ライフサイエンスコーパス: anteroposterior

1 neurons are guided: one dorsoventral and one anteroposterior.

2 superior anteroposterior, 0.60 for inferior anteroposterior, 0.50 for superior craniocaudal, and 0.6

3 rate, with kappa values of 0.54 for superior anteroposterior, 0.60 for inferior anteroposterior, 0.50

4 ircular with decreased ratio of mediolateral/anteroposterior (1.11+/-0.09 versus 1.32+/-0.09, P<0.000

5 est in the 'arm extension and thoracic cue' (anteroposterior, + 3.0%, P = 0.001; mediolateral, - 4.2%

6 h tall plus arm extension and thoracic cue' (anteroposterior, + 6.0%, P < 0.001; mediolateral, - 2.1%

7 same VR movie significantly reduced both the anteroposterior (62%, p < 0.001) and lateral (47%, p = 0

8 with distinct subregions varying across the anteroposterior (A-P) axis.

9 ion differs across the wing and is primarily anteroposterior (A-P) in the anterior and proximodistal

10 D-V pathfinding but to strongly perturb the anteroposterior (A-P) pathfinding process by which moton

11 mbryo by specifying segmental boundaries and anteroposterior (A-P) segmental polarity.

12 In phase 1, the initial anteroposterior (a-p) subdivision of the head mesoderm i

13 at will become the VD axon extends along the anteroposterior (A/P) axis in the ventral nerve cord (VN

14 f the fluoroscopy unit used and their supine anteroposterior abdominal diameter (group 1, 8.0-8.5-cm

15 in cross-sectional airway area, lateral and anteroposterior airway diameters, and tissue strain (str

16 lateral symmetry by establishing rudimentary anteroposterior and dorsoventral (DV) axes.

17 The functions of wg varied along both the anteroposterior and dorsoventral axes of the embryo.

18 It defines development along the anteroposterior and dorsoventral axes of the vertebrate

19 y networks pattern the neural tube along its anteroposterior and dorsoventral axes.

20 sitional information from genes important in anteroposterior and dorsoventral axis formation, includi

21 nclude: (i) malformations secondary to early anteroposterior and dorsoventral patterning defects, or

22 n explain gene expression patterns with both anteroposterior and dorsoventral polarities.

23 urs along three cardinal axes-proximodistal, anteroposterior and dorsoventral-that are established vi

24 Diagnosis is confirmed on anteroposterior and frog-leg lateral radiographs of both

25 th suggestive groin symptoms should have hip anteroposterior and frog-leg lateral radiographs to rule

26 ral annular dimensions (circumference, area, anteroposterior and intercommissural diameters, height,

27 he effective diameter, the average of aortic anteroposterior and lateral diameters, was independently

28 hen asked about knee pain and weight-bearing anteroposterior and lateral knee radiographs were obtain

29 Subjects were examined acutely with standard anteroposterior and lateral radiography, nuclear medicin

30 neural plate with a coarse pattern along its anteroposterior and mediolateral axes, this basis is pro

31 ed between temporal and condylar regions and anteroposterior and mediolateral directions.

32 sion cell movements are coordinated with the anteroposterior and mediolateral embryonic axes.

33 aintain gene expression boundaries along the anteroposterior and mediolateral neural axes that are im

34 bdominis thickness and length and multifidus anteroposterior and mediolateral thickness measured.

35 ery was typically oval shaped with decreased anteroposterior and normal lateral diameters.

36 Anteroposterior and septal/lateral scar localization was

37 Length, anteroposterior and superoinferior diameters, attenuatio

38 rom the dorsoventral axis, but also from the anteroposterior and terminal patterning systems in the b

39 t9a are required for palate extension in the anteroposterior and transverse axes, respectively.

40 nalyses included measurements of the maximum anteroposterior and transverse dimensions of the anterio

41 roximately 5 x 5 x 10 cm (in the transverse, anteroposterior, and craniocaudal directions, respective

42 Annular area and mediolateral, anteroposterior, and high (superior)-low (inferior) dist

43 he left-right (LR) body axis relative to the anteroposterior (AP) and dorsoventral (DV) axes is centr

44 In Drosophila melanogaster, the anteroposterior (AP) and dorsoventral (DV) axes of the o

45 asymmetric flow with previously established anteroposterior (AP) and dorsoventral (DV) axes remain p

46 rsors into distinct subpopulations along the anteroposterior (AP) and dorsoventral (DV) axes.

