ライフサイエンスコーパス: antagomir

1 fied and cholesterol-conjugated RNAs termed 'antagomirs'.

2 P, in this case to target microRNA function (antagomir).

3 nic microRNAs by antisense oligonucleotides (antagomirs).

4 miR-16-5p, miR-125b-5p, and let-7a-5p (i.e., antagomirs).

5 ein levels could be reversed with an miR-346 antagomir.

6 ated when miR-328 was inhibited by selective antagomir.

7 hese effects could be reversed by a miR-181b antagomir.

8 3'-UTR activity was blocked by a miR-199a-5p antagomir.

9 following treatment with miR-27b and miR-29b antagomiRs.

10 noparticles, conjugated to LNA-based miR-10b antagomirs.

11 ling occluded the antiseizure effects of the antagomirs.

12 at blocking miR-122 in murine livers with an antagomiR-122 (miRNA inhibitor) results in miR-122* accu

13 Intranasal administration of a single antagomiR-122-5p dose before irradiation effectively all

14 Proteomics analysis of livers from antagomiR-122-treated mice revealed novel regulators of

15 sterol measurements showed reduced levels in antagomir-122-treated mice.

16 The anti-angiogenic effect of antagomir-132 was reflected by a reduction in angiogenic

17 of miR-132 by the provision of anti-miR-132 (antagomir-132) nanoparticles to HSV-infected mice led to

18 els were reduced by miR-144 and increased by antagomiR-144 in cultured cardiac endothelial cells.

19 rkers, and transfection of RA monocytes with antagomir-155 allowed restoration of M2-like polarizatio

20 he restoration of CDC73 levels by the use of antagomir-155 may also have an important role in therape

21 ivo silencing of miR-155 by the provision of antagomir-155 nanoparticles to herpes simplex virus 1-in

22 ells and were specifically lowered by either antagomir-155 or elevated expression of SHIP1.

23 rsely, the delivery of a miR-155 antagonist (antagomir-155) to KB cells overexpressing miR-155 result

24 88 by intra-bone marrow injection of aptamer-antagomiR-188 increased bone formation and decreased bon

25 alloproteinases 2 and 9 in mice treated with antagomiR-195.

26 sed in Caco-2 cells incubated with IL1B; the antagomiR-200c prevented the IL1B-induced decrease in oc

27 The antagomiR-200C prevents the decrease in occludin in ente

28 levels of occludin mRNA; gavage of mice with antagomiR-200C reduced levels of MIR200C-3p and prevente

29 /or gavage with an antagonist to MIR200C-3p (antagomiR-200C) or the nonspecific antagomiR (control).

30 Meanwhile, treatment with antagomir-21 decreased STAT3 phosphorylation, alleviated

31 Transfected antagomir-21 decreased the IL-6-induced cardiac fibrobla

32 ent in cells treated with the miR-21 eraser, antagomiR-21, and in miR-21 knockout mice.

33 he role of miR-21 in vivo, empty vector- and antagomiR-21-transduced B16 melanoma cells were injected

34 We then show that antagomiR-214 treatment of IL-15 transgenic mice with sp

35 n systemic administration of MSC loaded with antagomiR-222/223.

36 Inhibition of miR-23b using antagomir-23b oligonucleotide (AM23b) reversed the PS-in

37 Furthermore, treatment with antagomiR-29c resulted in a 46 +/- 5% cell death in PC12

38 ize relative to the administration of mutant antagomir-320 and saline controls.

39 Conversely, in vivo treatment with antagomir-320 reduced infarction size relative to the ad

40 Infusion of antagomir-352 increased the number and proliferation of

41 In addition, antagomir-352 up-regulated the expression of insulin-lik

42 n of CDH2 in normal and IPF fibroblasts, and antagomiR-630 abrogated the effect of mEV on CDH2 expres

43 ltaneous in vivo blockade of both miRNAs via antagomiR (a chemically modified miRNA inhibitor) inject

44 treatment of tumor-bearing mice with miR-10b antagomirs-a class of chemically modified anti-miRNA oli

45 rmed bone marrow cells with mir-196-specific antagomir abrogates their replating potential in methylc

46 rthermore, in vivo silencing of miR-22-3p by antagomiR administration lowered random as well as fasti

47 report that targeting miR-135a in vivo using antagomirs after onset of spontaneous recurrent seizures

