ライフサイエンスコーパス: antibiotic

1 ic resistance upon exposure to a beta-lactam antibiotic.

2 sight into its mode of action beyond a basic antibiotic.

3 ta and IL-10 were similar prior to receiving antibiotic.

4 thereby addressing a key shortcoming of this antibiotic.

5 eria confers innate resistance to toxins and antibiotics.

6 efense against cytotoxic substances, such as antibiotics.

7 d death; or (3) use of long-term suppressive antibiotics.

8 and are often extensively resistant to many antibiotics.

9 e injection step to initiate AST against all antibiotics.

10 pecies as well as cellular stress induced by antibiotics.

11 are particularly difficult to eliminate with antibiotics.

12 tive barrier against the immune response and antibiotics.

13 ly occurs at environmental concentrations of antibiotics.

14 tion and permits evaluation of efficacies of antibiotics.

15 septic shock warrant emergent broad-spectrum antibiotics.

16 ldren's care in addition to the provision of antibiotics.

17 ureus, but also induce tolerance to multiple antibiotics.

18 rted allergies to both PCN and cephalosporin antibiotics.

19 mic datasets, revealing thousands of encoded antibiotics.

20 onal deficiencies, and the administration of antibiotics.

21 a major predictor of bacterial responses to antibiotics.

22 ndards, which consist of supportive care and antibiotics.

23 7 [0.30-1.54]; p = 0.35), nor fixed-duration antibiotics (1.21 [0.90-1.63]; p = 0.20) were associated

24 its lipid A core is the target of polymyxin antibiotics(3,4).

25 Of all antibiotics, 54.1% were from ambulatory care (95% CI, 52

26 withdrawal (23%), hydroxychloroquine (71%), antibiotics (74%), tocilizumab (13%), and antivirals (14

27 This is surprising because antibiotic action involves many additional effects downs

28 ibed antibiotics, revealed the potential for antibiotic adjustment in 70.7% of patients based on the

29 group had a mean of 12.9 cumulative systemic antibiotic administration days (95% CI, 0 to 18.05), and

30 on oxygenation and ventilation, prophylactic antibiotics after resuscitation, postresuscitation seizu

31 Thiostrepton is a potent antibiotic against a broad range of Gram-positive bacter

32 that 20 restored the activity of beta-lactam antibiotics against carbapenem-resistant Pseudomonas aer

33 ptibility tests with one, two, or even three antibiotics against two clinically isolated multi-drug-r

34 oid or 5-HT receptors, or minimally absorbed antibiotics (all of which are selected according to pred

35 treal antibiotics for patients with specific antibiotic allergies.

36 Nonoperative management with antibiotics alone has the potential to treat uncomplicat

37 which is comparable with that of commercial antibiotics ampicillin and gentamicin.

38 tes multi-drug resistant (MDR) to first-line antibiotics and 60% were extensively drug-resistant (XDR

39 The environmental spread of antibiotics and antibiotic resistance genes (ARGs) from

40 sary for metabolic regulation, resistance to antibiotics and antimicrobials, pathogenesis, and adhesi

41 lation to surface water, on the transport of antibiotics and ARGs in runoff and soil following land a

42 omplex procedure and includes peri-operative antibiotics and caloric restriction in addition to the a

43 scription; however, the risks of unwarranted antibiotics and lack of guidelines for procedures involv

44 FAS is an attractive target for antibiotics and many inhibitors are in clinical developm

45 ganic carbon (TOC) removal was achieved when antibiotics and metal oxides were allowed for preequilib

46 of the precise relationship between time-to-antibiotics and mortality for patients with possible sep

47 d assessing the relationship between time-to-antibiotics and outcomes, almost all of which are observ

48 wever, the evolutionary interactions between antibiotics and phages remain unclear, in particular, wh

49 s preassembled with custom titers of various antibiotics and splits bacterial samples upon a simple s

50 tion of potentially scarce resources such as antibiotics and supplemental oxygen.

51 model to project the effective life span of antibiotics and the number of gonorrhea cases expected u

52 ted for 3 days, often with a narrow-spectrum antibiotic, and asymptomatic bacteriuria is best left un

53 he first line of defense against beta-lactam antibiotics, and antibiotic stress leads to release EVs

54 nclude reduced virulence, resensitization to antibiotics, and colonization defects.

