ライフサイエンスコーパス: antiepileptic drug

1 site for levetiracetam, a second generation antiepileptic drug.

2 improved with age for infants exposed to any antiepileptic drug.

3 g lacosamide ((R)-1), a low-molecular-weight antiepileptic drug.

4 ed with introduction of a previously untried antiepileptic drug.

5 Randomization was stratified by antiepileptic drug.

6 ts with IGE and PGTCS taking 1-3 concomitant antiepileptic drugs.

7 patients (62%) were in remission, 5 without antiepileptic drugs.

8 and is blocked by prior ingestion of typical antiepileptic drugs.

9 many local anesthetics, antiarrhythmics, and antiepileptic drugs.

10 eizure per month and failure of at least two antiepileptic drugs.

11 tic effects that alter the concentrations of antiepileptic drugs.

12 of exploration for the development of novel antiepileptic drugs.

13 ce by reducing target-site concentrations of antiepileptic drugs.

14 ve been associated with a worse tolerance of antiepileptic drugs.

15 ssociated with the mode of action of several antiepileptic drugs.

16 isk associated with the 9 most commonly used antiepileptic drugs.

17 rebral lateralisation induced by exposure to antiepileptic drugs.

18 sistant epilepsy that cannot be treated with antiepileptic drugs.

19 vasopressors, and treatment with third-line antiepileptic drugs.

20 g NMDA receptors being potential targets for antiepileptic drugs.

21 e manic symptoms were more likely to receive antiepileptic drugs.

22 eficits, we treated hAPP mice with different antiepileptic drugs.

23 s differ from those targeted by conventional antiepileptic drugs.

24 6 weeks postpartum in women with epilepsy on antiepileptic drugs.

25 en severe and resistant towards conventional antiepileptic drugs.

26 res than those who had been exposed to other antiepileptic drugs.

27 gnitive difficulties associated with certain antiepileptic drugs.

28 f regulatory randomized controlled trials of antiepileptic drugs.

29 B2 may lead to development of first-in-class antiepileptic drugs.

30 eutic effectiveness of these potentially new antiepileptic drugs.

31 gnant women with epilepsy who are prescribed antiepileptic drugs.

32 eizures have adverse effects, independent of antiepileptic drugs.

33 2 weeks, depending on use of enzyme-inducing antiepileptic drugs.

34 ate the effects of epilepsy from the role of antiepileptic drugs.

35 channels may be attractive targets for novel antiepileptic drugs.

36 ome of childhood) are insensitive to classic antiepileptic drugs.

37 ifferentiated from common adverse effects of antiepileptic drugs.

38 may be considered for the development of new antiepileptic drugs.

39 suicide in current versus previous users of antiepileptic drugs.

40 d in people with epilepsy taking concomitant antiepileptic drugs.

41 o not achieve adequate seizure control using antiepileptic drugs.

42 ntrolled despite the availability of over 20 antiepileptic drugs.

43 uction of cortical network interactions with antiepileptic drugs.

44 relation to seizure burden and control with antiepileptic drugs.

45 uctive outcomes, with or without exposure to antiepileptic drugs.

46 I 1.00, 1.02) as did those who had used more antiepileptic drugs (1.05; 95% CI 1.01 to 1.09).

47 Despite the availability of numerous antiepileptic drugs, 20-30% of epileptic patients are ph

48 ilepticus etiologies included subtherapeutic antiepileptic drugs (43%), alcohol or other nonantiepile

49 5%, p < .001), and treatment with third-line antiepileptic drugs (51% vs. 17%, p < .001).

50 Despite the success of several new antiepileptic drugs, about one third of patients with ep

51 Conventional antiepileptic drugs act by blocking sodium channels or e

52 pective, longitudinal observational study of antiepileptic drug adherence in a consecutive cohort of

53 , the current study is the first to describe antiepileptic drug (AED) combination therapy patterns ac

54 Antiepileptic drug (AED) exposure during pregnancy incre

55 xposure to maternal epilepsy with or without antiepileptic drug (AED) therapy and pregnancy and perin

56 rn exists that breastfeeding during maternal antiepileptic drug (AED) therapy may be harmful.

