ライフサイエンスコーパス: anti-tumor effect

1 the ability of the elicited Abs to exert an anti-tumor effect.

2 because CD4 depletion does not diminish the anti-tumor effect.

3 ) iu of rAd resulted in augmentation of this anti-tumor effect.

4 nterferon induction therapy elicits a robust anti-tumor effect.

5 n the tumor microenvironment could boost the anti-tumor effect.

6 and MEK/ERK, as potential mechanisms of its anti-tumor effect.

7 immune system plays in radiotherapy-induced anti-tumor effects.

8 s), thereby forming immune synapses to exert anti-tumor effects.

9 atological malignancies due to the prominent anti-tumor effects.

10 tuents with demonstrated neuroprotective and anti-tumor effects.

11 ing transcription in MM elicited synergistic anti-tumor effects.

12 ex, with studies demonstrating both pro- and anti-tumor effects.

13 DPH oxidase inhibitor, was evaluated for its anti-tumor effects.

14 nstream target inhibitors exhibit remarkable anti-tumor effects.

15 ugh IFN response has been considered to have anti-tumor effects.

16 nse to immunotherapy, potentially via direct anti-tumor effects.

17 fications by biotin, which may affect RA16's anti-tumor effects.

18 ent in the microenvironment but have unclear anti-tumor effects.

19 yte infiltration of tumors and showed strong anti-tumor effects.

20 utically appealing, but has had very limited anti-tumor effects.

21 ta have been reported to have either pro- or anti-tumor effects.

22 aged mice receiving IT displayed significant anti-tumor effects.

23 to an enhancement of its anti-angiogenic and anti-tumor effects.

24 modulate infused T-cell responses to enhance anti-tumor effects.

25 ization, and down-regulation with subsequent anti-tumor effects.

26 ntibodies, and Sindbis viral vectors confers anti-tumor effects.

27 alpha-CD40 alone mediated partial transient anti-tumor effects.

28 expression imparts resistance to celecoxib's anti-tumor effects.

29 ith siRNA-loaded NPs may exhibit synergistic anti- tumor effects.

30 ivering potentially curative immune-mediated anti-tumor effects against a number of different hematol

31 cholesterol reducing drugs, statins, exhibit anti-tumor effects against cancer stem cells and various

32 ine (bromo) monotherapy produced significant anti-tumor effects against established melanoma cell lin

33 RRM domain antibodies are associated with an anti-tumor effect and paraneoplastic encephalomyelitis,

34 ional albumin was synthesized to enhance the anti-tumor effect and tumor target efficiency.

35 enic dacarbazine, Epacasome further enhances anti-tumor effects and immune responses through the upre

36 Moreover, IL-21 has potent anti-tumor effects and is implicated in the development

37 The anti-tumor effects and leukocyte recruitment mediated by

38 tral role for iNKTs in promoting RLI-induced anti-tumor effects and suggest that this pathway involve

39 th mature human NK cells, can define in vivo anti-tumor effects and systemic toxicities.

40 se-5 (PDE5) inhibitors are suggested to have anti-tumor effects and to inhibit surgery-induced immuno

41 nti-C6VL TCR Abs into na ive mice had modest anti-tumor effects and was not sufficient to prevent tum

42 ctory HCC is well-tolerated, associated with anti-tumor effects, and may be guided by ctDNA assessmen

43 evels of tumor PGE(2), suggesting that their anti-tumor effects are directly associated with the inhi

44 ltaneous toxicity mitigation and synergistic anti-tumor effects) are highlighted for special consider

45 s not profound enough to achieve comparative anti-tumor effects as EE.

46 larly evident in vivo and likely limited the anti-tumor effects, as confirmed by re-initiation of tum

47 This anti-tumor effect associated with clinical survival of b

48 l effector cells may also be involved in the anti-tumor effect at higher local concentrations of IL-1

49 ssays showed that Alox5 exhibited a moderate anti-tumor effect both in vitro and in vivo.

50 BKM120 or LEE011 yielded more than additive anti-tumor effects both in vitro and in vivo in a melano

51 of oncologic conditions and has demonstrated anti-tumor effects both in vitro and in vivo.

