ライフサイエンスコーパス: anti-apoptotic

1 ondrial hyperpolarization, a bax independent anti-apoptotic action.

2 cogene is suggested to largely depend on its anti-apoptotic action.

3 B is best known for its pro-inflammatory and anti-apoptotic actions, but in skeletal muscle, NF-kappa

4 ed potent antioxidant, anti-inflammatory and anti-apoptotic activities due to the synergistic effects

5 1 (HSV-1) latency reactivation depend on the anti-apoptotic activities of latency-associated transcri

6 ve stress and exerting anti-inflammatory and anti-apoptotic activities.

7 dditionally, HN mutations known to alter its anti-apoptotic activity affect fiber morphology.

8 bit IAPP misfolding which, along with direct anti-apoptotic activity and beneficial metabolic effects

9 tic function of Bcl-xL is independent of its anti-apoptotic activity and its residence in the mitocho

10 velopment of AREL1 inhibitors that block its anti-apoptotic activity in cancer.

11 uate its free radical scavenging ability and anti-apoptotic activity in cell-free and cellular system

12 this metastatic function is dependent on its anti-apoptotic activity in the mitochondria.

13 o adopt an alternative, monomeric state with anti-apoptotic activity is a general feature of FimA pro

14 no acids as essential and sufficient for the anti-apoptotic activity of AnkG.

15 contrast, mutation of Asp-219 abrogated the anti-apoptotic activity of GAAP but not its effects on c

16 phenotypes, and we provide evidence that the anti-apoptotic activity of Tctp is necessary for the nor

17 ective functions are generally attributed to anti-apoptotic activity, however, little is known about

18 can fold to a self-complemented monomer with anti-apoptotic activity, in which the Nte inserts intram

19 279), which leads to modulation of GSK3alpha anti-apoptotic activity, promoting pathogen survival ear

20 ed a diffuse downregulation of proteins with anti-apoptotic activity, some of which were targets of p

21 cl-xL promotes metastasis independent of its anti-apoptotic activity.

22 ted into host cells during infection and has anti-apoptotic activity.

23 sion leading to inhibition of Dnmt1-mediated anti-apoptotic activity.

24 find that interruption of this mechanism of anti-apoptotic adaptive resistance dramatically increase

25 CD44 signaling pathways exert anti-apoptotic and -inflammatory effects on tumor cells,

26 lphaB-Crystallin is a protein chaperone with anti-apoptotic and anti-inflammatory activity that is ap

27 rovided the first evidence that Malat1 plays anti-apoptotic and anti-inflammatory roles in brain micr

28 B-to-AP-1 switch), which compensated for the anti-apoptotic and barrier-repair functions of NF-kappaB

29 iletin might be related to its anti-oxidant, anti-apoptotic and insulinotropic properties.

30 alidated biomarkers, as well as PIK3C3, have anti-apoptotic and neurotrophic effects, are decreased i

31 pigenetic regulation, which triggers axes of anti-apoptotic and pro-survival pathways, enabling proli

32 otein (IAP) family and are key regulators of anti-apoptotic and pro-survival signaling pathways.

33 AS of the anti-apoptotic and proliferation-associated survivin (BI

34 Interestingly, the in vitro anti-apoptotic and the pro-survival actions seen after m

35 Possibly underlying its cytoprotective, anti-apoptotic, anti-oxidative effects, UDCA was reporte

36 TREM-1 expression in macrophages and confers anti-apoptotic attributes.NF-kappaB p65 silencing identi

37 of pluripotent molecules Sox2 and Nanog and anti-apoptotic B-cell lymphoma 2 (Bcl-2), respectively.

38 B virus (HBV) X protein, HBx, interacts with anti-apoptotic Bcl-2 and Bcl-xL proteins through its BH3

39 ollectively, we provide a novel facet of the anti-apoptotic Bcl-2 by demonstrating that its phosphory

40 Anti-apoptotic Bcl-2 expression decreased, while pro-apo

41 panied by increased expression of at least 1 anti-apoptotic Bcl-2 family member.

