 Anion exchanger 1 (AE1; Band 3; SLC4A1) is the founding

27 mutation is in a gene (slc4a1) encoding the anion exchanger 1 (also called band 3 and AE1), an eryth

28 cytoplasmic domain of the human erythrocyte anion exchanger 1 (cdAE1) serves as a center of organiza

29 to a major interacting loop of the erythroid anion exchanger 1 (eAE1) with ankyrin-R, whereas the mai

30 3)(-) ions is catalyzed by human erythrocyte anion exchanger 1 (hAE1) through a ping-pong mechanism w

31 ied mammalian transporters such as the human Anion Exchanger 1 (hAE1).

32 the bicarbonate/chloride transporter kidney anion exchanger 1 (kAE1), detected by yeast two-hybrid a

33 ia cells were transfected with human band 3 (anion exchanger 1 [AE1]) cDNA, using the pBabe retrovira

34 facing structures of two SLC4 members (human anion exchanger 1 [hAE1] and human electrogenic sodium b

35 in putative transmembrane domain 8 (TMD8) of anion exchanger 1 are involved in ion translocation, and

36 The renal ammonium transporter RhBG and anion exchanger 1 kAE1 colocalize in the basolateral dom

37 s (caused by a 27- base pair deletion in the anion exchanger 1 protein gene) and protection from cere

38 NBCe1-A-TM1 was previously modeled on the anion exchanger 1 TM1 (AE1-TM1); however, our data demon

39 genes encoding carbonic anhydrase II, kidney anion exchanger 1, and different subunits of the H+-ATPa

40 ribe a mutation in human erythrocyte band 3 (anion exchanger 1; SLC4A1) causing both hereditary spher

41 Anion exchanger-1 (AE1) mediates chloride-bicarbonate ex

42 Expression of the acid-loading transporter anion exchanger 2 (AE2) (SLC4A2 product) was detected in

43 Cl(-) /HCO3- anion exchanger 2 (AE2) participates in intracellular pH

44 odium bicarbonate co-transporter (NBCe1) and anion exchanger 2 (AE2) that are both components of the

45 equate expression of the key HCO3- exporter, anion exchanger 2 (AE2), and (3) an intact cholangiocyte

46 Anion exchanger 2 (AE2), the principal bicarbonate secre

47 To regulate pH, ameloblasts express anion exchanger 2 (Ae2a,b), chloride channel Cftr, and a

48 e conductance regulator/chloride bicarbonate anion exchanger 2 (cAMP-->CFTR-->Cl(-) /HCO 3- AE2) sign

49 ane regulator (CFTR), Cl(-) /HCO3 (-) (apex) anion exchanger 2 (Cl(-) /HCO3 (-) AE2), and adenylyl cy

50 sis transmembrane regulator, Cl(-)/HCO(3)(-) anion exchanger 2 and AC8, and responded to secretin.

51 sis transmembrane conductance regulator, and anion exchanger 2.

52 of the basolateral Cl(-) /HCO3(-) exchanger (anion exchanger 2; AE2).

53 Ameloblasts were immunostained for anion exchanger-2 (Ae2), a transmembrane pH regulator se

54 ranching ducts of cholangiocytes (expressing anion exchanger-2-AE2 and CFTR), or regulatable C-peptid

55 Anion exchanger 3 (AE3) is pivotal in regulating intrace

56 presence of the basolateral ion transporter anion exchanger 4.

57 ave indicated that the variant chicken AE1-4 anion exchanger accumulates in the basolateral membrane

58 Chloride uptake by basolateral anion exchanger activity (AE2) supports intracellular cA

59 Anion exchanger activity was also significantly reduced

60 ith activation of a DIDS-sensitive Cl--HCO3- anion exchanger (AE) to produce HCO3- efflux, and a DIDS

61 Anion exchanger (AE), sodium bicarbonate cotransporter (

62 Na(+)-K(+)-2Cl(-) cotransporters (NKCC1) and anion exchangers (AE), the 2 primary basolateral Cl(-) u

63 Human red cell anion exchanger AE1 (band 3) is an electroneutral Cl-HCO

64 ase II (CA II) binds to the C termini of the anion exchanger AE1 and the electrogenic Na/HCO3 cotrans

65 tif (D887ADD) in the carboxy-terminus of the anion exchanger AE1 binds to carbonic anhydrase II (CAII

66 We recently found that band 3 (the anion exchanger AE1) was present in the apical membrane

67 aemoglobin-binding cytoplasmic domain of the anion exchanger AE1.

68 tin, increased and redistributed basolateral anion exchanger AE1/2 protein, and redistributed Na-tran

69 H(+) secretion is removed by the basolateral anion-exchanger AE1.

70 used to detect immunoreactivity against the anion exchanger (AE1 or AE2).

