ライフサイエンスコーパス: anticancer activity

1 e of compounds with relevant antioxidant and anticancer activity.

2 tant class of nucleosides with antiviral and anticancer activity.

3 on the SAR of compound 2e may result in good anticancer activity.

4 onist showing promising in vitro and in vivo anticancer activity.

5 photodynamic agents, leading to significant anticancer activity.

6 ing the hydrolysis to PTX and increasing the anticancer activity.

7 intracellular distribution, and potentiated anticancer activity.

8 91, lambdamax up to 750 nm) and photodynamic anticancer activity.

9 cer-bearing host of immune cells with direct anticancer activity.

10 that the 1H-imidazole is essential for high anticancer activity.

11 class of fungal natural products with potent anticancer activity.

12 oxidant activity, antimicrobial activity and anticancer activity.

13 ng in different biological responses such as anticancer activity.

14 erebral ischemia, as a potentiator of statin anticancer activity.

15 itamin K2 has been shown to exert remarkable anticancer activity.

16 erocyclic base phenanthridine, has promising anticancer activity.

17 and have uncovered cyclotides with potential anticancer activity.

18 erpene constituents and has some interesting anticancer activity.

19 itro antiplasmodial activity as well as good anticancer activity.

20 stereochemistry is a significant factor for anticancer activity.

21 nd co-inhibition of mTOR and DNA-PK enhances anticancer activity.

22 to potent complexes with novel mechanisms of anticancer activity.

23 (6) were synthesized and evaluated for their anticancer activity.

24 adverse effects while preserving substantial anticancer activity.

25 uptake, and cellular retention for sustained anticancer activity.

26 in animals and plants, is well known for its anticancer activity.

27 f novel anthracycline variants with improved anticancer activity.

28 of natural products known to display potent anticancer activity.

29 ssant and more recently was shown to possess anticancer activity.

30 ivities as a measurement for their potential anticancer activity.

31 -tubulin that could account for the improved anticancer activity.

32 a small molecule with strong antibiotic and anticancer activity.

33 terospermum lanceolatum and is known to have anticancer activity.

34 lar disrupting agent with potent preclinical anticancer activity.

35 lipoxins may explain some of aspirin's broad anticancer activity.

36 gain deeper insights into the basis for its anticancer activity.

37 und 18 was orally bioavailable and possessed anticancer activity.

38 pounds should be further evaluated for novel anticancer activity.

39 of natural products with a broad spectrum of anticancer activity.

40 lkaloids that display both antibacterial and anticancer activity.

41 a nontoxic approach to harnessing aspirin's anticancer activity.

42 ric oxide (NO) prodrug JS-K is shown to have anticancer activity.

43 crucial for potent proteasome inhibition and anticancer activity.

44 developed as an iron chelator with selective anticancer activity.

45 ported that modified forms of pectin possess anticancer activity.

46 developed from curcumin and exhibited potent anticancer activity.

47 el small molecule antagonists with potential anticancer activity.

48 ctivated GLI3 with a special emphasis on the anticancer activity.

49 mination factor, GSPT1 to achieve its potent anticancer activity.

50 eas as mechanism-based SIRT2 inhibitors with anticancer activity.

51 tructural features required for the observed anticancer activity.

52 reactive oxygen species (ROS) generation and anticancer activity.

53 esponding ETP-triazoles without compromising anticancer activity.

54 inhibition and topoisomerase I inhibition on anticancer activity.

55 1 is a key mechanism by which aspirin exerts anticancer activity.

56 bility glycoprotein) advancing its potential anticancer activity.

57 under NIR irradiation, resulting in enhanced anticancer activity.

58 reparing stable nanoformulations with potent anticancer activity.

59 m is an aryl sulfonamide drug with selective anticancer activity.

60 HuR inhibition has profound anticancer activity.

61 ponent of saffron spice, is known to have an anticancer activity.

62 prepared and evaluated for hypoxia-selective anticancer activity.

63 frequently prescribed for schizophrenia with anticancer activity.

