ライフサイエンスコーパス: anti-sense

1 f 'UCU', or not reported at all, such as the anti-sense 5' -3' motif 'ACGA'.

2 either under reported in literature, such as anti-sense 5' -3' motif 'UCU', or not reported at all, s

3 B4 cells caused no observed phenotype due to anti-sense activities.

4 diversity, which included a higher ratio of anti-sense and inter-genic transcripts, reflecting a per

5 pared with wild type at day 21 after sowing, anti-sense and overexpressing lines showed, on average,

6 ranscriptase-polymerase chain reaction using anti-sense and sense primers designed from Exons 2 and 3

7 etermined using (51)Cr release in hsp25 cDNA anti-sense and sense-transfected cells expressing minima

8 ilarly, ROS production increased markedly in anti-sense and untransformed, but not overexpressor, roo

9 l sequences in the host genome gives rise to anti-sense, anti-viral piRNAs.

10 importance of these observations, sense and anti-sense (AS) ANX II RNA-expressing clones of intestin

11 ovel imaging probe composed of short-hairpin anti-sense (AS) endoglin RNA coupled to a fluorophore an

12 We show here that it is the anti-sense (AS) strand of these genes that is transcribe

13 ty of miRNA precursors, especially at the 5'-anti-sense (AS) terminal base pair.

14 Pre-treatment of RTLGA with anti-sense but not missense p21(waf1/cip1) oligonucleoti

15 Anti-sense but not sense oligonucleotides to the human N

16 hsp72 anti-sense (C2/AS) and vector-only transfected C2 (C2/CE

17 MtDNA-depleted cells stably expressing anti-sense cathepsin L RNA, TGFbeta1 RNA, or treated wit

18 reatment with an adenoviral vector harboring anti-sense caveolin-1 specifically potentiates transform

19 Transgenic Arabidopsis plants expressing an anti-sense cDNA encoding a type III peroxidase, French b

20 roteinase in cutaneous epidermal cells using anti-sense cDNA expression in human keratinocytes.

21 In situ hybridization with anti-sense cDNA probes was used to test for expression o

22 ered or slightly decreased, respectively, in anti-sense cDNA-infected cells compared with control cel

23 Likewise, the Brn-3b anti-sense cell lines showed reduced cellular growth and

24 Transfection of cells with sense or anti-sense CK2 constructs modulates c-myc protein levels

25 ines were studied in an organ culture model, anti-sense clones were highly invasive compared with vec

26 cognition succeeds or aborts before a stable anti-sense complex is achieved.

27 keratinocytes were transfected with sense or anti-sense constructs of the EP(2) receptor.

28 Sense and anti-sense constructs were identified and transfected, a

29 ch had been transfected with Brn-3b sense or anti-sense constructs.

30 In this study, in situ hybridization with anti-sense cRNA riboprobe was used to show expression of

31 t of hepatocytes with group II PLA2-specific anti-sense DNA oligonucleotides: 1) abolished accumulati

32 ed CpGs was concordant between the sense and anti-sense DNA strand, suggesting that it is a stable ep

33 that YUSAC-2 cells transfected with survivin anti-sense expressed less endogenous survivin and exhibi

34 rofiling and RT-PCR analysis showed that the anti-sense (FBP1) transgenic plants had reduced levels o

35 at an apparent slow rate with the sense and anti-sense forks moving at 0.32 and 0.23 kb/min.

36 This editing, directed by anti-sense gRNAs, creates canonical protein-encoding mRN

37 Interestingly, for some miRNAs sense and anti-sense hairpins score highly and mature miRNAs from

38 y stable transfection of PC3M-LN4 cells with anti-sense HAS2 or HAS3 expression constructs diminishes

39 Stable hsp anti-sense IEC-18 cell clones were obtained by electropo

40 itative analysis of melanin in the sense and anti-sense infectant cells demonstrated an increase and

41 erexpressing cells but slightly decreased in anti-sense infectant cells.

42 cts were only identified from the sense- and anti-sense-infected clones, not from the parental cells

43 induced mouse ESC differentiation, and their anti-sense inhibitors substantially reversed spontaneous

44 important for transcription termination and anti-sense initiation.

45 actions returned to control levels 12 h post anti-sense injection.

46 lity, we transfected MDA-231BO cells with an anti-sense IRS-2 construct.

47 n 12 cDNA, and in situ hybridization with an anti-sense keratin 12 riboprobe.

