ライフサイエンスコーパス: anti-parallel

1 enes are up and down-regulated together) and anti-parallel.

2 A discrete anti-parallel 1M6N-like dimer was the dominant if not ex

3 haped alpha-helical protein consisting of an anti-parallel 4-helix bundle base and two helical arms t

4 nt sets of alpha-actinin cross-links between anti-parallel actin molecules.

5 I sites can be bridged in either parallel or anti-parallel alignments.

6 is a 100 amino acid domain consisting of six anti-parallel alpha helices arranged in a Greek key stru

7 ncoding proteins with an ING domain with two anti-parallel alpha-helices and a plant homeodomain (PHD

8 res of Blo t 5 and Der p 5, comprising three anti-parallel alpha-helices arranged in a helical bundle

9 harged sequences forms pairs of amphipathic, anti-parallel alpha-helices flanked by beta-hairpin-like

10 e have explored the utility of (i) a pair of anti-parallel alpha-helices in a small highly disulfide-

11 major interface is formed by the C-terminal anti-parallel alpha-helices of the histone fold extensio

12 of the TNFR-DD shows that it consists of six anti-parallel alpha-helices.

13 At least one groove in anti-parallel and hybrid quadruplex structures is long a

14 ity: the helices may be arranged parallel or anti-parallel and may form a variety of oligomer states.

15 at the relative populations of photoreactive anti-parallel and non-photoreactive parallel conformers

16 3R) polytypes, respectively distinguished by anti-parallel and parallel orientation of consecutive mo

17 the coiled-coil segments in SMC proteins are anti-parallel and shows how the N and C-terminal domains

18 tablished that the dimers are arranged in an anti-parallel and staggered orientation at this site.

19 of five beta-strands in a mixed parallel and anti-parallel arrangement and three alpha-helices where

20 of five beta-strands in a mixed parallel and anti-parallel arrangement and three alpha-helices.

21 eraction at position 348 is the result of an anti-parallel arrangement of dimers.

22 wap to form dimers but unique to Cks1 is the anti-parallel arrangement of protomers within the dimer.

23 ll ordered, extended linker in an unexpected anti-parallel arrangement, followed by another short ext

24 xially stacked helices rather than the usual anti-parallel arrangement.

25 separated protofilaments are forced into an anti-parallel arrangement.

26 uring anaphase, MTs are incorporated into an anti-parallel array termed the spindle midzone (midzone

27 imately 31 nm in length; it is formed by the anti-parallel association of two Eps15 dimers.

28 ormation of intermolecular disulphide bonds, anti-parallel B-sheet and a-helix structures and lead to

29 increase in intermolecular disulphide bonds, anti-parallel B-sheet and a-helix structures was observe

30 iticale flours containing a higher amount of anti-parallel B-sheets and tyrosine exhibited higher lac

31 een sodium dodecylsulphate-SRC (SDS-SRC) and anti-parallel B-sheets percentages were noticed.

32 the human telomeric DNA were described as an anti-parallel basket-type and a parallel propeller-type.

33 two helices packing onto the same side of an anti- parallel beta sheet.

34 n them, hydrogen bonds relating parallel and anti- parallel beta strands, spatial adjacencies relatin

35 nt TDP-43 peptide indicate that it adopts an anti-parallel beta conformation.

36 main linker by the caspase-1 active site, an anti-parallel beta sheet at the caspase-1 L2 and L2' loo

37 ptide binds within the enzyme in an extended anti-parallel beta sheet conformation with substrate ami

38 e was found containing a beta hairpin and an anti-parallel beta sheet consisting of strands from the

39 comprised of an extremely flat, six-stranded anti-parallel beta sheet packed against two helices.

40 for three distinct modes of DNA recognition: anti-parallel beta strands (MetR), helix-turn-helix moti

41 e II receptor binding are located in the two anti-parallel beta strands of the TGF-beta proteins, als

42 ich is a twisted beta sheet composed of four anti-parallel beta strands.

43 nserved sequence that forms a tightly folded anti-parallel beta-barrel structure.

44 ists of an alpha-helix and an eight-stranded anti-parallel beta-barrel with large loop regions betwee

45 eta elements that form a central 10-stranded anti-parallel beta-barrel.

46 mains reveal that they are all six-stranded, anti-parallel beta-barrels.

47 be topologically similar to the 18-stranded, anti-parallel beta-motif observed for domain 5 of beta-g

48 main feature is an eight-stranded cup-shaped anti-parallel beta-pleated sheet.

