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1 th [14C]indole was similar to that with [14C]anthranilate.
2 of cis,cis-muconate but could still grow on anthranilate.
3 aryl cross-coupling between blennolide C and anthranilate.
4 s highly specific for its cognate substrate, anthranilate.
5 Cys112Ala active site mutant in complex with anthranilate.
6 enzoate and chloro and fluoro derivatives of anthranilate.
7 m which PQS is synthesized is the metabolite anthranilate.
8 amide or the intermediate amide with methyl anthranilate.
9 places pyruvate to form either salicylate or anthranilate.
10 odinitrotoluenes), as well as salicylate and anthranilate.
11 ing the ability to respond to salicylate and anthranilate.
21 g enzymes for the synthesis of catechol from anthranilate, a precursor of the PQS, were most affected
22 nge) SA methyltransferase can methylate both anthranilate (AA) and SA, we used this enzyme to examine
24 ain selectivities to identify and confirm an anthranilate-activating module in the fumiquinazoline A
28 exin during a 1.5-h pulse labeling with [14C]anthranilate also increased with time after fungal inocu
31 s p-methoxycinnamate, p-methoxycinnamide, or anthranilate and an alpha,beta- or alpha,beta,gamma,delt
32 thesis of secondary metabolites derived from anthranilate and chorismate is what impaired the biofilm
35 sing the functional AntDO-3C genes transform anthranilate and salicylate (but not 2-chlorobenzoate) t
36 catalyzed a conjugation reaction, with free anthranilate and UDP-glucose as substrates, that yielded
37 w that water-soluble bifunctional catalysts (anthranilates and phosphanilates) speed the reversal of
38 cation of the first ROY solvate (ROY. methyl anthranilate) and the first example of a ROY dimer, form
39 e ability to take up kynurenine, kynurenate, anthranilate, and N-formylanthranilate through OAT1, the
40 Benzyl alcohol, benzaldehyde, benzoate, and anthranilate are metabolized via catechol, cis,cis-mucon
45 hranilate synthase alpha subunit 1 in methyl anthranilate biosynthesis was supported via fruit transi
47 assembly line that efficiently activates two anthranilate building blocks and illustrates the remarka
48 derived from the conversion of chorismate to anthranilate by an anthranilate synthase or through the
49 tigate the degradation of tryptophan through anthranilate by Burkholderia cepacia, several plasposon
51 e results indicate that sugar conjugation of anthranilate by UGT74F2 allows its stable accumulation i
52 the cellular accumulation of phosphoribosyl anthranilate can result in nonenzymatic PRA formation su
54 ests that the ortho-carboxylate group in the anthranilate catalysts serves to aid in intramolecular p
56 nyltransferase, type II polyketide synthase, anthranilate:CoA-ligase, and several tailoring enzymes a
57 cumulate varying amounts of blue fluorescent anthranilate compounds, and only the two least severely
59 es of the enzyme, including that of the PqsD-anthranilate covalent intermediate and the inactive Cys1
60 ly, we investigated why mutants defective in anthranilate degradation have an impaired ability to for
61 An antA point mutation in ACN26 prevented anthranilate degradation, and this mutation was independ
64 produces tryptophan and elicitor-inducible, anthranilate-derived alkaloids by means of two different
65 epin-2-ones were synthesized by acylation of anthranilate-derived amino ketones with an aza-glycine e
66 provided the first structural bases for the anthranilate-derived production of the quinolone and acr
67 ever, since the single turnovers resulted in anthranilate dihydroxylation by the wild-type enzyme but
69 e mutant with the plasposon insertion in the anthranilate dioxygenase (AntDO) genes was chosen for fu
72 , a bacterium that normally does not degrade anthranilate, enabled the conversion of anthranilate to
74 cing valerolactam (bulk chemical) and methyl anthranilate (fine chemical) are developed by combinator
76 enine pathway is also the critical source of anthranilate for energy metabolism via the antABC gene p
77 the PqsA protein is responsible for priming anthranilate for entry into the PQS biosynthetic pathway
78 e kynurenine pathway is a critical source of anthranilate for PQS synthesis and that the kynurenine p
80 tABC gene products, as well as the source of anthranilate for synthesis of the P. aeruginosa quinolon
81 scent vinblastine derivative, vinblastine-4'-anthranilate, has been shown to inhibit polymerization o
82 nium being globally abundant, alkylaluminium anthranilates have not yet been considered as effective
83 enes encoding enzymes for the degradation of anthranilate (i.e. antABC), a precursor of the Pseudomon
84 tively low levels of radioactivity from [14C]anthranilate incorporated into camalexin in the noninocu
89 lic intermediates, 2,3-dihydroxybenzoate and anthranilate, involved in enterobactin and tryptophan bi
94 lished by coating the metal bead with methyl anthranilate (MeA) and allowing the birds to peck it onc
96 r of pqs system, which coordinately controls anthranilate metabolism and bacterial virulence in P. ae
98 expression, demonstrating that regulation of anthranilate metabolism is intimately woven into the quo
99 edlings are grown on media supplemented with anthranilate metabolites, their roots wave like wild typ