48 Further, a microarray study using an anti-sense line showed AOX influences outside mitochondr

49 wed no increase in oxidative damage, whereas anti-sense lines had levels of damage greater than those

50 This study uncovers an anti-sense lncRNA (APOA4-AS), which is co-expressed with

51 function and gain-of-function studies, using anti-sense locked-nucleic acids (LNAs) and synthetic RNA

52 Inhibition of MAPK activation by anti-sense MEK expression in MDA-MB-468 cells significan

53 erved 48-72 h after transduction with 1.4 kb anti-sense membrane type 1 matrix metalloproteinase cons

54 ved via retroviral expression of a 5' 1.4 kb anti-sense membrane type 1 matrix metalloproteinase cons

55 apoptotic nuclear fragmentation after 1.4 kb anti-sense membrane type 1 matrix metalloproteinase cons

56 al (AAV) vectors that preferentially express anti-sense miR against miR-21(miRzip-21) and show that m

57 Small interfering RNA (siRNA) as a promising anti-sense molecule can specifically silence inflammatio

58 ation to growth control in experiments using anti-sense molecules or dominant negative STAT protein e

59 Zebrafish anti-sense morpholino knockdown of DDX39B led to reduced

60 Using a dominant negative construct or anti-sense morpholino oligos (MOs) to disrupt meis3 func

61 Anti-sense morpholinos against lmx1b.1 and lmx1b.2 resul

62 Xtgfbi knockdown by anti-sense morpholinos causes defective organizer induct

63 vided in experiments that showed that cIAP-2 anti-sense morpholinos permit LIGHT to induce apoptosis

64 Trans-perturbations with anti-sense morpholinos reveal a co-dependency between si

65 lial development, we utilized site-directed, anti-sense morpholinos to inhibit scl mRNA.

66 As) ('CUTs'), along with ~642 predicted long anti-sense ncRNAs (asRNAs), ~178 intergenic ncRNAs and,

67 also seems to be regulated by a cis-acting, anti-sense non-protein-coding transcript.

68 A knock down agents, HBV release inhibitors, anti-sense nucleosides, exogenous interferon stimulation

69 orothioate intercellular adhesion molecule-1 anti-sense oligodeoxynucleotide in a cream formulation.

70 cr protein by incubating cells with a 3' BCR anti-sense oligodeoxynucleotide increased the growth rat

71 Using a specific anti-sense oligodeoxynucleotide to CTGF the procontracti

72 Anti-sense oligodeoxynucleotides were used to determine

73 Gelsolin anti-sense oligonucleotide (20 microM) treatment of NR6

74 Human LF were treated with circ-RORbeta anti-sense oligonucleotide (ASO) +/- ethanol, and sample

75 n, Pkd2WS25/- mice were treated with an mTOR anti-sense oligonucleotide (ASO) that blocks mTOR expres

76 FOXP3 anti-sense oligonucleotide (FOXP3-ASO), repolarises Treg

77 ents with CD and then incubated with a Smad7 anti-sense oligonucleotide (knock down).

78 ction of zebrafish embryos with a morpholino anti-sense oligonucleotide corresponding to the ortholog

79 model enzyme to test nuclease sensitivity of anti-sense oligonucleotide drugs.

80 An anti-sense oligonucleotide to feline SP (SP-asODN) was i

81 llagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, a

82 We further show that a miR-27a anti-sense oligonucleotide, by opposing the effects of m

83 ession, as well as by transfection of a FLIP anti-sense oligonucleotide.

84 Anti-sense oligonucleotides (ASOs) are modified syntheti

85 Here, anti-sense oligonucleotides (ASOs) were used to disrupt

86 use PCT and NIH3T3 fibroblast lines by using anti-sense oligonucleotides against PTEN.

87 Treatment with pharmacologic grade DNMT1 anti-sense oligonucleotides and STAT3 small-interfering

88 ults strongly suggest that topically applied anti-sense oligonucleotides can be delivered to target s

89 rvations suggest that cholesterol-conjugated anti-sense oligonucleotides may offer a novel approach t

90 Preincubation of CF-T43 cells with CFTR anti-sense oligonucleotides prevented an increase in 36C

91 transfected or microinjected with surviving anti-sense oligonucleotides produce significantly more p

92 Anti-sense oligonucleotides to the cloned sequence drama

93 eLa cells, whereas down-regulation of ALY by anti-sense oligonucleotides virtually eliminates TCR alp

94 P-expressing cells or cells treated with PS1 anti-sense oligonucleotides were less capable of taking

95 Pre-clinical data from knockouts, anti-sense oligonucleotides, and siRNA for Nav1.3, 1.7,

96 fere with EphA4 levels in feather buds using anti-sense oligonucleotides, demonstrating a severe effe

97 n or targeted lipid nanoparticle delivery of anti-sense oligonucleotides, proved to be sufficient to

98 een fluorescence protein-conjugated survivin anti-sense or green fluorescence protein-conjugated surv

99 ipocalin 2 (mouse 24p3) expression by either anti-sense or siRNA approaches strongly reduces the over

100 ith sense cDNA, not from cells infected with anti-sense or vector-alone, or from the uninfected-paren

101 fragment of the 1392 bp su cDNA in sense and anti-sense orientation, and a 403 bp 3' fragment.

