ライフサイエンスコーパス: antagonize

1 peptides could be an alternative strategy to antagonize a myriad of PPIs.

2 s have discovered that both glycoGag and Nef antagonize a novel host restriction factor Ser5 and prom

3 isms by which initial plant immune signaling antagonizes abscisic acid (ABA) signal transduction requ

4 SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mut

5 t month after birth to activate ADRbeta2 and antagonize ADRbeta1/3.

6 eukaryotic Hsp104 homologs that selectively antagonized alpha-synuclein condensation and toxicity in

7 How this joined binding allows RUNX1 to antagonize AML1-ETO-mediated transcriptional activation

8 In vivo, HSF1 antagonizes AMPK to control body fat mass and drive the

9 ation inside the tweezer cavity is needed to antagonize amyloidogenesis and is only achieved by CLR01

10 We propose this demethylation antagonizes an active transcription module, thus reducin

11 ocorticoids prolong expression of genes that antagonize and slow induction of genes that drive termin

12 The aminoglycoside antibiotics antagonized and down-regulated TRPC1 expression and, whe

13 Many Gram-negative bacterial pathogens antagonize anti-bacterial immunity through translocated

14 duced myofibroblast activation and partially antagonizes anti-fibrotic effects of halofuginone treatm

15 or mediating systemic immunosuppression that antagonizes anti-PD-1 checkpoint therapy.

16 collagenase injection were cultured with an antagonizing antibody against CD44.

17 ated with SGE-301, despite this compound not antagonizing antibody binding.

18 se M2-polarized macrophages are predicted to antagonize antitumor effects, targeting these cells may

19 ow that the NS3 protein of Zika virus (ZIKV) antagonizes antiviral gene induction by RIG-I and MDA5 b

20 Over half of these compounds (430) antagonized at least one of the ten ORs.

21 Scrib and Dlg do not directly antagonize atypical protein kinase C (aPKC), but may ins

22 This de-phosphorylation antagonizes Aurora B kinase to modify the functions and

23 nce: namely, the threat to survival posed by antagonizing bacteria.

24 th protein synthesis inhibitor cycloheximide antagonized BBR-induced beta-catenin reduction, suggesti

25 Our findings indicate that BBR antagonizes beta-catenin pathway by inhibiting beta-cate

26 nonanticoagulant agents that are capable of antagonizing binding of heparin-binding pathogens to HSP

27 the anti-inflammatory cytokine, IL-10, that antagonizes both innate and acquired immune responses, i

28 ghts into the antiobesogenic consequences of antagonizing brain GIP action.

29 um, rich in dopamine D2 receptors, which are antagonized by antipsychotic medications, plays a key ro

30 MAKR2 inhibitory effect on TMK1 signaling is antagonized by auxin itself, which triggers rapid MAKR2

31 We show that this activity is antagonized by C-rich motifs and correlated with protein

32 proallergic inflammation, and are partially antagonized by corresponding IgG idiotypes.

33 tions, referred to as neutrophil aging, were antagonized by CXCR4 (C-X-C chemokine receptor type 4) a

34 However, this mechanism can be antagonized by ectopically expressing a competitive inhi

35 response revealed that it was prospectively antagonized by etanercept or thalidomide, which resolved

36 This action of ethanol is antagonized by femtomolar concentrations of the neuropep

37 tory program in PALF non-survivors (which is antagonized by NAC), while driving an anti-inflammatory/

38 ted CDK1, and indirectly by Aurora B, and is antagonized by PP1-mediated dephosphorylation.

39 en low-complexity domains of TDP-43 that are antagonized by RNA binding.

40 Both enhancers are antagonized by RUNX/CBFbeta complexes, and SATB1 further

41 Hh signalling is antagonized by signals from the dorsal neural tube and l

42 lization to the PM facilitated by SNAREs but antagonized by SNORD50A/B.

43 H69 cleavage is antagonized by the 3 major host defense pathways defined

44 expression and function of PEAR proteins are antagonized by the HD-ZIP III proteins, well-known polar

45 hylation to promote its activation, which is antagonized by the Jumonji-family demethylase KDM4B.