55 here is increased time spent indoors, use of antibiotics, and consumption of processed foods and decr

56 in mortality associated with each hour until antibiotics, and failure to control for large potential

57 of bikaverin, a tetracyclic polyketide with antibiotic, antifungal and anticancer properties, in S.

58 Rifamycin antibiotics are a key component of TB therapy and a comm

59 Peptide antibiotics are an abundant and synthetically tractable

60 New structural classes of antibiotics are rare, structurally novel broad-spectrum

61 Betalactam (BL) antibiotics are the most common cause of drug hypersensi

62 Novel antibiotics are urgently needed to address the looming g

63 Novel antibiotics are urgently needed to combat multidrug-resi

64 uation dictates therapeutic decisions, where antibiotics are used for H. pylori eradication.

65 on to minimize the risk of overtreatment and antibiotic-associated harms for patients who are not inf

66 ephalexin was the most frequently prescribed antibiotic at the beginning, trimethoprim-sulfamethoxazo

67 age detection and exposure to the first-line antibiotic azithromycin, detected in stool samples by ma

68 e., the deactivation of the most widely used antibiotics, beta-lactams (penicillins, cephalosporines,

69 gy could increase the effective life span of antibiotics by 0.94 years, which is equivalent to succes

70 o-regulated with production of a beta-lactam antibiotic (carbapenem carboxylate) and a linear tripyrr

71 Data on clinical algorithms to guide antibiotic cessation are limited.

72 The antibiotic ciprofloxacin (CIP) is extensively employed t

73 rane drug delivery systems consisting of the antibiotic ciprofloxacin hydrochloride and FDA-approved

74 n, decay kinetics in the presence of various antibiotics (ciprofloxacin, cefixime, and amoxycillin),

75 thogen free Il10(-/-) mice were gavaged with antibiotic clindamycin and then infected with Cj-P0, Cj-

76 erve as a basis for the development of novel antibiotic compounds effective against this pathogen.

77 lony forming unit (CFU), not by the absolute antibiotic concentration, as shown by the treatment of b

78 treatment, up to 1 week after completing the antibiotics course.

79 arbapenems seems necessary to achieve a high antibiotic coverage.

80 ents, resulting in an average savings of 6.2 antibiotic days/patient.

81 The primary outcome measured was total antibiotic-days of therapy.

82 stant organisms, but usually did not lead to antibiotic de-escalation.

83 Immediate intravitreal antibiotic delivery was a universal first-line therapy.

84 atients have recurrence of flares, or become antibiotic-dependent, and require repeated courses or pr

85 The time to empiric antibiotics did not differ significantly, but optimal an

86 It also plays a regulatory function in antibiotic drug resistance and the immune response of ce

87 vide a narrative review of evidence to guide antibiotic duration in sepsis.

88 COMBAT can predict antibiotic efficacy in clinical isolates for quinolones

89 We found that antibiotic efficacy is determined by the amount of antib

90 Furthermore, this antibiotic eliminated challenging persisters as well as

91 Strain sharing was not associated with antibiotic eradication treatment failure; however, nosoc

92 Verigene result correlated with unnecessary antibiotic escalation and exposure to broader-spectrum a

93 are rare, structurally novel broad-spectrum antibiotics exceptionally so.

94 f antibiosis and of alternative functions of antibiotics exhibited at subinhibitory concentrations.

95 prescribing on exposures to frequently used antibiotics experienced by potentially pathogenic bacter

96 e results of the nuc-aAST after 15-30 min of antibiotic exposure and the results of the gold-standard

97 first 100 days posttransplantation; average antibiotic exposure was 41% of inpatient-days (interquar

98 l populations rapidly respond to intravenous antibiotic exposure.

99 ildren may preserve benefit while minimizing antibiotic exposure.

100 ists and is independent of disease status or antibiotic exposure.

101 lthough by a mechanism distinct from that of antibiotic fidaxomycin (lipiarmycin).

102 rug-resistant (XDR), resistant to first-line antibiotics, fluoroquinolones and third generation cepha

103 female mice (n = 18) were first treated with antibiotics for 4 weeks to ablate the microbiota.