42 Although no general pattern of individual anti-apoptotic Bcl-2 family members emerged, increased e

43 Indeed, small molecule inhibitors of the anti-apoptotic BCL-2 family members have been designed r

44 ometry to analyze the expression of pro- and anti-apoptotic Bcl-2 family members in T cells from 12 A

45 Among all the anti-apoptotic BCL-2 family members, infection preferent

46 The anti-apoptotic Bcl-2 family protein Bcl-xL plays a criti

47 BCL-XL is an anti-apoptotic BCL-2 family protein found both in the cy

48 a primed state in which the loss of a single anti-apoptotic Bcl-2 family protein is sufficient to tri

49 a BH3 domain but nevertheless binds certain anti-apoptotic Bcl-2 family proteins (Bcl-2, Bfl-1, and

50 e the interaction site of a Nur77 peptide on anti-apoptotic Bcl-2 family proteins and reveal a novel

51 Anti-apoptotic Bcl-2 family proteins are overexpressed i

52 Overexpression of anti-apoptotic Bcl-2 family proteins contributes to canc

53 ibrary screening and discovered that several anti-apoptotic Bcl-2 family proteins further upregulate

54 Pro-apoptotic and anti-apoptotic Bcl-2 family proteins reciprocally modula

55 A study of pro-apoptotic and anti-apoptotic Bcl-2 family proteins showed that neonata

56 ells hijack this mechanism by overexpressing anti-apoptotic BCL-2 family proteins to enforce cellular

57 (BH3)-only proteins bind and neutralize the anti-apoptotic Bcl-2 family proteins, how this neutraliz

58 rther, our study suggests that inhibitors of anti-apoptotic Bcl-2 family proteins, used in cancer tre

59 ammalian cells are known to express multiple anti-apoptotic Bcl-2 family proteins.

60 Furthermore, by combining different pro- and anti-apoptotic Bcl-2 pairings together with CRISPR/Cas9-

61 and suppressed apoptosis markers, increased anti-apoptotic Bcl-2 protein and increased mitochondrial

62 We further show that anti-apoptotic BCL-2 protein expression is reduced in mu

63 ddition, NR4A3 physically interacted with an anti-apoptotic Bcl-2 protein hence sequestering it from

64 roliferation, decreased apoptosis, increased anti-apoptotic Bcl-2 protein, impaired NADPH oxidoreduct

65 Viral homologs of the anti-apoptotic Bcl-2 proteins are highly diverged from t

66 proteins, WM samples expressed both pro- and anti-apoptotic Bcl-2 proteins at low levels similar to t

67 Overexpression of anti-apoptotic BCL-2 proteins contributes to tumor devel

68 apoptosis is known to involve degradation of anti-apoptotic Bcl-2 proteins during mitotic arrest; how

69 stance, we interrogated the contributions of anti-apoptotic BCL-2 proteins in determining the fate of

70 e data suggest that although the presence of anti-apoptotic BCL-2 proteins primarily dictates cellula

71 s the need for mechanism-guided targeting of anti-apoptotic BCL-2 proteins to effectively activate th

72 mito-priming, uses co-expression of pro- and anti-apoptotic Bcl-2 proteins to engineer Bcl-2 addictio

73 Our data suggest that inhibiting anti-apoptotic BCL-2 proteins will enhance primary respo

74 as the addition of ABT-737, an inhibitor to anti-apoptotic BCL-2 proteins, revealed massive apoptosi

75 efficiently when both Bcl-xL and Mcl-1, two anti-apoptotic Bcl-2 proteins, were inactivated or elimi

76 ollowing BH3-only-mediated neutralization of anti-apoptotic Bcl-2 proteins.

77 ro-apoptotic markers were increased, whereas anti-apoptotic Bcl-2 was decreased upon NDRG1 overexpres

78 of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-XL or MCL-1, which correlated

79 he overexpression of cytoprotective HO-1 and anti-apoptotic Bcl-2/Bcl-xL.

80 Similar analyses show that anti-apoptotic BCL-x(L) does not form fibers with humani

81 hanism(s) reveals that ER stress reduces the anti-apoptotic Bcl-x(L) protein in INS-1 cells.

82 uce either the pro-apoptotic Bcl-x(s) or the anti-apoptotic Bcl-x(L).

83 nd can be prevented by the overexpression of anti-apoptotic Bcl-X(L).

