ライフサイエンスコーパス: anthranilic acid

1 hurenic acid + 3'-hydroxy anthranilic acid + anthranilic acid)].

2 eavage of l-kynurenine to give l-alanine and anthranilic acid.

3 dent as was that of a downstream metabolite, anthranilic acid.

4 nt than CI-1040, the cyanoquinoline, and the anthranilic acid.

5 r the light (d(0)) or heavy (d(4)) form of 2-anthranilic acid (2-AA).

6 Anthranilic acid (2-aminobenzoic acid, 2-AA) has the rem

7 The procedure uses the fluorescent compound anthranilic acid (2-aminobenzoic acid; 2-AA) to label ol

8 ith the matrixes 6-aza-2-thiothymine and 80% anthranilic acid/20% nicotinic acid but not with 3-hydro

9 3,4,-Dimethoxycinnamoyl anthranilic acid (3,4-DAA), an orally active synthetic d

10 N-(3,4,-Dimethoxycinnamoyl) anthranilic acid (3,4-DAA), an orally active synthetic d

11 hen, tryptophan, kynurenine, kynurenic acid, anthranilic acid, 3-hydroxy-kynurenine, xanthurenic acid

12 nhibitors, the high-throughput screening hit anthranilic acid 4, the known benzofuran analogue 5, and

13 reninase that converts l-kynurenine (KYN) to anthranilic acid (AA) and 3-hydroxykynurenine (3HKYN) to

14 ides, with a phenylalkenoic acid (PA) and an anthranilic acid (AA) subunit, which are secondary metab

15 ns was made possible by the virtue of unique anthranilic acid (AA, 2-aminobenzoic acid [2AA]) chemist

16 hile KP metabolites (tryptophan, kynurenine, anthranilic acid [AA], picolinic acid, and quinolinic ac

17 itive fluorescent label 2-aminobenzoic acid (anthranilic acid, AA) for characterization of carbohydra

18 Gase F and labeled with 2-aminobenzoic acid (anthranilic acid, AA).

19 We found that N-(p-amylcinnamoyl) anthranilic acid (ACA) and 2-(p-amylcinnamoyl) amino-4-c

20 acid derivatives such as N-(p-amylcinnamoyl)anthranilic acid (ACA), which act as slow inhibitors.

21 nthurenic acid + 3-hydroxyanthranilic acid + anthranilic acid); an inverse marker of vitamin B6] and

22 ptophan precursors (14)C-, (13)C-, and (15)N-anthranilic acid and (14)C- and (13)C-ribose.

23 age of a multi-component cascade reaction of anthranilic acid and a precursor polyketide containing a

24 y amide (CI-1040), two CI-1040 analogues (an anthranilic acid and an N-alkyl amide), and a cyanoquino

25 s the hydrolytic cleavage of l-kynurenine to anthranilic acid and l-alanine.

26 e report that simple, commercially available anthranilic acids and aminobenzoic acids act as superior

27 xtension of this protocol to the coupling of anthranilic acids and isocyanides leading to medicinally

28 e:tryptophan ratio, and C-reactive protein), anthranilic acid, and 3-hydroxykynurenine were positivel

29 ith N-glycanase F, reductively aminated with anthranilic acid, and fractionated by normal phase high-

30 of the KP where kynurenine-tryptophan ratio, anthranilic acid, and picolinic acid were elevated.

31 s of tryptophan, kynurenic acid, kynurenine, anthranilic acid, and xanthurenic acid were higher in wi

32 demonstrated that the NRPS NanA incorporates anthranilic acid (Ant) and l-kynurenine (l-Kyn), which i

33 f commercially available ligands composed of anthranilic acid (anth-H(2)) and its N-substituted deriv

34 nurenic acid + xanthurenic acid + 3'-hydroxy anthranilic acid + anthranilic acid)].

35 acid fragment as a suitable isostere for the anthranilic acid appendage of 4, which led to the discov

36 order CI-1040 approximately cyanoquinoline < anthranilic acid approximately U-0126 < alkyl amide.

37 oxidative decarbonylation of isatin to form anthranilic acid as a fluorescent probe.

38 A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5

39 etic derivative of the tryptophan metabolite anthranilic acid, but not l-kynurenine, enhanced product

40 azone ligation were observed when polyvalent anthranilic acid catalysts operating on polyvalent aldeh

41 We conclude that ACA and other anthranilic acid derivatives are effective allosteric in

42 We here report the SAR of anthranilic acid derivatives as FXR modulators and devel

43 A series of novel anthranilic acid derivatives I-IV, of which COOH-NH(2) (

44 The favorable effects of anthranilic acid derivatives in atherosclerosis indicate

45 otection and produces a wide range of N-aryl anthranilic acid derivatives in up to 99% yield.

