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1 eractors, which can mediate their functional antagonism.
2 nized transition state between mutualism and antagonism.
3 servatism, cultural conservatism, and ethnic antagonism.
4 is suggested by its ability to overcome VEGF antagonism.
5 by systemic or SNr-localized 5-HT2C receptor antagonism.
6 ential selective advantage aside from sexual antagonism.
7 ortive of more recent studies that find more antagonism.
8 HIV-1 infection is reduced by P2X1 receptor antagonism.
9 ike activity has been attributed to the Ser5 antagonism.
10 on effects including synergy, additivity and antagonism.
11 these phenotypes are reversed following KOR antagonism.
12 interpretation of in vivo responses to CCR2 antagonism.
13 antimicrobial molecules or through signaling antagonism.
14 le sequence differences for subtype-specific antagonism.
15 n, and N-methyl-D-aspartate receptor, NMDAR, antagonism.
16 omain (FSD) important for ligand binding and antagonism.
17 e to the human intruder threat after 5HT(2A) antagonism.
18 nome-wide association study (GWAS) of sexual antagonism.
19 hibited enhancement, some mixtures exhibited antagonism.
20 hin the domain that are important for ligand antagonism.
21 me3 are maintained in that state by H3K36me3 antagonism.
22 gh-order combinations by strength of synergy/antagonism.
23 saccharides is of critical importance in the antagonism.
24 etion led to a partial rescue from oncogenic antagonism.
25 ependent of S7 phosphorylation and NF-kappaB antagonism.
26 he ubiquity and importance of interbacterial antagonism.
27 -mediated intra- and inter-species bacterial antagonism.
28 protein interactions required for potent A3 antagonism.
29 1)R, conveying a longer duration of receptor antagonism.
30 AT1 and the greatest reduction in interferon antagonism.
31 y inhibits CaSR activity via non-competitive antagonism.
32 ng the selectivity as well as agonism versus antagonism.
33 ssue tropism, viral pathogenesis, and immune antagonism.
34 ter to the long-standing pursuit of glucagon antagonism.
35 also be reversed by systemic 5-HT2C receptor antagonism.
36 nd pan-antagonists that exert broad-scope AR antagonism.
38 , as expected from the addition of sigma(1)R antagonism, 15au showed local, peripheral activity in th
39 t RNA sequencing analysis suggests that VEGF antagonism activates retinal degeneration, inflammation,
41 ltered colony and cell morphology, motility, antagonism against other microbes, and biofilm formation
42 Additional evidence for this mechanism of antagonism also comes from monitoring the reduction of p
44 rs, suggesting that pharmacologic purinergic antagonism, altering the innate and adaptive immune comp
45 relapse, we evaluated whether systemic CB1R antagonism (AM251; 3 mg/kg, i.p.) during memory reconsol
46 (EST73502) showed MOR agonism and sigma(1)R antagonism and a potent analgesic activity, comparable t
47 two-stressor combinations, we conclude that antagonism and additivity are the most frequent interact
49 sly undescribed mechanism for interbacterial antagonism and demonstrate a physiological role for the
50 t-regulated molecules show potent beta(2)-AR antagonism and enable a reversible and dynamic control o
51 several signature feedbacks behind the M1-M2 antagonism and investigated the dynamical shaping of mac
53 mulsion polyplexes to achieve combined CXCR4 antagonism and PAI-1 inhibition is a promising strategy
54 tion to II and III produced submicromolar AR antagonism and protein degradation selective to AR and A
57 e a comprehensive structural basis of NK(1)R antagonism and will facilitate the design of new therape
58 ed dual profile (i.e., MOR agonism and sigma antagonism) and a potent analgesic activity, comparable
59 and MYC goes further, beyond transcriptional antagonism, and governs a multitude of developmental pat
60 re generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in
65 shed light on pathogenic mechanisms for VEGF antagonism-associated adverse effects and potential ther
67 mitigated by normalizing mechanisms such as antagonism at the level of receptor-ligand interactions,
68 R-Ab-associated AE patients and simultaneous antagonism at the NMDAR by AP5, particularly in burst ac
70 nctional studies reveal that PX exploits the antagonism between beta-arrestin isoforms; in low ligand
74 other Hsp90 substrates, is fine-tuned by the antagonism between MEC-15 and the chaperones; this antag
75 rected repair of DSBs is delayed, indicating antagonism between nuclear migration and the mechanism o
77 ibitor treatment modes, we tested synergy or antagonism between several inhibitors with tungstate, an
81 In the present study, we investigate the antagonism between the microbiota and Klebsiella pneumon
84 lls with the ability to mitigate an inherent antagonism between transcription and DNA replication.