52 , simvastatin has also been reported to have anti-tumor effect, but the underlying mechanism is large

53 acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and in

54 that DOX-HK-MPEG-PCL micelles improved Dox's anti-tumor effect by enhancing tumor cell apoptosis, sup

55 ibody-mediated HER3 blockade exerts a potent anti-tumor effect by suppressing HER3-PI3K-AKT-mTOR onco

56 ound that gammaSI enhanced miR-34a-dependent anti-tumor effects by activating the extrinsic apoptotic

57 STAT3 inhibitors significantly increases the anti-tumor effect compared to single-agent treatments.

58 This effect results in improved anti-tumor effects compared to anti-PD-1 therapy or ther

59 changes predicted T-cell engraftment, while anti-tumor effects correlated with neutrophil-to-lymphoc

60 ession, however, has differing pro-tumor vs. anti-tumor effects, depending on the cancer types.

61 rapeutic compounds) strongly potentiates the anti-tumor effect due to repression of DNA repair machin

62 se, sequential regimen that imparts a robust anti-tumor effect for non-small-cell lung cancer (NSCLC)

63 ted pathways as being linked to the observed anti-tumor effects for both oxNaCl and cmc.

64 ls we tested that are bitter but do not have anti-tumor effects, gut tumors did not affect avoidance

65 L responses capable of producing therapeutic anti-tumor effects (i.e., prolongation of survival, tumo

66 s tested, CAY10603 exhibited the most potent anti-tumor effect in 3D neurosphere and macrophage co-cu

67 However, the mechanism of AR's anti-tumor effect in breast cancer is still not fully un

68 myrcene- induced a statistically significant anti-tumor effect in mice but not alpha-pinene, myrcene

69 compound, dexamethasone, which shows potent anti-tumor effect in multiple cancer cell lines when coc

70 ells are not likely to mediate a significant anti-tumor effect in vivo.

71 f human melanoma cells in vitro and a potent anti-tumor effect in vivo.

72 hemotherapeutic agents, but exhibits limited anti-tumor effects in a mouse model of metastatic breast

73 ARI had anti-tumor effects in all three of our gut hyperprolifer

74 ionally, cosmosiin has been shown to perform anti-tumor effects in cervical cancer, hepatocellular ca

75 n of cGMP-dependent protein kinase (PKG) has anti-tumor effects in colon cancer cells but the mechani

76 Although they show anti-tumor effects in culture and in mouse models, these

77 ing of these agents, as they generate potent anti-tumor effects in experimental animals.

78 argeting PFKP and c-Myc triggers synergistic anti-tumor effects in HNSCC.

79 otent, reversible type I PRMT inhibitor with anti-tumor effects in human cancer models.

80 cobimetinib (bromo/cobi) showed synergistic anti-tumor effects in multiple BRAFi-resistant PDX model

81 -molecule FTO inhibitors that exhibit strong anti-tumor effects in multiple types of cancers.

82 trast, IL-1H4 was able to confer substantial anti-tumor effects in NKT-deficient mice.

83 -1 pathway has consistently shown remarkable anti-tumor effects in patients with advanced cancers and

84 roxychloroquine [HCQ]) demonstrated striking anti-tumor effects in preclinical models and in a patien

85 dosed intratumorally, SHR1032 induced strong anti-tumor effects in the MC38 murine syngeneic tumor mo

86 ore, miR-497 exhibited anti-angiogenesis and anti-tumor effects in the VEGFR2-luc breast tumor model

87 Potent and durable anti-tumor effects in TNBC xenografts, including complet

88 demethylase FTO that demonstrate significant anti-tumor effects in various models of acute myeloid le

89 found that the HAT inhibitor C646 augmented anti-tumor effects in vitro by inhibiting cell prolifera

90 nistration of anti-CD40 antibodies has shown anti-tumor effects in vivo through a variety of mechanis

91 The combination demonstrated synergistic anti-tumor effects in vivo without toxicity and in the f

92 uses anti-proliferative effects in vitro and anti-tumor effects in vivo.

93 nd human T cells, which results in augmented anti-tumor effects in vivo.

94 MSC-delivered recombinant TRAIL has profound anti-tumor effects in vivo.

95 The anti-tumor effect induced by anti-MerTK treatment was lo

96 f recipient NK1.1(+) cells led to loss of an anti-tumor effect induced by RLI in mixed bone marrow ch

97 y, specific activation of iNKTs enhanced the anti-tumor effect induced by RLI.