57 between children who become seizure-free on antiepileptic drug (AED) treatment and those children wi

58 mine whether surgery soon after failure of 2 antiepileptic drug (AED) trials is superior to continued

59 To investigate antiepileptic drug (AED)-related weight changes in patie

60 Antiepileptic drugs (AEDs) are commonly prescribed for e

61 30% of epilepsy patients receiving antiepileptic drugs (AEDs) are not fully controlled by t

62 Antiepileptic drugs (AEDs) are relatively cheap but high

63 Antiepileptic drugs (AEDs) are the only neurotherapeutic

64 The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are

65 Currently available antiepileptic drugs (AEDs) fail to control seizures in 3

66 New antiepileptic drugs (AEDs) have been a major change in t

67 Antiepileptic drugs (AEDs) have cognitive side effects t

68 pectrometry (LC-MS/MS) method to quantify 14 antiepileptic drugs (AEDs) in human serum.

69 xcitability and controlling its degree using antiepileptic drugs (AEDs) is of prime importance for cl

70 Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is widely established for old

71 Antiepileptic drugs (AEDs) remain the primary treatment.

72 es join the chemical fragments of well-known antiepileptic drugs (AEDs) such as ethosuximide, levetir

73 operties of the widely used older generation antiepileptic drugs (AEDs) suggest that they might be re

74 alpha-aminoamides (AAAs) are two classes of antiepileptic drugs (AEDs) that exhibit pronounced antic

75 To evaluate the effects of epilepsy and antiepileptic drugs (AEDs) used during pregnancy on feta

76 Antiepileptic drugs (AEDs) were generally ineffective an

77 perspectives for the design and discovery of antiepileptic drugs (AEDs) with fewer side effects by fo

78 atients with Alzheimer's disease with select antiepileptic drugs (AEDs), in low doses, is usually wel

79 REVIEW: Despite the availability of many new antiepileptic drugs (AEDs), only around 50% of people wi

80 idal thoughts and behavior related to use of antiepileptic drugs (AEDs).

81 e simultaneous detection and quantitation of antiepileptic drugs (AEDs).

82 tly suffering with epilepsy are resistant to antiepileptic drugs (AEDs).

83 ed sensitivity or availability of targets to antiepileptic drugs (AEDs; i.e., carbamazepine and pheny

84 ants, drugs used in addictive disorders, and antiepileptic drugs) after prison release.

85 egister, we identified all incident users of antiepileptic drugs aged 15 years or older in Denmark be

86 hat captured the spectrum of nonadherence to antiepileptic drugs among children with newly diagnosed

87 regarding critical drug interactions between antiepileptic drugs and antiretrovirals, but are also pr

88 ldren of women with epilepsy who did not use antiepileptic drugs and children of fathers with epileps

89 yndromes, show specific responses to certain antiepileptic drugs and differentiate between responder

90 ing further advantage of 'simple' organisms, antiepileptic drugs and genetic modifiers of seizure act

91 that there may be drug interactions between antiepileptic drugs and hormonal therapies, which can pr

92 ted with incident epilepsy in the absence of antiepileptic drugs and in the absence of diagnosed psyc

93 s) with epilepsy who were taking concomitant antiepileptic drugs and not currently receiving lamotrig

94 ies compared with those exposed to the other antiepileptic drugs and on non-verbal and executive func

95 disrupted by long-term therapy with certain antiepileptic drugs and the antimicrobial agent rifampin

96 reports of significant interactions between antiepileptic drugs and the efficacy of human growth hor

97 eral visual field constriction of any of the antiepileptic drugs and the mechanisms that lead to thes

98 nomics of drug response (pharmacogenomics of antiepileptic drugs) and genomics of drug resistance.

99 erization of drugs that modulate SV2A (e.g., antiepileptic drugs) and potentially could be a biomarke

100 ificant association of epilepsy, exposure to antiepileptic drugs, and adverse outcomes exists in preg

101 week), had failed to respond to at least two antiepileptic drugs, and had not been treated previously

102 Patients were treated with sedation, antiepileptic drugs, and immunotherapy.

103 ubstrates including several antidepressants, antiepileptic drugs, and neuroleptics, which exert centr

104 Some new antiepileptic drugs are modifications of those already a

105 Older antiepileptic drugs are often prescribed at seizure pres

106 itive effects of fetal exposure of humans to antiepileptic drugs are uncertain.