104 Nine (40%) had received antibiotics for an average of 19 days (7-60) before CDI.

105 Although antibiotics for CDI exist, they are either expensive or

106 plexing clinical decision to choose multiple antibiotics for combination therapy against drug resista

107 ess of beta-lactams, which remain first-line antibiotics for many infections, is an important part of

108 therapeutic approach with new or re-purposed antibiotics for melioidosis prevention and treatment, es

109 d consent process when choosing intravitreal antibiotics for patients with specific antibiotic allerg

110 aureus (MSSA) (19/24 [79%]) and avoidance of antibiotics for skin contaminants (30/85 [35%]).

111 antibiotics were noninferior to intravenous antibiotics for the early treatment of KLA.

112 The development of new antibiotics for these pathogens is challenging because o

113 the best balance between assuring immediate antibiotics for those patients who truly need them versu

114 These pumps are critical for extrusion of antibiotics from the cell as well as the transport of li

115 the toxicity of commonly used broad-spectrum antibiotics geneticin and puromycin to kill the non-resc

116 5% CI, 1.30 to 3.98); the higher rate in the antibiotics group could be attributed to those with an a

117 Complications were more common in the antibiotics group than in the appendectomy group (8.1 vs

118 ic resistance and declining discovery of new antibiotics has created a global health crisis.

119 Direct bladder instillation of antibiotics has proved disappointing in treating UTI, li

120 Antibiotics have many different 'mechanisms of action' t

121 void diagnostic delay and unnecessary use of antibiotics, hospitalization and surgery.

122 In a complex environment exposed to antibiotics, however, the fate of a bacterial population

123 trains that have decreased susceptibility to antibiotics; however, little is known about how these mu

124 increased in recent years by the wide use of antibiotics in human populations and in livestock.

125 stimate B. bacteriovorus sensitivity against antibiotics in order to make feasible the development an

126 in 2X (PBP2X), a major target of beta-lactam antibiotics in pathogenic bacteria.

127 Bacterial resistance to antibiotics in this clinical setting further underlines

128 ts have inspired the development of numerous antibiotics in use today.

129 enem- and colistin-resistant GNB to multiple antibiotics in vitro and in vivo.

130 enzymes that confer resistance to nonrelated antibiotics, including extended-spectrum beta-lactamases

131 We observed significant PNA-antibiotic interaction with five different PNAs across s

132 insights into evolution under sub-inhibitory antibiotic levels.

133 s infections requiring prolonged intravenous antibiotics may face barriers to discharge, which could

134 essful reductions in consumption of targeted antibiotics may not see changes in infection rates with

135 for plasmid persistence, the application of antibiotics may promote MDR well after their original pe

136 h research has informed our understanding of antibiotic mechanisms of action and resistance at inhibi

137 Novel antibiotics must be used sparingly to hinder the spread

138 the methodological and reporting quality of antibiotic non-inferiority RCTs.

139 na that conferred resistance to colistin, an antibiotic of last resort used in treating multi-drug re

140 The drug and duration-dependent effects of antibiotics on the developing neonatal gut microbiota ne

141 The impact of perinatal antibiotics on vertical transmission of microbes and ant

142 colonic motility disorders related to use of antibiotics or other factors.

143 reate a comprehensive metric to characterize antibiotic overuse after discharge among hospitalized pa

144 tly associated with the number of courses of antibiotics (P-value > 0.05), but it was significantly a

145 regulator SpoT is required for HipA-mediated antibiotic persistence, but persister cells can form in

146 g on day 0 was associated with lower risk of antibiotic prescribing (RR, 0.4; 95% CI 0.2-0.8; P = .01

147 ing a hugely beneficial pathway for accurate antibiotic prescribing and thus a novel route to tacklin

148 e conditions should be considered to improve antibiotic prescribing at discharge.

149 Antibiotic prescribing for a presumed urinary tract infe

150 agnostic/risk prediction strategies to guide antibiotic prescribing for suspected UTI in older adults

151 Antibiotic prescribing was compared in the baseline (Jan

152 Antibiotic prescribing was significantly lower among pat

153 Outpatient antibiotic prescription rates, especially of broad-spect

154 stoperative infection is often the basis for antibiotic prescription; however, the risks of unwarrant

155 estimates of VE, coverage, and prevalence of antibiotic prescriptions and influenza.