49 The structure consists of a compact anti-parallel beta-sandwich fold that is composed of two

50 reveal that the mCPK-C2 domain has a typical anti-parallel beta-sandwich fold.

51 l copper binding domain, and a five-stranded anti-parallel beta-sandwich with the jelly roll topology

52 tetramer is characterized by a five-stranded anti-parallel beta-sheet and three major alpha-helices.

53 ded parallel beta-sheet and a three-stranded anti-parallel beta-sheet bearing an interstrand disulfid

54 e IDD shows a unique structural fold with an anti-parallel beta-sheet composed of three beta-strands

55 these conditions showed that Ca(2+) promotes anti-parallel beta-sheet conformations that repress fibr

56 around a hinge located at the end of a short anti-parallel beta-sheet connecting domains D1 and D2.

57 One anti-parallel beta-sheet consists of beta-strands beta1

58 e conserved tertiary structure comprising an anti-parallel beta-sheet core domain followed by a C-ter

59 embly of human wild-type Abeta into distinct anti-parallel beta-sheet fibrils.

60 ed "hot dog fold" composed of six strands of anti-parallel beta-sheet flanked on one side by a rather

61 H3(1-15)K4me3 interacts through anti-parallel beta-sheet formation on the surface of the

62 compatible, dry dimeric interface formed via anti-parallel beta-sheet interactions between neighborin

63 lar pilus structure with tight, double-layer anti-parallel beta-sheet interactions.

64 The remaining anti-parallel beta-sheet is formed from strands beta3 (I

65 connecting the bundles forms a two-stranded anti-parallel beta-sheet likely limiting the relative mo

66 y modeling revealed that Als members contain anti-parallel beta-sheet motifs interposed by extended r

67 ein consists of an N-terminal three-stranded anti-parallel beta-sheet which folds against a C-termina

68 e called the flap, which consists of a short anti-parallel beta-sheet with a turn.

69 cavity, and in SUD-C, several residues of an anti-parallel beta-sheet).

70 is18) is substantially formed as is also its anti-parallel beta-sheet, centred around a beta-hairpin

71 It is composed of a central five-stranded anti-parallel beta-sheet, flanked by a small two-strande

72 ike architecture through a pseudo-continuous anti-parallel beta-sheet.

73 the C-terminal motif contains two layers of anti-parallel beta-sheet.

74 contains six alpha-helices and two layers of anti-parallel beta-sheet.

75 a large helix packed against a five-stranded anti-parallel beta-sheet.

76 eight alpha-helices and a short two-stranded anti-parallel beta-sheet.

77 -turn linking the two strands of a distorted anti-parallel beta-sheet.

78 beta-helix with three adjoining segments of anti-parallel beta-sheet.

79 iticale flours containing a higher amount of anti-parallel beta-sheets and tyrosine exhibited higher

80 model, we examine the bending properties of anti-parallel beta-sheets comprised of uniform amino-aci

81 1 beta-strands, which form two large twisted anti-parallel beta-sheets folding into a beta-sandwich.

82 een sodium dodecylsulphate-SRC (SDS-SRC) and anti-parallel beta-sheets percentages were noticed.

83 tructure, which is mainly composed of coiled anti-parallel beta-sheets with the cross-beta-signature

84 to P3 residues of the substrate from forming anti-parallel beta-sheets with the non-specific substrat

85 f is dominated by two distinct four-stranded anti-parallel beta-sheets.

86 trands were aligned into two three-stranded, anti-parallel beta-sheets.

87 al between amino acids 60 and 120 is rich in anti-parallel beta-sheets.

88 opeller consisting of five radially oriented anti-parallel beta-sheets.

89 ly shown to form amyloid fibrils composed of anti-parallel beta-sheets.

90 adhesin of Streptococcus pyogenes, binds by anti-parallel beta-strand addition to discontinuous sets

91 and binds to a crystallographic dimer as an anti-parallel beta-strand at the same position as the ne

92 or three disulfide bonds to cross-brace the anti-parallel beta-strand that approximates a "beta-tile

93 ontaining peptide substrate binds as a short anti-parallel beta-strand to the C-terminal end of the A

94 ng of a compact beta-barrel made up of seven anti-parallel beta-strands along with two surrounding al

95 a-helix and a structured loop with two short anti-parallel beta-strands and adopts a tertiary structu

96 It forms a beta-barrel structure with five anti-parallel beta-strands and functions as an RNA chape

97 Our results integrate the occurrence of anti-parallel beta-strands as salient features of toxic

98 Consistent with reports of anti-parallel beta-strands being a defining feature of t

99 eorganization involves the transformation of anti-parallel beta-strands during the pre-fibrillar I1 s

100 is a beta-barrel structure formed from seven anti-parallel beta-strands in two beta-sheets.

