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1 used a siRNA-mediated approach to knock down annexin A5.
2 d to the peripheral membrane-binding protein annexin a5.
3 This binding could be efficiently blocked by annexin A5.
4          To modulate the pharmacokinetics of annexin A5, a 36-kDa protein that binds specifically wit
5                                              Annexins A5, A2, and A6 (Anx-A5, -A2, and -A6) are quant
6                                              Annexin A5 (A5) forms 2-dimensional crystals over phosph
7                                              Annexin A5 addition to choroid plexus cell cultures rest
8 Os via 3D immunofluorescence imaging through annexin A5, alpha-smooth muscle actin (alpha-SMA), and c
9                           The trimer-forming annexin A5 and B12 group had the following Ca(2+)-depend
10 er, we validated that two of these proteins, annexin A5 and phosphoglycerate kinase 1, can bind direc
11                                   Similarly, annexin A5 and phospholipase A2 blocked >95% of myosin-s
12 PL mAbs reduced the anti-coagulant effect of annexin A5 and promoted thrombin generation.
13 n C were also enhanced in the cortex at 12M, annexin A5 and the leukodystrophy-associated astrocyte p
14 tional (99m)Tc-labeled hydrazinonicotinamide annexin A5 and the plain CCPM control exhibited signific
15 proaches confirmed the well-known ability of annexins A5 and B12 to form trimers, but neither method
16 tablished that autoantibodies to troponin I, annexin-A5, and beta 1-adrenegic receptor best discrimin
17  The aPL antibody-mediated disruption of the annexin A5 anticoagulant shield may be an important prot
18 he cell surface and binding of extracellular annexin A5 (Anx A5).
19                                              Annexin A5 (AnxA5) binds with high affinity to PS extern
20                                              Annexin A5 (AnxA5) is a Ca(2+)-dependent phospholipid-bi
21                                              Annexin A5 (AnxA5) is a potent anticoagulant protein tha
22 The phospholipid- and Ca(2+)-binding protein annexin A5 (ANXA5) is the most abundant membrane-associa
23                      As an example, we chose annexin A5 (AnxA5), a recombinant 35-kD protein extensiv
24 -phosphate-lipid complexes (CPLX), and (iii) annexin A5 (AnxA5), the principal lipid-dependent Ca(2+)
25                             These effects of annexin A5 are mediated by its ability to inhibit lipopo
26                                              Annexin A5 belongs to a large family of calcium-binding
27 rimental data of the membrane repair protein annexin A5 binding to anionic lipid membranes in the pre
28 e hypothesis that aPL antibodies can disrupt annexin A5 binding to phospholipid membranes and permit
29                                 We find that annexin a5 binds Ca(2)(+) in solution according to a sim
30                                              Annexin A5 blocked platelet internalization and HepG2 pr
31                                              Annexin A5 blocks immunosuppressive apoptosis and promot
32                                We found that annexin a5 can induce formation of large PS domains, coi
33                                              Annexin A5-CCPM allowed visualization of tumor apoptosis
34                                     In mice, annexin A5-CCPM displayed a mean elimination half-life o
35                       In cell-based studies, annexin A5-CCPM exhibited strongly specific binding to a
36 o evaluate the specificity of the binding of annexin A5-CCPM to apoptotic cells, both fluorescence mi
37 blood was 22.4% of the injected dose/mL, and annexin A5-CCPM was mainly distributed in the central bl
38 ls to evaluate the potential applications of annexin A5-CCPM.
39 ptake in the tumors of the treated mice than annexin A5-CCPM.
40 ed with varying degrees of disruption to the annexin A5 crystallization pattern over the bilayer.
41                                              Annexin A5 depletion by siRNA led to decreased annexin A
42                                 Importantly, annexin A5 dose-dependently inhibited lipopolysaccharide
43 cell cultures from rats were used to analyse annexin A5 effects on Abeta-induced cytotoxicity.
44 he intratumoral burst release of the protein annexin A5 from intravenously injected hollow mesoporous
45                                 Radiolabeled annexin A5 has been successfully used to noninvasively i
46  imaging studies, only (18)F-FDG and (99m)Tc-annexin-A5 have been recently used in the settings of ac
47              We evaluated the feasibility of annexin A5 imaging in transgenic apoE(-/-) and LDLR(-/-)
48 To understand the functional significance of annexin A5 in renal cell death, we used a siRNA-mediated
49 is study, we aimed to verify the function of annexin A5 in the apoptosis of renal epithelial cells.