46 proinflammatory effect that is functionally antagonized by the presence of nicotine.

47 These effects were antagonized by the thioredoxin/thioredoxin reductase sys

48 Antagonizing calcium influx into the cell and into mitoc

49 ADCs) are emerging therapeutic products that antagonize cancers.

50 Antagonizing canonical Wnt activity in CD8(+) T cell CM

51 tional investigation demonstrates that Fbxl8 antagonizes cell cycle progression, hematopoietic cell p

52 tify non-native AHLs capable of agonizing or antagonizing CepR, and thereby QS, in a Bcc member.

53 SIVcpz, which utilizes Nef, but not Vpu, to antagonize chimpanzee BST-2.

54 xvirus CP77 as a unique inhibitor capable of antagonizing Chinese hamster SAMD9L (chSAMD9L).

55 MARCB1 represses bivalent genes in hESCs and antagonizes chromatin accessibility at super-enhancers.

56 Histone acetylation by p300 antagonizes chromatin phase separation, dissolving dropl

57 species showed that the ability of OPXVs to antagonize chSAMD9L correlates with CP77 gene status and

58 e find a novel role for the CLOCK protein to antagonize CREB-mediated transcriptional activity at the

59 As SSTR2 activation antagonizes CRF-mediated hormone release, this storage/r

60 demonstrated that selective FASN inhibition antagonizes CRPC growth through metabolic reprogramming

61 (17-epi-RvD1) through the receptor ALX/FPR2 antagonize cues from CpG DNA, preserve C5aR expression,

62 While inhibition of mTORC1 antagonizes dendritic cell (DC) differentiation and supp

63 umes the substrates of these pathways, which antagonizes differentiation and enforces terminal effect

64 Antagonizing dopamine receptors in the VLS blocked the s

65 Antagonizing dynein-mediated transport can rescue this e

66 E2F8 is a transcriptional repressor that antagonizes E2F1 at the crossroads of the cell cycle, ap

67 sviruses encode multiple viral proteins that antagonize each host antiviral response, thereby allowin

68 ings indicate that the Ryp and Msb2 circuits antagonize each other in a temperature-dependent manner,

69 (or so-called M1-M2 phenotypes) coexist and antagonize each other throughout the disease progress.

70 ein are coexpressed in t(8;21) AML cells and antagonize each other's gene-regulatory functions.

71 osing roles in podocyte biology and mutually antagonize each other.

72 Ena/VASP family members hitherto thought to antagonize efficient cell motility.

73 and of other downstream signaling effectors, antagonizes EGFR-driven cell phenotypes, and promotes su

74 Pharmacologically antagonizing either the angiotensin-converting enzyme or

75 muli into intracellular anabolic signals and antagonizes ER stress to promote T cell metabolic fitnes

76 tipronged strategy utilized by SARS-CoV-2 to antagonize essential cellular processes to suppress host

77 NAP potently antagonizes ethanol inhibition of L1 adhesion by stimula

78 hibits MRE11 binding to reversed forks, thus antagonizing excessive nascent-strand degradation.

79 Antibodies that antagonize extracellular receptor-ligand interactions ar

80 romoters by recruiting FOXM1 through EZH2 to antagonize EZH2-mediated effects at target genes.

81 n stemness genes, FOXM1 was absent and SCIRT antagonized EZH2 and SOX2 activity, balancing toward rep

82 cted with EZH2 via its carboxyl terminal and antagonized EZH2-mediated IFN responsiveness.

83 extracellular polysaccharides are capable of antagonizing F. graminearum and that the uronate content

84 sed with Bcl-6 at high levels to inhibit the antagonizing factor Blimp-1, but suppresses Bcl-6 by dir

85 ers, we show that FBXL16 stabilizes C-MYC by antagonizing FBW7-mediated C-MYC ubiquitination and degr

86 However, antagonizing FGF9 in wild-type control hiPSCs did not al

87 t critical frontline beta-lactam antibiotics antagonize fluconazole activity.

88 bias to the endogenous ligand by selectively antagonizing G protein signaling.

