ライフサイエンスコーパス: anthelmintic

1 y allows the parasite to adapt resisting the anthelmintic.

2 up 1B (PLA2g1B) as a host-derived endogenous anthelmintic.

3 understanding of the mode of action of this anthelmintic.

4 rent sensitivities to individual cholinergic anthelmintics.

5 work for the design of effective Cry5B-based anthelmintics.

6 ported to all three commonly used classes of anthelmintics.

7 s have different selectivity for cholinergic anthelmintics.

8 s have studies on the mechanism of action of anthelmintics.

9 are relatively easy to detect and treat with anthelmintics.

10 hways may allow for the development of novel anthelmintics.

11 infection, prompting the need to develop new anthelmintics.

12 is a site of action of DEC as well as other anthelmintics.

13 and RQ synthesis is thus an ideal target for anthelmintics.

14 -based approaches have failed to yield novel anthelmintics.

15 6-119% for 21 benzimidazoles, 79-115% for 12 anthelmintics, 81-118% for 12 coccidiostats and 75-119 %

16 enhance the Ca(2+) toxicity effects of other anthelmintics acting on the intestine or, increase the e

17 we show that necroximes exert highly potent anthelmintic activities.

18 ds tested, quercetin exhibited the strongest anthelmintic activity across all C. elegans strains and

19 mplex secondary metabolites that show potent anthelmintic activity and are characterized by the prese

20 t, N-methylbenzo[d]oxazol-2-amine (1) showed anthelmintic activity and lowest cytotoxicity.

21 The in vitro anthelmintic activity of the 18 ferrocenyl PZQ derivativ

22 d to have antinociceptive, insecticidal, and anthelmintic activity.

23 amongst other compounds, was associated with anthelmintic activity.

24 tify new small molecules with broad spectrum anthelmintic activity.

25 ples of changing parasite dynamics following anthelmintic administration, which do not fit the defini

26 hniques, we determined the MIC values of the anthelmintics against 16 C. difficile isolates of define

27 ne approach for discovery and development of anthelmintics against nematode and flatworm parasites.

28 otal synthesis of paraherquamide A, a potent anthelmintic agent isolated from various Penicillium sp.

29 304 ng/L, and paroxetine, 26 ng/L), and two anthelmintic agents (mebendazole, 65 ng/L, and albendazo

30 cently recognized to have great potential as anthelmintic agents in targeting parasitic roundworms (e

31 interact with deleterious substances such as anthelmintic agents, thus highlighting the necessity of

32 ies of nematotoxic lectins with potential as anthelmintic agents.

33 nt molecular mechanisms, emerge as promising anthelmintic agents.

34 selective spirocyclization of these powerful anthelmintic agents.

35 ere we have identified a synergy between the anthelmintic albendazole (ABZ) and drugs depleting the f

36 disulfonylmethane compounds that have shown anthelmintic and insecticidal (endectocidal) activity.

37 tell the story of ivermectin, describing its anthelmintic and insecticidal actions and recent studies

38 The standard theory of its anthelmintic and insecticidal mode of action is that it

39 r inoculation, the mice were treated with an anthelmintic and then rested, reinoculated with L3s, and

40 As a result of limited classes of anthelmintics and an over-reliance on chemical control,

41 ential to lead to the informed design of new anthelmintics and control strategies.

42 argeted by the macrocyclic lactone family of anthelmintics and pesticides, making the GluCls of consi

43 ity of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have promp

44 wards fasciolosis control, reducing usage of anthelmintics and thus delaying the spread of anthelmint

45 rs could be developed as novel insecticides, anthelmintics, and antimicrobials for agriculture and hu

46 Anthelmintics (anti-worm drugs) have historically been d

47 There was no evidence of effect for anthelmintics, antibiotics, probiotics, zinc, vitamin A,

48 maceutically useful natural products such as anthelmintics, anticancer agents, and immunosuppressives

49 Few anthelmintics are available for treatment, and only one

50 Control strategies reliant on anthelmintics are unsustainable due to the emergence of

51 New anthelmintics are urgently needed, and crystal (Cry) pro

52 Anthelmintics are used to treat human and veterinary par

53 Among n = 37 persons who received anthelmintics as PEP, 6 persons developed trichinellosis

54 Pgp may be a candidate target for new anthelmintics, as it plays critical roles in normal cell

55 cs, prebiotics, synbiotics, antibiotics, and anthelmintics, as well as when designing treatments for

56 enes involved in response to drugs and other anthelmintic-associated biological functions.

