ライフサイエンスコーパス: anion transport

1 ) preserve nonlinear capacitance, yet negate anion transport.

2 hat it may regulate subunit interactions and anion transport.

3 suggested that K370 is important for organic anion transport.

4 that this amino acid is required for organic anion transport.

5 el gating to restore 30-50% of CFTR-mediated anion transport.

6 cal insight into the evolution of epithelial anion transport.

7 IL-1 beta post-translational processing and anion transport.

8 rged polymer matrix, which facilitates rapid anion transport.

9 thermodynamic and kinetic information about anion transport.

10 (CF), a genetic illness caused by deficient anion transport.

11 lecular architecture, sensing, catalysis and anion transport.

12 , and the cellular physiology of glucose and anion transport.

13 other disorders of sulfur metabolism and/or anion transport.

14 e domain of AE1 (mdAE1) efficiently mediated anion transport.

15 tiport agent for lipid bilayer transmembrane anion transport.

16 xamples of [2]catenanes capable of selective anion transport across a lipid bilayer are reported.

17 Anion binding in solution and anion transport across lipid bilayers are found to incre

18 cent advances in anion binding catalysis and anion transport across phospholipid membranes speak to t

19 CFTR mediates regulated anion transport across the apical membrane of epithelial

20 Toward photocontrol of anion transport across the bilayer membrane, stiff-stilb

21 sport plays a major role in blood-to-aqueous anion transport across the ciliary body epithelium.

22 Our results suggest that anion transport across the vacuolar membrane in plant ce

23 However, anions transport across polycation clusters is amplified

24 6 nm in helical height, exhibits the highest anion-transport activities for iodide (EC(50) =0.042 mum

25 in A (GPA) enhances the expression of band 3 anion transport activity at the cell surface of Xenopus

26 ellular residues 68-70 increase the specific anion transport activity of band 3.

27 P4.2 deficiency does not affect band 3 anion transport activity, since uptake of radiolabeled s

28 r efficient supramolecular assembly and high anion transport activity.

29 ffect on growth suppression, indicating that anion transport and growth suppression are independent f

30 TR at least partially restored CFTR-mediated anion transport and improved the intestinal phenotype.

31 hing allows for switching between ON and OFF anion transport and is crucially achieved with biomimeti

32 onductance regulator (CFTR), which regulates anion transport and mucociliary clearance in the airways

33 nsights advance our understanding of organic anion transport and provide a foundation for designing i

34 s expressed in the same tissue in epithelial anion transport and suggest that transport specificity i

35 egulation of membrane-skeletal interactions, anion transport and the invasion and growth of malaria p

36 ological processes, including pH regulation, anion transport and water balance.

37 omplex from the membrane, (ii) inhibition of anion transport, and (iii) rupture of the band 3-ankyrin

38 mics, fluorescence changes, organocatalysis, anion transport, and halogen bonding.

39 carboxylic acid metabolic processes, organic anion transport, and organic acid transport.

40 Band 3 and band 3-mediated anion transport are decreased.

41 Since increased aged band 3 and decreased anion transport are initial steps in band 3 aging, which

42 ateral and canalicular bile acid and organic anion transport are markedly impaired in endotoxemia.

43 and the relationship between fatty acids and anion transport are unknown.

44 eal/bronchial epithelia and point to loss of anion transport as key to airway epithelial dysfunction

45 Vesicle anion transport assays using ion-selective electrodes sh

46 Anion transport assays were used to determine the mechan

47 l and optopharmacological tools for studying anion transport-associated diseases and to stimulate neu

48 atory cytokine secretion caused by defective anion transport at the apical membrane may contribute to

49 P and MRP transporters in organic cation and anion transport at the blood-cerebrospinal fluid interfa

50 ion of intrinsic anion binding affinities to anion transport behaviour, and demonstrates the key role

51 a2+ was held constant and was blocked by the anion transport blockers, DIDS and niflumic acid.

52 sarcoplasmic reticulum and are inhibited by anion transport blockers; however, the unitary single ch

53 revented the observed age-related decline in anion transport by lymphocytes and the generation of age

54 rst demonstration that regulation of organic anion transport by mOAT is likely to be tightly controll

55 Advances in anion transport by synthetic supramolecular systems are

56 Anion transport by the colonic mucosa maintains the hydr

57 Anion transport by the human sodium-iodide symporter (hN

58 ysts secreted sulfonefluorescein, an organic anion transported by the PAH system.