107 We analysed data from the Standard and New Antiepileptic Drug (arm B) study, a randomised trial tha

108 e seizure-free and had started withdrawal of antiepileptic drugs; articles also had to contain inform

109 Are antiepileptic drugs associated with reduced pain intensi

110 Fetal exposure of animals to antiepileptic drugs at doses lower than those required t

111 Nineteen patients (45.2%) had withdrawn from antiepileptic drugs at least once; 12 of those (63.2%) h

112 d case-control study and defined exposure to antiepileptic drugs at the index date (ie, time of suici

113 n issued a warning regarding suicidality and antiepileptic drugs based on meta-analyses of 199 random

114 epilepsy, who were receiving stable doses of antiepileptic drugs before study entry, were enrolled in

115 ore antiepileptic drug withdrawal, number of antiepileptic drugs before withdrawal, female sex, famil

116 amine recent studies of local anesthetic and antiepileptic drug binding to a sodium channel, revealin

117 do not show a good response to conventional antiepileptic drugs, but respond to immunotherapies.

118 Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal

119 es of epilepsy and the metabolic activity of antiepileptic drugs can adversely affect hypothalamic an

120 lation of brain excitability using available antiepileptic drugs can have serious side effects, espec

121 a mechanism by which early life exposure to antiepileptic drugs can impact cognitive and behavioral

122 substantial evidence indicates that several antiepileptic drugs can increase thyroid hormone metabol

123 t, the availability of more than 20 approved antiepileptic drugs can reduce the incentive to enrol in

124 The antiepileptic drug carbamazepine (CBZ) is one of the mos

125 In contrast, the antiepileptic drug carbamazepine was found to inhibit vo

126 Treatment options included antiepileptic drug changes, epilepsy surgery, and pacema

127 However, at this point, antiepileptic drug choice in patients with epilepsy rema

128 zure may afford improved treatments, such as antiepileptic drug chronotherapy, or timely warning to p

129 inical history, seizure types and frequency, antiepileptic drugs, cognitive, social and functional ou

130 to compare the efficacy and side effects of antiepileptic drug combinations in animals.

131 Use of multiple antiepileptic drugs compared with the reference group wa

132 The antiepileptic drugs currently available to treat mTLE ar

133 Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase

134 Clinical trials as part of antiepileptic drug development are increasingly expensiv

135 er adjustment for maternal IQ, maternal age, antiepileptic-drug dose, gestational age at birth, and m

136 development cohort comprised 399 women whose antiepileptic drug doses were adjusted based on clinical

137 provide the first evidence that exposure to antiepileptic drugs during a sensitive postnatal period

138 Clinical Question: Is maternal use of antiepileptic drugs during pregnancy associated with maj

139 Exposure to antiepileptic drugs during pregnancy is associated with

140 trials of topical agents (e.g., capsaicin), antiepileptic drugs (e.g., gabapentin), injection of oth

141 also could be relevant in reducing standard antiepileptic drug efficacy.

142 iconvulsant: Patients taking enzyme-inducing antiepileptic drugs (EIAEDs) received 340 mg/m2, and pat

143 s not currently treated with enzyme-inducing antiepileptic drugs (EIAEDs) with 100 mg/d of erlotinib

144 receiving and not receiving enzyme-inducing antiepileptic drugs (EIAEDs).

145 seizures despite treatment with at least two antiepileptic drugs, eight patients who had been seizure

146 The Equivalence among Generic Antiepileptic Drugs (EQUIGEN) chronic-dose study was a r

147 iconvulsants are of considerable interest as antiepileptic drugs, especially because of their potenti

148 d on cost, against the routine use of modern antiepileptic drugs, except when older drugs have failed

149 psy and undertook subgroup analysis based on antiepileptic drug exposure in women with epilepsy.