89 In nonrhythmic conditions, antagonizing GABA(A) receptors can initiate this synchro

90 mpairs ETO2-NuRD interaction and function in antagonizing gamma-globin/LCR looping.

91 TFII-I overexpression antagonized GLI2 induction by TGFbeta, a known activator

92 GLP-1R, whereas des-His(1)-[Glu(9)]glucagon antagonized glucagon action at the GluR, while having mi

93 allosteric inhibitors LY2409021 and MK 0893 antagonized glucagon and GLP-1 action at the GLP-1R, whe

94 2)W(30) motif was needed for SIVgsn71 Vpu to antagonize GSN BST-2, suggesting that the mechanism of t

95 sibility factor, and demonstrate that ANP32E antagonizes H2A.Z accumulation to restrict chromatin acc

96 -S binding, 16% E(max)) and in vivo and also antagonized hA(3)AR in vitro.

97 of LSD1 have been shown to either promote or antagonize heterochromatin expansion by removing H3K4me

98 Our data suggest that CAP antagonizes HFD-induced metabolic stress and inflammatio

99 anistically, our studies suggest, that ANKS6 antagonizes Hippo signaling in the liver during bile duc

100 Here, we report that PAD4 antagonizes histone MGO-glycation by protecting the reac

101 ncers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigene

102 e infection, suggesting that these drugs may antagonize HIV-1 Env at gp120 V1V2 to block viral membra

103 l the adaptations that allowed SIVrcm Vif to antagonize hominid A3G.

104 discovery of virus-mediated activities that antagonize host cell antiviral defense pathways, such as

105 FcgammaRs, we further demonstrate that Rh05 antagonizes host FcgammaR activation.

106 ally relevant therapeutic concentration, can antagonize hPXR agonist-induced gene expression and chem

107 ing of DNA ends, it remains unclear how PTIP antagonizes HR.

108 olate (SIVgsn-99CM71 [SIVgsn71]) was able to antagonize human BST-2 as well as BST-2 of its natural h

109 SIVcpz Nef is, however, unable to antagonize human BST-2, and Vpu was consequently chosen

110 xxxxxW (A(22)W(30) and A(25)W(33)) motifs to antagonize human BST-2, suggesting an as-yet-undefined w

111 , SIVgsn, SIVmon, or SIVmus isolates fail to antagonize human BST-2.

112 1(NL4-3)Vpu was reported to be important for antagonizing human BST-2, we show here that two Axxxxxxx

113 These findings indicate that myeloid RASSF1A antagonizes I/R-induced myocardial inflammation and sugg

114 n strategy utilized by EAV and PRRSV nsp4 to antagonize IFN induction, EAV nsp4 adopts a more complex

115 , these results demonstrate that PRRSV nsp11 antagonizes IFN signaling via mediating STAT2 degradatio

116 polysaccharide (LPS) receptor caspase-11 and antagonizes IFN-I production mediated by the DNA sensor

117 m inflammasome-mediated host cell death that antagonizes IFN-I.

118 nalysis identifies two compound classes that antagonize IFNalpha effects on human beta cells.

119 A/p65 induces Gremlin-1 transcription, which antagonizes induction of anabolic genes such as Sox9, Co

120 Viruses commonly antagonize innate immune pathways that are primarily dri

121 creased ability of NS1 from avian viruses to antagonize innate immune responses in human primary cell

122 rt and also houses a deamidase activity that antagonizes innate immune signaling.

123 We also found Gremlin 1 to antagonize insulin signaling and action in human primary

124 viruses studied thus far is their ability to antagonize interferon (IFN) signaling so as to enhance v

125 One of the possible reasons is that PRRSV antagonizes interferon induction and its downstream sign

126 Mechanistically, we show that BAs that antagonize intestinal farnesoid X receptor (FXR) functio

127 sory proteins hijack host cell E3 enzymes to antagonize intrinsic defenses, and thereby provide a mor

128 n phosphatase 1 (PP1) to kinetochores, which antagonizes Ipl1-mediated phosphorylation.

129 different regions of CD73 may be a means to antagonize its enzymatic activity.