156 We estimated ARI visits and antibiotic prescriptions averted by influenza vaccinatio

157 The proportion of antibiotic prescriptions for a 3GC reduced from 193/241

158 was to describe trends in US outpatient oral antibiotic prescriptions from 2011-2016.

159 t are able to reduce and/or prevent unneeded antibiotic prescriptions require highly specific probes

160 surgical site infections and post-procedural antibiotic prescriptions.

161 nem carboxylate) and a linear tripyrrole red antibiotic, prodigiosin.

162 Overall, 77 patients received antibiotic prophylaxis for an average of 93 days.

163 rditis and the effect of changes in national antibiotic prophylaxis guidelines on incident infective

164 High-dose drugs, especially beta-lactam antibiotics, RCM and clindamycin, are common elicitors o

165 r data elucidated intermediate states during antibiotic recognition and suggested structural changes

166 ges without altering susceptibility to other antibiotics, reducing growth rate, or deranging cell mor

167 ome, Clostridioides difficile infection, and antibiotic-related adverse effects necessitating change

168 ewater is a common pathway for the spread of antibiotic resistance (AR) genes and bacteria into the e

169 The rise of antibiotic resistance and declining discovery of new ant

170 an extensive repertoire of genes involved in antibiotic resistance and detoxification, including tran

171 Genes that confer antibiotic resistance can rapidly be disseminated from o

172 It is predicted that the antibiotic resistance crisis will result in an annual de

173 lass A serine beta-lactamases (SBLs) are key antibiotic resistance determinants in Gram-negative bact

174 The environmental spread of antibiotics and antibiotic resistance genes (ARGs) from the land applica

175 In total, 1206 antibiotic resistance genes (ARGs) of 52 different categ

176 ulon, a quorum-sensing circuitry, to acquire antibiotic resistance genes and initiate its attack on t

177 d distinct ecological niches of microbes and antibiotic resistance genes characterized by biofilm-for

178 eline (PRAP) for the rapid identification of antibiotic resistance genes from various formats of whol

179 For infectious diseases, the steady rise of antibiotic resistance has resulted in super pathogens th

180 ors that disable the most prevalent cause of antibiotic resistance in Gram-negative bacteria, i.e., t

181 rtality worldwide, exacerbated by increasing antibiotic resistance in many bacterial species.

182 ence-based characterization of virulence and antibiotic resistance may require testing of multiple de

183 hibitors are increasingly used to counteract antibiotic resistance mediated by beta-lactamase enzymes

184 equences within a controlled vocabulary, the Antibiotic Resistance Ontology (ARO), designed by the CA

185 The data included antibiotic resistance results of bacterial cultures from

186 E. coli but also prevented it from evolving antibiotic resistance upon exposure to a beta-lactam ant

187 Of note, the effect of the PPHD knockout on antibiotic resistance was phenocopied in bacteria expose

188 c has been limited by lengthy drug regimens, antibiotic resistance, and lack of a robustly efficaciou

189 s DNA origami as a tool in the fight against antibiotic resistance, and our results demonstrate the s

190 The continued emergence of antibiotic resistance, together with our increasing unde

191 e population dynamics, such as the spread of antibiotic resistance.

192 plications for protein design and combatting antibiotic resistance.

193 eded to address the looming global crisis of antibiotic resistance.

194 biotics, which are costly and risk spread of antibiotic resistance.

195 e mutations pleiotropically confer increased antibiotic resistance.

196 eed in the current environment of increasing antibiotic resistance.

197 an minimize the fitness cost associated with antibiotic resistance.

198 hages can drive evolutionary trade-offs with antibiotic resistance.

199 e genes (oprL, exoS, phzM, and toxA) and the antibiotic-resistance genes (bla(TEM), tetA, and bla(CTX

200 TX-M), bla(TEM), and tetA genes are the main antibiotic-resistance genes that induce resistance patte

201 t of a reservoir for outbreaks of high-level antibiotic resistant infections.

202 The rapid increase in antibiotic resistant pathogenic bacteria has become a gl

203 The antibiotic-resistant bacteria (ARB) and antibiotic-resis

204 Antibiotic-resistant bacterial infections arising from a

205 inued development of phage therapy targeting antibiotic-resistant bacterial infections generally.