57 d on isolation of the host and the use of an anthelmintic at a certain intervention instant t0.

58 cyclic lactones, the most important group of anthelmintics available.

59 iniscent of the spiroketal moiety present in anthelmintic avermectins isolated from actinomycete bact

60 wed that piperazine, an inexpensive and safe anthelmintic, both inhibits IRK1 channels and is antiarr

61 The anthelmintics broadly inhibited C. difficile growth in v

62 ts post-movement, primarily vaccinations and anthelmintics, but very few farms reported carrying out

63 development of resistance to nematicides and anthelmintics by these parasites and reduced availabilit

64 annel targeted by PZQ (TRPM(PZQ)), with both anthelmintic chemotypes targeting unique parasite TRPM p

65 These results uncover a new anthelmintic class affecting lipid metabolism.

66 en made in every livestock host and to every anthelmintic class.

67 y compare the in vitro efficacy of all major anthelmintic classes currently used in human therapy (be

68 d low oral bioavailability of salicylanilide anthelmintics (closantel, rafoxanide, niclosamide, oxycl

69 es, quinoxaline antibiotics, benzimidazoles, anthelmintics, coccidiostats and some others.

70 Our study provides a powerful means by which anthelmintic combination therapies can be examined and d

71 legans, we establish a paradigm for studying anthelmintic combinations using Cry proteins and nicotin

72 s been done to define the characteristics of anthelmintic combinations.

73 odes of ruminants is based largely on use of anthelmintics combined, where practical, with pasture ma

74 ) receptors and have recently shown that the anthelmintic compound morantel potentiates by enhancing

75 inic acetylcholine receptors (nAChRs) by the anthelmintic compound morantel.

76 x terpene-amino acid hybrid, and is a potent anthelmintic compound.

77 raction between beta-lactoglobulin (BLG) and anthelmintic compounds including levamisole (LEV) is a m

78 There is an urgent need to develop novel anthelmintic compounds.

79 of action and the evolution of resistance to anthelmintic compounds.

80 Old and new veterinary anthelmintics comprise a very large field, which could n

81 issue culture, at concentrations higher than anthelmintic concentrations, ivermectin shows antiviral,

82 on of the clinical efficacy of some of these anthelmintics could be achieved by altering the treatmen

83 Antenatal anthelmintics could be effective in reducing maternal an

84 The most extensively characterized of the anthelmintic Cry proteins is Cry5B.

85 Resistance is emerging to the anthelmintics currently used to treat nematode infection

86 Six analogues of the anthelmintic cyclodepsipeptide PF1022A were prepared, ea

87 1980, extraordinary success was achieved in anthelmintic development for animals.

88 compound 1 could be a potential molecule for anthelmintic development.

89 quercetin as a promising lead candidate for anthelmintic development.

90 e show here, is also a site of action of the anthelmintic, diethylcarbamazine.

91 /platyhelminth genomes continues to expedite anthelmintic discovery, we contend that future prioritie

92 ffective and cost-efficient model system for anthelmintic discovery.

93 While the major classes of anthelmintics do not affect the viability of isolated ce

94 nt preventive treatment for malaria, regular anthelmintic drug administration, and improved intake of

95 Niclosamide, a category B anthelmintic drug approved by the US Food and Drug Admin

96 Niclosamide is an anthelmintic drug approved by the US Food and Drug Admin

97 ion of PDM release has been reported for two anthelmintic drug classes, the benzimidazoles and macroc

98 e Caenorhabditis elegans, a model system for anthelmintic drug discovery, has a serotonin (5-HT)-gate

99 ceptor, which may provide new directions for anthelmintic drug discovery.

100 Anthelmintic drug efficacy (ADE) is generally estimated

101 nidazole in the intervention group, vitamins/anthelmintic drug in the control).

102 activity in CNS neurons upon exposure to the anthelmintic drug ivermectin (IVM).