84 ssion of its molecular targets CDK2/5/9, and anti-apoptotic BCL-XL and BCL2 proteins.

85 This sensitivity occurs in part through low anti-apoptotic BCL-xL expression, high pro-apoptotic NOX

86 he sensitivity to splicing modulation of the anti-apoptotic BCL2 family genes is a key mechanism unde

87 in intestinal inflammation, the loss of the anti-apoptotic BCL2 family members BCL2 and BCL2L1 has n

88 etic cell lines is oligomerized and bound to anti-apoptotic BCL2 family members in the absence of exo

89 (high) cells increased the expression of the anti-apoptotic BCL2 gene, enhances the proliferative act

90 erexpression decreased the expression of the anti-apoptotic BCL2 marker.

91 ession of BCL2 like 1 (BCL2L1 or BCL-xL), an anti-apoptotic BCL2-family member.

92 sed a unique cysteine (C55) in the groove of anti-apoptotic BFL-1 to selectively neutralize its oncog

93 1 decreases the expression of STAT-regulated anti-apoptotic BH3 family members MCL1 and BCL-XL sensit

94 function as pro-apoptotic (c-FLIPL only) or anti-apoptotic (c-FLIPL/c-FLIPS) regulators of procaspas

95 human pathogens that encode homologs of the anti-apoptotic cellular Bcl-2 proteins, which are critic

96 vating pro-apoptotic effectors or inhibiting anti-apoptotic components and by promoting MOM permeabil

97 uce the degradation of Mcl-1 and Bcl-XL, the anti-apoptotic counterparts of Bim.

98 The anti-apoptotic cytoplasmic CLU was decreased, while the

99 activation of drug efflux pumps, anti-apoptotic defense mechanisms, etc.

100 tment with testosterone was shown to have an anti-apoptotic effect against Bic, suggesting a better o

101 Ectopic expression of miR-1180 has an anti-apoptotic effect in HCC, while miR-1180 inhibition

102 Knockdown of PAR2 with siRNA eliminated the anti-apoptotic effect of 2f-LI and increased the sensiti

103 Consistent with an anti-apoptotic effect of autophagy, rapamycin-induced ap

104 g the release of nitrate, does not block the anti-apoptotic effect of MN10021 and derived octapeptide

105 or and exerts an additional BDNF-independent anti-apoptotic effect, both of which contribute to NB ch

106 AnkG is one of these anti-apoptotic effector proteins.

107 tion of Akt1, suggesting CD40 involvement in anti-apoptotic effects observed.

108 justified the role of Mcl-1 stabilization in anti-apoptotic effects of emotional stress.

109 ed the renoprotective, anti-inflammatory and anti-apoptotic effects of octreotide after HIR.

110 Furthermore, we provide evidence that anti-apoptotic effects of PDGF-BB on serum-deprived ST88

111 n, we investigated the anti-inflammatory and anti-apoptotic effects of the H2S donor sodium hydrosulf

112 n podocytes, including anti-inflammatory and anti-apoptotic effects, is involved in actin cytoskeleto

113 as, and shows survival properties due to its anti-apoptotic effects.

114 In summary, we identified the anti-apoptotic evolutionary conserved lncRNA Sarrah, whi

115 y targeting cell cycle regulators CDK4/6 and anti-apoptotic factor BCL-2, among other regulatory path

116 PIM1 knockdown reduced expression of the anti-apoptotic factor BCL2, and dynamic BH3 profiling of

117 Finally, we observed upregulation of the anti-apoptotic factor BIRC7 in MiTF-high RCC tumors, sug

118 me c, demonstrating its important role as an anti-apoptotic factor.

119 ectively and downregulated the expression of anti-apoptotic factors and multidrug resistance proteins

120 eatment with navitoclax, an inhibitor of the anti-apoptotic factors BCL-xL and BCL-2 restored sensiti

121 gh increased Egr-2 expression, which induces anti-apoptotic factors like MCL-1.

122 egulation, leading to the release of pro- or anti-apoptotic factors which mediate cell survival or de

123 thology and leads to increased expression of anti-apoptotic factors, allowing cell survival.

124 h as peroxiredoxins-1, heme oxygenase-1, and anti-apoptotic factors, including BCL2, BCL-XL, and MCL1

125 tage through upregulation of BCL-2 family of anti-apoptotic factors.