47 Two organizers that control anteroposterior (AP) and dorsoventral (DV) development a

48 ing and growth along the proximodistal (PD), anteroposterior (AP) and dorsoventral (DV) limb axes.

49 evelop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions,

50 SSDE conversion factors were derived from anteroposterior (AP) and lateral dimensions measured on

51 In the first, weight-bearing anteroposterior (AP) and lateral knee radiographs were o

52 entify the center of pressure (COP), and its anteroposterior (AP) and mediolateral (ML) displacements

53 to previously defined dorsoventral (DV) and anteroposterior (AP) axes.

54 re, we report that Sqd is also essential for anteroposterior (AP) axis formation.

55 Specification of the anteroposterior (AP) axis in Drosophila oocytes requires

56 in the developing secondary palate along the anteroposterior (AP) axis in mice.

57 found previously that cells elongate in the anteroposterior (AP) axis in the extending germband, sug

58 The establishment of the anteroposterior (AP) axis is a crucial step during anima

59 eport that DV patterning along the zebrafish anteroposterior (AP) axis is temporally coordinated with

60 and partially overlapping domains along the anteroposterior (AP) axis of the early embryo.

61 Patterning of the vertebrate anteroposterior (AP) axis proceeds temporally from anter

62 ch the embryo uncouples its midline from the anteroposterior (AP) axis.

63 iosis and the establishment of the embryonic anteroposterior (AP) axis.

64 for any of these cells to migrate along the anteroposterior (AP) axis.

65 rentially to cells near its source along the anteroposterior (AP) boundary of the wing disc.

66 itionally, squamous morphogenesis shifts the anteroposterior (AP) compartment boundary in the peripod

67 gence and extension (C and E) of the primary anteroposterior (AP) embryonic axis is driven by polariz

68 ee radiograph (anatomic(PA) axis), and 3) an anteroposterior (AP) full-limb radiograph (anatomic(AP)

69 one localizer radiographic examination with anteroposterior (AP) or posteroanterior (PA) projections

70 ress these issues, we first investigated the anteroposterior (AP) origin of the IP complex by fate-ma

71 ere, we investigated potential regulators of anteroposterior (AP) pattern during fin regeneration in

72 h conserved roles in deuterostome ectodermal anteroposterior (AP) patterning in developing embryos, t

73 During anteroposterior (AP) patterning of the developing hindbr

74 en is required for the dorsoventral (DV) and anteroposterior (AP) patterning of the retina.

75 The establishment of anteroposterior (AP) polarity in the early mouse epiblas

76 co-evolve with the mechanisms that establish anteroposterior (AP) polarity of the embryo.

77 Anteroposterior (AP) rotation of the hindbrain prior to

78 s, and includes Dpp signaling components and anteroposterior (AP) segmentation determinants.

79 ar to be key players in the specification of anteroposterior asymmetries in the zebrafish ear.

80 d gnathostomes already had well-defined otic anteroposterior asymmetries.

81 that Rho kinase 2b (Rock2b) is required for anteroposterior asymmetry and fluid flow in KV, but it r

82 ell shape changes control the development of anteroposterior asymmetry in KV, which is necessary to g

83 rms initial symmetry in KV architecture into anteroposterior asymmetry.

84 mb bud patterning along the proximodistal or anteroposterior axes functioning through induction of Me

85 etent to be patterned along dorsoventral and anteroposterior axes.

86 circular canals and ampullae - by conferring anteroposterior axial information to these structures.

87 Rotating rhombomeres 5 and 6 along the anteroposterior axis also impacts cochlear duct morphoge

88 tly associated, such as specification of the anteroposterior axis and anterior neural development, or

89 ry in the epiblast is regionalized along the anteroposterior axis as in lower vertebrates.

90 ablation of Aurora A properly establish the anteroposterior axis but fail to progress through gastru

91 orphogen controls cell fate along 70% of the anteroposterior axis but is translated from mRNA localiz

92 Blimp1 is required for the establishment of anteroposterior axis formation and the formation of head

93 s establish that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endod

94 cing atRAL levels and is required for proper anteroposterior axis formation, neuroectoderm patterning

95 The formation of the anteroposterior axis in mice requires a Wnt3-dependent s

96 ry, we identify new muscle domains along the anteroposterior axis in the zebrafish that are defined b

97 genes specify appendage identities along the anteroposterior axis independently of Tc-hth/Tc-exd and

98 ific factors in response to dorsoventral and anteroposterior axis information.