103 igations pursued resistance to the nicotinic anthelmintic drug levamisole in C. elegans at a genetic

104 The anthelmintic drug praziquantel (PZQ) is used to treat sc

105 Administration of the anthelmintic drug praziquantel decreases the risk of CCA

106 worm-infected hamsters were treated with the anthelmintic drug pyrantel pamoate before vaccination.

107 Anthelmintic drug resistance is widespread among parasit

108 and production are intensified by increasing anthelmintic drug resistance.

109 o nematodes, it is emerging as an attractive anthelmintic drug target, but details of MOD-1 function

110 rgets for ivermectin (IVM), a broad-spectrum anthelmintic drug used to treat human parasitic diseases

111 Ivermectin is a widely used anthelmintic drug whose nematocidal mechanism is incompl

112 Cs, we focused on pyrvinium pamoate (PP), an anthelmintic drug with documented anticancer activity in

113 eta-tubulin locus, a target of benzimidazole anthelmintic drug, are identified in independent populat

114 we discovered that mebendazole, an approved anthelmintic drug, could selectively inhibit TNIK kinase

115 sis of screening efforts, closantel, a known anthelmintic drug, was discovered as a potent and highly

116 Closantel, a known anthelmintic drug, was previously discovered as a potent

117 ementary hookworm control tools, such as new anthelmintic drugs (e.g. tribendimidine) and a recombina

118 ng candidates for further development toward anthelmintic drugs and/or highly cytotoxic metal compoun

119 Anthelmintic drugs are the major line of defense against

120 or global scale-up of mass administration of anthelmintic drugs for morbidity control of schistosomia

121 Anthelmintic drugs have limited efficacy and do not prev

122 Resistance to the few anthelmintic drugs is increasing.

123 growing emergence of resistance to frontline anthelmintic drugs such as albendazole and ivermectin un

124 mechanism that is distinct from widely used anthelmintic drugs such as ivermectin, levamisole, and a

125 Novel anthelmintic drugs that can kill both adult and juvenile

126 Existing anthelmintic drugs to treat LF are effective in reducing

127 We call for the efficacy of anthelmintic drugs used in MDA to be closely monitored.

128 ol strategy is to treat infected people with anthelmintic drugs, principally the safe and relatively

129 may drive the development of a new class of anthelmintic drugs.

130 ters are evaluated in experiments with three anthelmintic drugs.

131 ain the stage-specific efficacy of different anthelmintic drugs.

132 The majority of anthelmintics dysregulate neuromuscular function, a fact

133 A major determinant of its anthelmintic effect is the calcium-activated potassium c

134 The salicylanilide anthelmintics exhibit desirable properties for repositio

135 f TCBZ and the TCBZ-sulphoxide metabolite in anthelmintic exposed EVs, but limited TCBZ sulphone was

136 Long-term intensive use of anthelmintics for parasite control of livestock, compani

137 as occurred in response to widespread use of anthelmintics for parasite control, and threatens the su

138 The safety and efficacy of benzimidazole anthelmintics for the treatment of rat lungworm disease

139 The cholinergic anthelmintics had different selectivities for these rece

140 Resistance to anthelmintics has become a major problem in veterinary m

141 The increasing prevalence of resistance to anthelmintics has led to the search for alternative sust

142 Resistance to current anthelmintics has prompted the search for new drugs.

143 tional genomics of important target sites of anthelmintics have been restricted to Caenorhabditis ele

144 oteins contribute to host immune evasion and anthelmintics have been shown to modulate secretory beha

145 may lead to the discovery of entirely novel, anthelmintic-independent interventions against parasites

146 at the efficacy of this clinically important anthelmintic is supported by a broad, cross species poly

147 how that Nemacol enhances the ability of the anthelmintic Ivermectin to paralyze C. elegans and the r

148 luCl) channels are the site of action of the anthelmintic ivermectin.

149 ptors is expected to inform other studies on anthelmintics (ivermectin and emodepside) that act on io

150 fish), and identify 30 structurally distinct anthelmintic lead molecules.

151 holine receptors targeted by the cholinergic anthelmintic levamisole at neuromuscular junctions, can

152 me groups of children were dewormed with the anthelmintic levamisole before the feeding period, where

153 aptation of Brugia malayi to exposure to the anthelmintic, levamisole that activates muscle AChR ion-

154 The benzimidazole anthelmintics, mebendazole and albendazole, are commonly

155 esent key targets for the development of new anthelmintic medicines.

