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1 ine Panc-1 is dependent on the expression of annexin A2.
2 e targets, Rab14, co-immunoprecipitated with annexin A2.
3 d S100A10, a dimeric protein associated with annexin A2.
4 licit a significant conformational change in annexin A2.
5 mplexes of heparin oligosaccharides bound to annexin A2.
6  situated at the convex face of domain IV of annexin A2.
7 the calcium dependence of heparin binding to annexin A2.
8  Lys279 and Lys281, on the convex surface of annexin A2.
9 ent manner after binding of beta(2)GPI to EC annexin A2.
10 ction of tPA required its membrane receptor, annexin A2.
11                                              Annexin A2, a calcium-, actin-, and lipid-binding protei
12                                              Annexin A2, a calcium-dependent phospholipid-binding pro
13  apoptosis in host cells by interacting with annexin A2, a novel virulence mechanism in Mycoplasma ga
14 IR requires transcriptional induction of the annexin A2 (A2) gene through the direct action of the hy
15                                              Annexin A2 (A2) heterotetramer (A2.p11)(2) is a key prof
16                                          The annexin A2 (A2) heterotetramer, consisting of two copies
17                      Evidence indicates that annexin A2 (A2), a receptor for tissue plasminogen activ
18                                              Annexin A2 accumulates at the wound to nearly twice the
19  endosomal tubules along microtubules to the Annexin A2/actin-dependent stabilization and detachment
20  (A2t) of p11 and annexin A2, but not p11 or annexin A2 alone, directly binds cPLA(2)alpha via Ser(72
21 r annexins and mu subunits demonstrated that annexin A2 also binds the mu1 subunit of the AP-1 comple
22 uired for transport (ESCRT) machinery and on Annexin A2, an RNA-binding protein involved in membrane
23                                Consistently, annexin A2 and a cell-internalizing, penetratin-fused ve
24                   We also identified porcine annexin A2 and a glycosyltransferase with homology to th
25                          The knowledge, that annexin A2 and A5 act as ligands for C1q on apoptotic ce
26 d that the two phospholipid-binding proteins annexin A2 and A5 are, beside DNA, significant C1q ligan
27 whereas the anti-inflammatory proteins (e.g. Annexin A2 and Annexin A6) were significantly upregulate
28 rdx knockdowns in response to RSV, including annexin A2 and desmoplakin.
29 ochemical analyses confirmed localization of annexin A2 and glyceraldehyde 3-dehydrogenase (GAPDH), p
30                                              Annexin A2 and heparin bind to one another with high aff
31 s were made for binding interactions between annexin A2 and heparin polysaccharide in solution at pH
32  an anti-inflammatory tick protein, binds to annexin A2 and impairs the formation of the NLRC4 inflam
33         Rab14 also co-localized in part with annexin A2 and lamellar bodies in alveolar type II cells
34 ells exhibit a perinuclear redistribution of annexin A2 and p11 and show increased fusion of perinucl
35                                     Both the annexin A2 and p11 subunits of calpactin I coimmunopreci
36 ibition of MMP-1 production with Abs against annexin A2 and S100A10, a dimeric protein associated wit
37  obtained at high resolution for uncomplexed annexin A2 and three complexes of heparin oligosaccharid
38 gnized functional link between intracellular annexin A2 and tumor cell adhesion, migration and in viv
39  in which the N-terminal and core domains of annexins A2 and A5 were swapped showed that trimer forma
40  confirmed that GroEL proteins could bind to annexin A2, and confocal analysis further demonstrated t
41  several SNPs in bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell
42  be more important than ANG association with annexin A2, and KSHV probably uses annexin A2 to maintai
43 loproteinase 2 (MMP-2), regulators of MMP-2, annexin A2, and neuropilin 1 (NRP1).
44 analyses, we observed annexin A2-ANG-LANA-1, annexin A2-ANG, and ANG-LANA-1 colocalizations.
