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1 the NHC backbone (vs the initially expected anti).
2 ucleobase into two different domains (syn or anti).
3 ers (cis/syn, cis/anti, trans/syn, and trans/anti).
4 hoxy group is oriented toward the other (syn-anti).
5 "Pro") or away from it, toward its reverse ("Anti").
6 naute-like gene) that are antimorphic [alg-1(anti)].
7 on correlated with ribosome affinity for the anti (1,4)-regioisomers as revealed by measured Kd value
8 nocyclohexane can be differentiated using Sc[anti-(-)-1](2) in the same ligand displacement assay.
9 of compound 6 can be fixed predominantly to anti (17a and 17b) by introducing bulky alkyl groups (e.
16 e that an approximately 370-MBq injection of anti-(18)F-FACBC yields good imaging and acceptable dosi
17 3-(18)F-fluorocyclobutane-1-carboxylic acid (anti-(18)F-FACBC) is a recently developed ligand that pe
18 3-(18)F-fluorocyclobutane-1-carboxylic acid (anti-(18)F-FACBC)is a synthetic l-leucine analog that ha
20 a right-handed helix with all nucleotides in anti, 2'-deoxyribose conformations within the C2'-endo/C
21 P (4b) with epi-isozizaene synthase gave [11(anti)-(2)H]epi-isozizaene (3b), indicating that the S(N)
22 levels of spontaneously appearing monoclonal anti-(2-->8)-alpha-Neu5Ac did not cause autoimmunity.
26 Synthesis of a variety of 8,16-disubstituted-anti-[2.2]metacyclophanedienes (CPD) with alkenyl and al
27 mbinant DH4 with chemoenzymatically prepared anti-(2R,3R)-2-methyl-3-hydroxypentanoyl-ACP (2a-ACP) ga
28 EBS [KS6][AT6], DEBS ACP6, and TYLS KR1 gave anti-(2R,3R)-6-ACP that underwent syn dehydration cataly
29 y syn-dehydration of the ACP-bound substrate anti-(2R,3R,4S,5R)-2,4-dimethyl-3,5-dihydroxyheptanoyl-A
30 e syn-(2S,3R)-2b-ACP, syn-(2R,3S)-2c-ACP, or anti-(2S,3S)-2d-ACP generated in situ by DEBS KR1, DEBS
31 4, with a 20-fold greater kcat/K(m) than the anti-(2S,3S)-diketide-SNAC 14, and a 40-fold advantage o
32 ree isomeric forms with hydrides in syn (2), anti (3), and cis (4) conformations have been characteri
33 y of previously unavailable (3E)-2,5-syn-2,6-anti-, (3E)-2,5-anti-2,6-anti-, and (3E)-2,5-anti-2,6-sy
34 (OHMT)Cl in solution as a mixture of syn and anti (60:40 at 0.015 M) nitrile-free isomers, but these
36 formed on Sprague-Dawley rats using syn- and anti-(99m)Tc-L- and -D-MAEC coinjected with (131)I-OIH.