156 orphological characteristics, production and anthelmintic metabolite content.

157 shields its host from nematode attacks with anthelmintic metabolites.

158 Originally, closantel's anthelmintic mode of action was believed to rely solely

159 omplementary strengths of both to understand anthelmintic modes of action and mechanisms of resistanc

160 We have postulated that the anthelmintic morantel (Mor) positively modulates (potent

161 The paraherquamides are potent anthelmintic natural products with complex heptacyclic s

162 This industrial scale anthelmintic neglected tropical disease (NTD) screening

163 Oral anthelmintic niclosamide has potent in vitro antiviral a

164 Emodepside is a resistance-breaking anthelmintic of a new chemical class, the cyclooctadepsi

165 moved from the host environment, established anthelmintics often show no obvious phenotype - raising

166 ype animals, we identified the benzimidazole anthelmintic oxfendazole.

167 e calmodulin-inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural di

168 al traits, which could have implications for anthelmintic performance.

169 This study aimed to investigate the anthelmintic potential of orange-derived flavonoids usin

170 Administration of anthelmintic (praziquantel) and antioxidant (N-acetylcys

171 amon bark were shown to have potent in vitro anthelmintic properties against the swine nematode Ascar

172 In this study, in vivo anthelmintic properties were evaluated using Trichinella

173 The structure of the unusual anthelmintic pyrrolobenzoxazine terpenoid natural produc

174 nd also to the development of compounds with anthelmintic relevance.

175 The genetic basis of resistance to most anthelmintics remains poorly resolved.

176 demiological circumstances, thereby limiting anthelmintic resistance (AR) and boosting agricultural e

177 ng our understanding of the genetic basis of anthelmintic resistance (AR) and epidemiological studies

178 Anthelmintic resistance (AR) in parasitic nematodes pose

179 Here, we discuss how our understanding of anthelmintic resistance and modes of action came from th

180 minthiases control has raised awareness that anthelmintic resistance could develop.

181 so consider other possible examples in which anthelmintic resistance has clearly established, but whe

182 The rapid evolution of anthelmintic resistance in a number of parasites of live

183 The appearance of anthelmintic resistance in Ascaris is a risk for the tar

184 scuss whether they might also be involved in anthelmintic resistance in parasitic nematodes.

185 ed parasite epidemiology in combination with anthelmintic resistance requires the adaptation of curre

186 imals, and humans has resulted in widespread anthelmintic resistance, a problem of great socioeconomi

187 n for a better understanding of Pgp-mediated anthelmintic resistance.

188 stration, which do not fit the definition of anthelmintic resistance.

189 accines necessitated by the global spread of anthelmintic resistance.

190 trol and delay or prevent the development of anthelmintic resistance.

191 nthelmintics and thus delaying the spread of anthelmintic resistance.

192 Hence, Nemacol represents a promising new anthelmintic scaffold that acts through a validated anth

193 Taken together, our results suggest that anthelmintic screening with A. ceylanicum larval stages

194 oors for elucidating subunit arrangement and anthelmintic selectivity.

195 rch has not been undertaken investigating EV anthelmintic sequestration.

196 t-parasite interface in the search for novel anthelmintic strategies.

197 particularly sensitive and useful model for anthelmintic studies and should be incorporated early on

198 r, with recent progress in understanding how anthelmintics subvert host-parasite interactions, and br

199 Resistance of nematodes to anthelmintics such as avermectins has emerged as a major

200 intic scaffold that acts through a validated anthelmintic target.

201 al animal and crop health groups as a viable anthelmintic target.

202 and non-secretory cell and tissue types, and anthelmintic targets display distinct expression pattern

203 ased identification of chokepoint enzymes as anthelmintic targets.

204 potentially other nuclear receptors as novel anthelmintic targets.

205 Diethylcarbamazine is a classic anthelmintic that is used for the prevention and treatme

206 intestine or, increase the effects of other anthelmintics that are metabolized and excreted by the n

207 isole and pyrantel are old (1965) but useful anthelmintics that selectively activate nematode acetylc

208 man hosts and may aid in the design of novel anthelmintics that target the CO(2)-sensing pathway.