64 synthesized compounds have shown a very high anticancer activity.

65 cluding compounds with significantly greater anticancer activity.

66 nd find it to exhibit potent, broad-spectrum anticancer activities.

67 may be the plausible mechanisms behind their anticancer activities.

68 fibrate, a lipid-lowering drug with multiple anticancer activities.

69 atural products with potent insecticidal and anticancer activities.

70 e dithiopyrrolone derivatives display potent anticancer activities.

71 ic effects of curcumin are important for its anticancer activities.

72 emonstrating promising anti-inflammatory and anticancer activities.

73 NF-kappaB inhibitors, and to evaluate their anticancer activities.

74 same seeds, has been shown to have potential anticancer activities.

75 Vitamin D may have anticancer activities.

76 de A is a novel polyketide displaying potent anticancer activity across a broad range of cancer cell

77 Here, we show that tivantinib has potent anticancer activity across several AML cell lines and pr

78 d structurally related compounds showed weak anticancer activities against HeLa and U-937 cells.

79 These new HDACi possess anticancer activities against various cancer cell lines

80 Compound 19 has significant in vivo anticancer activity against a human breast cancer xenogr

81 elective flavonoid with significant in vitro anticancer activity against a multidrug resistant (MDR)

82 utaminase activity of L-ASP is necessary for anticancer activity against ASNS-positive cell types but

83 monstrated low in vivo toxicity but profound anticancer activity against both the L1210 leukemia and

84 cell panel and exerted selective synergistic anticancer activity against ErbB2-overexpressing breast

85 ned, synthesized, and evaluated for in vitro anticancer activity against four human tumor cell lines.

86 Entire compounds were evaluated for their anticancer activity against HeLa (cervical cancer), MCF-

87 Vorinostat has demonstrated significant anticancer activity against hematologic and solid tumors

88 In several clinical trials Triapine showed anticancer activity against hematological diseases, howe

89 lus licheniformis KT921419) displayed strong anticancer activity against HT-29 colon cancer cell line

90 rings and ten stereogenic centers that shows anticancer activity against lymphoma L1210 cells.

91 several of the compounds revealed promising anticancer activity against MCF-7 cells.

92 its parent drug, P-SMART showed significant anticancer activity against melanoma cells in cytotoxici

93 These compounds have shown remarkable anticancer activity against multiple human cancer cell l

94 tor that binds the inactive hTS and exhibits anticancer activity against ovarian cancer cells.

95 ring of this natural product is critical for anticancer activity against PC3 cells.

96 12u demonstrates potent anticancer activity against primary chronic lymphocytic

97 In addition, PTX-S-S-VE had greater anticancer activity against the KB-3-1 cell line tumor x

98 Anticancer activity against various malignancies was typ

99 gate in vitro the health-promoting benefits (anticancer activity, alpha-amylase and alpha-glucosidase

100 Specifically, their combined anticancer activities and selective visual signal respon

101 compounds 2d-f, and 2h exhibited encouraging anticancer activity and also selectivity towards particu

102 novel microtubule inhibitors have promising anticancer activity and can be potentially used to overc

103 ndings on the association between elesclomol anticancer activity and cellular metabolic state.

104 ets and correlated them to that required for anticancer activity and determined that Des1 inhibition

105 These results suggest that l-ase anticancer activity and glutamine uptake inhibition are

106 I-2 were synthesized and evaluated for their anticancer activity and impact on drug resistance in com

107 ted receptor gamma (PPARgamma) agonists have anticancer activity and influence cell differentiation.

108 ion with redox modulators can potentiate the anticancer activity and maximize the selectivity of orga

109 s, with the three most important areas being anticancer activity and selective cytotoxicity, anti-Alz

110 CRGs have an essential role in drug-mediated anticancer activity and that anticancer agents can be id

111 To identify targets that contribute to its anticancer activity and therapeutic index, we used lung

112 g these peptides, LTX-315 displayed superior anticancer activity and was selected as a lead candidate

113 mains, showed enticing anti-inflammatory and anticancer activities, and several compounds have since

114 However, the mechanism of mistletoe's anticancer activity, and its effectiveness in treating H

115 tive compound, isofuranodiene, known for its anticancer activity, and of its Cope rearrangement produ

116 The library was screened for their anticancer activity, and several cytotoxic lead compound

117 analyzed for sensitivity patterns, synergy, anticancer activity, and were validated in low-throughpu

118 ave been proposed, but the mechanisms of its anticancer activities are not clearly understood.