71 an alternately spliced form of the erythroid anion exchanger (AE1, band 3), but unlike band 3 it does

72 amino acid sequence 30-35% identical to the anion exchangers (AE1-3), a superfamily of HCO3- transpo

73 sket" model for transport in the erythrocyte anion exchanger, AE1.

74 tramembrane domain of the erythrocyte band 3 anion exchanger, AE1.

75 nel AQP1, the chloride channel CFTR, and the anion exchanger AE2) that account for ion-driven water t

76 Anion exchanger AE2, CAII, and CAIV were abundant in the

77 chimeras between AE1 and the closely related anion exchanger AE2, which does not bind ankyrin, we hav

78 any change in mRNA and protein levels of the anion exchanger Ae2.

79 The mouse anion exchanger AE2/SLC4A2 Cl(-)/HCO(-)(3) exchanger is

80 posing HCO(3) (-) efflux via the basolateral anion exchanger AE2; and (3) inhibits NaCl reabsorption

81 ino acids, is 34% identical to the mammalian anion exchanger (AE2); approximately 50% to the electrog

82 n the cytoplasmic domain of the nonerythroid anion exchanger, AE2, that serves as an intracellular pH

83 ate cotransporter Nbce1, and the basolateral anion exchanger Ae2a,b in maturation ameloblasts suggest

84 ABSTRACT: The anion exchanger AE3, expressed in hippocampal (HC) neuro

85 The anion exchanger AE3, expressed in hippocampal (HC) neuro

86 as suggested that CA4 acts in a complex with anion exchangers (AEs) to facilitate Cl(-)-HCO(3)(-) exc

87 via a pathway that requires participation of anion exchangers (AEs).

88 capillaries were coated with 65-nm-diameter anion exchanger (AEX) latex nanoparticles that attach el

89 ing TM3-5 and TM8 that should function as an anion exchanger and a cation leak.

90 n adsorbed layer of quaternary ammonium type anion exchanger and a phenolic azo type proton chromoion

91 teractions of the repeats with the Cl/HCO(3) anion exchanger and clathrin.

92 is mediated by the downregulated in adenoma anion exchanger and is stimulated by estrogens.

93 is distinct from the erythrocyte band-3 type anion exchanger and may belong to the monocarboxylate-ty

94 raction between the two major domains of the anion exchanger and suggest a novel substrate feedback m

95 ng assay to quantify the binding affinity of anion exchangers and a recombinant fragment of ANK1, R13

96 can also recognize the cytoplasmic tails of anion exchangers and aquaporins.

97 ites are used in technology as catalysts and anion exchangers and are important sinks for environment

98 mology and predicted topology similar to the anion exchangers and NBCs.

99 ructurally homologous transporters including anion exchangers and prestin.

100 ligomeric state of two SLC26 multifunctional anion exchangers and to determine the oligomeric state o

101 nt pool of ankyrin is complexed with the AE1 anion exchanger, and the solubility properties of this p

102 study examined whether rat Oatp2 is also an anion exchanger, and, if so, whether it is energized by

103 + mature B-cells bound with high affinity to anion exchangers, and eluted as an intact trimeric compl

104 wise conferred high affinity NF-Y binding to anion exchangers, and stabilized NF-Y interaction with C

105 adical polymerization, derivatized as strong anion exchangers, and used for lipoproteins enrichment.

106 In addition to plasma membrane staining, anion exchanger antibodies stain a perinuclear compartme

107 After delivery to the plasma membrane, anion exchangers are internalized and recycled to the Go

108 This result suggests that AE2 anion exchangers are involved in the regulation of intra

109 s, suggest that ion transporters such as the anion exchanger associate in a large central cavity form

110 front separation is performed over a strong anion exchanger at pH 7.5.

111 allowed to reach confluence, it located the anion exchanger band 3 in the apical membrane and an H+-

112 the skate homolog of the mammalian red cell anion exchanger band 3.

113 ecognizes an ectodomain of human erythrocyte anion-exchanger, band 3/AE1, as a host receptor.

114 Furthermore, AE1 anion exchangers become detergent insoluble more rapidly

115 During recycling, some of the anion exchangers become detergent insoluble.

116 ities of apical proton pumps and basolateral anion exchangers, both of which interact with spectrin.

117 , nonmammalian prestin orthologs function as anion exchangers but are apparently nonmotile.

118 e cell-free extract was also retained by the anion exchanger, but was removed with repeated washing w

119 n added to quaternary alkylammonium chloride anion exchangers, but with a striking dependence on the

120 of compounds, traditionally considered to be anion exchangers, can also be considered cation exchange

121 Furthermore, the apical anion exchanger cannot be stained by antibodies that rea

122 in the isolation of two chicken stomach AE2 anion exchanger cDNAs, AE2-1 and AE2-2.