85 id cation channels (TRPVs) since TRPV1/TRPV4 antagonism blocked the febrile Th2 switch, while TRPV1 a
86 une myeloid cells and show that systemic EP2 antagonism blocks monocyte brain entry in male mice.
87 trast, reversal learning was impaired by D2R antagonism, but not D1R antagonism, in the dorsal striat
88 lization of contact-dependent interbacterial antagonism by AID systems helps to shape human gut micro
89 tigated protease-activated receptor 4 (PAR4) antagonism by developing and evaluating a tool compound,
90 ological inhibition of CypA rescues PKR from antagonism by HCV NS5A, leading to activation of an inte
92 cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of r
93 ast, effector T cells responded to glutamine antagonism by markedly up-regulating oxidative metabolis
94 nal, increases the sensitivity of SERINC5 to antagonism by Nef, while it has no effect on the intrins
95 these findings identify STAT5 as a target of antagonism by specific pathogenic flaviviruses to subver
96 these findings identify STAT5 as a target of antagonism by specific pathogenic flaviviruses to subver
97 d not increase the sensitivity of SERINC5 to antagonism by the glycoGag protein of MLV, suggesting th
98 Therefore, our results suggest that TRPV4 antagonism can attenuate aortic inflammation and remodel
102 tative associations between thyroid receptor antagonism, chemical concentrations, and papillary thyro
105 nse to exercise suggests that ET(A) receptor antagonism could be a therapeutic approach to improve bl
106 These data indicate that ET(A) receptor antagonism could be a viable therapeutic approach to imp
107 noprecipitation (CLIP) experiments and miRNA antagonism demonstrated that these alternative variants
108 high-level PE responses, implying that NMDAR antagonism disrupts the inference on abstract statistica
109 al deficits were prevented by CB(1) receptor antagonism during maternal exposure, showing that the CB
110 typed marmosets with responsivity to 5HT(2A) antagonism during the human intruder test of anxiety.
114 ale, sex, and political attitudes, is ethnic antagonism-especially concerns about the political power
116 their amplification is driven by X versus Y antagonism for increased transmission, where sex chromos
117 the potential of kappa-opioid receptor (KOR) antagonism for treating anhedonia with a POM study deter
118 d inhibited HPA activity via non-competitive antagonism from two allosteric sites, by channeling the
119 ivatives of 1 by Trp turned Y(4)R agonism to antagonism, giving Y(4)R antagonists with pK(i) values <
123 in's antiviral activities and viral tetherin antagonism have been studied in detail for a number of d
124 tis (AD), but the molecular effects of IL-22 antagonism have not been defined in human subjects.
127 ple characterized by elevated anhedonia, KOR antagonism improved the ability to modulate behavior as
129 of ER degradation does not guarantee full ER antagonism in breast cancer cells; ER "degraders" exhibi
130 on, raising the hypothesis that IL-6 pathway antagonism in CHIP carriers would decrease cardiovascula
131 n help determine significance of synergy and antagonism in drug combination screens with few data poi
132 nd was used in a bioassay to quantify TRbeta antagonism in human embryonic kidney cells (HEK293/17) a
133 e find that nonselective muscarinic receptor antagonism in mice as well as epithelial-specific ablati
135 into the structural basis of agonism versus antagonism in steroid receptors with potential implicati
136 understanding selfish replication and sexual antagonism in the evolution of mitochondrial genomes and
138 ehog activation signalling to upregulate BMP antagonism in the progenitor niche that promotes metapla
140 mal MN development raising caution about JNK antagonism in this pediatric neuromuscular disease.