99 In Xenopus, the establishment of the anteroposterior axis involves two key signalling pathway

100 The Caenorhabditis elegans anteroposterior axis is established in response to ferti

101 Specification of the otic anteroposterior axis is one of the earliest patterning e

102 The elongating mouse anteroposterior axis is supplied by progenitors with dis

103 t control neural crest development along the anteroposterior axis of a jawless vertebrate, the sea la

104 ans, Hox genes determine cell fate along the anteroposterior axis of embryos and are implicated in dr

105 eneity was observed between groups and along anteroposterior axis of healthy hippocampus in both grou

106 nases are asymmetrically localized along the anteroposterior axis of newly fertilized C. elegans embr

107 lished in the one-cell embryo determines the anteroposterior axis of the developing animal and is ess

108 ntial nuclear organisation of Hoxb along the anteroposterior axis of the developing neural tube is co

109 ern of expression with that of Mn1 along the anteroposterior axis of the developing palatal shelves a

110 A exhibits differential expression along the anteroposterior axis of the developing secondary palate,

111 les and cellular hairs (trichomes) along the anteroposterior axis of the Drosophila thorax (notum).

112 develop at two specific positions along the anteroposterior axis of the embryo, whereas other region

113 f polarising activity, which establishes the anteroposterior axis of the limb bud and maintains proli

114 he long-distance movement of ShhN across the anteroposterior axis of the limb bud.

115 rhythmic movements are distributed along the anteroposterior axis of the nervous system.

116 mediated activation of Vent2 and Cdx4 during anteroposterior axis specification.

117 like gene are expressed in domains along the anteroposterior axis that reset to new positions during

118 nin specifies the posterior character of the anteroposterior axis throughout the Bilateria and specif

119 al germ layer becomes regionalized along its anteroposterior axis to give rise to a variety of organs

120 dition, disrupts the proper alignment of the anteroposterior axis with the shape of the embryo and th

121 erning of the pharyngeal apparatus along the anteroposterior axis, and local regulation of retinoic a

122 uman gastruloids undergo elongation along an anteroposterior axis, and we use spatial transcriptomics

123 The neural crest is regionalized along the anteroposterior axis, as demonstrated by foundational li

124 otic vesicle is highly asymmetric about the anteroposterior axis, both morphologically and molecular

125 n signaling to polarize the termini of their anteroposterior axis, but little is known about how rege

126 By contrast, Bozozok can rescue the complete anteroposterior axis, but not notochord, in embryos bloc

127 eotides resulted in a phenotype of shortened anteroposterior axis, reduced head structure, and pertur

128 ertebrates is relatively symmetric about the anteroposterior axis, with only two semicircular canals

129 of the conceptus or failure to elongate the anteroposterior axis.

130 new gut branches are added along the entire anteroposterior axis.

131 ange in signaling by the notochord along the anteroposterior axis.

132 ng the complete pattern of digits across the anteroposterior axis.

133 ogical and molecular heterogeneity along the anteroposterior axis.

134 arget area because of guidance errors in the anteroposterior axis.

135 as somite pairs sequentially form along the anteroposterior axis.

136 lling polarizes neural progenitors along the anteroposterior axis.

137 f cilia, depending on the location along the anteroposterior axis.

138 in a continuous range of locations along the anteroposterior axis.

139 t is the establishment of polarity along the anteroposterior axis.

140 that of visceral muscle precursors along the anteroposterior axis.

141 enesis is differentially regulated along the anteroposterior axis.

142 spatially varying tissue mechanics along the anteroposterior axis.

143 gradient and initiates patterning along the anteroposterior axis.

144 ical neurons or white matter cells along the anteroposterior axis.

145 rently depending on their location along the anteroposterior axis.

146 or a functional division primarily along the anteroposterior axis.

147 he dorsal adult muscles are polarised in the anteroposterior axis: we disprove the hypothesis that mu

148 A large decline in anteroposterior bending strength of the femur and tibia

149 s of cell intercalations are altered and the anteroposterior bias of radial intercalations is lost.