119 he type of cancer and cells where they exert anticancer activity, are described and summarized in tab

120 therapeutic agents, while maintaining potent anticancer activity, are of particular interest.

121 -targeting capability and exerted measurable anticancer activities as confirmed with percent tumor ne

122 nes and 1,4-heterocyclic quinones with known anticancer activity as potent and selective splicing inh

123 to mertansine (DM1) also showed significant anticancer activity at nanomolar concentrations.

124 Importantly, Cmpd-43 exerted potent anticancer activity both in vitro and in vivo in a murin

125 ontradictory impact on drug accumulation and anticancer activity both in vitro and in vivo.

126 po2L/TRAIL) has shown remarkable preclinical anticancer activity but lacked broad efficacy in patient

127 enoic acid (DHA; n-3, 22:6) is known to have anticancer activity, but its mechanisms of action remain

128 Mithramycin demonstrates preclinical anticancer activity, but its therapeutic dose is limited

129 Paclitaxel has powerful anticancer activity, but some tumors are inherently resi

130 tification of small molecules with promising anticancer activity, but the difficulty in characterizin

131 In summary, GE exerts anticancer activities by inducing apoptosis and suppress

132 eveloping therapeutic drugs that exert their anticancer activities by producing massive chromosome an

133 whether AhR plays a role in 17-AAG-mediated anticancer activity by functioning as a downstream targe

134 Moreover, it showed high anticancer activity by growth inhibition in the MDA-MB-2

135 hese spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing d

136 op1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1-DNA clea

137 leic acid (DNA) bis-intercalator with potent anticancer activity, can bind the estrogen response elem

138 Despite its promising anticancer activity, CB-5083 failed its phase I clinical

139 bundant cyclotide in this plant, hyen D, had anticancer activity comparable to that of cycloviolacin

140 The new gold-NHC derivatives show superior anticancer activity compared to other standards such as

141 The improved anticancer activity compared with i.v. Taxotere, observe

142 rocess and so with their neuroprotective and anticancer activity; cooking of dark beans improves thei

143 udies for discovering natural compounds with anticancer activities, coupled with clinical evaluation

144 Preliminary anticancer activity demonstrated clinical benefit for th

145 ts on DNA having a structure and spectrum of anticancer activity distinct from those of the parent dr

146 ate new therapeutic candidates with improved anticancer activity, distinct mechanisms of action(s) an

147 owever, some indenoisoquinolines with potent anticancer activity do not exhibit strong topoisomerase

148 rlier studies demonstrated that DFO exhibits anticancer activity due to its ability to deplete cancer

149 mulation as the q-NTD conjugate but superior anticancer activity due to its more effective release of

150 our most potent compounds showed substantial anticancer activity (EC50 37-150 nM) vs MCT1-expressing

151 ,5,4'-truhydroxystilbene) possesses a strong anticancer activity exhibited as the induction of apopto

152 platform through the identification of novel anticancer activities for cycloviolacins by their cytoto

153 g combinations of approved drugs with potent anticancer activity for further mechanistic study and tr

154 Its potential anticancer activity has been validated in preclinical in

155 rstanding of the mechanisms underlying their anticancer activity has remained elusive.

156 ysates or peptides with immunomodulatory and anticancer activities have been reported from a variety

157 tioxidant compounds that display significant anticancer activity have been described.

