1 The
antichlamydial activities of two of these INPs, INPs 034
2 nsive search of the chemical space for novel
antichlamydial activities, we identified over 60 compoun
3 ere chlamydicidal and induced MdM to express
antichlamydial activity and (ii) although polymorphonucl
4 Finally, both
antichlamydial activity and cytotoxicity of the lead com
5 the present study 25 INPs were screened for
antichlamydial activity at a concentration of 50 muM, an
6 Despite their potent
antichlamydial activity in vitro, neither heparin nor de
7 oniae is a target organism, antibiotics with
antichlamydial activity may be able to ameliorate plaque
8 that C. trachomatis Pgp3 can neutralize the
antichlamydial activity of human cathelicidin LL-37, a h
9 The
antichlamydial activity of INP0341 was retained when tes
10 In conclusion, the potent
antichlamydial activity of INPs is directly or indirectl
11 Antichlamydial activity resided principally in residues
12 ydrothiazepine library and characterized its
antichlamydial activity using a modified semi-high-throu
13 cation of LpxC inhibitors as unique class of
antichlamydial agents.
14 onditioned medium from these macrophages was
antichlamydial and contained elevated levels of interleu
15 There was no staining with any of the 3
antichlamydial antibodies in formalin-fixed brain tissue
16 In vitro,
antichlamydial antibodies increased the rate of Th1 acti
17 in-fixed brain tissue, by use of 3 different
antichlamydial antibodies.
18 delayed-type hypersensitivity responses, but
antichlamydial antibody responses were unaffected.
19 n improving the developability profile of an
antichlamydial chemical class previously reported by our
20 Critically, we found the most potent
antichlamydial compound to inhibit fatty acid biosynthes
21 rting point for the development of selective
antichlamydial drugs.
22 int for the development of new and selective
antichlamydial drugs.
23 acylhydrazides with the goal to uncouple the
antichlamydial effect from iron starvation.
24 ydial infection, which may contribute to the
antichlamydial effect of IL-17.
25 However, the role of NO as an
antichlamydial effector could not be clearly demonstrate
26 chelate iron, and it is possible that their
antichlamydial effects are caused by iron starvation.
27 response, including elevated titers of serum
antichlamydial IgG2a and IgG2b, not IgG1, and elevated l
28 that infection fails to elicit a protective
antichlamydial immune response.
29 esence did not correlate with evidence of an
antichlamydial immune response.
30 pes, leading to the generation of protective
antichlamydial immunity and making these mice a valuable
31 r mononuclear infiltrates, primarily mediate
antichlamydial immunity.
32 Because of the potent
antichlamydial immunizing properties of DC, we hypothesi
33 rt tool in the identification of more potent
antichlamydial molecules.
34 is one of the main challenges of the current
antichlamydial pharmacotherapy.
35 as holo-transferrin, was able to negate the
antichlamydial properties of the INPs.
36 Longer-term and larger studies of
antichlamydial therapy are indicated.
37 ng the foundation for an additional specific
antichlamydial therapy by small molecules.
38 a small molecule lead compound for specific
antichlamydial therapy, which showed drastically lowered
39 ng subjects who may potentially benefit from
antichlamydial therapy.
40 has proven to be a promising new target for
antichlamydial therapy.
41 Despite considerable effort,
antichlamydial vaccines have proven to be elusive using