48 Furthermore, macrophage transfection with antagomirs against miR-155 and miR-146b prevented both t

49 Intravenous administration of antagomirs against miR-16, miR-122, miR-192 and miR-194

50 Furthermore, systemic treatment of mice with antagomiRs against these miRs relieved claudin-14 gene s

51 , injection of an antisense oligonucleotide (antagomiR) against miR-25 markedly halted established he

52 er surface area, were used to adsorb miR200c antagomir/agomir molecules as well as assemble lipid mem

53 Finally, we show that antagomirs, although incapable of silencing miRNAs in th

54 Antagomir AM27b regulated E2F1 expression, but did not a

55 se therapeutic potential of miRNAs and their antagomirs, an ever growing number of delivery approache

56 nt validation analyses, including the use of antagomir and 3'-UTR reporter vectors with swapped allel

57 Combined treatment with a miR-146a antagomiR and anti-PD-1 resulted in improved survival ov

58 and both intrathecal delivery of a miR-21-5p antagomir and conditional deletion of miR-21 in sensory

59 B16 cells with lentivirus encoding a miR-21 antagomir and isolated miR-21 knockdown B16 cells.

60 Studies using cellular delivery of miR-210 antagomir and mimic demonstrated a key role of miR-210 i

61 d -phosphorus medium), and experiments using antagomirs and mimics to modify miR-29b, miR-133b, and m

62 Several kinds of antagomirs and siRNAs are now being developed to prevent

63 0% in MCF-7 cells transfected with a miR-328 antagomir, and disruption of miR-328 response element wi

64 ng miRNA target predictions and RT-qPCR from antagomir Ant-2940-3p-treated fat body tissues identifie

65 Treatment with an miR-21-specific antagomir (Ant-21) increased phosphatase and tensin homo

66 We used antagomirs (antago) to reduce the level of miR-31 in pri

67 We used antagomirs (antago) to reduce the levels of miR-205 and

68 lipid nanoparticles (MLNPs) enclosing miR-17 antagomir (Anti-17 MLNPs), which are targeted to mannose

69 ssion of miR-433 but were induced by miR-433 antagomir (anti-miR-433).

70 Moreover, miRNA92a antagomir application reduced immune infiltration and ac

71 d pathways implicated in the action of these antagomirs are altered in humans.

72 Our findings show that antagomirs are powerful tools to silence specific miRNAs

73 isorders, and efforts to develop therapeutic antagomirs are underway.

74 mically engineered oligonucleotides, termed 'antagomirs', are efficient and specific silencers of end

75 oited for the development of an anti-miR-122 antagomir as a host-targeting antiviral, the molecular m

76 nesis and highlight the potential of svRNA-N antagomirs as antivirals.

77 gulation of functional ATP6 protein, whereas antagomir blockade restored functional ATP6 protein and

78 ndogenous miR-9 expression by an appropriate antagomiR can significantly inhibit cell growth/viabilit

79 mal uptake during NMP conditions facilitated antagomir co-localization with proteins involved in the

80 Importantly, a miRNA92a antagomir completely blocked induction of human TFH prec

81 R200C-3p (antagomiR-200C) or the nonspecific antagomiR (control).

82 small complementary miRNA sequences known as antagomirs could be used to inhibit miRNA activity, whil

83 s a proof of concept for clinical use of the Antagomir counterpart.

84 right ventricular systolic pressure, and all antagomirs decreased pulmonary arterial muscularization.

85 ed for functional characterization: systemic antagomir depletion and spatiotemporal inhibition using

86 es of primary DCs treated with antisense RNA antagomirs directed against miR-451 secreted elevated le

87 udy was to assess whether a specific miR-122 antagomir down-regulates HCV protein replication and up-

88 tion of different chemically protected miRNA/antagomir duplexes in mouse livers and localization of a

89 Inhibition of both miRNAs by antagomirs during differentiation of the myeloid cell li

90 was unchanged, indicating specificity of the antagomir effect.

91 Both sets of antagomir effects were mimicked by infecting cells with

92 contrast, inhibition of renal miR-466o-3p by antagomiR, either prior to or after ADR injection, subst

93 miR-545 function was inhibited by a specific antagomir, endogenous p220 expression increased in G0/G1

94 nhibiting miR-503 by using an antisense RNA (antagomir) enhanced CUGBP1 biosynthesis and elevated its

95 Injection of the specific antagomir for miR-309 resulted in smaller developing ooc

96 ic miR-134 using antisense oligonucleotides (antagomirs) had potent antiseizure effects in animal mod

97 We demonstrate that antagomirs harbor optimized phosphorothioate modificatio

98 and its inhibition by a cholesterol-modified antagomir has been reported to prevent cardiac hypertrop

99 tosis of hPAECs, while miR410 inhibition via antagomirs has the opposite effect.