59 manifested by a substantial loss of organic anion transport capacity in kidney and CP was identified

60 it is proposed that eosin is located in the anion transport channel such that it is accessible from

61 on receptors can be applied such as sensing, anion transport, control of molecular motion and gelatio

62 This key segregation of cation and anion transport could explain the extraordinary fluid tr

63 ular basis and physiological implications of anion transport during pollen tube (PT) growth in Arabid

64 out mice manifest a profound loss of organic anion transport (e.g. para-aminohippurate) both ex vivo

65 CNTPs block anion transport, even at salinities that exceed seawater

66 Anion transport experiments in POPC-based large unilamel

67 cient off-on activation profiles observed in anion transport experiments in vesicles.

68 gs underscore the importance of H(+)-coupled anion transport for pH(i) homeostasis.

69 an increase in CFTR-mediated transepithelial anion transport from the CF ferret trachea transfected w

70 ons to the observation of a reduced cellular anion transport function is discussed.

71 ggest that the Ser667Phe does not affect the anion transport function of band 3, but causes a traffic

72 uld occur in two ways, enhancement of band 3 anion transport function or enhancement of band 3 traffi

73 ides prompted systematic comparison of their anion transport functions in Xenopus oocytes.

74 M, the resistance associated gene, gidB, and anion-transport genes Rv3679c and Rv3680c.

75 Two inhibitors of anion transport, glyburide and ethacrynic acid, blocked

76 l chloride diarrhea and results in a loss of anion transport had no effect on growth suppression, ind

77 the design of pnictogen-based strategies for anion transport has prompted an investigation into the p

78 ance regulator (CFTR) channel for epithelial anion transport, how its expression is regulated remains

79 The results show that anion transport imposes an upper limit on mitochondrial

80 Ga(3+)/Ge(4+) cation distribution and oxygen anion transport in a family of solid electrolytes with l

81 Our results demonstrate that anion transport in a HBM is best described by the solubi

82 y of Bot1 detects Na(+)-dependent polyvalent anion transport in a Nernstian manner with channel-like

83 were screened for their ability to activate anion transport in CF cells grown on permeable supports.

84 es related to metabolic pathways and organic anion transport in cKO mice compared with control litter

85 ycosylation, significantly inhibited organic anion transport in COS-7 cells expressing a mouse organi

86 and the buffering reaction, but the role of anion transport in determining mitochondrial Ca(2+) dyna

87 hat the point mutation in prestin disrupting anion transport in other proteins of the SLC26 family do

88 ifferences between ALMTs and their impact on anion transport in plants.

89 Our results demonstrate that anion transport in polyILs occurs through a mechanism in

90 s were assayed in single cells by monitoring anion transport in real time through fluorescence emissi

91 al but not sufficient for the fast uncoupled anion transport in SLC26A9; (ii) the conserved polar res

92 of the Schiff base counterion could initiate anion transport in the related protein, halorhodopsin, i

93 ibrosis, reflects transepithelial cation and anion transport in the respiratory epithelium.

94 We used fluorescent probes to measure H+ and anion transport in vesicles reconstituted with purified

95 tration of peptide required for half-maximal anion transport induced across Madin-Darby canine kidney

96 ional processing by a mechanism dependent on anion transport inhibition.

97 They were also inhibited by the anion transport inhibitor 100microM 2,2'-(1,2-ethenediyl

98 The anion transport inhibitor 4, 4'-diisothiocyanostilbene-2

99 The anion transport inhibitor 4,4-diisothiocyanatostilbene-2

100 followed cell injury in the presence of the anion transport inhibitor DIDS and the Cl(-) channel inh

101 We used the anion transport inhibitor DIDS to investigate other memb

102 ansport with GMP, and was susceptible to the anion transport inhibitor DIDS.

103 It is unaltered by the broad spectrum anion transport inhibitor SITS, and is not accompanied b

104 on-radioactive ALA or probenecid (an organic anion transport inhibitor) and, therefore, appears to be

105 othiocyanatostilbene-2,2'-disulfonate (DIDS; anion transport inhibitor), or with NBCe1-specific small

106 ed by cell death and requires activity of an anion transport inhibitor-sensitive component, but this

107 an inhibitor of protein kinase A or with an anion transport inhibitor.