150 Since foetal antiepileptic drug exposure is associated with lower ver

151 , we examined dose-related effects of foetal antiepileptic drug exposure on verbal and non-verbal cog

152 At 36 months, prenatal antiepileptic drug exposure was associated with adverse

153 The association of epilepsy and antiepileptic drug exposure with pregnancy outcomes need

154 Sodium valproate has been a first-line antiepileptic drug for 40 years.

155 eight patients who had been seizure-free on antiepileptic drugs for at least a year after 3 or more

156 al postoperative seizure outcomes and use of antiepileptic drugs for different brain lesions causing

157 Two patients who had received multiple antiepileptic drugs for several years presented with a b

158 fficacy of epilepsy surgery and use of newer antiepileptic drugs for the treatment of intractable epi

159 The Equivalence Among Antiepileptic Drug Generic and Brand Products in People

160 Although the number of available antiepileptic drugs has increased substantially during t

161 The introduction of 10 new antiepileptic drugs has provided greater choice for pati

162 study conducted in the UK (Standard and New Antiepileptic Drugs) has confirmed what most practising

163 Cenobamate (YKP3089), an investigational antiepileptic drug, has shown broad-spectrum anticonvuls

164 Antiepileptic drugs have been implicated in causing psyc

165 ular drugs, painkillers, contrast media, and antiepileptic drugs have been recorded well above thresh

166 Several antiepileptic drugs have multiple or uncertain mechanism

167 tenuate mutant seizure activity; seven other antiepileptic drugs have no effect.

168 Some newer antiepileptic drugs have novel mechanisms of action, inc

169 the risk of suicide following treatment with antiepileptic drugs identified in randomized trials is e

170 0.2 mg/kg), and only two did not need rescue antiepileptic drugs (ie, met rescue criteria; one on 0.0

171 Seizures may persist despite antiepileptic drugs if the precipitating cause is untrea

172 g because: (i) there may be some response to antiepileptic drugs; (ii) in infants with multisystem pa

173 ponse to the addition of a previously unused antiepileptic drug in a cohort of 155 people with refrac

174 lammation, valproic acid (VPA), an effective antiepileptic drug in this seizure model, mesalazine (MS

175 lsive epilepsy without detectable amounts of antiepileptic drugs in blood.

176 Although the effects of antiepileptic drugs in central hypothyroidism have not y

177 Mucocutaneous discoloration induced by antiepileptic drugs in general and ezogabine in particul

178 of more than 80% without the need for rescue antiepileptic drugs in more than 50% of infants.

179 The aim is to review rational polytherapy of antiepileptic drugs in terms of conventional and novel m

180 nitive and behavioural impact of exposure to antiepileptic drugs in utero.

181 e age of 6 years after exposure to different antiepileptic drugs in utero.

182 Other antiepileptic drugs increase sex hormone-binding globuli

183 Switching between generic antiepileptic drugs is a highly debated issue that affec

184 The use and selection of antiepileptic drugs is often further complicated by the

185 proate, as compared with other commonly used antiepileptic drugs, is associated with an increased ris

186 re also scanned after a blocking dose of the antiepileptic drug levetiracetam (20 mg/kg).

187 The antiepileptic drug levetiracetam (LEV) is a potential tr

188 50, and 150 mug/kg) or preblocking with the antiepileptic drug levetiracetam at 10 and 30 mg/kg.

189 urthermore, the addition of the SV2A-binding antiepileptic drug levetiracetam to the medium inhibited

190 ncluding an expedient total synthesis of the antiepileptic drug levetiracetam.

191 The antiepileptic drug, levetiracetam, blocked Kv4.2 depleti

192 indicate that the effectiveness of VPA as an antiepileptic drug may be partially explained by the HDA

193 Antiepileptic drugs may also cause EDS or influence slee

194 erological response to immunotherapies, when antiepileptic drugs may be ineffective.

195 suggest conventional sodium channel blocking antiepileptic drugs may worsen the disease, we predicted

196 However, neither such methods nor antiepileptic drug mechanisms of action have yet proven

197 pilepsy who became seizure-free while taking antiepileptic drugs might consider discontinuing their m

198 uicide and whether psychiatric disorders and antiepileptic drugs modify the risk of attempted suicide

199 we enrolled pregnant women with epilepsy on antiepileptic drug monotherapy (carbamazepine, lamotrigi

200 At age 6 months, infants of mothers using antiepileptic drugs (n = 223) had a higher risk of impai

201 with carbamazepine (n = 31), other aromatic antiepileptic drugs (n = 24), abacavir (n = 11), nevirap

202 The onset and evolution of antiepileptic drug nonadherence in children with newly d

203 Changes in doses of antiepileptic drugs occurred more frequently in pregnant

204 icus episodes were treatment with third-line antiepileptic drugs (odds ratio, 12.08; 95% confidence i

205 Lamotrigine was selected as the antiepileptic drug of interest because of its wide use,

206 We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up

207 fects of traditional and recently introduced antiepileptic drugs on excitatory and inhibitory brain m

208 ailable for the effects of second-generation antiepileptic drugs on hypopituitarism treatment.