126 anti-apoptotic gene, B13R, and confirmed its anti-apoptotic function against chemically induced apopt

127 The anti-apoptotic function and tumor-associated expression

128 cl-2 and Bcl-XL proteins exert part of their anti-apoptotic function by directly targeting Ca(2+)-tra

129 PKM2's anti-apoptotic function could help explain its preferent

130 potent caspase inhibitor, best known for its anti-apoptotic function in cancer.

131 activity of GIMAP6 was not essential for its anti-apoptotic function in Huh-7 cells.

132 roduction of AA from adipocytes or block its anti-apoptotic function may potentially inhibit chemores

133 p53 tumor suppressor while antagonizing the anti-apoptotic function of Bcl-2 is highly active in pre

134 P(+/-) mice indicate that TCTP activates the anti-apoptotic function of Bcl-xL, in contrast to all ot

135 novel class of BH3-proteins potentiating the anti-apoptotic function of Bcl-xL.

136 Therefore, the anti-apoptotic function of miR-1180 in HCC may occur thr

137 miR-30b-5p and miR-30c-5p, essential to the anti-apoptotic function of these miRs.

138 cells, indicating that GIMAP6 might display anti-apoptotic function through NF-kappaB activation.

139 rdinated repression of molecules with shared anti-apoptotic function which precedes active cell apopt

140 The BCL-2 BH4 domain also confers anti-apoptotic functionality, but the mechanism is unkno

141 tanding of the key mechanisms underlying the anti-apoptotic functions of caspase-8 which may act as a

142 n were involved in xenobiotic metabolism and anti-apoptotic functions respectively.

143 is required for hydrogen peroxide-induced SG anti-apoptotic functions.

144 tes a unique carboxyl terminus with specific anti-apoptotic functions.

145 n be partially attributed to alterations in (anti)-apoptotic gene expression.

146 H1(R132H) mutation in AML and identified the anti-apoptotic gene BCL-2.

147 /-) cells, and upregulated expression of the anti-apoptotic gene Bcl-xL.

148 n of cell survival through expression of the anti-apoptotic gene BCL2 enables EpiSCs and Sox17(+) end

149 sulted in transcriptional suppression of the anti-apoptotic gene BCL2.

150 ted 181R/182R genes of MVA with a functional anti-apoptotic gene, B13R, and confirmed its anti-apopto

151 we find that the NF-kappaB target Bcl-2, an anti-apoptotic gene, is specifically expressed in ISCs i

152 RNA-seq analysis confirmed that a set of anti-apoptotic genes (for example, BCL2, BCL-XL and DAD1

153 ector, MVA-B13R, by replacing the fragmented anti-apoptotic genes 181R/182R with a functional version

154 The expression of the pro- and anti-apoptotic genes bcl-2 and bax, respectively, was me

155 Additionally, gene expression level of anti-apoptotic genes BCL2 and BCL2L1 was downregulated a

156 We query the anti-apoptotic genes BCL2L1 and MCL1, and the DNA damage

157 ecies, the identity of the -1 nt in critical anti-apoptotic genes is conserved such that the overall

158 tandem delivery of siRNAs that downregulate anti-apoptotic genes overexpressed in cisplatin resistan

159 hereas after 24 hours anti-proliferative and anti-apoptotic genes were upregulated.

160 eshold is due to drug-dependent induction of anti-apoptotic genes, predominantly in the inhibitors of

161 e PAR-dependent NF-kappaB transactivation of anti-apoptotic genes.

162 mage-stimulated NF-kappaB transactivation of anti-apoptotic genes.

163 of various mitochondrial proteins, including anti-apoptotic Hax1.

164 n Bfl-1, but not in cells dependent on other anti-apoptotic homologs.

165 d lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes.

166 One anti-apoptotic intrabody, intrabody 5 (IB5), recognized

167 ationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and cancer, however w

168 GSPE also modulated pro- and anti-apoptotic markers in the pancreas of rats fed a caf

169 r in combination with ABT-199, downregulated anti-apoptotic MCL-1 and BCL-XL levels, which likely con

170 However, most AID+ immature B cells lacked anti-apoptotic MCL-1 and were deleted by apoptosis.

171 activation also increased the expression of anti-apoptotic MCL-1.