123 Na-H exchanger NHE3 and Cl-anion exchanger CFEX (SLC26A6, PAT1) play principal role

124 for the normal expression and function of Cl-anion exchanger CFEX in the proximal tubule of the mamma

125 SLC26 proteins function as anion exchangers, channels, and sensors.

126 o its effects on the human intestinal apical anion exchanger Cl(-)/OH- (HCO3-).

127 chanism of isocratic CEC for proteins on the anion-exchanger column was illustrated by the results of

128 By providing an efflux pathway for base, anion exchangers constitute a key component of the plasm

129 The association of ankyrin with the AE1 anion exchanger contributes an essential function to the

130 oration of [125I]iodine into this residue in anion exchanger could be monitored.

131 ted by mice lacking NKCC1 is associated with anion exchanger-dependent Cl(-) uptake.

132 The variant chicken kidney AE1 anion exchangers differ only at the NH(2) terminus of th

133 e report the crystal structure of the band 3 anion exchanger domain (AE1(CTD)) at 3.5 angstroms.

134 e plasma membrane expression of major apical anion exchanger DRA (SLC26A3) was considerably reduced i

135 rget genes include the Na/K-ATPase, Na/H and anion exchangers, E-cadherin, and mineralocorticoid rece

136 For anion exchangers, EOF is reversed.

137 Pendrin (SLC26A4) is a Cl(-)/anion exchanger expressed in the epithelium of inflamed

138 SLC26A6 is an anion exchanger expressed on the apical membrane in many

139 namics and functional specificity within the anion exchanger family, enhancing our understanding of t

140 physiological and pathological roles of the anion exchanger family.

141 dy, we used nonporous and monolithic polymer anion exchangers for purification and demonstrated a met

142 transporter (NBC), we found that NBC and the anion exchangers form a bicarbonate transporter superfam

143 lar mass approximately 40kDa) of band 3, the anion exchanger from human erythrocyte membranes, previo

144 roximately 135 kDa that is homologous to AE2 anion exchangers from other species.

145 de YIVGR, which contains tyrosine 486 of the anion exchanger, from the products of the digestion.

146 ked with 5-microm silica beads having strong anion-exchanger functions attached to hydrophilic spacer

147 oplasmic tail derived from the chicken AE1-4 anion exchanger (G(AE)).

148 rat IMCD cells expresses two members of the anion exchanger gene family, AE1 and AE2, and both of th

149 minated by selective inactivation of the AE1 anion exchanger gene, thus allowing us to study the effe

150 ma membrane of aspartate 821 in erythrocytic anion exchanger has been determined by labeling inside-o

151 injection (FI) system with a microcolumn of anion exchanger has been used to effect rapid on-line se

152 ncoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel

153 Mice null for the AE2 anion exchanger have abnormal enamel.

154 itors, protein purification or homology with anion exchangers, have so far been unsuccessful.

155 f [35S]sulfanilic acid into aspartate 821 of anion exchanger in erythrocytes when the two preparation

156 f [35S]sulfanilic acid into aspartate 821 of anion exchanger in inside-out vesicles was at least 10-f

157 The AE2 anion exchanger in pig and rabbit gastric mucosal membra

158 Cl-/HCO3- exchange mediated by the AE1 anion exchanger in the basolateral membrane of type A in

159 Similar effects were observed with the anion exchanger inhibitor 4,4' -diisothiocyanatodihydros

160 The demonstration that erythroid anion exchangers interact with elements of the cytoskele

161 e-spanning domain convert the electroneutral anion exchanger into a Na(+) and K(+) conductance or ind

162 he substitutions convert the protein from an anion exchanger into an unregulated cation channel.

163 /HCO3- exchange activity mediated by the AE1 anion exchanger is reduced by carbonic anhydrase II (CA2

164 Physiological activity of an apical anion exchanger is weak in cultured BCECs.

165 The recycling pool of newly synthesized anion exchangers is reflected in the steady-state distri

166 two hydrophobic segments in the sequence of anion exchanger, is located on the cytoplasmic surface o

167 ess with characteristics consistent with the anion exchanger isoform AE2.

168 on the oligomeric states of the AE1 (band 3) anion exchanger, little is known about the physiological

169 for the actin cytoskeleton in regulating AE1 anion exchanger localization and stability in this epith

170 was based on the isolation of FPP using the anion exchanger Macro Prep High Q and conversion of FPP

171 sporters, the Cl(-)/HCO(3)(-) exchanger (AE [anion exchanger], mainly AE1, AE2, and AE3) and Slc26a6

172 deletion in mice of solute carrier family 4 anion exchanger member 2 (Slc4a2) results in osteopetros

173 f oocytes with the solute carrier family 26 (anion exchanger)-member 9 (SLC26A9) cRNA, promoted WNK4

174 chloride exchanger, solute carrier family 4, anion exchanger, member 2 (SLC4A2), is up-regulated duri

175 Use of an anion-exchanger membrane doped with the tetraalkylphosph

176 mpatible and nonpolarizable Donnan exclusion anion-exchanger membrane reference/counter electrode.