130 in, bound to the Stat3 C-terminal region and antagonized its transcriptional and ventralizing activit

131 OR (T1135), while intracellular AGR2 (iAGR2) antagonizes its levels and phosphorylation.

132 Influenza viruses antagonize key immune defence mechanisms via the virulen

133 ote dendrite-specific pruning mainly through antagonizing Klp10A activity.

134 alpha-CGRP antagonized KLRG1(+) ILC2s proliferation but promoted IL

135 traits specific to cholinergic MNs, but also antagonizes LIN-39's ability to activate terminal featur

136 ght to determine whether LTD(4) functionally antagonizes LTC(4) signaling at CysLT(2)R.

137 rs can drive tumour-cell differentiation and antagonize malignant progression.

138 BBR treatment also antagonized mammalian target of rapamycin (mTOR) activit

139 ters the ER lumen through a cytosolic Ca(2+)-antagonized mechanism, or CaATiER (Ca(2+)-Antagonized Tr

140 e domain forms a sensory complex with UzcRS, antagonizing metal dependent stimulation by virtue of it

141 rationally-designed peptide that selectively antagonizes Mfn1-betaIIPKC association.

142 e kinetochore accumulation has been shown to antagonize microtubule stability.

143 How femtomolar concentrations of NAP antagonize millimolar concentrations of ethanol is unkno

144 Carbenoxolone, a gap junction inhibitor, antagonized modafinil, but not methylphenidate potentiat

145 These observations reveal that SNF5 antagonizes MYC and provide a mechanism to explain how l

146 t progenitor cells via a novel pathway, that antagonized MyD88-dependent quiescence, and engaged Weck

147 and complex functions that both promote and antagonize neural repair.

148 in stabilizing selenoprotein transcripts by antagonizing nonsense-mediated decay (NMD).

149 nappropriate beta-catenin modifications that antagonize normal stabilization by Wnt signals.

150 Here, we show that the PB component Pat1 antagonizes Not1 and promotes PB assembly via its direct

151 lations is to disrupt molecular processes or antagonize novel metabolic targets required for the prod

152 at inhibits RAD51 filament formation and may antagonize other ssDNA-binding proteins on RPA-coated ss

153 with Notch1 intracellular domain (NICD) and antagonized p63/p73-mediated repression of HES1 and ECM1

154 ese data suggest maternally expressed miRNAs antagonize paternally driven gene programs in neurons.

155 able of disrupting the PD-1/PD-L1 complex by antagonizing PD-L1 and, therefore, restores activation o

156 length dependent, impair pathogen clearance, antagonize phagocyte recruitment, diminish phagocytosis

157 onserved serine residues is hierarchical and antagonizes phosphorylation by PKCepsilon, and vice vers

158 vels of an unstable protein phosphatase that antagonizes phosphorylation of PRD-4 by mTOR complex 1 (

159 Both autophagy and alphaKlotho antagonizes phosphotoxicity.

160 At the cellular level, shade antagonizes phyB signaling by triggering phyB disassembl

161 onstrate that AHLs repress petiole growth by antagonizing PIF-mediated transcriptional activation of

162 is that inhibition of vascular thrombosis by antagonizing platelet integrin alphaIIbbeta3 cannot be a

163 ic activities as exhibited by the ability to antagonize PPARgamma-dependent adipocyte differentiation

164 PrP ligands could theoretically antagonize prion formation by protecting the native prot

165 hat in medaka, two RNA-binding proteins with antagonizing properties target this D3U-box, promoting e

166 1 displays high specificity for PTPsigma and antagonizes PTPsigma via unique non-competitive, alloste

167 An inhibitor of the UPR antagonized PV expansion in macrophages, indicating this

168 ategies rely on intraocular delivery of VEGF-antagonizing reagents, which results in sustained suppre

169 Activation of the adenosine A(1)-receptor antagonizes responses elicited by dopamine D(1)-receptor

170 Although SPRY1 antagonizes Ret-GDNF signaling, which modulates renal br

171 a widespread antitermination mechanism that antagonizes Rho to facilitate complete transcription of

172 nces of an R21Q mutation on NS1's ability to antagonize RIG-I signaling.

173 studied, the complete mechanism by which NS1 antagonizes RIG-I signaling remains unclear.