209 ines in comparison to UN individuals; again, anthelmintic therapy augmented these levels.

210 But anthelmintic therapy may also select for other biologica

211 For this reason, anthelmintic therapy may be a potent tool for indirectly

212 In vivo, specific anthelmintic therapy resulted in decreased CD66 and CD25

213 Anthelmintic therapy resulted in significantly increased

214 In addition, anthelmintic therapy resulted in significantly increased

215 of the altered monocyte function 6 mo after anthelmintic therapy.

216 arameters in T2DM and its reversal following anthelmintic therapy.

217 d postulates MOD-1 as a potential target for anthelmintic therapy.

218 d whether this modulation is reversible upon anthelmintic therapy.

219 oides stercoralis infection before and after anthelmintic therapy.

220 er from undisturbed communities by comparing anthelmintic-treated and control hosts.

221 crease in the reproductive number of BTB for anthelmintic-treated compared with untreated buffalo.

222 amined prospectively the association between anthelmintic treatment and maternal anaemia, birthweight

223 Our results indicate that anthelmintic treatment can enhance the spread of microbi

224 that besides decreasing eosinophil numbers, anthelmintic treatment does not significantly change the

225 Therefore, we evaluated the anthelmintic treatment effect on changes in IR.

226 Furthermore, resistance and anthelmintic treatment had nonoverlapping effects on BTB

227 Children who benefited the most from anthelmintic treatment in terms of increased hemoglobin

228 Anthelmintic treatment may be a cost-effective method of

229 gs from previous studies have suggested that anthelmintic treatment might delay immunosuppression in

230 Anthelmintic treatment moderated, but did not eliminate,

231 We calculated anthelmintic treatment needs on the basis of WHO guideli

232 Anthelmintic treatment of T. spiralis-infected rodents w

233 ly inform farmers about the likely impact of anthelmintic treatment on animal and herd performance.

234 We evaluated the effects of anthelmintic treatment on bovine tuberculosis (BTB) acqu

235 Anthelmintic treatment reduces STH prevalence, total IgE

236 Anthelmintic treatment resulted in significant increases

237 as increasing dietary fat concentrations and anthelmintic treatment should be considered along with i

238 Anthelmintic treatment significantly reduced the prevale

239 cently advocated policy of routine antenatal anthelmintic treatment, and the value of such a policy m

240 amma responses increased significantly after anthelmintic treatment, from 166 to 322 pg/mL (n=42; P<.

241 Finally, after anthelmintic treatment, the baseline levels of CCL1, CCL

242 Anthelmintic treatment, which is recommended during preg

243 levels of these analytes 6 months following anthelmintic treatment.

244 f Ss diagnosis and 6 months after definitive anthelmintic treatment.

245 fection is reversible (for the most part) by anthelmintic treatment.

246 he disappearance or reduction of cysts after anthelmintic treatment.

247 n (HDM) and current wheeze were assessed pre-anthelmintic treatment.

248 ial dynamics in the development of effective anthelmintic treatments and vaccines.

249 We estimated that 126 million doses of anthelmintic treatments are required per year.

250 nical parasite infection detection, reducing anthelmintic use on sheep farms.

251 The goal of reducing anthelmintic use while preserving effective parasite con

252 vealed that niclosamide, a drug approved for anthelmintic use, possessed promising activity in vitro

253 It is hoped that, ultimately, anthelmintic vaccination will be linked to deworming as

254 nd more effective peptide- and protein-based anthelmintic vaccines is explored herein.

255 et should provide a basis for developing new anthelmintics, vaccines, and improved diagnostic tests a

256 ected before and after treatment with either anthelmintic were assessed for evidence of Wolbachia DNA

257 Most anthelmintics were discovered through in vivo screens us

258 hms include use of dual corticosteroids plus anthelmintics when radicular symptoms are present.

259 Monepantel is a recently developed anthelmintic with a novel mode of action.

260 Mebendazole (MBZ) is an efficacious anthelmintic with known anti-inflammatory and fibrinolyt

261 Closantel, a veterinary anthelmintic with known proton ionophore activities, was

262 ugh the frequent 'blanket' administration of anthelmintics (wormers) has been, and remains, the corne