108 Na+ and HCO3- dependent, and blocked by the anion-transport inhibitor DIDS, and conclude that it is

109 nrelated compounds, and (6) inhibited by the anion transport inhibitors 4,4'-diisothiocyanatostilbene

110 rt of [(3)H]E(2)17betaG was inhibited by the anion transport inhibitors 4,4'-diisothiocyanatostilbene

111 On the other hand, anion transport inhibitors and alkylating agents arrest

112 going apoptosis was inhibited by the organic anion transport inhibitors MK571, sulfinpyrazone, and pr

113 IL-1 beta post-translational processing, and anion transport inhibitors such as tenidap that suppress

114 roM), 4) inhibited by structural analogs and anion transport inhibitors, and 5) energy-dependent.

115 post-translational processing was blocked by anion transport inhibitors, including 4,4'-diisothiocyan

116 citation medium were exposed to a battery of anion transport inhibitors.

117 The transport process was inhibited by anion transport inhibitors.

118 have a 7 + 7 inverted repeat structure with anion transport initiated by chloride binding at the int

119 Similarly for the AEM, currents governing anion transport into the center channel from the AEM cha

120 shown to have unique functional relevance in anion transport, ion sensing, and organocatalysis.

121 To test whether organic anion transport is coupled to HCO3- extrusion, we compar

122 Here anion transport is investigated both in guinea-pig outer

123 We hypothesize that this residual level of anion transport is sufficient to eliminate or postpone t

124 Anion transport kinetic assays were performed on isolate

125 ree cell lines, suggesting that promotion of anion transport may not be deleterious to cells.

126 substrate selectivity and the Na(+)-coupled anion transport mechanism by the human SLC13 family and

127 otential and, when functionally coupled with anion transport mechanisms, could facilitate transport-m

128 5-maleimide (EMA) is a specific inhibitor of anion transport mediated by the erythrocyte membrane pro

129 Transmembrane anion transport modality is enjoying a renewed interest

130 udies implicate a role in hepatocyte organic anion transport of a plasma membrane protein that has be

131 function, suggesting that the potential weak anion transport of prestin is not essential in the mamma

132 ential (DeltaPsim) to examine the effects of anion transport on mitochondrial Ca(2+) flux and bufferi

133 fects of probenecid, an inhibitor of organic anion transport, on K+-evoked SD in vivo.

134 Here we directly demonstrate an anion transport pathway in lysosomes that has the defini

135 r the bile acid and the nonbile acid organic anion transport pathways, respectively.

136 A expression of hepatic transporters organic anion transporting polypeptide (Oatp) 1a1, Oatp1a4, Oatp

137 a functional contribution of rodent organic anion transporting polypeptide (OATP) 1A5 towards the CS

138 Human organic anion transporting polypeptide (OATP) 1B1 and sodium-dep

139 Organic anion transporting polypeptide (OATP) 1B1 is crucial for

140 P450 (CYP) 3A4, CYP2C9, and CYP2D6, organic anion transporting polypeptide (OATP) 1B1, and breast ca

141 tive liver uptake via members of the organic anion transporting polypeptide (OATP) family.

142 Organic anion transporting polypeptide (oatp) is an integral mem

143 s were determined in wild-type (WT), organic anion transporting polypeptide (OATP) knockout mice (lac

144 xylic acid-based ACC inhibitors with organic anion transporting polypeptide (OATP) substrate properti

145 Here, we investigated the role of organic anion transporting polypeptide (OATP) transporters to th

146 e dramatically reduced expression of organic anion transporting polypeptide (OATP)1A1, a transporter

147 c transporters, such as those of the organic anion transporting polypeptide (OATP, SLC21) and multidr

148 Several members of the organic anion transporting polypeptide (OATP/Oatp) family of upt

149 on, protein mass and function of the organic anion transporting polypeptide (Oatp1), another sinusoid

150 Understanding organic anion transporting polypeptide (OATP1B1) regulation is k

151 due to the presence of T4-selective organic anion transporting polypeptide (OATP1C1).

152 Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3), a splic

153 esonance imaging (MRI) reporter gene organic anion transporting polypeptide 1B3 (OATP1B3).

154 Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is

155 Organic anion transporting polypeptide 2 (Oatp2) mRNA was decrea

156 he basolateral membrane transporter, organic anion transporting polypeptide 2 (Oatp2), was not affect

157 The rat organic anion transporting polypeptide 2 (oatp2; Slc21a5) is a l

158 Human organic anion transporting polypeptide 2B1 (OATP2B1) is a membra

159 Organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is al

160 The organic anion transporting polypeptide family member (OATP) 1B3

161 The organic anion transporting polypeptide family member (OATP) 1B3

162 ce with a targeted disruption of the organic anion transporting polypeptide Oatp1b2.