158 abilizes cyclin D1, resulting in significant anticancer activity in a subset of KRAS mutant tumors in

159 tors of histone deacetylases (HDACi) exhibit anticancer activity in a variety of tumor cell models an

160 acetate (designated BaP) has potent in vivo anticancer activity in acute myelogenous leukemia (AML)

161 FR) tyrosine kinase have demonstrated modest anticancer activity in advanced bronchioloalveolar carci

162 is an experimental clinical drug with broad anticancer activity in animal models, owing to its abili

163 ric nanoparticles (ARV-NPs) showed promising anticancer activity in both 2D cell culture and 3D multi

164 tion of AZD6244 with PLX4720 had synergistic anticancer activity in BRAF-mutant cells but not in Galp

165 a new CDC25 inhibitor endowed with promising anticancer activity in breast, prostate, and leukemia ce

166 entially superior candidates with comparable anticancer activity in cell culture, enhanced metabolic

167 bitor, is currently under evaluation for its anticancer activity in clinical trials.

168 pophilic derivative of DIM, has demonstrated anticancer activity in different types of cancers.

169 bitor cytochalasin B, and by comparing their anticancer activity in DU145 cells and a GLUT1 knockdown

170 ity in endocrine-resistance models and shown anticancer activity in early-phase mBC clinical trials.

171 a safe therapy with encouraging and durable anticancer activity in patients with R/R NHL.

172 ine kinase inhibitor, demonstrated increased anticancer activity in preclinical and early clinical st

173 t the cell membrane has been associated with anticancer activity in preclinical and early clinical st

174 factor receptor (PDGFR), with broad-spectrum anticancer activity in preclinical and early-phase trial

175 drug GDC-0941, which exhibits excellent oral anticancer activity in preclinical models and is now und

176 e (PP), an anthelmintic drug with documented anticancer activity in preclinical models.

177 a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbo

178 Preliminary evidence of anticancer activity in sarcoma was demonstrated.

179 ed PK11007, to be mild thiol alkylators with anticancer activity in several cell lines, especially th

180 Most compounds have anticancer activity in several solid tumor cell lines an

181 G-quadruplex binders and have examined their anticancer activity in T24 bladder cancer cells bearing

182 gly correlate intracellular accumulation and anticancer activity in tether and nontether complexes.

183 bitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing mice.

184 inhibitor, called SP141, which exerts potent anticancer activity in various breast cancer models.

185 2 in disease and has demonstrated impressive anticancer activity in vitro and in vivo.

186 one-based iron chelators that exhibit marked anticancer activity in vitro and in vivo.

187 unctional cytokine displaying broad-spectrum anticancer activity in vitro or in vivo in preclinical a

188 /IL-24 (mda-7/IL-24) displays broad-spectrum anticancer activity in vitro, in vivo in preclinical ani

189 four decades for their exceptionally potent anticancer activity, in addition to strong Gram-positive

190 s a type of parasitic plant reported to have anticancer activity including in hepatocellular carcinom

191 mitochondrial targeting of Met enhances its anticancer activities, including aggressive cancers like

192 ure and has derivatives possessing important anticancer activity, including the recently Food and Dru

193 ifferent types of tumors, report a promising anticancer activity induced by CB2R agonists due to thei

194 The anticancer activity is associated with reduced mitochond

195 Here we show that vitamin C anticancer activity is limited by the up-regulation of t

196 ajor target in the cell, responsible for the anticancer activity, is nuclear DNA, which is packaged i

197 Although cisplatin shows a broad spectrum of anticancer activity, its utility is limited due to acqui

198 ed several analogues with increased in vitro anticancer activity, most notably D-threoside 60 (NSC 74

199 study provides mechanistic insights into the anticancer activities of 1,25(OH)2D3 in human breast can

200 Evaluation of the in vitro and in vivo anticancer activities of 3 SMART compounds, SMART-H (H),

201 rambucil, herein we report the synthesis and anticancer activities of a 63-member library of chloramb

202 report the first comparative analysis of the anticancer activities of all naturally occurring commune

203 The immunomodulatory and anticancer activities of food derived protein hydrolysat

204 TIGIT) play a crucial role in regulating the anticancer activities of immune effector cells.

205 fine and characterize the antiangiogenic and anticancer activities of itraconazole in relevant precli

206 his study, antioxidant, antiinflammatory and anticancer activities of leave extracts and its isolates

207 Therefore, the potent anticancer activities of NR4A1 antagonists are also acco

208 strategies have been employed to improve the anticancer activities of oncolytic PVs, including develo

209 al constituents that are responsible for the anticancer activities of propolis were analyzed.