98 Second, partial abrogation of the anti-tumor effect is induced with anti-CD40L antibodies

99 of 14 evaluable patients showed evidence of anti-tumor effects lasting up to 26 months, based on phy

100 PDAC, while rescuing this pathway mitigates anti-tumor effects observed with chemotherapy and high g

101 nce and immuno-response, we investigated the anti-tumor effect of a glutamine analog (6-diazo-5-oxo-L

102 e model, Bif.BEVs are found to synergize the anti-tumor effect of anti-PD-1 via modulation of key cyt

103 etion of CD20+ B cells partially blocked the anti-tumor effect of APCP and significantly reduced the

104 -bearing mice receiving anti-IL-17A mAb, the anti-tumor effect of APCP was ablated.

105 Moreover, the anti-tumor effect of beta-glucan-induced trained granulo

106 The anti-tumor effect of beta-glucan-induced trained immunit

107 matory loop that paradoxically mitigates the anti-tumor effect of chemotherapy and triggers metastati

108 t, and its inactivation further enhances the anti-tumor effect of CUL5 KO.

109 ified two bacterial species potentiating the anti-tumor effect of cyclophosphamide that are kept in c

110 esence of essential factors required for the anti-tumor effect of GM-CSF.

111 the critical role of FasL regulation in the anti-tumor effect of HDACIs.

112 uncovering a novel mechanism underlying the anti-tumor effect of HDACIs.

113 We also provide evidence for anti-tumor effect of IGFBP-3R in vivo using prostate and

114 Mechanistically, the anti-tumor effect of IL-18Ra(hi) subset is mediated by I

115 delicate balance between immunosuppression, anti-tumor effect of immune checkpoint inhibitor therapy

116 RANKL inhibition increases the anti-tumor effect of immunotherapies in breast cancer th

117 In this study, we investigated the anti-tumor effect of MLN4924 in human clear cell renal c

118 n image-based assessment of distribution and anti-tumor effect of nano- and macromolecular systems.

119 In various mouse tumors, the anti-tumor effect of pro-IL-15 depends on intratumoral C

120 Herein, we characterize the anti-tumor effect of rapamycin in a mouse model of T-cel

121 Previously, we observed potent anti-tumor effect of Sch-B in colorectal cancer (CRC) an

122 The anti-tumor effect of silencing ZNF180 is further validat

123 The greatest anti-tumor effect of single injection of Doxil(R) was ac

124 ential therapeutic strategies to enhance the anti-tumor effect of trabectedin using integrated in sil

125 The anti-tumor effect of vitamin D has been well recognized

126 The anti-tumor effect of VTX-2337 was determined in SCCVII/C

127 ls and NK cells were all able to abolish the anti-tumor effect of VTX-2337+ cetuximab.

128 to cancer initiation, our work demonstrates anti-tumor effects of 2HG in inhibiting proliferation/su

129 TGF-beta pathway using PFD may increase the anti-tumor effects of 5-FU and reduce tumor development,

130 Herein, we characterize anti-tumor effects of a unique human CD4(+) helper T-cel

131 To better characterize the protective anti-tumor effects of alphabeta T cells, we examined the

132 rationalize conflicting reports of pro- and anti-tumor effects of antioxidant treatment.

133 RAIL-resistant malignancies sensitive to the anti-tumor effects of Apo2L/TRAIL in vitro and in vivo.

134 To investigate the anti-tumor effects of avicin D in cutaneous T-cell lymph

135 hether HSPC reprogramming contributes to the anti-tumor effects of BCG administered into the bladder

136 erapeutic drug has been shown to enhance the anti-tumor effects of cancer vaccines and adoptive cell

137 hey reverse established CIPN and may enhance anti-tumor effects of chemotherapy.

138 rived from these cells were resistant to the anti-tumor effects of digoxin, demonstrating that HIF-1

139 ibitor, has been demonstrated to enhance the anti-tumor effects of DNA damaging agents such as gemcit

140 ents a pharmacological target to enhance the anti-tumor effects of DNA damaging modalities in the tre

141 This commentary highlights the anti-tumor effects of exercise and evaluates how exercis

142 TAT1 may be an early step in the cooperative anti-tumor effects of IFN and RA.

143 data differentiate the mechanism for primary anti-tumor effects of IL-2/alpha-CD40 immunotherapy, whi

144 The described anti-tumor effects of indomethacin are evident whether i

145 Inhibition of FOSL1 enhances the anti-tumor effects of IR by preventing IR-induced PMT.

146 IRF4 expression was required for the anti-tumor effects of Jag2 deletion in lung tumors.

147 The long-term anti-tumor effects of LNP-M-delivered anti-p53(R282W) an

148 he signaling network thought to diminish the anti-tumor effects of mTORC1 inhibition.