206 The antibiotic-resistant bacteria (ARB) and antibiotic-resistant genes (ARGs) in human gut microbiot

207 the coexistence of phylogenetically diverse antibiotic-resistant lineages, widespread geographical m

208 Corneal infections with antibiotic-resistant microorganisms are an increasingly

209 may not see changes in infection rates with antibiotic-resistant organisms in the 2 to 6 years post-

210 different microbial pathogens including two antibiotic-resistant species [methicillin-sensitive Stap

211 cal records, including clinically prescribed antibiotics, revealed the potential for antibiotic adjus

212 o defined glucose media without and with the antibiotic rifampicin.

213 Regardless, these findings may inform antibiotic selection and surgical management to maximize

214 wborn screening, routine testing panels, and antibiotic sensitivity testing all lead to different pol

215 on stress exposure as diagnostics to predict antibiotic sensitivity.

216 The choice of antibiotics should reflect local resistance patterns and

217 children at highest risk of death may be an antibiotic-sparing and cost-effective, or even cost-savi

218 n integrated healthcare system to prioritize antibiotic stewardship efforts.

219 Consequently, efforts to improve antibiotic stewardship should be coupled with improving

220 defense against beta-lactam antibiotics, and antibiotic stress leads to release EVs with high defense

221 photosensitized oxidation of the sulfonamide antibiotic sulfadiazine (SDZ) was studied.

222 (7/25, 28.0%), vancomycin (4/25, 16.0%), and antibiotic sulfonamides (4/25, 16.0%).

223 Among the S. aureus isolates that exhibited antibiotic susceptibilities, 231/331 (69.8%) were methic

224 mp mtrCDE operon as a mechanism of increased antibiotic susceptibility and demonstrate that these mut

225 The EAST predicts the antibiotic susceptibility of bacteria within 15 min, whi

226 of patients, rapid, automated, and reliable antibiotic susceptibility testing (AST) of bacterial pat

227 form rational drug design for this important antibiotic target.

228 The prototype sensor for derivatives of the antibiotic tetracycline exhibits nanomolar sensitivity w

229 escalation and exposure to broader-spectrum antibiotics than needed.

230 Vancomycin, an antibiotic that acts mainly on gram-positive bacteria an

231 better than that of nitrofurantoin, a known antibiotic that, although structurally similar to ES24,

232 pper dependent inhibitors (CDIs), a class of antibiotics that are only active in the presence of copp

233 for the design of sustainable peptide-based antibiotics that can be hydrolyzed by wastewater peptida

234 anding is critical to the development of new antibiotics that disrupt cell wall biogenesis, a process

235 development and testing of co-therapies with antibiotics that would increase its antimicrobial effica

236 trate the utility of an insect host to model antibiotic therapies in vivo and the approach lays a fou

237 < 0.001), but not clinical algorithm-guided antibiotic therapy (-7.41 [-18.18 to 3.37]; p = 0.18), w

238 led pilot trial, a post-debridement systemic antibiotic therapy course for DFO of 3-weeks gave simila

239 s may be as effective as 8 weeks of combined antibiotic therapy in curing lesions without surgery.

240 Of patients on inappropriate antibiotic therapy in surgical ICUs, a statistically sig

241 tinguish bacterial pneumonia, which requires antibiotic therapy, from viral pneumonia, which does not

242 lesions of TB patients responding poorly to antibiotic therapy, supporting the role of NETs in a lat

243 L hypersensitivity and an immediate need for antibiotic therapy, when referral to an allergist is not

244 However, they are scarcely used for empiric antibiotic therapy.

245 18), was associated with shorter duration of antibiotic therapy.

246 demicity, where treatment requires prolonged antibiotic therapy.

247 ire repeated courses or prolonged periods of antibiotic therapy.