102 library containing inserts in both sense and anti-sense orientation.

103 carrying a 623 bp portion of luc in sense or anti-sense orientation.

104 transposon transcription but does not reduce anti-sense piRNAs targeting half of the transcriptionall

105 e generated: AtAOX1a overexpressors, AtAOX1a anti-sense plants, and overexpressors of a mutated, cons

106 We used anti-sense pp32 and RNAi transfection to study the effec

107 ce to DOX, we inhibited PR3 expression by an anti-sense PR3 oligodeoxynucleotide and showed that inhi

108 RT-PCR analysis with exon 9 anti-sense primer generated 2 major amplicons with the u

109 is known about the regulation or function of anti-sense promoters and the non-coding RNAs they genera

110 We propose that anti-sense promoters serve as platforms for TF binding a

111 strated by showing that transfection with an anti-sense RAR beta construct blocked atRA-induced STAT1

112 e genome, and disclosing a potential natural anti-sense regulation for gene expressions.

113 e maternal DNA methyltransferase (xDnmt1) by anti sense RNA during cleavage stages is associated with

114 onvergent promoters, we find no evidence for anti-sense RNA control.

115 ed by RNAse protection assays using a 710 bp anti-sense RNA probe that spanned the alternatively spli

116 utilizes fluorescently labeled mRNA-specific anti-sense RNA probes and dsRNA-binding protein to ident

117 trkB and p75 mRNA using digoxigenin-labeled anti-sense RNA probes.

118 ed to be mediated by the generation of short anti-sense RNA species expressed with low abundance.

119 Together, we have identified new sense and anti-sense RNA transcripts, novel mRNAs and mi/siRNA-siz

120 t RNA II could regulate RNA I function as an anti-sense RNA.

121 as measured by quantitative real-time PCR of anti-sense RNA.

122 es into transcription units, an abundance of anti-sense RNAs, and transcripts from intergenic regions

123 ents the formation of polycistronic RNAs and anti-sense RNAs, which are generally detrimental to the

124 ssociated with the location of the sense and anti-sense segments in the genome.

125 engths (36 nt and 100 nt) each of a sense or anti-sense single-strand oligonucleotide (ssODN).

126 roliferation, while depletion of SOCS1 by an anti-sense SOCS1 cDNA construct enhances cell proliferat

127 xpression and activity) by transfection with anti-sense Src expression vectors increases susceptibili

128 rved when CRISPR/nuclease and 36 nt sense or anti-sense ssODNs were injected into embryos.

129 an enzymatic ligation reaction (leaving the anti-sense strand dissociable).

130 by deleting transcription start sites on the anti-sense strand of the Gpr27 coding exon.

131 NA duplex internal stability and siRNA sense/anti-sense strand secondary structure.

132 oded reverse transcriptase which cleaves the anti-sense strand.

133 ed in intestinal epithelia stably expressing anti-sense to hsp25.

134 useful near promoters where sufficient sense/anti-sense transcript mapping information is lacking.

135 ntains a promoter for a paternally expressed anti-sense transcript, Kcnq1ot1, and we define the exten

136 Anti-sense transcription originating upstream of mammali

137 suggesting that some of them might regulate anti-sense transcription.

138 ncRNAs comprise microRNAs, anti-sense transcripts and other Transcriptional Units c

139 he flanking DNA nor levels of DMPK sense and anti-sense transcripts could obviously explain individua

140 and tick-specific operons and paralogs, and anti-sense transcripts that suggest novel expression reg

141 , including trans-acting non-coding RNAs and anti-sense transcripts.

142 As, 5' untranslated regulatory elements, and anti-sense transcripts.

143 We further discover a group of anti-sense TSSs in macrophages with an enhancer-like chr

144 Notably, as the distance between sense and anti-sense TSSs increases, so does the size of the NDR,

145 We find that coupled sense and anti-sense TSSs precisely define the boundaries of a nuc

146 otein levels by stable transformation of the anti-sense VDR in MCF-7 reduced the sensitivity of MCF-7

147 Introduction of anti-sense wt-p53 into wt-p53 cells abrogated the 2-MeOE

148 In situ hybridization with anti-sense zGCAP4, zGCAP5 and zGCAP7 RNA showed exclusiv