38 a clearance ratio in humans ranged from 45% (anti-(99m)Tc-L-MAEC) to 74% (syn-(99m)Tc-D-MAEC) with th
39 (rGGCAAGCCU)(2) duplex has sheared A(anti).A(anti) (A.A trans Hoogsteen/Sugar-edge) pairs in which th
40 The 5'(rGGCAAGCCU)(2) duplex has sheared A(anti).A(anti) (A.A trans Hoogsteen/Sugar-edge) pairs in
41 he N(CH2)3N units on each side are in doubly anti (aa) conformations that put the aryl rings as far a
43 ogen-containing coronene-type molecules like anti-(ab)2-PBI 15, syn-(ab)2-PBI 16, and syn-(ab)2-PTE 1
44 tion having one PD(+) ring syn and the other anti (abbreviated uns) was seen, and the relative amount
46 rotonated retinal photoproducts, 13-trans/15-anti (all-trans) and 13-cis/15-syn, after relaxation to
47 odies (mAb), designed to stimulate immunity [anti-(alpha)-CD137, alpha-CD40] or relieve immunosuppres
48 pid syndrome, or red blood cells coated with anti-(alpha)-Rh(D) antibodies that mediate hemolysis in
49 sensing element as it is functionalised with anti-(alpha-synuclein) antibodies using a dual strategy:
52 in various orientations [C*C, A*G, and G*G (anti) and A*G and G*G (syn)] and compare the results to
53 or the purine base, as expected for A(syn)*T(anti) and G(syn)*C(+)(anti) HG base pairing, HG type hyd
55 s performed with beta-hydroxy aldehydes 37a (anti) and the corresponding p-methoxybenzyl (PMB) ether
56 having the same G-arrangement (anti:anti:syn:anti) and the top G-tetrad having the reversed G-arrange
57 le (3E)-2,5-syn-2,6-anti-, (3E)-2,5-anti-2,6-anti-, and (3E)-2,5-anti-2,6-syn-substituted enediols, a
58 symmetric (er > 99:1) total synthesis of (+)-anti- and (-)-syn-mefloquine hydrochloride from a common
59 ymmetric (>99:1 e.r.) total synthesis of (+)-anti- and (-)-syn-mefloquine hydrochloride from a common
60 stallographic analysis of derivatives of (+)-anti- and (-)-syn-mefloquine is used to lay to rest a 40
64 crotyl reagents afford the corresponding 1,3-anti- and 1,3-syn-methyl-substituted "homocrotylated" al
67 idely used, either to evaluate the effect of anti- and pro-angiogenesis drugs of interest, or to test
68 ngaging in protein-protein interactions with anti- and pro-apoptotic Bcl2 family members, thereby exe
69 dihydrodiol and BPDE-2 treatment, changes in anti- and pro-apoptotic events in the Bcl-2 family of pr
73 ein transduction to identify novel, opposing anti- and pro-cytokine-inducing roles for RhoA in the re
74 t directly affect the expression of Foxp3 or anti- and pro-inflammatory cytokines in T(reg) cells, su
75 or necrosis factor-alpha (TNF-alpha) are key anti- and pro-inflammatory mediators elicited during the
77 us, Paneth cell lysozyme balances intestinal anti- and pro-inflammatory responses, with implications
78 aging to date and the first to discriminate anti- and pro-longevity genes, revealing new insights on
79 Tiam1 and P-Rex1, two Rac GEFs, promote Rac1 anti- and pro-migratory signalling cascades, respectivel
80 l is proposed for quantifying simultaneously anti- and pro-oxidant activities as function of concentr
81 -induced dysregulations of the expression of anti- and pro-oxidant enzymes, mitochondrial biogenesis
85 phages have been shown previously to be both anti- and proangiogenic, and their role in regulating an
91 DL(Healthy) on the activation of endothelial anti- and proapoptotic pathways and to determine which c
93 the first to show that Hax-1 is a family of anti- and proapoptotic regulators that may modulate cell
94 s a pleiotropic cytokine that activates both anti- and proapoptotic signaling pathways, with cell fat
95 CP in modulating the responses between these anti- and profibrotic cytokines in the initiation and pr
96 pe I IFNs regulate the balance between IL-10 anti- and proinflammatory activity, and provide insight
98 appaB (nuclear factor kappaB), expression of anti- and proinflammatory factors and of the MAP (mitoge
99 was undertaken in order to exploit both the anti- and proinflammatory properties attributed to the v
101 ferentiation remains elusive given that both anti- and promyogenic activities have been described.