172 The canonical anti-apoptotic mechanism involves entrapment of activate

173 The dual anti-apoptotic mechanism of pUL37 x 1 may be considered

174 r IL-15-mediated NK cell survival through an anti-apoptotic mechanism.

175 LI1 cells, indicating that GLI1 may activate anti-apoptotic mechanisms(s) independently of Bcl2.

176 Changes in the equilibrium of pro- and anti-apoptotic members of the B-cell lymphoma-2 (Bcl-2)

177 Pro- and anti-apoptotic members of this family keep each other in

178 Anti-apoptotic members suppress cell death by deploying

179 1), the anti-oxidant, anti-inflammatory, and anti-apoptotic microsomal stress protein, migrates to th

180 n part through maintaining expression of the anti-apoptotic molecule A1, and provide new insight into

181 d metabolism, expresses increased amounts of anti-apoptotic molecules and subsequently displays enhan

182 epinephrine as well as the levels of several anti-apoptotic molecules are elevated in tumours from mi

183 cells treatment repressed the expression of anti-apoptotic molecules Bcl-2, Bcl-xL and survivin, cou

184 nction of immune costimulatory receptors and anti-apoptotic molecules by RT-PCR, Western blot analysi

185 lls (CECs), thus hampering the expression of anti-apoptotic molecules in situ and facilitating CECs t

186 appaB-dependent induction of pro-survival or anti-apoptotic molecules is a well-known late checkpoint

187 lpha-cleavage, has been shown to produce the anti-apoptotic N1 and the scrapie-resistant C1 peptide f

188 otein as a critical regulator of E6-mediated anti-apoptotic network in HPV18-infected cervical adenoc

189 eceptor tyrosine kinases are known for their anti-apoptotic, oncogenic, and anti-inflammatory roles.

190 einase-2 (TIMP2), and phosphor-activation of anti-apoptotic p70s6 kinase, Akt and Erk (immunoblot).

191 at PAL/HCQ co-delivery nanoparticles trigger anti-apoptotic pathway after repetitive intravenous admi

192 duced cell death via inducing HSP70-mediated anti-apoptotic pathway but also promotes a robust EMT/CS

193 bined targeting of HER2 and the BCL-XL/BCL-2 anti-apoptotic pathway may increase responses to anti-HE

194 Here, we focus on the BCL2 anti-apoptotic pathway.

195 7p21.1 AHR, the dioxin receptor involved in anti-apoptotic pathways and melanoma progression; and 9q

196 Analysis of the pro- and anti-apoptotic pathways indicated no significant changes

197 further supporting its role in conferring an anti apoptotic phenotype.

198 SUM149) derived from SUM149 with an enhanced anti-apoptotic phenotype was resistant to FOXP3-specific

199 t to healthy PASMCs, a pro-proliferative and anti-apoptotic phenotype, sustained in time by the activ

200 xhibit a "cancer-like" pro-proliferative and anti-apoptotic phenotype.

201 x switch to control the accessibility of the anti-apoptotic pocket.

202 croRNA-21 as a STAT3 target gene with strong anti-apoptotic potential, suggesting that noncoding RNAs

203 iptional downregulation of cellular anabolic/anti-apoptotic processes but its effect on bone marrow m

204 ed mDCs from primary human-monocytes display anti-apoptotic profile, exhibited by elevated phosphoryl

205 the importance of endocytic recycling in the anti-apoptotic properties of FPR2/ALX and identifies the

206 uced colitis model via anti-inflammatory and anti-apoptotic properties.

207 cation of family members with either pro- or anti-apoptotic properties.

208 ed by blocking TLR2 signaling indicating its anti-apoptotic property.

209 Caspase 3 levels with a parallel decrease in anti-apoptotic protein B-cell leukemia/lymphoma 2 levels

210 mplex in the mitochondria phosphorylates the anti-apoptotic protein B-cell lymphoma extra-large (Bcl-

211 ed by the intrinsic expression levels of the anti-apoptotic protein B-cell lymphoma-extra large (BCL-

212 neonatal platelets had higher levels of the anti-apoptotic protein Bcl-2 and were more resistant to

213 cleaved caspase-3, and downregulation of the anti-apoptotic protein Bcl-2.