100 134 using antisense oligonucleotides, termed antagomirs, has potent and long-lasting seizure-suppress

101 at increasing PELI3 levels with a miR-744-5p antagomir in an inflammatory environment resulted in red

102 Inhibiting miR-871 with an antagomir in females shortened ventricular repolarizatio

103 duplexes in mouse livers and localization of antagomirs in a cytosolic compartment that is distinct f

104 In contrast, expression of miR-34a antagomirs in CD44(-) prostate cancer cells promoted tum

105 ontrolled delivery of miR-133a-3p mimics, or antagomirs in diseased endothelial cells, might open new

106 ommon pathway, and also establish the use of antagomiRs in fish for temporal knockdown of miRNA funct

107 ion, inhibition of miR-K12-11 function using antagomirs in KSHV-infected human primary effusion lymph

108 characterize the properties and function of antagomirs in mice.

109 n endogenous miR-23b was knocked down by its antagomirs in renal cancer cells.

110 r data further validate the effectiveness of antagomirs in vivo and should facilitate future studies

111 i-microRNAs results in functional siRNAs and antagomirs in vivo.

112 iR-126 mimic, whereas inhibition of miR-126 (antagomir) in healthy CD31(+) cells fully mimicked the P

113 oducing modified antisense oligonucleotides (antagomiRs) in ovo during chick development.

114 ppressed osteoblast differentiation, whereas antagomirs increased bone marker expression.

115 vels, while treatment with the corresponding antagomiRs increased cyclin T1 protein levels.

116 were suppressed at 32 degrees C and miR-155 antagomirs increased Ship1 and Socs1 and reversed the al

117 OX-mediated tumor suppression pathway, these antagomirs induced ROS, inhibited HIF signaling and incr

118 ation was significantly increased by miR-494 antagomir infusion, indicating their regulation by miR-4

119 of ZBTB4 or restoration of ZBTB4 by using an antagomir inhibit growth and invasion of breast cancer c

120 Antagomir inhibition of miR-223 reactivated CLDN8 and im

121 The local application of an miR-342-5p antagomir inhibits the development of atherosclerosis in

122 iation, was increased during sepsis and that antagomiR injection reduced its expression.

123 the immunosuppressive mediators, similar to antagomiR injection.

124 also investigated via infusion of a miR-494 antagomir into the central nucleus of amygdala.

125 methyl-mimic miR-122, or nonspecific control antagomir, into wild-type (WT) Huh-7 cells or Huh-7 stab

126 silencing of endogenous miR-155 or -802, by antagomir intra-ventricular injection, resulted in the n

127 rior intracerebroventricular injection of an antagomir, kainic acid-induced seizures were delayed and

128 The inhibition of miR-19a-3p with an antagomir led to a significant increase in 5-LO mRNA exp

129 Genetic deletion of let-7, antagomir-mediated blockage of let-7 and miR-184* action

130 Antagomir-mediated inhibition of svRNA-N significantly r

131 Conversely, antagomiR-mediated miR-23b and -27b silencing produces t

132 recent reports have suggested that an miR-21 antagomir might be therapeutically useful in preventing

133 ain biologically active Agomir (miRNA mimic)/Antagomir (miRNA inhibitor) adsorbed on magnetic ZnO par

134 Antagomir of miR-122 also decreased Bach1 and increased

135 Antagomir of miR-122 reduced the abundance of HCV RNA by

136 We transfected antagomir of miR-122, 2'-O-methyl-mimic miR-122, or nons

137 eleted, elevate mRNA translation, as does an antagomir of miR-122.

138 Furthermore, antagomir of miR-27b suppressed cell invasion in 4175 ce

139 function and survival relative to a control antagomiR oligonucleotide.

140 man embryoid bodies to hsa-miR-1294 mimic or antagomir oligonucleotides yielded directionally opposit

141 man embryoid bodies to the microRNA mimic or antagomir oligonucleotides, and we observed the effects

142 a miR mimic (tumour suppressor miRNA) and an antagomiR (oncomiR inhibitor)-provides outstanding capab

143 Administration of the miR-181b antagomir or recombinant Sema3A to TGF-beta-transgenic m

144 Blockage of miR-205 activity with an antagomir or via ectopic expression of miR-184 could be

145 stranded, stabilized oligonucleotides called antagomirs or anti-siRNAs.