104 f this reaction are seen in the synthesis of anti- and syn-1,3 amino alcohol vitamin D3 analogue inte
105 determine how pol beta discriminates between anti- and syn-8-oxoG, we introduced a point mutation (R2
107 roup increases the energy difference between anti- and syn-chairs with primary amino acid catalysts a
108 n has dual coding potential by virtue of its anti- and syn-conformations, base pairing with cytosine
109 (BTBPE), and hexabromocyclododecane (HBCDD), anti- and syn-Dechlorane plus were detected at levels co
110 N2-H)(.) is corroborated by DFT studies, and anti- and syn-dG(N2-H)(.) are resolved for the first tim
111 ion results in stereodivergent products with anti- and syn-diastereomers both in good diastereoselect
113 the assignment of the stereochemistry of the anti- and syn-diepoxy and -tetraepoxy derivatives as wel
122 diastereoselective syntheses of a variety of anti, anti-stereotriads, the direct synthesis of which h
123 and to determine the lower cut-off value of anti- anti-TTG level that best predicts CD in children w
126 8), microRNA guide strand selection by ALG-1(anti) appeared normal, but microRNA* strand release was
127 some microRNA* strands present in the ALG-1(anti) Argonaute far in excess of the corresponding matur
130 m the dual coding potential where 8-oxo-dGTP(anti) base pairs with cytosine and 8-oxo-dGTP(syn) uses
131 simple model accurately predicts the bonding/anti- bonding modes that are measured experimentally.
132 he two distinct CH3CHOO conformers, syn- and anti-, both of which react readily with SO2 and with NO2
133 ailable for these 10S (+)- and 10R (-)-trans-anti -[BP]-N(2)-dG adducts in double-stranded deoxyoligo
134 ene-derived N (2)-dG adduct, 10 S(+)- trans- anti-[BP]- N (2)-dG ([BP]G*), reveal that an incoming dA
136 pyrene-derived N(2)-dG adduct, 10S-(+)-trans-anti-[BP]-N(2)-dG ([BP]G*), is processed in Dpo4, the we
137 vironmental carcinogen, is the 10S (+)-trans-anti-[BP]-N(2)-dG adduct (G*), which resides in the B-DN
140 mental observations concerning the (+)-trans-anti-[BP]-N(2)-dG adduct in double-stranded DNA with the
142 Dpo4 is able to bypass the 10S (+)-trans-anti-[BP]-N(2)-dG adduct, albeit to a lesser extent than
143 attacks DNA to form the major 10S (+)-trans-anti-[BP]-N(2)-dG adduct, which has been shown to be mut
146 utational studies suggest that 10S (+)-trans-anti-[BP]-N(2)-dG can be accommodated in the active site
147 zation of each nucleotide opposite (+)-trans-anti-[BP]-N(2)-dG in the +1 position (T > G > A > or = C
148 eferential insertion of A opposite (+)-trans-anti-[BP]-N(2)-dG is independent of the sequence context
152 udies of nucleotide incorporation, (+)-trans-anti-[BP]-N(2)-dG was modeled in the syn conformation in
153 ss of the base positioned opposite (+)-trans-anti-[BP]-N(2)-dG, extension of the primer past the lesi
155 er-extension of each base opposite (+)-trans-anti-[BP]-N(2)-dG, we carried out molecular modeling and
156 n intermediate preference opposite (+)-trans-anti-[BP]-N(2)-dG, were accommodated reasonably well, bu
157 ernary complex containing this 10S (+)-trans-anti-[BP]-N(6)-dA adduct in the templating position with
158 formations of the 10S (+)- and 10R (-)-trans-anti-[BP]-N(6)-dA adducts through molecular dynamics (MD
159 dies have been carried out for 10S-(+)-trans-anti-[BP]-N2-dG ((+)-ta-[BP]G), a lesion derived from th
160 [a]pyrene-derived N2-dG adduct, 10S(+)-trans-anti-[BP]-N2-dG ([BP]G*), is processed in a well-charact
161 bserved for the stereoisomeric 10S (+)-trans-anti-[BP]G adduct in both the C-[BP]G and meC-[BP]G sequ