45     In triple-staining analyses, we observed annexin A2-ANG-LANA-1, annexin A2-ANG, and ANG-LANA-1 co
46 studies suggest that LANA-1 association with annexin A2/ANG could be more important than ANG associat
47 tion, but blocked activation induced by anti-annexin A2 antibodies and F(ab')2 fragments, as well as
48 sence of beta2GPI, and demonstrate that anti-annexin A2 antibodies directly cause endothelial cell ac
49 , we show that similar to dysferlin, lack of annexin A2 (AnxA2) also results in poor myofiber repair
50 plex consisting of the lipid-binding protein annexin A2 (AnxA2) and S100A10 as such a factor.
51    Human-derived H1650 SP cells over-express annexin A2 (AnxA2) and SOX2, and are resistant to conven
52                  Further analysis identified annexin A2 (ANXA2) as a critical downstream mediator in
53 1R phosphorylated the prometastatic molecule Annexin A2 (AnxA2) at Y23 and Y333 in response to stroma
54           AIIt is composed of 2 molecules of annexin A2 (ANXA2) bound together by a dimer of the prot
55                       We recently found that annexin A2 (ANXA2) co-localizes with PS-ASOs in late end
56 ion of plasmin, a key fibrinolytic agent, by annexin A2 (ANXA2) distinctly impacts progression of BCR
57 eport that the phospholipid-binding protein, annexin A2 (ANXA2) functions to maintain vascular integr
58                    Here we reveal a role for annexin A2 (AnxA2) in host defense against infection as
59  novel role for the membrane binding protein Annexin A2 (ANXA2) in modulating the composition of spec
60                  Progressive accumulation of Annexin A2 (AnxA2) in the myofiber matrix causes FAP dif
61                                              Annexin A2 (AnxA2) is a multifunctional Ca(2+)-dependent
62                                              Annexin A2 (AnxA2) is a peripherally associated membrane
63                                              Annexin A2 (ANXA2) overexpression is required for cancer
64                                              Annexin A2 (ANXA2) promotes myeloma cell growth, reduces
65                                              Annexin A2 (AnxA2) was reported to be an extracellular e
66 ach we uncovered the physical association of Annexin A2 (AnxA2) with native TRPA1 in mouse sensory ne
67                                              Annexin A2 (AnxA2), a Ca(2+)-dependent phospholipid-bind
68                      We investigated whether Annexin A2 (AnxA2), a progastrin receptor, activates NF-
69  revealed the relevant target of PY-60 to be annexin A2 (ANXA2), a protein that directly associates w
70  membrane-associated, actin binding protein, annexin A2 (AnxA2), is up-regulated in migrating IECs an
71                            The mRNA encoding Annexin A2 (ANXA2), one of the most abundant proteins in
72 -206 directly targets the oncogenes KRAS and annexin a2 (ANXA2), thereby acting as tumor suppressor i
73 ne peripherally associated membrane protein, annexin A2 (AnxA2), to induce the formation of phosphati
74 n the membrane phospholipid binding protein, annexin A2 (ANXA2), we observed a significant decrease i
75 followed by mass spectrometry, we identified annexin A2 (ANXA2), which binds actin and cellular membr
76  We also identify the S100A10 subunit of the annexin A2 (AnxA2)-S100A10 protein complex as a novel Mu
77 ion between NKCC2 and the cytosolic protein, annexin A2 (AnxA2).
78 ve enzyme and co-localizes with cell surface annexin A2 (ANXA2).
79 orylation and extracellular translocation of annexin A2 (AnxA2).
80                                              Annexin A2 appeared as punctate nuclear dots in LANA-1-p
81                            Identification of annexin A2 as a binding partner for TM601 is also consis
82 tif that binds to and inhibits intracellular annexin A2 as a candidate therapeutic lead for potential
83 omatography-mass spectrometry, we identified annexin A2 as a factor H binding partner.
84 , we identified the calcium-effector protein annexin A2 as a novel binding partner for ICAM-1.