101 the DNA minor groove with its methoxyacrylyl-anthranilate moiety intercalating into the helix at the
102 e of esperamicin A1 lacking an intercalating anthranilate moiety, and calicheamicin, both groove bind
103 nucleosome cores due to intercalation of an anthranilate moiety, did not detect the presence of a nu
104 , anthocyanin O-hydroxycinnamoyltransferase, anthranilate N-hydroxycinnamoyl/benzoyltransferase, deac
105 in O-hydroxycinnamoyltransferase], HCBT [for anthranilate N-hydroxycinnamoyl/benzoyltransferase], and
107 d M43K variant, however, did not hydroxylate anthranilate or benzoate at either the permissive (23 de
109 hydrogenases, one polyamine oxidase, and one anthranilate-phosphoribosyl-transferase as candidate gen
111 D2 proteins show high structural homology to anthranilate phosphoribosyltransferase (TrpD) and nucleo
112 RA synthesis was reconstituted in vitro with anthranilate phosphoribosyltransferase (TrpD), threonine
113 roduce an internal transcript that increases anthranilate production and greatly elevates the express
115 hthalene, xylene, phthalate & terephthalate, anthranilate, protocatechuate & homoprotocatechuate, sal
117 32 that we named MpaR (MvfR-mediated PQS and anthranilate regulator) for its regulation of Pseudomona
118 ent to the first irreversible step, which is anthranilate release, is general base catalyzed, and inv
119 sitional exchange between the valine and the anthranilate residues within the macrolactam ring in the
120 etype inducers, salicylate or salicylate and anthranilate, respectively, and did not restore the high
121 rm-extractable metabolites labeled with [14C]anthranilate revealed a transient increase in the incorp
123 ove, good stacking between the intercalating anthranilate ring and flanking purine bases and intermol
124 orescence spectroscopy to reveal that methyl anthranilate spontaneously binds to BSA (DeltaG degrees
125 , benC substituted for antC during growth on anthranilate, suggesting relatively broad substrate spec
126 vated tryptophan levels and exhibited higher anthranilate synthase (AS) activity that showed increase
127 a naturally occurring, feedback-insensitive anthranilate synthase (AS) alpha-subunit gene, ASA2, has
131 NA clone that encodes a feedback-insensitive anthranilate synthase (AS), ASA2, isolated from a 5-meth
132 chanism with isochorismate synthase (IS) and anthranilate synthase (AS), in which nucleophile additio
134 p of tryptophan biosynthesis is catalyzed by anthranilate synthase (AS), which is normally subject to
135 the gene coding for the TrpD subunit of the anthranilate synthase (AS)-phosphoribosyl transferase (P
138 nd Acyrthosiphon pisum contain the genes for anthranilate synthase (trpEG) on plasmids made up of one
139 of tryptophan, rather than the demonstrated anthranilate synthase activity of TrpE, mediated the dev
140 e cells of tryptophan, both the AT level and anthranilate synthase activity were observed to increase
144 the action of the WEAK ETHYLENE INSENSITIVE2/ANTHRANILATE SYNTHASE alpha1 (WEI2/ASA1) and WEI7/ANTHRA
145 zing enzyme family, e.g. the TrpE subunit of anthranilate synthase and the PabB subunit of 4-amino-4-
146 ANILATE SYNTHASE alpha1 (WEI2/ASA1) and WEI7/ANTHRANILATE SYNTHASE beta1 (ASB1) genes that encode alp
147 4-amino-4-deoxychorismate (ADC) synthase as anthranilate synthase component I (ASI) homologues that
149 bility to independently enhance and activate ANTHRANILATE SYNTHASE in the auxin production pathway.
153 gulated enzymes of the shikimate pathway are anthranilate synthase on the branch leading to Trp and c
154 nversion of chorismate to anthranilate by an anthranilate synthase or through the degradation of tryp
155 PabB enzymes from the closely related enzyme anthranilate synthase, which typically contains a PIAGT
157 The tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase, compose
161 via the kynurenine pathway and two separate anthranilate synthases, TrpEG and PhnAB, the latter of w
164 ough P. aeruginosa has multiple pathways for anthranilate synthesis, one pathway-the kynurenine pathw
166 erstanding of how P. aeruginosa produces the anthranilate that serves as a precursor to PQS and other
167 plays a bound pyruvate as well as a putative anthranilate (the nitrogen group is ambiguous) in the Tr
168 catalyzes the conversion of chorismate into anthranilate, the biosynthetic precursor of both tryptop
169 tion of the fluorescent tryptophan precursor anthranilate, the bulk of which is found in a glucose-co
174 ted anthraniloyl-CoA thioester that shuttles anthranilate to the PqsD active site where it is transfe
175 perons encode enzymes for the degradation of anthranilate to tricarboxylic acid cycle intermediates.
176 have redundant conjugating activities toward anthranilate, UGT74F2 is the major source of this activi
177 he positional exchange of the valine and the anthranilate units of the structure originally proposed
179 ed from the tryptophan pathway intermediate, anthranilate, which is derived either from the kynurenin
180 nine pathway, tryptophan is broken down into anthranilate, which is further degraded into tricarboxyl
181 ismate is converted to the aromatic compound anthranilate, which is then conjugated to a phosphoribos
183 tubulin complex at the absorption maximum of anthranilate, yields a covalent adduct confined to beta-