141 gether our data unravel a mechanism of viral antagonism in which a virus hijacks the Nup98-Rae1 compl
142 ained by a shared genome, leading to 'sexual antagonism', in which different alleles at given loci ar
143 was impaired by D2R antagonism, but not D1R antagonism, in the dorsal striatum: raclopride increased
145 distances, we found that the probability of antagonism increased the more metabolically similar the
147 miR-25 and miR-124 overexpression, or let-7 antagonism, induced Ascl1 expression and conversion of ~
148 this bi-stable circuit of mutual cRel-Blimp1 antagonism into a multi-scale model revealed that dynami
155 evidence that dual MOR agonism and sigma(1)R antagonism may be a useful strategy for obtaining potent
156 evidence that dual MOR agonism and sigma(1)R antagonism may be a useful strategy for obtaining potent
157 ntific interest in the possibility that CGRP antagonism may disrupt vascular responses to CSD and the
162 athology, and we observed that acute Adora2a antagonism normalized BBB permeability in wild-type mice
163 preserving perturbations - strength of cross-antagonism, number of operator sites in a promoter, and
165 nally, primed IFP-MSC demonstrated sustained antagonism of activated human peripheral blood mononucle
167 mal phenotypes driven by ARID1A loss through antagonism of ARID1A target gene expression, resulting i
169 the LC-BLA pathway and intra-BLA or systemic antagonism of beta-adrenergic receptors abolished both l
178 ng to CRL4(DCAF1) E3, thereby disrupting Vpr antagonism of helicase-like transcription factor (HLTF)
181 f IFN-stimulated genes, which occurs through antagonism of IFN regulatory factor 1 (IRF1)-mediated tr
182 of patients with CRSwNP, demonstrating that antagonism of IL-4Ralpha signaling suppresses IL-4-/IL-1
183 se data identify a novel mechanism for viral antagonism of innate immune signaling which relies on se
185 Moreover, inhibition of S100a4 signaling via antagonism of its putative receptor, RAGE, also decrease
189 , we identified and characterized type I IFN antagonism of MERS-CoV open reading frame (ORF) 8b acces
191 independently of opioidergic mechanisms, as antagonism of mu-opioid receptors with systemically-admi
195 the limited cognitive benefit of the direct antagonism of NMDA receptors in AD, we here focus on an
202 ted here offer significant insights into NS1 antagonism of RIG-I and illustrate the importance of und
206 We envision the role of NOX proteins in the antagonism of T. guizhouense as an example of metabolic
209 roper morphogenesis, evoking the classic A-C antagonism of the ABC model for floral organ development
210 the mutually exclusive expression and cross-antagonism of the B cell identity factor Pax5 and the pl
211 model of PCa and associated fibroblast, the antagonism of the C3a receptor and the fibroblastic knoc
217 ammatory cytokine IL-1beta in the brain, and antagonism of the P2X7 receptor is a novel therapeutic s
220 In this study, we identified RSV-mediated antagonism of this pathway, independent of the NS1 and N
222 hermore, genetic deficiency or pharmacologic antagonism of TRPV4 blocked cytokine-induced FBGC format
223 l sites of infection have been linked to the antagonism of type I IFN induction by N(pro) This protei
224 action with IRF3 is involved not only in its antagonism of type I IFN, but also dsRNA-mediated mitoch
225 e-tuned regulation of Ctgf through Hnf4alpha antagonism of Yap and Tgf-beta activities to balance reg
226 se C1s to evaluate the impact of upstream CP antagonism on activation and proliferation of normal and
227 a to investigate the putative effects of KOR antagonism on anhedonic behavior with more precision by
228 (BE) procedure to assess the effects of OxR1 antagonism on demand for the highly abused opioid fentan
229 t hydrolysis, opens channels when nucleotide antagonism on Kir6.2 is minimized and SUR1 mutants with
231 l possible effects of NMDA receptor (NMDA-R) antagonism on this behaviour, we simulated the effects o
234 ic (PD) approaches based on bioreceptor.drug antagonism or by pharmacokinetic (PK) approaches that se
236 ry human CD4 T cells and macrophages, whilst antagonism or genetic disruption of REV-ERB increased pr
237 te a reduced MAP response to VRS using TRPV1 antagonism or in Trpv1 null mice while the response to p
238 position to that produced by selective D(2)R antagonism or nonselective D(2)-like receptor antagonist
239 treatment, whereas local SNr 5-HT2C receptor antagonism or optogenetic activation of SNc DAergic neur
240 th, soil nutrient dynamics and interactions (antagonism or synergism) in a nutrient-poor greenhouse s
243 The diversity and ubiquity of interbacterial antagonism pathways is becoming increasingly apparent, a
244 reviously undocumented phenomenon that P2Y1R antagonism patterns could vary in different signaling pa
245 ated by colony-stimulating factor 1 receptor antagonism (PLX5622) and allowed to repopulate, and resp
246 mera-type galectin-3 design makes functional antagonism possible, we underscore the value of versatil
248 our results demonstrate that selective D(3)R antagonism potentiates the behavioral-stimulant effects
252 sequence alignment to achieve a dual TLR7/8 antagonism profile and (ii) introduction of a fluorine i
255 ive capillary growth, suggesting that ligand antagonism regulates coronary primary plexus formation.