85                            Here, we identify annexin A2 as a novel binding partner for TM601 in multi
86                            Here, we identify Annexin A2 as an autophagy modulator that regulates auto
87         We thus propose membrane exposure of annexin A2 as an oxidative stress signal for some Vdelta
88 , vimentin, actin, caldesmon, myosin IC, and annexin A2 as major proteins and was noted to exhibit co
89 creased MMP-1 synthesis by signaling through annexin A2, as demonstrated by inhibition of MMP-1 produ
90 evel, indicating that these genes are indeed annexin A2-associated targets.
91                                              Annexin A2 associates with CD44 in lipid rafts; therefor
92 r, the results indicate a functional role of annexin A2 binding to endosomal membranes following orga
93 he current study, we show that extracellular annexin A2 binds to the region of Factor H encompassing
94                                At this site, annexin A2 binds up to five sugar residues from the nonr
95 howed that a heterotetramer (A2t) of p11 and annexin A2, but not p11 or annexin A2 alone, directly bi
96                                              Annexin A2 can contribute to AP-mediated tissue inflamma
97 phages through a signaling pathway involving annexin A2/CD11b-mediated integrin-linked kinase.
98                                              Annexin A2 coimmunoprecipitated with LANA-1 and ANG in T
99                                              Annexin A2 colocalized with several LANA-1 punctate spot
100                                          The annexin A2 complex (termed "A2") is the cell surface cor
101 graphy showed that cortical actin bundled by annexin A2 connected docked secretory granules to the pl
102 that the membrane curvature-inducing protein annexin A2 contributes to the formation of these vesicle
103                                 Accordingly, Annexin a2-deficient mice were more susceptible to A. ph
104                        Lipidomic analysis of annexin A2-deficient mouse cells indicates that this pro
105                        They now show that an annexin A2-deficient mouse rendered hyperhomocysteinemic
106 tion of retinal pigment epithelial cells are annexin A2-dependent, and stimulated by macrophage infla
107                           We determined that annexin A2 does not play an essential role in infection
108                                              Annexin A2 does not, however, impair Factor H function o
109             This process is dependent on the Annexin A2 effectors ARP2 and Spire1.
110  our findings demonstrate that inhibition of annexin A2 expression in glioma cells could become a new
111  associated proteins, we silenced endogenous annexin A2 expression in rat alveolar type II cells by R
112                                              Annexin A2 expression increases after starvation in cell
113 t starvation-induced autophagy by regulating Annexin A2 expression levels.
114 uced kidney injury in mice and deficiency of annexin A2 expression reduces complement activation on t
115 nt GroEL protein in PBMCs, and knocking down annexin A2 expression resulted in significantly reduced
116                                    Moreover, annexin A2 expression was significantly induced by a rec
117                      Moreover, bivalent anti-annexin A2 F(ab')2 fragments also caused endothelial cel
118                                              Annexin A2 facilitates the binding of Vamp8 to the autop
119                          This suggested that annexin A2 forms a complex with LANA-1 and ANG as well a
120                                Specifically, annexin A2, found in a heterotetrameric complex with S10
121                                              Annexin A2 functions in angiogenesis by binding to tissu
122 onation, confocal analysis of endogenous and annexin A2-GFP transfected cells, and immunogold labelli
123 rinsic actin-bundling activity of endogenous annexin A2 had the opposite effects.
124                                              Annexin A2 has been shown to play roles in cell prolifer
125 asmon resonance analysis showed that A2t and annexin A2 has modest selectivity for PtdIns(4,5)P2 over
126       We show that S100A11 in a complex with Annexin A2 helps reseal the plasma membrane by facilitat
127  through a recently identified receptor, the annexin A2 heterotetramer (A2t).
128                          The protein complex annexin A2 heterotetramer (AIIt) is an important plasmin
129 a newly identified L2-specific receptor, the annexin A2 heterotetramer.
130 n-remodeling factor, is a target for the p11/annexin A2 heterotetrameric complex.
131                                  Recombinant annexin A2 impaired complement regulation by factor H an
132                                    Silencing annexin A2 in BCBL-1 cells resulted in significant cell
133                                 Knockdown of annexin A2 in glioma cells decreased tumor size and slow
134 her demonstrated that GroEL colocolized with annexin A2 in HEK293T cells and PBMCs.
