ライフサイエンスコーパス: anti conformation

1 forms a base-pair with G6, but is now in the anti conformation.

2 een or Watson-Crick base pairing in -syn or -anti conformation.

3 (syn-anti conformation), transformed to anti-anti conformation.

4 and decoding nucleotide G530 flips into the anti conformation.

5 in the syn conformation and the other in the anti conformation.

6 yn conformation and the template base in the anti conformation.

7 , results in preferred binding of 8OG in the anti conformation.

8 syn conformation and the template is in the anti conformation.

9 the incoming pyrimidine which remains in the anti conformation.

10 n of Lys-60F such that it adopts an extended anti conformation.

11 bind poorly) model shows a preference for an anti conformation.

12 tituent on the adjacent C are disposed in an anti conformation.

13 mation, while the adenosine moiety adopts an anti conformation.

14 a medium anti conformation, and GTP by a low anti conformation.

15 that the noncatalytic site binds cGMP in the anti-conformation.

16 mismatched structure with 8-oxoG adopting an anti-conformation.

17 e in the A(3)AR/3 complex, which featured an anti-conformation.

18 eotides in (CTG)5 and (CTG)6 adopt C2'-endo, anti conformations.

19 d a binding pocket near AA base pairs in syn-anti conformations.

20 he template base may be in either the syn or anti conformations.

21 terchange of this adduct between the syn and anti conformations.

22 tuted base allows it to flip between syn and anti conformations.

23 erence in the preference for a syntau versus anti conformation about the bond from pyrrole C3 to the

24 results for AdoMet indicate a predominantly anti conformation about the glycosidic bond with a varie

25 nicotinamide riboside moiety are both in the anti conformation about the glycosidic bond, and both ri

26 latter, all guanine nucleosides possess the anti conformation about the glycosidic bond, while in th

27 AdoMet and AMPPNP both bind in an anti conformation about the glycosidic bond.

28 plex (Y = dPer) reveals that dPer adopts the anti conformation about the glycosyl bond and forms a le

29 establishes that 1,N(2)-epsilondG adopts the anti conformation about the glycosyl bond and that the e

30 The PdG adduct remained in the anti conformation about the glycosyl bond in each of the

31 The mismatched dA was in the anti conformation about the glycosyl bond.

32 M1G was in the anti conformation about the glycosyl bond.

33 The adducted dG maintains the anti-conformation about the glycosyl bond.

34 keto reductase, binds NADP(+) in an extended anti-conformation across an (alpha/beta)(8)-barrel.

35 ent space to accommodate 5' substrates in an anti conformation and 3' substrates in a syn conformatio

36 termediate, the chromophore has a 13-cis, 15-anti conformation and a deprotonated Schiff base.

37 t this base interconverts between the normal anti conformation and a less populated syn conformation.

38 es of Pf1 DNA exhibit sugars in the C2'-endo/anti conformation and bases that are largely unstacked,

39 ncoming dTTP, the templating oxoA adopted an anti conformation and formed Watson-Crick base pair.

40 rror-free replication, with MeFapy-dG in the anti conformation and forming Watson-Crick pairs with dC

41 n the BrG.dCTP ternary structure, BrG adopts anti conformation and forms Watson-Crick base pairing wi

42 w calix[6]arene derivatives 3 and 4 in a 1,4-anti conformation and one calix[8]arene derivative 5 wer

43 3'-endo conformation, the glycosyl angles in anti conformation and the majority of the C4'-C5' torsio

44 steen geometry with the incoming dNTP in the anti conformation and the template base in the syn confo

45 eties from the C2'-endo/anti to the C3'-endo/anti conformation, and appreciable unstacking of purines

46 by a high anti conformation, ITP by a medium anti conformation, and GTP by a low anti conformation.

47 bond, while in the former, half possess the anti conformation, and half possess the syn conformation

48 All residues adopted an anti conformation, and Watson-Crick alignments were obse

49 irs, and two hydrogen bonds in the G(syn).A+(anti) conformation are formed.

50 t bypass occurs only when O(6)-meG adopts an anti conformation around its glycosidic bond, with the m

51 C2'-endo/C3'-exo range, residues adopting an anti conformation around the glycosidic torsion angle an

52 GMP binds in the same anti conformation as GTP, whereas 8-pyrrolidino-GMP bind

53 With dG* in the normal B-DNA anti conformation, BP seriously disturbs the polymerase

54 that LDH binds the cofactor in both syn and anti conformations, but that binding interactions in the

55 The G(syn).A+(anti) conformation can provide a different surface for r

56 the purine at the primer terminus is in the anti conformation during mispair extension.

57 esponding triphosphate possess different syn/anti conformations during replication which influence ba

58 atechol analog in the solid phase with a syn-anti conformation for CAP.

59 t the CpG steps in the stem; (iii) C2'-endo, anti conformations for all the nucleotides.

60 xoG), is highly mutagenic in vivo due to its anti-conformation forming a Watson-Crick base pair with

61 Mechanistically the product with anti conformation forms by a hemiketal-oxy-Cope type [3,

62 rmation around the N-cPr bond instead of the anti conformation generally preferred by secondary aceta

63 e torsion angle of N-glycosyl bond from the +anti conformation in 3.dATP to -syn in cAMP; such a rota

64 acked inside the core of the helix with anti-anti conformations in RNA and (high-anti)-(high-anti) co

65 i conformations in RNA and (high-anti)-(high-anti) conformations in DNA.