248 e-site beta-lactamases hydrolyze beta-lactam antibiotics through the formation of a covalent acyl-enz

249 ng UTI, likely due to the failure of infused antibiotics to penetrate the bladder epithelium and accu

250 kably high loading capacities of hydrophilic antibiotic tobramycin (Tob) and a novel lipophilic QSI a

251 ed the molecular mechanism of indole-induced antibiotic tolerance in Pseudomonas species and had impo

252 further show that respiratory burst induces antibiotic tolerance in the spleen during a murine syste

253 all wild-type bacterial populations exhibit antibiotic tolerance, bacterial mutants with higher or l

254 microbiota from schizophrenic patients into antibiotic-treated mice caused behavioral abnormalities

255 Using antibiotic-treated or germ-free mice, we show that parat

256 Median (IQR) incidence of symptomatic antibiotic-treated UTIs was 1.0 (0.5-2.5) in the WOCA gr

257 -1.01]; p = 0.09), clinical algorithm-guided antibiotic treatment (0.67 [0.30-1.54]; p = 0.35), nor f

258 Neither procalcitonin-guided antibiotic treatment (0.91 [0.82-1.01]; p = 0.09), clini

259 5735 total participants, 68% were prescribed antibiotic treatment (n = 3902), despite only 28% given

260 carditis (IE) is influenced by pre-operative antibiotic treatment (preop-AT).

261 In addition, antibiotic treatment enriched for strains that acquired

262 ubjective symptoms for >= 6 months following antibiotic treatment for Lyme disease.

263 n burden, and visualize the effectiveness of antibiotic treatment in E. coli-induced myositis and a c

264 The median number of additional antibiotic treatment was 0.0 (IQR, 0.0-2.0) versus 3.0 (

265 Potentially suboptimal antibiotic treatment was identified in 65.0% of resident

266 with pneumonia not responding to appropriate antibiotic treatment within 48-72 h.

267 bition of ATM, YAP1, or caspase-1 as well as antibiotic treatment, dramatically reduces IL-18 and int

268 s was administered twice daily upon start of antibiotic treatment, up to 1 week after completing the

269 e (23% vs 12%) and mortality, despite longer antibiotic treatment.

270 urate UTI diagnosis and reduce inappropriate antibiotic treatment.

271 Comparisons between antibiotic types, doses, administration routes or durati

272 udy was to develop a methodology to evaluate antibiotic use across inpatient and ambulatory care site

273 Antibiotic use and bacterial transmission are responsibl

274 Pneumonia is the leading cause of antibiotic use and hospitalization in Vietnam.

275 ; this variability is associated with higher antibiotic use and rates of C. difficile infection.

276 icts BSI risk and safely reduces unnecessary antibiotic use in febrile, nonseverely neutropenic pedia

277 rimental effects conferred by broad-spectrum antibiotic use on the health of the beneficial microbiot

278 Antibiotic use prior to seeking care at a hospital may r

279 For total antibiotic use, it was 24% more accurate (respective mea

280 During the past 85 years of antibiotic use, we have learned a great deal about how t

281 otic efficacy is determined by the amount of antibiotic used per bacterial colony forming unit (CFU),

282 Delaying or withholding antibiotics was associated with increased odds of death

283 Inpatient antibiotics were administered to 2020 (94%) patients dur

284 Antibiotics were detected in 39% (1145/2939) of urine sa

285 Risk quotients for test antibiotics were generated to quantify risk.

286 f antibiotics were prescribed optimally (ie, antibiotics were indicated, and a guideline-concordant a

287 Oral antibiotics were noninferior to intravenous antibiotics

288 /136), 36.6% (66/180), and 34.9% (67/192) of antibiotics were prescribed optimally (ie, antibiotics w

289 cs did not differ significantly, but optimal antibiotics were started earlier after introduction of t

290 14,138 (36%), escalation in 5,129 (13%), and antibiotics were unchanged in 19,959 (51%).

291 drive whether patients seek care or request antibiotics when they have subsequent ARIs.

292 gn selection agents serve as alternatives to antibiotics, which are costly and risk spread of antibio

293 iverse functions, including siderophores and antibiotics, which often require export to the extracell

294 Structure-based design led to AA139, an antibiotic with broad-spectrum in vitro activity against

295 cally mixed for 10 min with serially diluted antibiotics with a novel, membrane-type micromixer consi

296 sis is suspected, broad-spectrum intravenous antibiotics with ability to penetrate pancreatic necrosi

297 acterial evaluation of group A streptogramin antibiotics with extensive structural variability.

298 urgent need for novel bacterial targets and antibiotics with novel modes of action.

299 from patients with very long intervals until antibiotics with patients with shorter intervals and rep

300 less likely to fail the goal of beta-lactam antibiotics within 1 hour (44.6% vs 57.3%; odds ratio, 2