135 , we report that the levels of expression of annexin A2 in human glioma samples correlate with their
136                         Targeted deletion of annexin A2 in mice attenuates cyclosporine-induced kidne
137 a membrane repair in general and S100A11 and Annexin A2 in particular as new targets for the therapy
138 er, our analyses highlight the importance of annexin A2 in vesiculation of a population of Atg16L-pos
139 ic distribution in normal tissue (prohibitin/annexin A2 in white adipose tissue) or cancer (RAGE/leuk
140 protein) and endogenous genes (lamin A/C and annexin A2) in alveolar type II cells, but not other lun
141 a glycoprotein (gD), and a cellular protein (annexin A2) in the primary enveloped virion preparation.
142 mococcal otitis media, the administration of annexin A2 increased AP-mediated bacterial opsonization
143                                        Thus, annexin A2-induced actin bundling is apparently essentia
144  Furthermore, binding of inactive plasmin to annexin A2 inhibited plasmin induction of MMP-1, suggest
145        ICAM-1 clustering promotes the ICAM-1-annexin A2 interaction and induces translocation of ICAM
146                                              Annexin A2 is a calcium-regulated protein that, in compl
147                                              Annexin A2 is a phospholipid-binding protein that forms
148  kidney transcription datasets revealed that annexin A2 is expressed by several cell types in the kid
149                            A higher level of annexin A2 is expressed in KSHV+ but not in Epstein-Barr
150                    It has been reported that annexin A2 is involved in binding to phosphatidylinosito
151                                      Because annexin A2 is not a transmembrane protein, the mechanism
152                                              Annexin A2 is overexpressed in many cancers and correlat
153                                              Annexin A2 knockdown abrogates starvation-induced autoph
154 as well as stable clones transfected with an annexin A2 knockdown construct.
155                             We find that the annexin A2 knockdown decreased glioma cell migration in
156 creased apoptosis in the tumor tissue of the annexin A2 knockdown group.
157            In conclusion, our data show that annexin A2 limits neutrophil transendothelial migration
158 results provide clear evidence that CD44 and annexin A2 mediate the C5a chemotactic cofactor function
159  an ERK-independent pathway to promote rapid annexin A2 membrane recruitment and enhance microvesicle
160 reveal that dysfunction of the BLOC-1-KIF13A-Annexin A2 molecular network underlies the pathophysiolo
161 l cell activation occurs via dimerization of annexin A2 molecules on the cell surface.
162                                      When an annexin A2 mutant with impaired actin filament-bundling
163 1 production is seen in dendritic cells from annexin A2-null mice, following exposure to polyethylene
164 S TX binds to human surfactant protein A and annexin A2 on airway epithelial cells and is internalize
165 ed that beta2GPI binds with high affinity to annexin A2 on the endothelial surface, though the releva
166  initiated by cross-linking or clustering of annexin A2 on the endothelial surface.
167  of mice with intraocular antibody to either annexin A2 or macrophage inflammatory protein dampens th
168 show that siRNA-mediated knockdown of either annexin a2 or p11 protein significantly inhibits C-1-P-d
169                                 Although the annexin a2-p11 heterotetramer constituents do not bind t
170 actions between ceramide 1-phosphate and the annexin a2-p11 heterotetramer constituents.
171 ular C-1-P, acting through the extracellular annexin a2-p11 heterotetrameric protein, can mediate vas
172 ared dye selectively binds to phosphorylated Annexin A2 (pANXA2), with high affinity at high levels o
173 hat 30% of Atg16L-positive vesicles are also annexin A2-positive.
174 upled with mass spectrometry identified that annexin A2 possibly interacted with GroEL protein.
175 n turn, enhances the trans-activation of the Annexin A2 promoter.