66 conjunction with Phe961 helps attenuate the anti-conformation in human pol gamma for error free bypa

67 tion reveals that 1 reacts from its syn- and anti-conformations in competition with trapping by thiol

68 In addition, dG and cladribine adopt the anti conformation, in contrast to the syn conformation o

69 The enzyme-bound ATP adopts an anti conformation, in contrast to the syn conformation r

70 difference in the energies of these syn and anti conformations, in contrast to control calculations

71 dopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best in

72 reference of guanine ribonucleosides for the anti conformation is the driving force for the change in

73 ding partner for N3-H of T when dA is in the anti conformation, is 6.31 A away from this proton.

74 ATP and XTP are characterized by a high anti conformation, ITP by a medium anti conformation, an

75 he A:G mismatch has been shown to prefer the anti conformation moA substitution is destabilizing to t

76 pairs were dynamic and sampled multiple anti-anti conformations, no syn-anti <--> anti-anti transform

77 The stabilized anti conformation occurs without notable contacts from t

78 aphyrin instead of corrole suggests that the anti conformation of 2,2'-bipyrrole is the relevant form

79 However, the anti conformation of 8-morpholino-GMP is selected by Bs-

80 tential role for Arg(332) in stabilizing the anti conformation of the 8-oxoG template base by means o

81 The anti conformation of the hydroxyl group with respect to

82 hat this RNA might selectively recognize the anti conformation of the N-glycosidic bond of cAMP.G.U p

83 The anti conformation of the nicotinamide riboside moiety is

84 xyl group at position 124 in stabilizing the anti conformation of the nicotinamide ring as observed i

85 approximately 230 cm-1 ascribable to syn and anti conformations of the 5-OH group.

86 surprisingly adsorbs with gauche rather than anti conformations of the octyl groups.

87 uorophenyl) TEFDDOL, a quite unusual "pseudo-anti" conformation of the diol, with no intramolecular (

88 from amino acid side chains, which limit the anti-conformation of the 8-oxo-dG template base during t

89 All of them display the expected anti-conformation of the nucleoside with 2'-endo sugar p

90 The structure reveals both the syn- and anti-conformations of template 8-oxoG in the confines of

91 the modeling studies show that both syn- and anti-conformations of the 1,N(2)-epsilon G are stericall

92 The NI lesion can adopt both syn and anti conformations on the DNA duplex level, with the gua

93 hromophore (RSBH(+)) adopts an all-trans,C=N-anti conformation only.

94 similar to 8-oxo-dGTP, r8-oxo-GTP adopts an anti conformation opposite a templating cytosine and a s

95 oxidized and undamaged dGTP in the canonical anti-conformation opposite template cytosine.

96 n the Watson-Crick face to the higher-energy anti conformation, positioning the methyl group in the m

97 8-dihydroadenosine) that could adopt an anti-anti conformation proceeded with high efficiencies.

98 s that fd DNA nucleosides favor the C3'-endo/anti conformation, rather than the C2'-endo/anti conform

99 d nucleotide to the energetically disfavored anti conformation required for Watson-Crick pairing is r

100 ve, with the modified cytosine in the syn or anti conformation, respectively.

101 ertion is accommodated in either the syn- or anti-conformation, respectively.

102 inaphthylurea exists as a mixture of syn and anti conformations separated by a barrier of ca. 14 kcal

103 aining substrate is largely populated in the anti conformation state.

104 Different syn/anti conformations suggest that the mechanism involves a

105 dG (propensity to bind to the enzyme in its anti conformation), suggesting that dA analogues with a

106 de and dinucleotide fragments in the syn and anti conformations support these conclusions.

107 /anti conformation, rather than the C2'-endo/anti conformation that is characteristic of the lowest e

108 anning about 260 degrees and passing for the anti conformation (the two nitrogen atoms at opposite si

109 is very similar; the nicotinamide is in the anti conformation, the A-face is exposed to solvent, and

110 d configuration relative to 1,N(6)-dA in the anti conformation, thus opposite the 5'-T in the templat

111 th uridine with the methylamino group in the anti conformation to form a Watson-Crick base pair that

112 ee DNA synthesis involves 8-oxoG adopting an anti-conformation to base pair with cytosine whereas mut

113 One of the terminal AA base pairs (syn-anti conformation), transformed to anti-anti conformatio

114 ics associated with the 8oxoG O8 atom in the anti conformation were the major driving forces for this

115 tures show that the 8-oxoG residue is in the anti conformation when paired opposite dCTP, but it flip

116 Tg is in the anti conformation, whereas 5-OHU adopts both anti and sy

117 t Dpo4 holds the incoming dNTP in the normal anti conformation while allowing the template nucleotide

118 ed protein, the nicotinamide ring adopts the anti conformation while in the oxidized enzyme the syn c

119 The modified guanine remained in the anti conformation, while the 3-oxo-1-propenyl moiety was

120 *G and G*G mispair with the incoming dGTP in anti conformation, while the protein remains near the op

121 overed that 1 x 1 7A:A and 7AL:A prefer anti-anti conformations, while 1 x 1 7A:G and 7AL:G prefer sy

122 onformation 11 kcal/mol more stable than the anti conformation with a barrier of 17 kcal/mol connecti

123 DFT calculations suggest that 6a assumes an anti conformation with a dihedral O horizontal lineFe-Fe

124 However, with the normal partner dCTP, the anti conformation with close to Watson-Crick alignment r

125 The inhibitors are proposed to bind in the anti conformation with the hydrophobic C6 and C8 substit

126 The second structure showed N2-Naph G in an anti conformation with the primer terminus largely disor

127 (i) the nicotinamide cofactor is bound in an anti-conformation, with the amide carbonyl occupying the