177 on-selective electrodes (ISEs) with fluorous anion-exchanger membranes for the potentiometric detecti

178 71% to mouse NCBE; and 47% to a Na(+)-driven anion exchanger (NDAE1) from Drosophila.

179 ur functional data suggest this Na(+) driven anion exchanger (NDAE1) is responsible for the Na(+)-dep

180 he cytoskeletal association of the recycling anion exchangers occurs after release from the compartme

181 More dramatically, the anion exchanger of a clonal cell line of intercalated ce

182 lasma membrane of tyrosine 486 in the native anion exchanger of human erythrocytes has been determine

183 The widely expressed anion exchanger polypeptide AE2/SLC4A2 is acutely inhibi

184 ing technique was used to immunolocalize AE2 anion exchanger polypeptide to basolateral plasma membra

185 e inhibitory effects of ammonium chloride on anion exchanger processing are rapidly reversible.

186 The anion exchanger protein 1 (AE1; band 3) is an abundant e

187 Targeted mutagenesis of the anion exchanger protein band 3 in mice has demonstrated

188 minant red blood cell (RBC) autoantigen, the anion exchanger protein Band 3, to the development of NZ

189 column composed of a quinine carbamate weak anion exchanger (QN-AX) and a zwitterionic chiral ion-ex

190 Chicken erythroid AE1 anion exchangers receive endoglycosidase F (endo F)-sens

191 Normal pH sensitivity of the SLC4A2/AE2 anion exchanger requires transmembrane domain (TMD) amin

192 As a strategy to identify one or more anion exchangers responsible for mediating Cl(-) reabsor

193 OH(-), membranes containing the alternative anion exchanger (Rf6(CH2)3)3PN(+)P((CH2)3Rf6)3 with a bi

194 As an anion exchanger, RFC couples the import of folates and a

195 activated chloride channel, TMEM16A, and the anion exchanger, SLC26A4, have been proposed as targets

196 We conclude that the anion exchanger SLC26A6 has a major constitutive role in

197 Band 3 (also known as the anion exchanger, SLCA1, AE1) constitutes the major attac

198 It follows that the polypeptide of anion exchanger spans the membrane three times before it

199 These values are greater than current anion exchangers such as the resins Amberlite IRA-400 (2

200 ic for Na+/HCO3- cotransporters, but not for anion exchangers, suggesting that the sea urchin protein

201 of transporters, rat Oatp1, functions as an anion exchanger that is driven in part by the glutathion

202 Pendrin (SLC26A4) is an anion exchanger that mediates bicarbonate (HCO(3)(-)) ex

203 n integral membrane protein and facilitative anion exchanger that mediates delivery of 5-methyltetrah

204 Erythroid band 3 (AE1) is one of three anion exchangers that are encoded by separate genes.

205 e carrier (Slc) family 26A encodes different anion exchangers that exchange Cl(-)/HCO3 (-), including

206 These variant transcripts encode AE1 anion exchangers that possess alternative N-terminal cyt

207 pid fraction, employing an organic polymeric anion exchanger through the enrichment of lipoproteins/p

208 However, both channels can couple to SLC26A4 anion exchanger to maximise bicarbonate secretion.

209 oride uptake and bicarbonate extrusion by an anion exchanger to provide Cl(-) permissive for apical a

210 whereas the trafficking of a Cl(-)/HCO(3)(-) anion exchanger to the plasma membrane is not altered in

211 by adding a calculated amount of lipophilic anion exchanger to the polymer film.

212 ions into a polymeric film that contains the anion exchanger tridodecylmethylammonium chloride, a lip

213 f interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin

214 trifugation, the modified polypeptide of the anion exchanger was isolated from each sample and digest

215 rt of a protein that is related to the known anion exchangers was identified in the GenBankTM express

216 gp330, aquaporin-2, H+ ATPase, and the AE1 anion exchanger were all relocated into numerous vesicle

217 ion exchangers and strong base and weak base anion exchangers were evaluated as stationary phases for

218 sporters, apart from Cl- -HCO3- exchangers ('anion exchangers'), whose complementary DNAs were cloned

219 ility correlates with the association of the anion exchanger with cytoskeletal ankyrin.

220 RFC1 is an anion exchanger with seven conserved positively charged

221 oproteins are enriched by the interaction of anion exchanger with the phosphate groups and eluted at