46 d protection and produces N-aryl and N-alkyl anthranilic acid derivatives in up to 99% yield.

47 Crystallographic analysis of seven anthranilic acid derivatives showed formation of two dis

48 of the family are sensitive to inhibition by anthranilic acid derivatives such as N-(p-amylcinnamoyl)

49 Anthranilic acid derivatives were identified as DFMO adj

50 nds related in structure to flufenamate, all anthranilic acid derivatives, as potential inhibitors of

51 enolic kynurenine catabolites kynurenine and anthranilic acid did not reduce either metal.

52 rticularly promising set of analogues is the anthranilic acid esters 63-66 in which the phenyl ring i

53 iviral activity of diarylamines derived from anthranilic acid (FAMs) against ZIKV.

54 , followed by N-(9-fluorenylmethoxycarbonyl)-anthranilic acid (Fmoc-anthranilic acid) with an IC(50)

55 sosome-related organelles (gut granules), as anthranilic acid glucosyl esters--not, as previously sur

56 N-(1-Pyrene)anthranilic acid has been employed in metal ion-selectiv

57 f ortho-C-H bonds in anilides to form N-acyl anthranilic acids has been developed.

58 somerism of appropriately substituted N-aryl anthranilic acids has been investigated in the solid sta

59 enzyne intermediates by the diazotization of anthranilic acids in the presence of Barton esters.

60 Notably, these anthranilic acid inhibitors exhibit a strong negative co

61 The structure-based design of novel anthranilic acid inhibitors of AcpS, a potential antibac

62 Anthranilic acid is a competitive inhibitor with benzoic

63 Anthranilic acid is derived from tryptophan by action of

64 oceed in 14 steps from protected tryptophan, anthranilic acid, leucine, and alanine in 7% overall yie

65 r X-ray complex structures of representative anthranilic acid ligands bound to AcpS are described in

66 ence of BBA5 were synthesized to include the anthranilic acid/nitrotyrosine fluorescence quenching pa

67 stered tranilast, N-(3,4-dimethoxycinnamoyl) anthranilic acid, on histologic and histomorphometric ch

68 of the broad spectrum TRP channel inhibitor, anthranilic acid or ACA, and we find that both inhibitor

69 een the indole-nitrogen of tryptophan and an anthranilic acid residue, and a high yielding macrolacta

70 e synthetic derivative of the Trp metabolite anthranilic acid, reversed paralysis in mice with experi

71 are also important interaction sites for the anthranilic acid S0100176 (N-benzyl-N-pyridin-3-ylmethyl

72 hen discovered and structurally confirmed an anthranilic acid scaffold that binds this pocket with hi

73 novel class of GPR17 antagonists based on an anthranilic acid scaffold.

74 An anthranilic acid series of allosteric thumb pocket 2 HCV

75 rally active class of MetAP2 inhibitors, the anthranilic acid sulfonamides exemplified by A-800141, w

76 reversible inhibitors of MetAP2, a series of anthranilic acid sulfonamides with micromolar affinities

77 econd step (microwave-assisted reaction with anthranilic acid) takes approximately 14 h in total to c

78 thurenic acid + 3'-hydroxyanthranilic acid + anthranilic acid), termed HK ratio (HKr), was related to

79 We find that anthranilic acid, the product of the PhnAB synthase, is

80 QF) with a 6-6-6 tricyclic core derived from anthranilic acid, tryptophan, and alanine.

81 serum levels of kynurenine, kynurenic acid, anthranilic acid, tryptophan, nicotinamide and N1-methyl

82 s can be reacted with commercially available anthranilic acids under microwave irradiation conditions

83 MurA inhibitors, derivatives of 5-sulfonoxy-anthranilic acid, using high-throughput screening.

84 oxyanthranilic acid, and 3-hydroxykynurenine:anthranilic acid were significant discriminating variabl

85 Higher concentrations of nicotinamide and anthranilic acid were, however, associated with a lower

86 metabolites: kynurenine, kynurenic acid, and anthranilic acid, were substantially, but differentially

87 also inhibited by ACA, ONO-RS-082, and Fmoc-anthranilic acid, whereas the Na(+)/citrate transporter

88 which is synthesized by the condensation of anthranilic acid with a 3-keto-fatty acid.

89 renylmethoxycarbonyl)-anthranilic acid (Fmoc-anthranilic acid) with an IC(50) value of approximately

90 ng PLP, kynurenine, HK, kynurenic acid (KA), anthranilic acid, xanthurenic acid (XA), and 3-hydroxyan