101 l changes that result in the ordering of two anti-parallel beta-strands that protrude from each monom

102 ng of two beta-sheets each composed of three anti-parallel beta-strands.

103 of four alpha-helices separated by two short anti-parallel beta-strands; a less well defined helical

104 the interaction likely involves an extensive anti-parallel beta-zipper in which FUD interacts with th

105 se two subspaces that prefer parallel versus anti-parallel binding topologies.

106 allel) oligomerization and trans-homophilic (anti-parallel) binding.

107 hologue of Prc1, and Kif4A were recruited to anti-parallel bundles at interaction zones between aster

108 lis SMC (BsSMC) homodimer is composed of two anti-parallel coiled-coil arms, each having an ATP-bindi

109 Deletion of the anti-parallel coiled-coil forming region, but not the EK

110 Deletion of the single alpha-helical and anti-parallel coiled-coil forming regions, which lie bet

111 Most unusually, the molecule forms an anti-parallel coiled-coil in which three of the five his

112 The inter-SH2 domain is assigned as a rigid anti-parallel coiled-coil whose primary function is to b

113 Rad50 contains an anti-parallel coiled-coil with two absolutely conserved

114 We find that SSNA-1 forms an anti-parallel coiled-coil, with self-assembly facilitate

115 region of PRK1, and we show that it forms an anti-parallel coiled-coil.

116 elix bundle in which two helices comprise an anti-parallel coiled-coil.

117 mprises three helices that form two separate anti-parallel coiled-coils and a loop that packs tightly

118 l 26-nm four-helix bundle, consisting of two anti-parallel coiled-coils at its center, stabilized by

119 Dimer-related alpha-helices form anti-parallel coiled-coils, including an N-terminal "min

120 observed as pairs of trimers oriented in an anti-parallel conformation to support potential interact

121 s a heterodimer with U-STAT1 in an inactive, anti-parallel conformation.

122 opose a model for myosin interactions in the anti-parallel dimer of coiled-coils that guide the first

123 cteriophage lambda terminase assembles as an anti-parallel dimer-of-dimers nuclease complex at the pa

124 , conferring kinetic stability to the mutant anti-parallel dimer.

125 uence and topology, forming a tightly packed anti-parallel dimer.

126 ith one another in the form of a symmetrical anti-parallel dimer.

127 In the anti-parallel dimerization model, the rod domain region

128 in the assembly of Acanthamoeba myosin-II is anti-parallel dimerization of the coiled-coil tails with

129 rom cryo-EM structure shows Augmin undergoes anti-parallel dimerization through conserved surfaces on

130 lytic domains, enabling their activation via anti-parallel dimerization.

131 e is accomplished through autoinhibition via anti-parallel dimerization.

132 Anti-parallel dimers induced cognitive impairments with

133 They interact through the formation of anti-parallel dimers to mediate cell adhesion, migration

134 n from cells, procollagen VII molecules form anti-parallel dimers with a C-terminal 60-nm overlap.

135 structural characterisation of a bimolecular anti-parallel DNA quadruplex d(G(3)ACGTAGTG(3))(2) conta

136 lves in a zigzag pattern to form crystalline anti-parallel domains.

137 ent of protein and lipids of nascent HDL, an anti-parallel double superhelix wrapped around an ellips

138 oly(dA) in the presence of coralyne forms an anti-parallel duplex, however attempts to determine the

139 ds, we constructed 40 hypothetical homo-(dA) anti-parallel duplexes and docked coralyne into the six

140 SWAP-70 bundles filaments in parallel and anti-parallel fashion through its C-terminal F-actin bin

141 evealed that 12 alpha-helices can pack in an anti-parallel fashion to form a hollow cylinder of nearl

142 the sites are preferentially synapsed in an anti-parallel fashion.

143 ion through its spontaneous assembly into an anti-parallel four-helix bundle approximately 50 A in le

144 lated to stability of the a-d packing of the anti-parallel four-helix bundle of KCM, a relationship p

145 cture shows that the maquette scaffold is an anti-parallel four-helix bundle with "up-up-down-down" t

146 that it stems from the intrinsic tendency of anti-parallel four-way junctions to splay apart, a tende

147 elated dimer in the crystal to form a short, anti-parallel, four-helix bundle.