214 ) signaling pathways and increased levels of anti-apoptotic protein Bcl-xL and Mcl-1, which are downs

215 Furthermore that the anti-apoptotic protein Bcl-xL is regulated by CLPTM1L in

216 e) polymerase activation, down-regulation of anti-apoptotic protein Bcl-XL, an arrest of the cell cyc

217 ription factor MYC and its downstream target anti-apoptotic protein BCL-XL.

218 des with respect to their affinities for the anti-apoptotic protein Bcl-xL.

219 In circumstances where expression of the anti-apoptotic protein BCL2 is high, Casp8p41 instead bi

220 Overexpression of the anti-apoptotic protein Bcl2, but not the oncoprotein Myc

221 the systemic delivery of siRNA that targets anti-apoptotic protein Bcl2.

222 HIV also upregulates the anti-apoptotic protein BIRC5, which when blocked promote

223 cumulating pro-apoptotic signal arising from anti-apoptotic protein degradation, generation of a swit

224 and increases the ratio of the apoptotic to anti-apoptotic protein expression.

225 A2 overexpression degraded the mitochondrial anti-apoptotic protein HAX-1, an effect attenuated by Uc

226 a yeast two-hybrid screen, we identified the anti-apoptotic protein HAX1 to interact with RNF217.

227 Survivin, an overexpressed anti-apoptotic protein in cancer, represents a pharmacol

228 ecific actin-binding protein functions as an anti-apoptotic protein in the gastrointestinal epitheliu

229 (hVDAC-2) functions primarily as the crucial anti-apoptotic protein in the outer mitochondrial membra

230 The target gene was survivin, an anti-apoptotic protein induced by chemotherapy and assoc

231 er with computational modeling and selective anti-apoptotic protein inhibitors, uncovers new mechanis

232 ommunications define a critical role for the anti-apoptotic protein MCL-1 as a driver of adaptive sur

233 ed that L. donovani exploited the macrophage anti-apoptotic protein MCL-1 to prevent BAK-mediated mit

234 ctor NOXA, thus creating a dependence on the anti-apoptotic protein MCL-1.

235 pproaches, we documented that the macrophage anti-apoptotic protein myeloid cell leukemia 1 (MCL-1) i

236 The anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1) p

237 t PPAN is a novel interaction partner of the anti-apoptotic protein nucleophosmin (NPM).

238 udies in vitro and in vivo, we show that the anti-apoptotic protein poly(ADP-ribose) polymerase (PARP

239 ficant increase in mRNA levels for the known anti-apoptotic protein serum and glucocorticoid-regulate

240 The anti-apoptotic protein survivin (Sur) plays an important

241 cytoplasmic C terminus of Kv3.3 to Hax-1, an anti-apoptotic protein that regulates actin nucleation t

242 er the levels of pro-apoptotic protein, Bax, anti-apoptotic protein, Bcl-2, caspase-3 and cytochrome

243 we examined the critical role of Bcl-xL, an anti-apoptotic protein, during brain development.

244 from apoptosis, suggesting that GIMAP6 is an anti-apoptotic protein.

245 (P < 0.05) increased expression of p-Akt and anti-apoptotic proteins (Bcl-2 and Bcl-xL), while reduce

246 Golgi anti-apoptotic proteins (GAAPs) are multitransmembrane p

247 Extracts decreased expression of anti-apoptotic proteins (survivin, cIAP-2, XIAP), induce

248 cs detects production of only a few critical anti-apoptotic proteins against a background of general

249 the protein levels of survivin, a member of anti-apoptotic proteins and a known mediator of melanoma

250 erm sites of hnRNPA1 promotes translation of anti-apoptotic proteins and is indispensable for the pro

251 ABT-737 inhibits the anti-apoptotic proteins B-cell lymphoma 2 (BCL-2) and BC

252 senolytic' agent, ABT263, which inhibits the anti-apoptotic proteins BCL-2 and BCL-xL and selectively

253 entified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent se

254 contains two distinct binding sites for the anti-apoptotic proteins Bcl-XL and Bcl-2.

