1 A target expands its potential utility as an
antigene agent or hybridization probe.
2 The novel TFO can be developed into a potent
antigene agent, and its design strategy applied to simil
3 Here we describe a protocol for designing
antigene agents and introducing them into cells.
4 ecognition properties which may be useful as
antigene agents or tools in molecular biology.
5 ave been extensively studied as antisense or
antigene agents that can potentially modulate the expres
6 f the progesterone receptor (PR) function as
antigene agents to block PR expression.
7 s are good candidates for further testing as
antigene agents.
8 onucleotides have been used as antisense and
antigene agents.
9 attractive features as diagnostic probes and
antigene agents.
10 omings by serving as effective antisense and
antigene agents.
11 of the present work was to characterize the
antigene and antiproliferative activity of a triple heli
12 at the c-myc-targeted PS-TFO is an effective
antigene and antiproliferative agent, with potential for
13 se of their successful use within antisense,
antigene,
and other gene-targeting strategies.
14 tions should be considered for antisense and
antigene applications.
15 These findings support the feasibility of an
antigene approach for the therapeutic regulation of spec
16 Earlier, we developed an
antigene approach, using a type alpha1(I) collagen gene
17 cations to phototriggered antisense-based or
antigene-
based genetic tools, diagnostic agents and drug
18 the biological activity of TFOs as potential
antigene compounds has been limited by cellular uptake.
19 ed (e.g., when PNAs are used as antisense or
antigene drugs).
20 antigene peptide nucleic acids (agPNAs) and
antigene duplex RNAs (agRNAs) block gene expression and
21 The tumor-selective ganglioside
antigene GD2 is frequently expressed on neuroblastomas a
22 To test this hypothesis, we synthesized
antigene LNAs (agLNAs) complementary to sequences within
23 Here, we show that
antigene locked nucleic acids (agLNAs) reduce RNA levels
24 chromosomal DNA and that LNAs are bona fide
antigene molecules.
25 xo- containing oligomers may find utility as
antigene oligonucleotide reagents.
26 BGA002 is a potently improved MYCN-specific
antigene oligonucleotide that reverts N-Myc-dysregulated
27 We have shown that
antigene peptide nucleic acids (agPNAs) and antigene dup
28 A second generation
antigene peptide oligonucleotide targeting MYCN induces
29 Here, we evaluated a novel MYCN-specific
antigene PNA oligonucleotide (BGA002) in MYCN-amplified
30 plex DNA by strand invasion, suggesting that
antigene PNAs (agPNAs) can be important tools for explor
31 y may complicate attempts to identify potent
antigene PNAs.
32 Neu, mutants of c-Neu, polyomavirus middle T
antigene (
PyV-mT), Ras, and bi-transgenic for ErbB2/Neu
33 They are attractive as antisense and
antigene reagents, as well as building blocks for molecu
34 Antigene RNAs (agRNAs) are small RNA duplexes that targe
35 ulating gene expression by promoter-targeted
antigene RNAs (agRNAs) will require identification of th
36 Equally important was that an
antigene strategy, the sense PNA, was shown in vivo to b
37 chniques such as in situ hybridization, PCR,
antigene targeting, and microarrays.
38 zing ligands, with potential applications in
antigene therapeutics.
39 making them highly appealing in the field of
antigene therapeutics.
40 otides in biological solutions, antisense or
antigene therapies aimed at modulation of specific gene
41 In the field of
antigene therapy, triplex-forming oligonucleotides (TFOs