256 se VHL interacts with Daam2 and their mutual antagonism regulates oligodendrocyte differentiation dur
257 twork modeling indicates that VIP-SST mutual antagonism regulates the gain of the cortex to achieve s
258 nism between MEC-15 and the chaperones; this antagonism regulates TRN development, as well as synapti
259 BST-2, suggesting that the mechanism of this antagonism resembles that of HIV-1(NL4-3) Vpu against hu
261 We found that, relative to placebo, KOR antagonism resulted in significantly higher learning rat
262 etR repression strength, which hinders cross-antagonism, resulted in a loss of mutually exclusive cel
263 for Setd1a and show that its pharmacological antagonism results in a full rescue of the behavioral an
264 ypothesize that gene degeneration and social antagonism shaped the evolution of the fire ant supergen
265 e, surprisingly little is known about how OR antagonism shapes neuronal representations in the detect
269 variant and by extension, suggest that a D3 antagonism strategy in substance use disorders should co
270 ficant advancement has been achieved in VEGF antagonism, substantial adverse effects have been report
271 ression with the same efficiency as IL-12p40 antagonism, suggesting that the efficacy of anti-IL-12p4
272 ntial effect on seizure susceptibility, TLR4 antagonism suppressed cellular inflammatory responses af
275 al multipronged mechanisms of action of CD39 antagonism that rely not only on preventing the accumula
276 d euchromatin are globally poised for mutual antagonism, the mechanisms underlying precise spatial en
278 therapeutics due to its capacity for full ER antagonism, thought to be achieved through ER degradatio
281 up solidarity) and divisiveness (inter-group antagonism) to capture balance within and among subgroup
282 ll caged glutamates are known to have strong antagonism toward receptors of gamma-aminobutyric acid,
287 the biphenyl carbamates 13m and 13n, neutral antagonism was observed for 14m and 14n and tiotropium u
289 ased on the genetic evidence supporting GIPR antagonism, we previously developed a mouse anti-murine
291 ts during gastrulation induced by Hh pathway antagonism were mitigated by the addition of FGF4 protei
292 s are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contra
293 sex ratio, as well as conditions for sexual antagonism when mitochondrial variants increase transmis
294 human intruder after 5HT(2A) pharmacological antagonism, while CT/T/C individuals showed no effect.
295 cts in a common decision-making motif, cross-antagonism with autoregulation, by synthetically constru
296 little effects, but platelet P2Y12 receptor antagonism with clopidogrel, fibrinolysis with urokinase
297 cannabinoids, evidence of isolated vitamin K antagonism with or without bleeding, and detectable leve
298 aspirin-induced reactions, P2Y(12) receptor antagonism with prasugrel completely inhibited all aspir
299 t concentration exhibited significant TRbeta antagonism, with a mean of 30% and a range of 0-100%.
300 atly among opioids and it is unclear if OxR1 antagonism would reduce demand for all opioids, particul