174 we showed that EGFR inhibitors successfully antagonized RMS RD cells, whereas other cell lines were

175 We then demonstrated that Akt inhibition antagonizes RMS-including RMS resistant to EGFR inhibiti

176 In addition, virus-encoded VP3 antagonizes RNase L activity both in vitro and in vivo T

177 of c-Jun NH(2)-terminal kinases (JNKs) also antagonizes RNase L-dependent cell death in response to

178 USP14 antagonized RNF168-dependent ubiquitin signaling and dow

179 tioned in neuroprotective and muscle atrophy-antagonizing roles.

180 family, as a transcriptional repressor that antagonizes RORgammat function in Th17 cells.

181 The commensal S epidermidis can antagonize S aureus, although its role in AD is unclear.

182 Deposition of N(6)-mA also antagonizes SATB1 function in vivo by preventing its bin

183 We also found that androgen exposure antagonizes Ser/Thr kinase 4 (STK4/MST1) signaling, stim

184 Here, we investigated how glycoGag antagonizes Ser5 using MLV glycoMA and murine Ser5 prote

185 coGag and EIAV S2 proteins, which, like Nef, antagonize SERINC-mediated diminishment of HIV-1 infecti

186 pe polymorphisms may impair Nef's ability to antagonize SERINC5 and thereby influence viral fitness i

187 r single mutation, impaired Nef's ability to antagonize SERINC5 and was associated with decreasing vi

188 t retroviruses that use Nef-like proteins to antagonize SERINC5.IMPORTANCE Cellular membrane proteins

189 Clinical studies indicate that antagonizing serotonin (5-HT) type 3AB (5-HT(3AB)) recep

190 get scaffolding proteins G3BP1 and G3BP2 and antagonize SG formation to modulate the integrated stres

191 release of cholesterylated SHH, and Patched1 antagonizes Smoothened activation by cholesterol.

192 However, via association, OTULIN antagonizes SNX27-dependent cargo loading, binding of SN

193 A synthesis and encodes accessory genes that antagonize specific antiviral effectors.

194 H3K4 methylation, the Set1 product, antagonizes spreading in two ways: directly inhibiting c

195 We find that AcrIIA11 antagonizes SpyCas9 using a different mechanism than oth

196 n or enforced alpha-ketoglutarate production antagonizes squamous cell carcinoma growth.

197 ls that a recently evolved SRY gene sequence antagonizes SRY protein stability, necessitating splicin

198 he STAT3/Sin3A axis as a druggable target to antagonize STAT3-addicted tumors.

199 the yellow fever 17D vaccine strain, did not antagonize STAT5 phosphorylation.

200 tin early during infection stabilizes it and antagonizes subsequent HCMV-mediated vimentin destabiliz

201 studies confirmed the ability of H(2)O(2) to antagonize susceptible oral bacterial species, including

202 eukaryotic Hsp104 homologs that specifically antagonized TDP-43 condensation and toxicity in yeast an

203 Together, this is consistent with ASY1 antagonizing telomere-led recombination and promoting sp

204 RA globally antagonized Th9-promoting transcription factors and inhi

205 12/UBP13 (ubiquitin-specific protease 12/13) antagonize the action of NLA (nitrogen limitation adapta

206 (-)2,3,5,6TMP-TQS was shown to antagonize the allosteric activation of alpha7 by the st

207 Many pesticides can antagonize the androgen receptor (AR) or inhibit androge

208 Heparin and heparan sulfate antagonize the binding of these pathogens to HSPGs and s

209 rial natriuretic peptide (ANP; vasodilatory) antagonize the biological actions of each other.