146 g with miR-205 function by using a synthetic antagomir, or by the ectopic expression of miR-184, lead

147 Inhibition of miR-223 in vivo using specific antagomirs potentiated postnatal retinal angiogenesis in

148 ar tropic nanoparticles that deliver miR-30c antagomiRs promoted PAI-1-dependent tumor growth and inc

149 Cell transfection with miR-223 mimic or antagomiR proved the role of this microRNA in EV-induced

150 of amygdala, through infusion of a specific antagomir, provoked anxiolysis, mimicking the action of

151 Inhibition of miR-146a with a selective antagomir restored the immunoregulatory activity of nBMS

152 tralizing virus-induced miR-146a by specific antagomiR restores expressions of IRAK1 and TRAF6, augme

153 COPD small airway epithelial cells, using an antagomir, restores sirtuin-1 and suppresses markers of

154 ypti females after injection of its specific antagomir resulted in severe defects in blood digestion,

155 Blockade of miR-99b expression by antagomirs resulted in significantly reduced bacterial g

156 imilarly, the inhibition of miR-196a with an antagomir results in an increased level of ANXA1.

157 cing sirtuin-1/6, and its inhibition with an antagomir results in their restoration, reducing markers

158 cal administration of cholesterol-conjugated antagomiRs revealed better inhibition of miR-195 compare

159 Use of specific miRNA antagonists, antagomirs, revealed that miR-301a contributed to the de

160 Therefore, miR-92a antagomir seems as a new atheroprotective therapeutic st

161 Temporal-specific knockdown of miR-138 by antagomiRs showed miR-138 function was required during a

162 vitro and in vivo, silencing of miR-10b with antagomirs significantly decreases miR-10b levels and in

163 RNAs can be blocked by a new class of drugs, antagomirs, some of which have been shown to improve car

164 Injection of antagomirs specific to miR-26a into neonatal mice derepr

165 Down-regulation of HCV replication using an antagomir targeted to miR-122 is effective, specific, an

166 apacity, whereas intraocular injection of an antagomir targeting miR-132, anti-miR-132, reduced postn

167 An antagomir targeting mir-24-3p localized to the endotheli

168 An antagomir to miR-BART20-5p might be an effective therape

169 portantly, in vivo application of a miRNA92a antagomir to nonobese diabetic (NOD) mice with ongoing i

170 trated that in vivo administration of miR-22 antagomir to SHR causes substantial ( approximately 18 m

171 ciated cultures of MG using either mimics or antagomiRs to increase or reduce expression, respectivel

172 Administration of miR-10b antagomirs to mice bearing highly metastatic cells does

173 /16-1 in cells increased cell death, whereas antagomirs to miR-15a/16-1 abolished the proapoptotic ef

174 Treatment with antagomiRs to miR-29b induced excess fibrosis after aort

175 Antagomirs to miR-326 that knocked down this cell endoge

176 rfusion recovery from hindlimb ischemia, and antagomirs to miR-93 attenuated perfusion recovery.

177 Hence, antagomirs to miR-BART20-5p or miR-494-3p, miR-142-3p mi

178 uated by exogenously preloading CHF-EVs with antagomirs to Nrf2-targeting miRNAs.

179 Furthermore, delivery of miR-486-5p antagomirs to preestablished orthotopic GBM neurosphere-

180 tested the impact of exogenously loading of antagomirs to specific Nrf2-related miRNAs on CHF-EV-ind

181 bioinformatic analysis of messenger RNA from antagomir-treated animals revealed that the 3' untransla

182 Inhibiting proinflammatory miR-155 by antagomir treatment could help reduce this complication

183 Both Mir324 knockout (KO) and miR-324-5p antagomir treatment significantly reduce dendritic spine

184 subregion, and Mir324 KO, but not miR-324-5p antagomir treatment, shift dendritic spine morphology, r

185 of mitochondria functions are observed after antagomir treatment.

186 In atherosclerotic lesions, the miR-342-5p antagomir upregulated Akt1 expression and suppressed the

187 miR-690 knockdown using peptide nucleic acid-antagomiR was able to unblock and significantly increase

188 Blocking miR-339-3p by an antagomiR was sufficient to increase melanoma cell invas

189 ificance of silencing miRNAs with the use of antagomirs was studied for miR-122, an abundant liver-sp

190 1b(+) cells isolated from mice injected with antagomiRs were able to differentiate ex vivo into macro

191 Additionally, when antagomirs were used to knock down miR-93 and miR-130b i

192 first tested the effects of miR inhibitors (antagomirs), which were specifically designed to block m

193 The miR-10b antagomir, which is well tolerated by normal animals, ap