209 ortex and striatum and probed the effects of antiepileptic drugs on neural excitability and the effec

210 5-0.99), treatment history (taking non-SANAD antiepileptic drugs [other than those listed above] vs t

211 (p=0.052) and a lower number of concomitant antiepileptic drugs (p=0.03).

212 e effective than either of two commonly used antiepileptic drugs, phenobarbital and diazepam, in prev

213 was applied to the "green" synthesis of the antiepileptic drug Phenytoin, with no use of any harmful

214 usual concomitant medications, including an antiepileptic drug (phenytoin or carbamazepine), dexamet

215 We tested whether two commonly prescribed antiepileptic drugs (phenytoin, lamotrigine), as well as

216 g patients discharged with a prescription of antiepileptic drugs, phenytoin and levetiracetam were pr

217 s epilepticus episodes treated by third-line antiepileptic drugs, predictors of poor outcome were old

218 born to women enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2

219 Phenytoin was the most common antiepileptic drug prescribed de novo (61%).

220 Exclusion of antiepileptic drugs prescribed before the index date did

221 and be influenced by seizure mechanisms and antiepileptic drugs, presenting unique management challe

222 its application to the total synthesis of an antiepileptic drug (R)-lacosamide 2 are described.

223 uire concurrent treatment with more than one antiepileptic drug (rational polytherapy), but there is

224 pilepsy of childbearing potential because of antiepileptic drug-related teratogenicity and hormonal i

225 y 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need.

226 caffold the chemical fragments of well-known antiepileptic drugs such as ethosuximide, levetiracetam,

227 e and are often resistant to treatments with antiepileptic drugs, such as carbamazepine and phenytoin

228 ary axis have shown that chronic use of many antiepileptic drugs, such as carbamazepine, oxcarbazepin

229 Phenytoin, one of the most widely used antiepileptic drugs, suppresses the abnormal brain activ

230 report (p=0.03), a lower number of previous antiepileptic drugs taken (p=0.052) and a lower number o

231 e has been pursued as an antinociceptive and antiepileptic drug target.

232 Most antiepileptic drugs target neuronal mechanisms.

233 Although many clinically-approved antiepileptic drugs target voltage-gated persistent sodi

234 hat they are important currently unexploited antiepileptic drug targets.

235 rovide an example of cross-over pharmacology antiepileptic drug testing.

236 Levetiracetam (LEV) is a prominent antiepileptic drug that binds to neuronal synaptic vesic

237 AZA is an antiepileptic drug that has been shown to inhibit AQP4 e

238 daily injections of phenytoin (40 mg/kg), an antiepileptic drug that prevents CA3 dendritic retractio

239 Retigabine (RTG) is a first-in-class antiepileptic drug that suppresses neuronal excitability

240 nces between splice variants are occluded by antiepileptic drugs that bind to and stabilize inactivat

241 ts with nonepileptic seizures are prescribed antiepileptic drugs that do not treat nonepileptic seizu

242 ociated with the dosing of two commonly used antiepileptic drugs that elicit their pharmacologic acti

243 We also compared changes in the doses of antiepileptic drugs that were administered in the two gr

244 need for a thyroxine dose increase with some antiepileptic drugs, the effect of excessive thyroxine i

245 n part be attributed to the use of GABAergic antiepileptic drugs, the stability in glutamine across p

246 Our results signify that no matter how many antiepileptic drug therapies have failed, there is alway

247 Third-line antiepileptic drug therapies with sedating or anesthetic

248 l seizures who do not respond to appropriate antiepileptic drug therapy consisting of 2 or more medic

249 re predicting seizure outcome after starting antiepileptic drug therapy, measured by both time to fir

250 Antiepileptic drug therapy, though beneficial for restra

251 or selective alpha(2A)AR agonists as a novel antiepileptic drug therapy.