210 g insights on how I-branches can potentially antagonize the cancer-promoting activity of beta-galacto

211 ycerol (POPG) and phosphatidylinositol (PI), antagonize the cognate ligand activation of TLRs 2 and 4

212 block cofactor recruitment to PPARgamma, and antagonize the effects of the PPARgamma agonist rosiglit

213 ry pathways active in NT5C2 mutant cells may antagonize the emergence of NT5C2 mutant clones driving

214 idely consumed psychoactive substance, could antagonize the endogenous protective role of these recep

215 herapeutic approaches are being developed to antagonize the events preceding and following DUX4 expre

216 essing neurons in the central amygdala (CeA) antagonize the extinction memory following immediate ext

217 A virus nonstructural protein 1 (NS1) is to antagonize the host cellular antiviral response.

218 tion of RSV p3, we reveal a new mechanism to antagonize the infection of RSV, and thereby provide the

219 Monoclonal antibodies that antagonize the interaction of 'don't eat me' signals wit

220 re also the first AgRP-based chemotypes that antagonize the MC5R.

221 These interneurons appear to antagonize the otolith circuit until they themselves are

222 ed, all three together are not sufficient to antagonize the Par complex.

223 wever, some species of oral streptococci can antagonize the phenotypes induced by P. gingivalis, indi

224 nked ubiquitination of BRAF recruits PP2A to antagonize the S365 phosphorylation and disrupts the inh

225 HSV-1 encodes two key proteins that antagonize the shutdown of host translation, US11 throug

226 ATASE, which are homologous to proteins that antagonize the state transition kinases (STN7 and STN8)

227 article associated, and expressed HIV-1 Vpr, antagonize the stimulatory effect of a variety of pathog

228 sivity and accuracy, rather than uniquely to antagonize the type I interferon response.

229 Consistently, treatment with PARP1 inhibitor antagonized the anti-inflammatory effect of both RSV and

230 these derivatives, NFP and NYP significantly antagonized the antinociception effect of morphine.

231 ng of Clostridia and increased Desulfovibrio antagonized the colonization of beneficial Clostridia.

232 rference with production or signaling of TNF antagonized the expression of DECTIN-2 family CLR, thwar

233 siRNA knockdown of DPP6 antagonized the I(to) inhibition by NS5806 in hiPSC-CMs.

234 e B cells and T follicular helper cells, and antagonized the induction of phosphorylated AKT in germi

235 The small molecule ISRIB antagonizes the activation of the integrated stress resp

236 reveal that FBXL16 is an F-box protein that antagonizes the activity of another F-box protein, FBW7,

237 Finally, we present evidence that Sema-5c antagonizes the activity of Lar, another transmembrane g

238 Nerfin-1 as a transcriptional repressor that antagonizes the activity of the Sd-Yki complex by bindin

239 Wnt16 antagonizes the ANE restriction mechanism and this activ

240 al role activating the Fzl1/2/7 pathway that antagonizes the ANE restriction mechanism; and (2) a sub

241 in 7 (NS7) of MNV co-localizes with GBP2 and antagonizes the anti-MNV activity of GBP2.

242 Furthermore, 2-AG antagonizes the bacterial receptor QseC, a histidine kin

243 population that drives reward behaviors and antagonizes the BLA's original fear neurons.

244 s recruitment of the phosphatase calcineurin antagonizes the effect of PKA.

245 Pyruvate antagonizes the effects of hypoxia on preferential self-

246 In turn, IAV strongly antagonizes the HDAC4, by down-regulating its expression

247 dentified a novel mechanism by which H3K4me3 antagonizes the HIR/Asf1/Rtt106 repressor complex to pro

248 interacts with the FACT component SPT16 and antagonizes the histone H2A deposition at DSB lesions.

249 ses a PLK1-dependent signaling response that antagonizes the involvement of NOTCH1 in the DNA damage

250 complement Factor H-related 5 protein (FHR5) antagonizes the main circulating complement regulator Fa

251 These data indicate that TCF21 antagonizes the MYOCD-SRF pathway through multiple mecha

252 osphatase activity converts PIP3 to PIP2 and antagonizes the PI3K-Akt pathway.

253 PTEN is a lipid phosphatase that antagonizes the PI3K/AKT pathway and is recognized as a

254 zyme is implicated in tissue repair but also antagonizes the production of NO by type 2 NO synthase i

255 shown that non-canonical Fzl1/2/7 signaling antagonizes the progressive posterior-to-anterior downre

256 y identified a dominant negative ligand that antagonizes the TRAIL-dependent pathway of cell death, w

257 its paralogue and interaction partner Mdm2, antagonizes the tumor suppressor p53.