163 Organic anion transporting polypeptide OATP1B3 is a membrane-bou

164 nion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1) are exp

165 sized as contrast agents targeted to organic anion transporting polypeptide transporters (OATP) for l

166 cifically up-regulates I. scapularis organic anion transporting polypeptide, isoatp4056 and kynurenin

167 The human organic anion transporting polypeptide-C (OATP-C) (gene SLC21A6)

168 ed bile salts, a process mediated by organic anion-transporting polypeptide (OATP) 1B2.

169 Human organic anion-transporting polypeptide (OATP) 2B1 (OATP-B; SLCO2

170 lates cellular entry of drugs is the organic anion-transporting polypeptide (OATP) 2B1.

171 n model by showing that a Drosophila organic anion-transporting polypeptide (OATP), which we named Ec

172 The organic anion-transporting polypeptide (OATP/Oatp) superfamily i

173 e also targeting hepatocyte-specific organic anion-transporting polypeptide 1 (Oatp1) channels as a m

174 the hepatic anion uptake transporter organic anion-transporting polypeptide 1A1 (Oatp1a1), the hepato

175 Organic anion-transporting polypeptide 1A2 (OATP1A2) (gene symbo

176 In this study, organic anion-transporting polypeptide 1A2 (OATP1A2) from chicke

177 Organic anion-transporting polypeptide 1A2 (OATP1A2) is a drug u

178 The organic anion-transporting polypeptide 1b family (Oatp1b2 in rod

179 on of the hepatic transport proteins organic anion-transporting polypeptide 1B1 (OATP1B1) and 1B3 (OA

180 An organic anion-transporting polypeptide 1b3 (oatp1b3) was used as

181 zebrafish to understand the role of organic anion-transporting polypeptide 1C1 (Oatp1c1), and the ch

182 The organic anion-transporting polypeptide 1C1 (OATP1C1/SLCO1C1) and

183 OATP1C1 (organic anion-transporting polypeptide 1C1) transports thyroid h

184 sulfotransferase 2a1 (Sult2a1), and organic anion-transporting polypeptide 2 (Oatp2) in liver in mic

185 agonist-stimulated platelets via an organic anion-transporting polypeptide and is retained in the cy

186 sistance protein (ABCC/MRP), and the organic anion-transporting polypeptide protein (SLCO/OATP) famil

187 morphism in the SLCO1B1 gene for the organic anion-transporting polypeptide that regulates statin upt

188 t was dependent on hepatic uptake by organic anion-transporting polypeptide transporters and target-m

189 ressed comparable MRP and OATP/SLCO (organic anion-transporting polypeptide) mRNA levels, and MRP1 pr

190 e bile acid taurocholate (TC) by the organic anion-transporting polypeptide, (OATP)4A1, its effects o

191 Human organic anion transporting polypeptides (OATP) 1B1 and 1B3 are m

192 Organic anion transporting polypeptides (Oatp) are transporters

193 ioG) using cell lines overexpressing organic anion transporting polypeptides (OATP1B1, OATP1B3, and O

194 The organic anion transporting polypeptides (OATPs) are a superfamil

195 The hepatic organic anion transporting polypeptides (OATPs) influence the ph

196 Rifampicin, an inhibitor of organic anion transporting polypeptides (OATPs), completely bloc

197 drug resistance protein 1 (mrp1) and organic anion transporting polypeptides (oatps).

198 P) tissues suggested the presence of organic anion transporting polypeptides (OATPs, encoded by SLCOs

199 t pump (Bsep), and the expression of organic anion transporting polypeptides 1 and 2 (Oatp1 and 2) an

200 the collaborated function of apical organic anion transporting polypeptides and basolateral multidru

201 The organic anion transporting polypeptides OATP1B1 and OATP1B3 are

202 esized NBD-BA was transported by the organic anion transporting polypeptides OATP1B1 and OATP1B3.

203 and simultaneous deficiencies of the organic anion transporting polypeptides OATP1B1 and OATP1B3.