252 precipitating cause; determine the need for antiepileptic drug therapy; and recognize nonconvulsive

253 rom immediate remission after taking a first antiepileptic drug to frequent unremitting seizures with

254 The choice of which antiepileptic drug to use may also be influenced by the

255 defined as failure of adequate trials of two antiepileptic drugs to achieve sustained seizure freedom

256 CSD was also decreased by the antiepileptic drug topiramate, but not by carbamazepine.

257 ional anaesthetics (isoflurane, desflurane), antiepileptic drugs (topiramate, lacosamide, pregabalin,

258 re the absence of a control group continuing antiepileptic drug treatment and a consistent definition

259 Antiepileptic drug treatment necessarily confounds analy

260 to treatment failure were treatment history (antiepileptic drug treatment prior to randomisation), EE

261 ergency that is typically terminated through antiepileptic drug treatment, leads to hippocampus dysfu

262 to breastfeed their children irrespective of antiepileptic drug treatment.

263 in children exposed, in utero, to different antiepileptic drug treatments.

264 of improvement is similar to that of recent antiepileptic drug trials in drug resistant epilepsy (DR

265 linear regression adjusted for maternal IQ, antiepileptic drug type, standardised dose, gestational

266 herapy were not different from those without antiepileptic drug use at both time points (PFS: HR, 0.9

267 combined analysis of survival association of antiepileptic drug use at the start of chemoradiotherapy

268 Stiripentol is an antiepileptic drug used to treat children affected by Dr

269 The effects of the antiepileptic drugs used in the MESS study are greater f

270 We show here that the antiepileptic drug valproic acid (VPA) potently blocked

271 definite cause of pancreatitis is due to the antiepileptic drug valproic acid (VPA).

272 that exposing mouse brain capillaries to the antiepileptic drug, valproic acid (VPA; 5 muM), signific

273 1.35), treatment history (taking a non-SANAD antiepileptic drug vs treatment naive, 0.64, 0.52-0.78),

274 Current versus previous use of any antiepileptic drug was associated with an increased risk

275 During pregnancy, the dose of an antiepileptic drug was changed at least once in 74% of p

276 Use of antiepileptic drugs was associated with an increased ris

277 Prenatal exposure to antiepileptic drugs was associated with impaired fine mo

278 ous breastfeeding in children of women using antiepileptic drugs was associated with less impaired de

279 ional risk of suicide associated with use of antiepileptic drugs was generally low and should be bala

280 Third-line antiepileptic drugs were administered in 47 cases (33%).

281 Bottom Line: Certain antiepileptic drugs were associated with increased rates

282 Antiepileptic drugs were categorized by MOA: sodium chan

283 andomised controlled trial in which standard antiepileptic drugs were compared with new treatments.

284 Additionally, six epilepsy patients on other antiepileptic drugs were examined five times with SKP as

285 sy-proved low-grade glioma treated only with antiepileptic drugs were examined longitudinally with su

286 antile epilepsies (<3 months), whereas other antiepileptic drugs were less effective.

287 ndations include the following: prophylactic antiepileptic drugs were not recommended for routine use

288 tive function (r=-0.42, p=0.0004), but other antiepileptic drugs were not.

289 th focal seizures despite treatment with 1-3 antiepileptic drugs were randomly assigned (1:1:1:1) via

290 ne phase) receiving one to three concomitant antiepileptic drugs were recruited from 99 centres acros

291 aving not responded positively to at least 2 antiepileptic drugs) were identified in 2000 and followe

292 Carbamazepine (CBZ) is an antiepileptic drug which is persistent in wastewater tre

293 ften fatal syndrome, initially responsive to antiepileptic drugs which over time becomes refractory a

294 Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large exte

295 VPA is a commonly prescribed antiepileptic drug with known teratogenic effects.

296 spiny neurons from neonatal rats exposed to antiepileptic drugs with proapoptotic action (phenobarbi

297 tients; however, data for the interaction of antiepileptic drugs with the pituitary axis have shown t

298 With increasing age and treatment duration, antiepileptic drug withdrawal may be justified.

299 fore remission, seizure-free interval before antiepileptic drug withdrawal, age at onset of epilepsy,

300 fore remission, seizure-free interval before antiepileptic drug withdrawal, number of antiepileptic d