150 process that allows for divergence along the anteroposterior body axis in arthropods.

151 nal position of the QR descendants along the anteroposterior body axis, is mediated through a cell-au

152 er of Nap1 mutants is the duplication of the anteroposterior body axis.

153 is the primary driving force elongating the anteroposterior body axis.

154 new somites are permitted to form along the anteroposterior body axis.

155 dth, distance from the lateral border of the anteroposterior bone crest to the sinus wall, and height

156 s and two experienced operators catheterized anteroposterior (celiac, superior mesenteric, and inferi

157 Anteroposterior cell migration and patterning in C. eleg

158 Anteroposterior chest radiography and enhanced chest CT

159 Anteroposterior chest radiography and enhanced chest CT

160 s during double support and they had reduced anteroposterior CM-CP divergence (P < 0.001) during doub

161 well established compartment boundaries: the anteroposterior compartment boundary is always respected

162 hese findings suggest that there is a direct anteroposterior connection between the retrolental and p

163 ed greater concordance with reference to the anteroposterior coordinate (P<0.001).

164 strocaudal coordinates; the mean lateral and anteroposterior coordinates of the directly localized PP

165 at cross-cord projections participate in the anteroposterior coupling.

166 Some axon growth cones also respond to an anteroposterior cue, following a segmented pathway, and

167 hyseal form, dental morphology and size, and anteroposterior dental proportions, as well as aspects o

168 The horizontal (width) and anteroposterior (depth) dimensions of the bursa were rec

169 arizing activity is the major determinant of anteroposterior development of the amniote limb.

170 This major heterochronic shift in the anteroposterior developmental sequence enables early app

171 the anterior and middle thirds of the tibial anteroposterior diameter and was not age dependent.

172 highest rated quantitative criterion was the anteroposterior diameter of the osseous canal, with a me

173 All recorded data were stratified by patient anteroposterior diameter to determine effects of patient

174 sulted in extensive polydactyly with loss of anteroposterior digit patterning and shortening of the p

175 s the SI enhancement measured in the largest anteroposterior dimension in the axial plane 1 minute af

176 nd increasing annular area, primarily in the anteroposterior dimension.

177 vely) and for failure load and anisotropy in anteroposterior direction (r = -0.65) were found.

178 ntal group, the largest RMSDs were 1.1 mm in anteroposterior direction and 2.6 degrees in pitch orien

179 es were compressed to varying degrees in the anteroposterior direction to create 3 datasets: thin-sli

180 technology suggest that axons project in an anteroposterior direction within the Probst bundle.

181 iate regions of the disc when sheared in the anteroposterior direction, both shear and compressive mo

182 and the posterior superior attachment in the anteroposterior direction.

183 evaluated for tilt angle in mediolateral and anteroposterior directions, CT appearance of tip embeddi

184 ins, disrupted KV cell shape changes and the anteroposterior distribution of KV cilia.

185 otile behaviors of cells with respect to the anteroposterior embryonic axis.

186 al) and epichordal (caudal) neuroepithelium, anteroposterior encroachment of alar lunatic fringe (L-f

187 egurgitation annulus, which, despite similar anteroposterior enlargement, is narrower and essentially

188 ng Shh signalling in early wing buds reduced anteroposterior expansion, and posterior digits were los

189 ting proliferation also irreversibly reduced anteroposterior expansion, but instead anterior digits w

190 ck of rugae is also associated with retarded anteroposterior extension of the hard palate and precoci

191 The anteroposterior extent of the damage to Meyer's loop was

192 ients using depth probes implanted along the anteroposterior extent of the supratemporal plane during

193 pa Values were 0.43 for determining superior anteroposterior extent, 0.47 for determining superior cr

194 caudal extent, 0.57 for determining inferior anteroposterior extent, and 0.48 for determining inferio

195 nitiation and suggests that a pre-pattern of anteroposterior fate specification is already present in

196 dispersed within a coarse somatotopographic anteroposterior (foot to face) gradient in the dentate a

197 The embryonic tectum displays an anteroposterior gradient in development and produces the

198 tages regrew at the same rate but with fewer anteroposterior guidance errors, and were more likely to

199 ggest that a pre-existing genetic system for anteroposterior head patterning was co-opted for pattern

200 the selective lamina I input to VMpo and the anteroposterior (head to foot) topography.