204 The organic anion transporting polypeptides, Oatp1 (Slc21a1) and Oat

205 Organic anion-transporting polypeptides (OATP) 1B1 and 1B3 are w

206 e characterization of H. longicornis organic anion-transporting polypeptides (OATPs) in interactions

207 Organic anion-transporting polypeptides (OATPs) mediate the live

208 disposition are OATP1B1 and OATP1B3 (organic anion-transporting polypeptides 1B1 and 1B3, respectivel

209 The organic anion-transporting polypeptides represent an important f

210 lude sinusoidal influx transporters (organic anion-transporting polypeptides) responsible for hepatic

211 Facilitated anion transport potentially represents a powerful tool t

212 covery of pathologies involving anomalies in anion transport processes.

213 Finally, this work shows that the anion transport properties of these compounds are extrem

214 thiourea groups have been prepared and their anion transport properties studied.

215 library of indole-based perenosins and their anion transport properties.

216 The membrane anion transport protein (band 3 or AE1) is thought to fa

217 Although many organic anion transport protein (Oatp) family members have PDZ c

218 an co-administered with rifampin, an organic anion transport protein (OATP) inhibitor and potent cyto

219 The mRNA for organic anion transport protein (oatp) was previously shown to b

220 protein that has been termed oatp1 (organic anion transport protein 1).

221 nsport of (99m)Tc-mebrofenin through organic anion transport protein 1a and 1b (Oatp1a/1b) and multid

222 aevis oocytes was used to isolate an organic anion transport protein from rat kidney.

223 Band 3, the major anion transport protein of human erythrocytes, forms the

224 Band 3, the anion transport protein of the erythrocyte membrane, exi

225 In summary, OATP2 is a novel organic anion transport protein that has overlapping but not ide

226 The membrane domain of the human red cell anion transport protein, band 3, is too large to be stud

227 Rat organic anion transporting protein 1a1 (oatp1a1), a hepatocyte b

228 e here a gene reporter, based on the organic anion transporting protein Oatp1a1, which mediates uptak

229 Organic anion transport proteins (OATPs) on the basolateral surf

230 SLC26 family constitute a conserved class of anion transport proteins, which encompasses uncoupled tr

231 xpression and/or function of hepatic organic anion transport proteins.

232 e similarity to pendrin and related sulphate/anion transport proteins.

233 A subclass of bacterial CLC anion-transporting proteins, phylogenetically distant fr

234 ans cells with pharmacological inhibitors of anion transport provided complete or substantial protect

235 ndamental chemical trends and determine that anion transport quantitatively correlates to polarity an

236 However, aromatic anion transport resulting from PGP and PIN expression in

237 This assay reveals that anion transport selectivity for this amphiphilic bis-cat

238 Record chloride over nitrate anion transport selectivity was also observed.

239 mal assay that allows one to readily measure anion transport selectivity.

240 ine, these membranes show neither cation nor anion transport selectivity.

241 catenane mechanical bond effect for enhanced anion transport selectivity.

242 that a far greater number of unloaded band 3 anion transport sites face the cytoplasm than face the e

243 ed blood cells, including the outward-facing anion transport sites of band 3, an integral membrane pr

244 A4 but not for motor (SLC26A5) and uncoupled anion transport (SLC26A9) functions; (iii) the hydrophob

245 Transmembrane anion transport studies conducted in POPC LUVs revealed

246 Anion transport studies of red cells from two affected i

247 lectrophysiological characteristics of their anion transport such as single-channel conductance, outw

248 tment of diseases caused by dysregulation of anion transport (such as cystic fibrosis), and in treati

249 ting that DMPS is transported by the organic anion transport system and that this transport is linked

250 have implicated at least one of the organic anion transport systems in the basolateral uptake of ino

251 nate (DIDS), an inhibitor of band 3-mediated anion transport that dissociates band 3 into dimers (inc

252 d Oat6 appear to function largely in organic anion transport, they also bind and transport some organ

253 on to establishing the use of such motifs in anion transport, this investigation shows that the Lewis

254 These features can be utilized in anion transport through phospholipid bilayers under aque

255 8del-CFTR activity, as indicated by enhanced anion transport through the plasma membrane.

256 It is an anion transporting transmembrane protein, possessing nin

257 re more consistent with electrically passive anion transport via MDR-TCBD protein, but only at low [A

258 in from Halobacterium salinarum (shR) during anion transport was analyzed at the molecular level usin

259 localization of choroid plexus (CP) organic anion transport were determined in apical (or brush bord

260 ot display a dominant negative phenotype for anion transport when coexpressed with wild-type AE1.

261 thus inserts into lipid bilayers to turn on anion transport, which can then be turned off through ad

262 is Communication, we introduce transmembrane anion transport with pnictogen-bonding compounds and com