148 substrates up to 10-fold and on bimolecular anti-parallel G-quadruplex DNA structures and three-stra

149 This rule is consistent with most of the anti-parallel G-quadruplex structures in the Protein Dat

150 s suggests the following rule: when folding, anti-parallel G-quadruplexes tend to maximize the number

151 tDNA variant that increases G4 stability and anti-parallel G4-forming character shows a stronger resp

152 Combining parallel and anti-parallel genes for analysis resulted in fewer signi

153 ociated with the same GO categories, whereas anti-parallel genes were not.

154 each tract showed that only parallel CT and anti-parallel GT TFOs formed stable triplex on the AT- a

155 Their anti-parallel head-to-head-to-tail 'triplex' strand arra

156 the putative Nse6 orthologue SLF2 to form an anti-parallel helical dimer resembling the yeast Nse5/6

157 Our NMR study shows that the B box forms an anti-parallel helical hairpin in which four highly conse

158 PyJ possesses a three-helix fold, in which anti-parallel helices II and III are bridged by helix I,

159 and the species specificity of Vpu using an anti-parallel helix-helix packing model.

160 S100 proteins exist in cells as anti-parallel hetero- and homodimers and upon calcium bi

161 t coiled-coils studied to date by forming an anti-parallel heterodimeric complex between two peptides

162 Spectrin assembles into an anti-parallel heterodimeric flexible rod-like molecule t

163 Because talin exists as an anti-parallel homodimer in focal adhesions, the two inte

164 the other the 3'-coupled conjugate, so that anti-parallel hybridization allows the membrane surfaces

165 ns important information of the parallel and anti-parallel hydrogen-bond patterns between the beta-st

166 coat, leg segments entwine into parallel and anti-parallel interactions.

167 s mitotic spindle stability by cross-linking anti-parallel interpolar MTs.

168 e anchored to the phage coat by a synthetic, anti-parallel leucine zipper, which had been selected fr

169 These aspects of Vpu and BST-2 form an anti-parallel, lipid-embedded helix-helix interface.

170 , and the peptide and CaM are oriented in an anti-parallel manner.

171 nimal cell division, the central spindle, an anti-parallel microtubule bundle structure formed betwee

172 a disk-shaped interaction zone consisting of anti-parallel microtubule bundles coated with chromosome

173 Neuronal dendrites are characterized by an anti-parallel microtubule organization.

174 MKlp2 targets the CPC to the anti-parallel microtubule overlap of the midzone, after

175 arily conserved MAP65 family proteins bundle anti-parallel microtubules (MTs).

176 biditis elegans disrupt the spindle midzone (anti-parallel microtubules and associated proteins that

177 complex, its function primarily is to slide anti-parallel microtubules apart from one another.

178 uorescence assay, we found that Kif15 slides anti-parallel microtubules apart with gradual force buil

179 spindle - both structures being composed of anti-parallel microtubules.

180 kinesin-1 moves nuclei indirectly by sliding anti-parallel microtubules.

181 er of each fibril, where the fibril contains anti-parallel molecules in equal numbers.

182 ation by purine-rich oligonucleotides in the anti-parallel motif is inhibited by physiological concen

183 ind in an anti-parallel orientation (purine, anti-parallel motif).

184 Regions of anti-parallel MT organization behind the centrosome were

185 ently reverse direction when encountering an anti-parallel MT overlap, suggesting that the two motor

186 MAP65-3 and MAP65-4 to engaging and bundling anti-parallel MTs in the phragmoplast and disclosed a no

187 emonstrate that dynein crosslinks and slides anti-parallel MTs in vitro.

188 Kinesin-1 protein is able to cross-link anti-paralleled MTs in vitro.

189 The rods of anti-parallel myosin molecules overlap at the centre of

190 Due to the anti-parallel nature of DNA, the leading strand is copie

191 The anti-parallel nature of the four-helix bundle positions

192 here adjacent strands have both parallel and anti-parallel neighbors and connecting T(4) segments whi

193 ring spins, but theoretically skyrmions with anti-parallel neighbouring spins are also possible.

194 ved prominent nucleosome stacking in cis and anti-parallel nucleosome interactions, which are consist

195 ffinity for parallel-stranded G4 than either anti-parallel or hybrid folds.

196 ons indicate local moments with parallel and anti-parallel ordering along and across the edges, respe

197 Anti-parallel ordering is observed in 2-D segments with

198 lel motif), or purine TFOs, which bind in an anti-parallel orientation (purine, anti-parallel motif).

199 rted a model in which CacyBP/SIP occupies an anti-parallel orientation mediated by the N-terminal dim

200 tidimensional NMR spectroscopy to define the anti-parallel orientation of the four-helix bundle and i

201 igned to bind simultaneously in parallel and anti-parallel orientation to the polypurine strand.