149 cer, FTY720 administration also enhanced the anti-tumor effects of paclitaxel, leading to reduced tum

150 Therefore, our results indicated that the anti-tumor effects of photofrin based PDT was strongly a

151 thway has been highlighted as central to the anti-tumor effects of PKG.

152 ion and cancer growth but also abrogates the anti-tumor effects of PPARgamma and rosiglitazone.

153 vide novel molecular insights related to the anti-tumor effects of prolonged cetuximab treatment with

154 and whose therapeutic targeting enhances the anti-tumor effects of radiotherapy.

155 nd its oncogenic activities and evaluate the anti-tumor effects of reducing IGF2 signaling.

156 mmary tumor development but also impairs the anti-tumor effects of rosiglitazone.

157 In this study, we investigated the anti-tumor effects of SAHA in CTCL cell lines and freshl

158 he purpose of this study was to evaluate the anti-tumor effects of selinexor, used in combination wit

159 molecular target of SFN, which mediates the anti-tumor effects of SFN.

160 tivation of the STING pathway, enhancing the anti-tumor effects of STING agonists and radiotherapy.

161 ntation has provided evidence for the potent anti-tumor effects of T cells.

162 The anti-tumor effects of the CD4+ T cells required the pres

163 re, we investigated the in vitro and in vivo anti-tumor effects of the FDA-approved ETAR antagonist,

164 s also effective in potentiating the in vivo anti-tumor effects of the PI3Kdelta inhibitor in mice tr

165 The anti-tumor effects of the tetravalent antibody are media

166 Finally, we showed the inhibitory and anti-tumor effects of this small molecule in vitro and c

167 The anti-tumor effects of TMZ and DOX were mediated in part

168 Therefore, the synergistic anti-tumor effects of type I IFNs and MSCs were achieved

169 We report potent anti-tumor effects of unacylated ghrelin, dependent on c

170 Preclinical studies have demonstrated the anti-tumor effects of varied anti-angiogenic agents in s

171 The anti-tumor effects of VTX-2337+ cetuximab were accompani

172 RAS signaling, thereby exerting synergistic anti-tumor effects on ovarian cancers with PTEN deficien

173 cally and then penetrates the brain to exert anti-tumor effects, or whether it directly penetrates th

174 crobubbles significantly improved curcumin's anti-tumor effects, particularly under specific conditio

175 extracellular fluid translated into a strong anti-tumor effect prolonging survival of mice bearing GD

176 These anti-tumor effects result from trained immunity-induced

177 of Rheb by FTI is responsible for the drug's anti-tumor effects, such that a farnesylation-independen

178 TRAIL and LHT7 in tumor tissue exerted their anti-tumor effects synergistically.

179 emically administered toxin produced greater anti-tumor effects than wild-type LT toward human xenogr

180 tizes GBM to temozolomide and confers potent anti-tumor effects that combat GBM (e.g., reducing proli

181 shRNA-mediated CDK9 inhibition led to robust anti-tumor effects that correlated with MYC expression l

182 ivery and magnetic hyperthermia, the in vivo anti-tumor effect under a low-frequency magnetic field u

183 es not necessarily translate to the enhanced anti-tumor effect unless it is accompanied by the tempor

184 The anti-tumor effect was diminished in mice deficient in CD

185 After irradiating with an NIR laser, a good anti-tumor effect was observed owing to the enhanced pho

186 were immune-deficient, it is likely that the anti-tumor effect was primarily through direct inhibitio

187 Anti-tumor effects were seen in both indolent and aggres

188 ongs animal survival, and exerts synergistic anti-tumor effects when combined with conventional chemo

189 antibody resulted in only partial, transient anti-tumor effects whereas combined treatment with IL-2/

190 single injection of Combo NP had synergistic anti-tumor effects while the same molar ratio of combine

191 sults demonstrated enhanced cytotoxicity and anti-tumor effect with palbociclib plus taxanes at clini

192 A novel approach to achieving anti-tumor effects without the risk of GVHD is suggested