255 rimarily from differential expression of the anti-apoptotic proteins Bcl-xL and Mcl-1 relative to Bak

256 g proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1.

257 apoptosis that correlated with inhibition of anti-apoptotic proteins being sufficient to permeabilize

258 pathways or of altered expression of pro- or anti-apoptotic proteins can thus be compared.

259 The increased cap-independent translation of anti-apoptotic proteins is involved in the development o

260 Overexpression of anti-apoptotic proteins MCL1 and Bcl-xL are frequently o

261 se-12 were dramatically decreased, while the anti-apoptotic proteins of Bcl-2 and NF-kappaB were sign

262 oresistant cells that express high levels of anti-apoptotic proteins such as BCL-XL is thought to res

263 Infected AmEpCs up-regulated anti-apoptotic proteins survivin and Bcl-xL by mechanism

264 vival dependence on individual or subsets of anti-apoptotic proteins that could be effectively target

265 ies, which become dependent on expression of anti-apoptotic proteins to counter expression of pro-apo

266 to BH3 mimetics reflects the identity of the anti-apoptotic proteins to which BAK is constitutively b

267 d CD4(+) T cells facilitated the transfer of anti-apoptotic proteins via nanotubes, resulting in incr

268 d PLGA-NP were internalized in HCC cells and anti-apoptotic proteins were down regulated with apoptos

269 Notably, the same anti-apoptotic proteins were previously found to reduce

270 aperones, the protein degradation machinery, anti-apoptotic proteins, and transcription factors.

271 aster regulator of numerous antioxidants and anti-apoptotic proteins, including HO-1, also accumulate

272 pounds show selectivity for Mcl-1 over other anti-apoptotic proteins, possess cytotoxicity to cancer

273 l differentiation protein (Mcl-1), two major anti-apoptotic proteins, were present within the nanotub

274 rgins were characterized by pro-survival and anti-apoptotic proteins, whereas perinecrotic regions we

275 ing, but also primes cells for inhibitors of anti-apoptotic proteins.

276 ncoding protein chaperones (e.g. iHsp70) and anti-apoptotic proteins.

277 e subverted by pathogens through use of host anti-apoptotic proteins.

278 ly in cancer cells by downregulating several anti-apoptotic proteins.

279 ics to derepress proapoptotic molecules from anti-apoptotic proteins.

280 iR-34a directly inhibits Bcl2 and XIAP, both anti-apoptotic proteins.

281 membranes, instead contributes to binding to anti-apoptotic proteins.

282 teins impact the expression of oncogenes and anti-apoptotic proteins.

283 nd BBC3, and with decreased abundance of the anti-apoptotic regulator Mcl1.

284 ombined inhibition of Bid and Bax elicits an anti-apoptotic response that is effective over a range o

285 tumor target in IBC cells however increased anti-apoptotic signaling can lead to immune evasion.

286 hose ligation triggers pro-proliferative and anti-apoptotic signaling cascades.

287 et of rapamycin (mTOR), proinflammatory, and anti-apoptotic signaling pathways, as well as downregula

288 ading to the activation of proliferative and anti-apoptotic signaling pathways.

289 ed xenografts induces both pro-apoptotic and anti-apoptotic signaling responses that limit cell killi

290 ighted associations with immune response and anti-apoptotic signaling.

291 for SrcFKs in multiple pro-proliferative and anti-apoptotic signalling pathways relating to oxidative

292 s through induction of Bcl-2 family-mediated anti-apoptotic signalling.

293 n of homologous recombination DNA repair and anti-apoptotic signals in this population.

294 such as activation of cell cycle regulators, anti-apoptotic stimuli, metabolic aberrations, and their

295 Anti-apoptotic survivin, along with other inhibitor of a

296 eins, Mcl-1(S) (pro-apoptotic) and Mcl-l(L) (anti-apoptotic); the latter isoform is predominant in di

297 evated PAR production and NF-kappaB-mediated anti-apoptotic transcription in human and mouse colon ca

298 can compete with canonical MOMP to act as an anti-apoptotic tuning mechanism, reducing the mitochondr

299 2 that positively regulate growth, and V1 is anti-apoptotic when overexpressed.

300 ction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP, simultaneously decreasing expressio