210 id within the RasGAP317-326 sequence for the anticancer activities of TAT-RasGAP317-326.

211 For example, the anticancer activities of tazarotene, adapalene, acitreti

212 mistry of their tetrapeptidic backbones, the anticancer activities of these precursors largely match

213 h is regulated by AhR, was shown to increase anticancer activity of 17-AAG in cells.

214 wnstream target of 17-AAG, but also enhances anticancer activity of 17-AAG in lung AD cells.

215 Anticancer activity of 17-AAG was determined by measurin

216 n in lung AD cells, AhR expression increased anticancer activity of 17-AAG.

217 Chirality influenced the anticancer activity of 3 and 4 in human prostate cancer

218 of endoplasmic reticulum (ER) stress in the anticancer activity of 3-AP and the derivative N(4),N(4)

219 ay, use of reduction, to improve the in vivo anticancer activity of a prodrug for nanocarrier deliver

220 The direct comparison of the anticancer activity of all naturally occurring (-)-agela

221 t decade, many studies have demonstrated the anticancer activity of alpha-tocopherol, the main and mo

222 pirin ratios in serum, it is likely that the anticancer activity of aspirin is also due to the salicy

223 ercoils and because it is the target for the anticancer activity of camptothecins, we assessed TOP1 t

224 Thus, the anticancer activity of CDDO-Me is due, in part, to activ

225 cal and clinical evidence indicates that the anticancer activity of CDK4/CDK6 inhibitors results not

226 The anticancer activity of cGMP signaling in animal studies

227 , CH1iB, reactivates p53 and potentiates the anticancer activity of cis-platinum in HPV-positive HNSC

228 The anticancer activity of cytarabine (AraC) and gemcitabine

229 ling ability of small molecules controls the anticancer activity of EISA.

230 hway and HSPB1 phosphorylation increases the anticancer activity of erastin in human xenograft mouse

231 et ligands, which may be used to enhance the anticancer activity of existing PDK1 inhibitors.

232 The phenomenon is reminiscent of the anticancer activity of gamma-tocopherol, which reduces N

233 uated the effect of these differences on the anticancer activity of ginger by performing efficacy-bas

234 ation, and vascular damage contribute to the anticancer activity of Ing3A in vivo.

235 CsA also impaired the anticancer activity of Ing3A, whereas the anti-inflammat

236 ron, thus laying the basis for the promising anticancer activity of iron chelators.

237 mechanism underpinning the well-established anticancer activity of isothiocyanate.

238 nce cancer-selective expression and targeted anticancer activity of mda-7/IL-24, we created a tropism

239 These data demonstrated clearly that the anticancer activity of NH125 was more correlated with in

240 We further propose that the anticancer activity of noscapine arises from a bioactive

241 Here, we describe the anticancer activity of novel congeners of the tubulin-po

242 The anticancer activity of papaya pectin is dependent on the

243 ighting a novel mechanism accounting for the anticancer activity of perifosine and a potential strate

244 Nuclear DNA is the target responsible for anticancer activity of platinum anticancer drugs.

245 Finally, we show the anticancer activity of SC66 by using a soft agar assay a

246 izotinib and GSK1363089 greatly enhanced the anticancer activity of SM-164 in all resistant cell deri

247 The anticancer activity of some of the obtained compounds ag

248 e has been growing interest in the potential anticancer activity of statins based on preclinical evid

249 ynergize with statins to further enhance the anticancer activity of statins in vivo.

250 Apoptosis was the mechanism involved in the anticancer activity of such compounds.

251 are incompletely effective and decrease the anticancer activity of the allogeneic graft.