162 d NMR study indicates that the 10R (-)-trans-anti-[BP]G adduct undergoes a transition from a minor gr
165 These observations have demonstrated that an anti- but not proapoptotic activity is the prevailing ev
166 dry mouth but F = 0, increased expression of anti- CA6 was noted compared to the F <1 group (p = .032
168 he total (CD68(+)), pro- (CD14(+) = M1), and anti- (CD206(+) = M2) inflammatory macrophages, crown-li
170 enger) strands, and immunoprecipitated ALG-1(anti) complexes contained nonstoichiometric yields of ma
172 uorophenyl) TEFDDOL, a quite unusual "pseudo-anti" conformation of the diol, with no intramolecular (
175 ar-reaching analogies are established among (anti-) cooperative collective behaviors in chemical kine
176 ly associated with RA (P<10(-4)): *0301 with anti- cyclic citrullinated peptide-negative RA and *0701
181 IgA anti-tissue transglutaminase and/or IgA anti- endomysium permitted diagnosis or exclusion of CD
182 collective behaviors in chemical kinetics, (anti-)ferromagnetic spin models in statistical mechanics
183 Phase boundaries in multiferroics, in which (anti-)ferromagnetic, ferroelectric and ferroelastic orde
184 one- and two-dimensional spin systems with (anti)-ferromagnetic interactions controlled by their sym
186 s the cap in multiple conformations (syn and anti) giving rise to a relatively plastic and nonspecifi
187 modulation was done by treatments with DTA-1 anti- glucocorticoid-induced tumor necrosis factor recep
188 he (NIASF), no increase in the prevalence of anti- gp130-RAPS antibodies was observed in serum or syn
191 expected for A(syn)*T(anti) and G(syn)*C(+)(anti) HG base pairing, HG type hydrogen bonding could on
199 evels for pro (IFN-gamma and TNF-alpha)- and anti (IL-4 and IL-10)-inflammatory cytokines also were d
205 a postinsertional complex shows 8oG(syn).dA (anti) in a Hoogsteen-like base pair at the 3' terminus,
206 atio of the two limiting conformers (syn and anti) in solution and the extent of conjugation between
208 nsition states, endo-prox-anti and endo-dist-anti, in the pentadiene/PyrNO reaction, leading to nearl
209 RNA* strands were selected as guide by ALG-1(anti), indicating a defect in normal specificity of the
210 ponses by differentially regulating pro- and anti- inflammatory cytokine production in innate immune
211 modulate the expression of selected pro- and anti- inflammatory mediators such as IL-6 and IL-33.
212 ave been reported to modulate either pro- or anti- inflammatory programs, which may be specific to th
214 stances is linked mainly to the antioxidant, anti- inflammatory, anti-proliferative and cardioprotect
222 to three contiguous stereocentres in a (syn, anti)-mode with excellent regio and diastereoselectiviti
224 Sjorgen's Syndrome (SS) and HCV, presence of anti- muscarinic receptor type 3 (M3R) antibodies in SS,
227 (syn, Pseudomonas fluorescens, gi 70731221 ; anti, Mycobacterium smegmatis, gi 118470554 ) document t
229 number of PLA-positive signals generated by anti-(Nav1.5 alpha-subunit) antibodies, mainly at the pl
230 )+(R)] and the elimination mechanism (syn or anti), not substituent effects, determined the configura
232 he N-heterocyclic carbene ligand IMes to fac,anti-(ONO(Cat))Re(O)(mu-O)2Re(O)(ONO(Cat)) cleaves the d
234 ular flux analysis of cells transfected with anti- or pre- miR-29a confirmed that miR-29a inhibits mi
237 d their ES-evoked activation produces either anti- or pro-inflammatory effects due to disease-state-d
240 as a bifunctional regulator promoting either anti- or profibrogenic response, depending on milieu.