202 eries of short TFOs directed in parallel and anti-parallel orientation to the purine strand of each t

203 ding site and inconsistent with parallel and anti-parallel orientations of the regions surrounding hi

204 ither FRL1 or mDia2 are in both parallel and anti-parallel orientations.

205 -crosslinking proteins, MTs form parallel or anti-parallel overlaps and self-assemble reversibly into

206 ation, dynamics and orientation, and exhibit anti-parallel overlaps in the middle of the cell.

207 al regulation of MT dynamics in parallel and anti-parallel overlaps is critical for the self-assembly

208 The ENT domain forms a homodimer via the anti-parallel packing of the extended N-terminal alpha-h

209 st conserved Gln-226 residues present on the anti-parallel pair of helices.

210 nduced tubulin polymers, characterized by an anti-parallel protofilament arrangement, are depolymeriz

211 together with catastrophe factors, promote "anti-parallel pruning" that enforces radial organization

212 KH domains are arranged in an intramolecular anti-parallel pseudodimer conformation with the canonica

213 Anti-parallel quadruplex structures are favored in the p

214 Peptides generated from both parallel and anti-parallel readings of the non-coding strand of DNA h

215 e we show that the writhe is conserved under anti-parallel reconnection.

216 e linear response regime, will show a single anti-parallel resistance larger than the parallel resist

217 , we make the surprising prediction that the anti-parallel resistance of a spin valve can be either l

218 s and features a central flat seven-stranded anti-parallel sheet that is flanked by helices.

219 immunity protein to complete a six-stranded anti-parallel sheet.

220 if (DFSLDPTF) forms a loop that connects two anti-parallel sheets between SF2 motifs 5 and 6.

221 ort-range initiation sites, such as those in anti-parallel sheets connected by turns.

222 The core of the protein is formed by stacked anti-parallel sheets that are individually very similar

223 in arrays that may make a contiguous set of anti-parallel single-stranded nucleic acid binding cleft

224 inting data were consistent with a symmetric anti-parallel solution dimer (AP dimer) distinct from th

225 In contrast, dark excitons (XD) show anti-parallel spin configuration with generally forbidde

226 on Cooper pairs in most superconductors form anti-parallel spin singlets with total spin S = 0 (ref.

227 binds zinc in a cross-brace topology between anti-parallel ss-strands reminiscent of RING (really int

228 An additional anti-parallel strand in the PTCR structure also blocks t

229 We show that anti-parallel strand orientation is essential for such a

230 le, we identify an evolutionary advantage of anti-parallel strand orientation of duplex DNA, within a

231 s benefit, such as strand directionality and anti-parallel strand orientation, which together result

232 native-like conformation to better mimic the anti-parallel structure of VEGF.

233 s, which differ starkly between parallel and anti-parallel structures; (2) preferred superhelical rad

234 EAT-repeat proteins that form an intertwined anti-parallel superhelical assembly, which docks intrace

235 psed DNA molecules supports the selection of anti-parallel target site alignment prior to the chemica

236 coiled-coil protrusion to form an elongated anti-parallel tetramer.

237 s with significantly higher affinity than an anti-parallel TFO.

238 dipoles of split-ring resonators parallel or anti-parallel to each other, leading to the strong chira

239 ed of two pairs of parallel helices that are anti-parallel to each other.

240 howed a switch in alpha-helical packing from anti-parallel to parallel and rotation of the alpha-heli

241 BAA receptor alpha subunit beta1 strand runs anti-parallel to the beta2 strand, which contains loop D

242 It lies anti-parallel to the beta2 strand, which is known to par

243 , actin motility was orientated parallel and anti-parallel to the direction of flow during myosin adh

244 egment tilts at a 30 degrees -angle and runs anti-parallel to the dsDNA helix to facilitate translati

245 del in which the spin is aligned parallel or anti-parallel to the effective field, with a rotating-fr

246 hose electronic magnetic moments are aligned anti-parallel to the magnetic field.

247 ion initiation protein 1 (EIF4G1), while the anti-parallel topology G4s do not have inhibitory effect

248 e beta-sheet with an unusual mixed parallel, anti-parallel topology.

249 ne and found that this site can fold into an anti-parallel two-tetrad G-quadruplex.

250 A key conserved hairpin feature is its anti-parallel, two beta-strand stem, which we show by mu

251 Herein parallel and anti-parallel variants of Abeta(1-40) dimers were design

252 the Protein Data Bank included parallel and anti-parallel variants of two, three and four-stranded c