252 In addition, lucanthone enhanced the anticancer activity of the histone deacetylase inhibitor

253 Here, we investigated a potential anticancer activity of the recently developed non-BET fa

254 In vitro anticancer activity of the synthesized compounds was tes

255 te that the GHRH agonists can potentiate the anticancer activity of the traditional chemotherapeutic

256 The anticancer activity of these complexes was further inves

257 The anticancer activity of these heavier tetraponerines agai

258 observations provide an explanation for the anticancer activity of this class of compounds, which ha

259 The anticancer activity of WL-276 was manifested in its supp

260 Consistent with the potential anticancer activity of zoledronic acid, overall survival

261 tile derivatization while maintaining potent anticancer activity, offering exciting opportunity for t

262 of the heat-shock response and had no overt anticancer activity on its own, it dramatically impaired

263 Most of them displayed anticancer activity on leukemia, melanoma, lung, colon,

264 novel compounds having potentially promising anticancer activity, one of which induces cell death in

265 a distinct mechanism to selectively enhance anticancer activity over cardiotoxicity, the most signif

266 We propose that GA, as part of its anticancer activity, perturbs early/recycling endosome s

267 ibition of HDAC1 and 2 may be sufficient for anticancer activity, providing an experimental framework

268 he literature on the phenolic compounds with anticancer activity published between 2008 and 2012 is p

269 , has received considerable attention to its anticancer activity recently.

270 or varied biological applications, including anticancer activity, regulation of gene expression, and

271 Structure-anticancer activity relationship studies indicated the i

272 ty, topoisomerase I-inhibitory activity, and anticancer activity reveals a synergistic effect of MYC

273 corresponding chemoselective linker upon the anticancer activity/selectivity of the drug chlorambucil

274 preferred compound, 14, with 10-fold greater anticancer activity than 1, was shown to release H2S in

275 Quinacrine, a drug with antimalarial and anticancer activities that inhibits NF-kappaB and activa

276 Curcumin activates diverse anticancer activities that lead to inhibition of cancer

277 ment of compounds 2 and 3 having appreciable anticancer activities that seem to be due to inhibition

278 re thiazole-containing natural products with anticancer activity that are biosynthesized by polyketid

279 Excitingly, lead Tam-HDACi conjugates show anticancer activity that is selectively more potent agai

280 developed at City of Hope Cancer Center, has anticancer activity that stems primarily from the inhibi

281 ic inhibitor of canonical Wnt signaling with anticancer activity that warrants further development fo

282 Compound 7f and 8 exhibited anticancer activity that was 300-fold and 1 x 10(6)-fold

283 palm and rice bran oil, has been linked with anticancer activities, the mechanism of this action is p

284 d enhances DNA repair as a mechanism for its anticancer activity, the nucleotide excision repair gene

285 Despite the promising anticancer activity, these molecules showed a poor aqueo

286 s indicated that these compounds exert their anticancer activity through inhibition of tubulin polyme

287 the lactone and diene as moieties conferring anticancer activity, thus identifying priorities for the

288 ess dose) was 1.89 and 1.92 fold superior in anticancer activity to Los respectively in A549 orthotop

289 sp. SF2575 and displays exceptionally potent anticancer activity toward a broad range of cancer cell

290 s (AMPs) have recently been shown to display anticancer activity via a mechanism that usually entails

291 -AR silenced PC-3 cells confirmed that their anticancer activity was alpha(1d)-AR-dependent.

292 This synergistic improvement in the anticancer activity was apoptosis-dependent that was con

293 In particular, enhanced anticancer activity was demonstrated in acute myeloid le

294 When the first titanium complex with anticancer activity was identified in the 1970s, it was

295 cturally unique 16-membered macrolide having anticancer activity, was synthesized according to a stra

296 Anticancer activities were evaluated on three different

297 human breast cancer cell line MCF7 in vitro anticancer activity, which defines the molecular level u

298 se so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five dif

299 IL-10 family cytokine, exhibits pleiotropic anticancer activities without adversely affecting normal

300 OdDHL has also demonstrated anticancer activity, yet its ability to enhance pathogen