258 ributed to its LPS-neutralizing activity and antagonizing the activation of LPS-induced Toll-like rec

259 otomorphogenesis by directly interacting and antagonizing the activity of another group of repressors

260 logs capable of either strongly agonizing or antagonizing the AgrC quorum sensing (QS) receptor in th

261 Inhibiting LTB4 synthesis or antagonizing the BLT1 receptor after zymosan challenge r

262 nd other AHLs restrict petiole elongation by antagonizing the growth-promoting PHYTOCHROME-INTERACTIN

263 of 4c as an anti-obesity candidate drug via antagonizing the H3R.

264 domain that is important for replication and antagonizing the host innate immune response.

265 tial role in enhancing virion infectivity by antagonizing the host restriction molecule SERINC5.

266 ses acute diarrhea in swine, plays a role in antagonizing the innate response in porcine epithelial c

267 survival, cell growth, and proliferation by antagonizing the PI3K-AKT-mTOR pathway.

268 ancer, affects transcription via its role in antagonizing the PI3K/AKT signaling pathway.

269 s with diabetic retinopathy and suggest that antagonizing the RAAS improves patients' responsiveness

270 , thus affecting coactivator recruitment and antagonizing the transcriptional regulation induced by 1

271 naptic potentials in SPNs and enhances - not antagonizes - the induction of long-term potentiation (L

272 ifferentiation ability of leukemia cells and antagonize their proliferation.

273 Thus, metastable oligomers antagonize their replacement by amyloid fibrils both by

274 Therefore, antagonizing their effects post-radiation could increase

275 iption factors Blimp1 and Runx3 and acted by antagonizing their expression.

276 /int) monocytes in vivo, and S100A9 blockade antagonized these effects.

277 such as the HIV-1 accessory protein Nef can antagonize this antiviral activity of TIM-1 while host r

278 cooperatively facilitate KLF14 expression by antagonizing this multisubunit repressor complex in EBV-

279 Antagonizing this signalling axis allows the proto-oncog

280 Nef proteins of HIV-1 and other lentiviruses antagonize TIM-mediated restriction.

281 lectively, our work reveals a role of Nef in antagonizing TIM-1 and highlights the complex interplay

282 otein endocytic trafficking are incapable of antagonizing TIM-mediated inhibition of HIV-1 release.

283 landscape and highlights the role of Uls1 in antagonizing Top2 function.

284 siRNA-induced knockdown of these receptors antagonized TOPflash reporter activity and spheroid grow

285 lls, siRNA-induced LRP5/6 or FZD10 knockdown antagonized TOPflash reporter activity.

286 We initially identified apoptosis antagonizing transcription factor (AATF) to be associate

287 These effects are overcome with drugs that antagonize translational reprogramming caused by eIF2alp

288 +)-antagonized mechanism, or CaATiER (Ca(2+)-Antagonized Transport into ER).

289 ults in a marked deficit in NS1's ability to antagonize TRIM25-mediated ubiquitination of the RIG-I C

290 competes TRIM9 for interacting with VASP and antagonizes TRIM9-dependent VASP ubiquitination.

291 the unique C-terminal sequence of Tuba8 that antagonizes tubulin tyrosination and Delta2 cleavage, tw

292 Unlike pro-inflammatory M1 macrophages that antagonize tumorigenesis, MMe macrophages are pro-tumori

293 as(G12D) -driven PDAC through its ability to antagonize Twist1.

294 Conversely, c-Maf antagonized type 1 programming, largely through restrain

295 to actin filaments without bundling them and antagonized UNC-87-mediated filament bundling.

296 L-28170, ONO 5334 and apilimod were found to antagonize viral replication in human pneumocyte-like ce

297 h the protein backbone that are critical for antagonizing viruses containing the Q148H and G140S muta

298 BMP signaling serves as a key regulator that antagonizes WNT and FGF signaling to regulate MSC lineag

299 hieve such deleterious outcome in bone is by antagonizing Wnt/beta-catenin signaling.

300 3 and USP21 as deubiquitylating enzymes that antagonize ZNF598-mediated 40S ubiquitylation and can li