242 ies in both mice and humans suggest that the anti- or proinflammatory nature of high density lipoprot
244 nin is a convergent site for the activity of anti- or propsychotic drugs, opening a possibility for n
245 possessing di- or trisubstituted alkenes and anti- or syn- relative stereochemistry at the allylic an
247 with aromatic aldehydes and preparing either anti- or syn-aldol adducts with very high enantioselecti
249 n them, hydrogen bonds relating parallel and anti- parallel beta strands, spatial adjacencies relatin
252 t mammary gland and the pro-(BAX:Bcl(2)) and anti-[PKC alpha*(Bcl(2)/BAX)] apoptotic ratios were eval
253 '-epi-46, and 61) and several low-micromolar anti- Plasmodium falciparum lead compounds (i.e., 46, 2,
255 r in vivo anti- Pp IgG antibody nor in vitro anti- Pp T-cell response and resultant production of RAN
256 llate (EGCG), and matrix pH (2-7) on the net anti-/pro-oxidant activity of EGCG in flaxseed oil-in-wa
258 ing that quinoxaline antibiotics could exert anti- proliferative effects by inhibition of chromosomal
259 mutant ALG-1 and found that the mutant ALG-1(anti) protein fails to interact with numerous miRISC cof
261 he different stereochemical courses (syn and anti) result from different structural strategies for de
262 ) are compared with a commercially available anti- Salmonella antibody and the antimicrobial peptide
263 t)/anti-OH, SERO(B) at 32548 cm-1 to Gpy(up)/anti, SERO(C) at 32545 cm-1 to Gph(out)/anti, SERO(D) at
264 (up)/anti, SERO(C) at 32545 cm-1 to Gph(out)/anti, SERO(D) at 32560 cm-1 to Anti(py)/anti, SERO(E) at
265 out)/anti, SERO(D) at 32560 cm-1 to Anti(py)/anti, SERO(E) at 32537 cm-1 to Anti(up)/anti, SERO(F) at
266 (py)/anti, SERO(E) at 32537 cm-1 to Anti(up)/anti, SERO(F) at 32353 cm-1 to Gpy(out)/syn, SERO(G) at
267 ection, survival, yearly posttransplantation anti- serology, development of acute toxoplasmosis, and
268 ed on pretransplantation donor and recipient anti- serology, immunosuppression, allograft rejection,
270 5.2 (111.1) kJ/mol for the conversion of the anti (syn) to the syn (anti) isomer at 66.2 degrees C.
271 6.0 (112.1) kJ/mol for the conversion of the anti (syn) to the syn (anti) isomer at 71.0 degrees C.
272 rase interactions that influence templating (anti-/syn-equilibrium) of 8-oxoG while modulating fideli
274 n mast cells was suppressed by anti-IL-1 and anti- thymic stromal lymphopoietin (TSLP) and was enhanc
275 tive and specific screening serologic tests (anti- tissue transglutaminase antibodies IgA [anti-TTG]
276 r tests (IgA anti-dpgli, IgG anti-dpgli, IgA anti- tissue transglutaminase, and IgA anti-endomysium)
277 ) (2) converts into its anti form [Fe(IV) (O(anti) )(TMC)(NCMe)](2+) (1) in MeCN, an isomerization fa
281 " cytokine in cancer, changing its role from anti- to pro-tumorigenic in a context-dependent manner.
282 D74-dependent way, shifting the balance from anti- to proinflammatory cytokines in antimycobacterial
285 rug conjugate (ADC) comprised of a humanized anti- Trop-2 antibody, conjugated with active metabolite
289 ate (CL) nanoparticles to facilitate priming anti- tumor T cells by tumor lysate-loaded DC vaccine.
293 isease activity following 3 loading doses of anti- vascular endothelial growth factor (VEGF) agents,
297 ncreases 15-syn-retinal at the expense of 15-anti, which is the predominant isomer in the wild type,
298 in polymorph A away from each other (termed anti), while in polymorph B one methoxy group is oriente
299 15, AN11251) was shown to have good in vitro anti- Wolbachia activity and physicochemical and pharmac