201 In the anteroposterior (horizontal) plane, chemical connectivit

202 the specification of neurons with different anteroposterior identities.

203 s a molecular switch to specify and maintain anteroposterior identity during regeneration and homeost

204 e insight into the mechanisms that establish anteroposterior identity in the developing mammalian bra

205 Furthermore, we show that the anteroposterior identity of tail bud progenitor cells ca

206 rmation of rhombomeres, each with a distinct anteroposterior identity.

207 etermined in highly standardized, semiflexed anteroposterior images.

208 o (dorsoventral axis in amphibians and fish, anteroposterior in amniotes).

209 agittal and reformatted axial-oblique views, anteroposterior including three conjugates of pelvic inl

210 rticipants underwent standard weight-bearing anteroposterior knee radiography and posteroanterior han

211 t knee pain and had bilateral weight-bearing anteroposterior knee radiography to define radiographic

212 ding edge of active states propagated in the anteroposterior/lateral direction over the cortex at app

213 re analyzed to determine trabecular meshwork anteroposterior length and 3 anterior chamber angle widt

214 tive association between trabecular meshwork anteroposterior length and all anterior chamber angle wi

215 tive association between trabecular meshwork anteroposterior length and all anterior chamber angle wi

216 the association between trabecular meshwork anteroposterior length and anterior chamber angle width

217 Mean trabecular meshwork anteroposterior length was 824.86 +/- 181.77 mum.

218 associated with greater trabecular meshwork anteroposterior length.

219 Thus, in the newborn rat, anteroposterior limb coordination relies on active burst

220 d the number of transition points at CT, the anteroposterior location of each transition point relati

221 ncreatic islet formation, and specifying the anteroposterior location of foregut organs.

222 ore Hox paralogous groups functioning in any anteroposterior location.

223 t significantly reduced from control at most anteroposterior locations, but this reduction was much m

224 ation by using a scale of grades 0-3, thymic anteroposterior measurement, and mean maximal thymic lob

225 Anteroposterior measurements of the middle facet (MF) an

226 We also observed an anteroposterior migration of medial edge epithelial cell

227 ased significantly for each 1-cm increase in anteroposterior, minimum, and mean nodule diameter (1.78

228 ity and increased energy in two more complex anteroposterior modes.

229 patterned gene expression domains along the anteroposterior neuraxis, midline, and streak/tailbud.

230 path finding defects along the length of the anteroposterior neuraxis.

231 g cell fate specification, axon guidance and anteroposterior neuronal polarization.

232 o the anatomo-functional parcellation of the anteroposterior OFC gradient observed for secondary vers

233 n and patient orientation in the x-ray beam (anteroposterior or posteroanterior).

234 (P < 0.001) during double support and slower anteroposterior (P < 0.001) and mediolateral (P = 0.002)

235 Normal annulus displayed early-systolic anteroposterior (P<0.001) and area (P=0.04) contraction,

236 0, co-regulated by GLI3, is required for the anteroposterior pattern in which the flank ectoderm acqu

237 s not known whether these progenitors confer anteroposterior pattern to the embryo.

238 of neural markers in apparently appropriate anteroposterior pattern.

239 ior of the Drosophila oocyte is required for anteroposterior patterning and germ cell development dur

240 ng is not required for limb proximodistal or anteroposterior patterning but that RA inhibition of FGF

241 Thus, the study of anteroposterior patterning in insects that lack Bicoid c

242 ral midlines of the entire neuraxis, whereas anteroposterior patterning is controlled by several disc

243 per culture volume) deterministically alters anteroposterior patterning of primitive streak (PS)-like

244 ulating the gurken transport factor K10, and anteroposterior patterning of the blastoderm by tuning t

245 transcription factors have crucial roles in anteroposterior patterning of the nervous system and mes

246 hat NotoPs act as a progenitor niche whereas anteroposterior patterning originates within NMPs and LP

247 ing Shh-signaling inhibited Fgf8 expression, anteroposterior patterning, and distal cell proliferatio

248 In contrast to earlier stages of Drosophila anteroposterior patterning, this transition is not well

249 , such as the segmentation genes controlling anteroposterior patterning.