176                            To understand how annexin A2 promotes this membrane remodeling, the involv
177 hese data suggest that reduced expression of annexin A2 protein is associated with cell surface hypof
178 lococcal leukotoxin E) and eukaryotic (human annexin A2 protein tagged with mouse IgG1) recombinant p
179                                              Annexin A2 recruitment to damaged organelles is shown by
180 ments, using fluorescent liposomes, confirms annexin A2 recruitment to endosomes containing phagocyto
181                                   Absence of annexin A2 reduces both vesicle formation and homotypic
182              Further experiments showed that annexin A2 reduces the binding of factor H to cell surfa
183                                  To identify annexin A2-regulated or associated proteins, we silenced
184                                  The loss of annexin A2 resulted in the change of 61 genes.
185                  Interaction of plasmin with annexin A2 resulted in the stimulation of ERK1/2 and p38
186 g and undergoing cytoskeleton remodeling via annexin A2, S100A10, transgelin, and myosin.
187                                          The annexin A2/S100A10 complex serves as a coreceptor for pl
188 sma phagocytophilum Macrophages deficient in annexin A2 secreted significantly smaller amounts of int
189  rescued by overexpressing EGFP-tagged human annexin A2, six of seven selected targets returned to th
190 ses the amount of the ternary complex of p11/annexin A2/SMARCA3.
191 peripheral blood mononuclear cells and other annexin A2-specific Vdelta2(neg) gammadelta T-cell clone
192          We reported previously that soluble annexin A2 tetramer (A2t) activates human monocyte-deriv
193  activation by posttranslationally modifying annexin A2, the coreceptor for plasminogen and tissue pl
194 apable of binding to target proteins such as annexin A2, the tumor-suppressor protein p53 and myosin
195                                              Annexin A2, therefore, may serve as an intrinsic "positi
196 ling complex on the EC surface that includes annexin A2, TLR4, calreticulin, and nucleolin.
197  different lengths were co-crystallized with annexin A2 to elucidate the structural basis of the inte
198 tion with annexin A2, and KSHV probably uses annexin A2 to maintain the viability and cell cycle regu
199 l support to our findings, better binding of annexin A2 to sialostatin L2 in sera from 21 out of 23 i
200        These factors induce translocation of annexin A2 to the cell surface, thus enabling retinal pi
201 the cell triggers recruitment of S100A11 and Annexin A2 to the site of injury.
202 raldehyde 3-phosphate dehydrogenase (G3PDH), annexin A2, triose phosphate isomerase, and ubiquitin B
203                     Depletion of endothelial annexin A2 using RNA interference enhances ICAM-1 membra
204 cium, and to be functional in the sense that annexin A2 was able to recruit the mu2 to immobilized li
205                           Moreover, purified annexin A2 was able to stimulate the proliferation of a
206  The interaction between mu2 and full-length annexin A2 was demonstrated in vitro to be direct, to re
207           In LANA-1-negative TIVE-LTC cells, annexin A2 was detected predominately in the cytoplasm,
208                    The host cellular protein annexin A2 was identified as a binding partner of the LC
209 ication and mass spectrometry, intracellular annexin A2 was identified as the corresponding binding p
210 entify antigenic ligands of gammadelta TCRs, annexin A2 was identified as the direct ligand of Vgamma
211  CTX with MMP-2 and NRP1, whereas binding to annexin A2 was not confirmed.
212                                              Annexin A2 was previously shown to bind to Factor H and
213                         When the loss of rat annexin A2 was rescued by overexpressing EGFP-tagged hum
214 nd ANG interaction with one of the proteins, annexin A2, was validated.
215  that interact with the N-terminal domain of annexin A2 we identified the mu2 subunit of the clathrin
216         Notably, caveolin-1, caveolin-2, and annexin A2, which are proteins associated with lipid raf
217 ut not nonphosphorylated PS1, interacts with Annexin A2, which, in turn, interacts with the lysosomal
218 etermined the membrane binding properties of annexin A2 wild type and mutants both as monomer and as
219 ogen activation through its interaction with annexin A2 with concomitant reduced plasmin generation b
220 A induced the aggregation and interaction of annexin A2 with integrin CD11b, and ablation of CD11b or
221       In conclusion, the local production of annexin A2 within tissues suppresses regulation of the A

 
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