50 imaging of atherosclerosis with radiolabeled annexin A5 in transgenic mouse models of human atheroscl
51 cavenging hemopexin and by the PS antagonist annexin-a5, in vitro and in vivo.
52 e evidence that substoichiometric amounts of annexin A5 inhibit h-IAPP and alpha-synuclein misfolding
53                               Treatment with annexin A5 inhibited myocardial mitogen-activated protei
54  cisplatin strongly induced translocation of annexin A5 into mitochondria.
55                                              Annexin A5 is a 35-kDa protein with high affinity bindin
56                                              Annexin A5 is a potent anticoagulant protein, expressed
57                                 We find that annexin A5 is coexpressed in human beta-cells and that e
58            There is increasing evidence that annexin A5 is related to cytotoxicity, but the precise f
59 id plexus exhibited progressive reduction of annexin A5 levels along with progressive increased Abeta
60 o analyse Abeta accumulation, cell death and annexin A5 levels compared with control subjects.
61 res, Abeta administration reduced endogenous annexin A5 levels in a time-course dependent manner and
62                           On the other hand, annexin A5 levels in CSF from patients were found progre
63 ependent manner and simultaneously increased annexin A5 levels in extracellular medium.
64 ignificantly (r(2) = 0.8203) correlated with Annexin A5 levels in liver tissue from week 12 and gradu
65          Intravenously injected biotinylated annexin A5 localized in apoptotic and nonapoptotic macro
66                      Our study suggests that annexin A5 may have therapeutic potential in the treatme
67        Taken together, our data suggest that annexin A5 may play a crucial role in cisplatin-induced
68                             We conclude that annexin A5 might act as a molecular safeguard against th
69         Here, we investigated the effects of annexin A5 on Abeta toxicity in choroid plexus.
70          Our aim was to study the effects of annexin A5 on myocardial tumor necrosis factor-alpha exp
71 ge established tumours, the burst release of annexin A5 owing to diselenide-bond cleavage under the o
72 onoclonal antibody to Del-1 (P=0.027) and by annexin A5 (P=0.027), abciximab (P=0.027), a monoclonal
73                  In this study, we show that annexin A5 plays a role in interacting with and reducing
74  We discuss how weak membrane association of annexin a5 prior to Ca(2)(+) influx is the basis for the
75  determined that in the presence of calcium, annexin A5 reduced the level of baseline leakage from ve
76 ynuclein in Caenorhabditis elegans show that annexin A5 reduces alpha-synuclein inclusions in vivo.
77 essed in human beta-cells and that exogenous annexin A5 reduces the level of h-IAPP-induced apoptosis
78                                        This "annexin A5 resistance" identifies a novel mechanism for
79 h as that achieved by technetium-99m labeled Annexin-A5 scintigraphy.
80 ody-mediated disruption of the anticoagulant annexin A5 shield could be a thrombogenic mechanism in t
81          Notably, increased plasma levels of Annexin A5 significantly (r(2) = 0.8203) correlated with
82 ence analysis, showed that the expression of annexin A5 significantly increased in the presence of ci
83                                              Annexin A5 siRNA also increased cell viability compared
84 viously used to study the crystallization of annexin A5, to image the effects of monoclonal human aPL
85 is the basis for the cooperative response of annexin a5 toward Ca(2)(+), and the role of membrane org
86 nexin A5 depletion by siRNA led to decreased annexin A5 translocation into mitochondria and significa
87                                 Furthermore, annexin A5-treated animals showed significant reductions
88 dotoxemia with and without recombinant human annexin A5 treatment (5 or 10 mug/kg, i.v.).
89 d by either an immediate or a 4-hour delayed annexin A5 treatment after lipopolysaccharide challenge.
90                                              Annexin A5 treatment decreases cytokine expression and i
91  binds specifically with phosphatidylserine, annexin A5 was conjugated to polyethylene glycol-coated,
92                   The quantitative uptake of annexin A5 was highest in the cholesterol-fed apoE(-/-)
93                      Moreover, expression of annexin A5 was induced by other nephrotoxicants such as
94                                      (99m)Tc-annexin A5 was injected in 31 animals for noninvasive im
95 of precise target localization, biotinylated annexin A5 was injected in the remaining 2 normally fed
96                       One of these proteins, annexin A5, was previously demonstrated implicated in bl
97  involves direct interactions between La and Annexin A5, which anchors La to transiently exposed phos
98 ites of elevated metabolic activity; (99m)Tc-annexin A5, which reveals regions of enhanced apoptosis
99                              We propose that annexin A5 would exert a protective role in choroid plex