250 Figure 1: Anteroposterior pelvic radiograph.

251 Anteroposterior pelvic radiography and unenhanced pelvic

252 R-sequences, coronal SWMR and radiographs in anteroposterior pelvic view.

253 These measurements can be made on an anteroposterior pelvis radiograph, which is an inexpensi

254 On anteroposterior pelvis radiographs, we measured "pistol

255 (jbug)/filamin, we show that maintenance of anteroposterior planar polarization requires the notum e

256 In the anteroposterior plane, the neuropil possesses four layer

257 ntered on and tilted parallel to hippocampal anteroposterior plane.

258 developing gill arches establishes gill arch anteroposterior polarity and maintains the proliferative

259 , palatal shelves display oronasal (O-N) and anteroposterior polarity before the onset of fusion, but

260 Anteroposterior polarity in early C. elegans embryos is

261 utants lacking RIG-3 also had defects in the anteroposterior polarity of the ALM mechanosensory neuro

262 nt and Frizzled proteins in establishing the anteroposterior polarity of the mechanosensory neurons A

263 PLR-1 activity in the neuron AVG causes its anteroposterior polarity to be symmetric or reversed bec

264 tivation rescued membrane protrusion but not anteroposterior polarization of F-actin dynamics of PI(3

265 Here we show that initial anteroposterior polarization of the early forelimb field

266 hedgehog (Shh), that progressively specifies anteroposterior positional identities in the posterior d

267 The anteroposterior positioning and the mechanism inducing S

268 tures support the distinct role of the OL in anteroposterior positioning of connective tissues propos

269 nals modulate the responses to Dpp/Tin along anteroposterior positions by cooperating with Dpp/Tin du

270 In all subjects, the anteroposterior positions of the horizontal rectus pulle

271 and and Gli3, genes previously implicated in anteroposterior pre-patterning of the limb-forming regio

272 th regard to their origin in the three early anteroposterior progenitor domains, and their comparison

273 ), and unit recordings in rats, we show that anteroposterior propagation of neocortical slow-waves co

274 a 7% improvement in SNR at the mean maximal anteroposterior prostate dimension in this cohort and a

275 rotational axis horizontal (R(2) = 0.06) or anteroposterior (R(2) = 0.07) position.

276 Standardized anteroposterior radiographs of the knee in extension wer

277 ma representative of acute inflammation, and anteroposterior radiographs of the pelvis and lateral ra

278 All patients underwent standing anteroposterior radiography of the knee prior to arthros

279 ancient bilaterian roles in dorsoventral and anteroposterior regionalisation of the ectoderm.

280 tes, and individual mutant NC from different anteroposterior regions underwent fate changes, losing n

281 OIS response ("activation") in an extensive anteroposterior sector of SII.

282 organization in each area displays a global anteroposterior SF gradient and local patches.

283 genes we identified, rax-2 and rax-3 affect anteroposterior signaling or fate specification and rax-

284 Anteroposterior standing radiographs with the knee in ex

285 ed along the dorsoventral, mediolateral, and anteroposterior striatal axis.

286 Xenopus revealed three molecularly distinct anteroposterior subdivisions, identified as precommissur

287 structure primarily exposed to predominantly anteroposterior tension via anterior and posterior attac

288 ons of the disc under either mediolateral or anteroposterior tension.

289 : the proximodistal (shoulder to finger) and anteroposterior (thumb to little finger) axes.

290 Mediolateral and anteroposterior tilt angle, degree of perforation, and d

291 e/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.

292 ed at different levels in VMpo, based on the anteroposterior topographic organization of selectively

293 minations were distributed with a consistent anteroposterior topography over the posterior half of th

294 ed many STT cells in laminae I and V with an anteroposterior topography.

295 yes, 61.5%) and thick stage 3 membranes with anteroposterior traction concerning for progression to s

296 Controls were matched for anteroposterior tumor epicenter and follow-up duration.

297 These findings mirror the anteroposterior valence-specific gradient reported in ro

298 easible and comparable to x-ray guidance for anteroposterior vessels at 3 T in a vascular phantom.

299 In bichir embryos, we find that the anteroposterior way of formation of cranial segments is

300 ts suggested that the dorsoventral (BMP) and anteroposterior (Wnt/GSK3) patterning gradients are inte