ライフサイエンスコーパス: antimicrobials

1 ns, dietary choices, microbe immigration and antimicrobials.

2 bacteria, consistent with SMG production of antimicrobials.

3 often carry acquired resistance to multiple antimicrobials.

4 ar mechanisms underlying resistance to other antimicrobials.

5 ion of ClpB as a target for developing novel antimicrobials.

6 ) and assessed its potential as a target for antimicrobials.

7 lones and to test the efficacy of additional antimicrobials.

8 t-line treatment (median, 7 days) with other antimicrobials.

9 es in the absence of selection pressure from antimicrobials.

10 in increased hospital costs and exposure to antimicrobials.

11 urrence rates, and combined with traditional antimicrobials.

12 as recommended 14-28 days post-completion of antimicrobials.

13 ates for broadening the available choices of antimicrobials.

14 tuberculosis to sublethal concentrations of antimicrobials.

15 ow this corresponds with the introduction of antimicrobials.

16 tend the lifespan of current narrow-spectrum antimicrobials.

17 lve these issues and enable their use as new antimicrobials.

18 and continuation of empirical broad-spectrum antimicrobials.

19 ely) are important for the evaluation of new antimicrobials.

20 loration of novel analogues as potential new antimicrobials.

21 t for evolutionary success in the absence of antimicrobials.

22 s for governments to reduce the human use of antimicrobials.

23 a general principle for the design of future antimicrobials.

24 ions (cIAIs) supports the development of new antimicrobials.

25 resistance to currently used broad-spectrum antimicrobials.

26 hogens' resistance to all empiric first-line antimicrobials.

27 prompting increased interest in phage-based antimicrobials.

28 have systematically explored microbiomes for antimicrobials.

29 roach in the pursuit of a next generation of antimicrobials.

30 care over the study period were for targeted antimicrobials.

31 the basis for a new generation of precision antimicrobials.

32 ting in high mortality and irrational use of antimicrobials.

33 sceptible to other quaternary ammonium based antimicrobials.

34 s to play a significant role in tolerance to antimicrobials.

35 treatment strategies, with a focus on novel antimicrobials.

36 these cases were treated with QT-prolonging antimicrobials.

37 pulations to tolerate high concentrations of antimicrobials.

38 simple concept for rapid development of new antimicrobials.

39 drugs that restore the efficacy of existing antimicrobials.

40 livery, bio-imaging, tissue engineering, and antimicrobials.

41 in vitro characterization of sensitivity to antimicrobials.

42 T-160 (n = 106) were susceptible to all four antimicrobials.

43 cteriocins, a diverse group of proteinaceous antimicrobials.

44 fforts to develop kinase inhibitors as novel antimicrobials.

45 ent failure rates in comparison to all other antimicrobials.

46 bacteria under therapeutic concentrations of antimicrobials.

47 of the wasp Vespula lewisii, into synthetic antimicrobials.

48 in standard culture, and when treated with 2 antimicrobials.

49 ould facilitate the design of new, effective antimicrobials.

50 membrane-selective and sequence-independent antimicrobials.

51 ainst the known side-effect profile of these antimicrobials.

52 anoparticles (Ag NPs) have long been used as antimicrobials.

53 should include prophylactic and pre-emptive antimicrobials.

54 hasis on early administration of appropriate antimicrobials.

55 ts early recognition and prompt provision of antimicrobials.

56 erm impact on AMR and on access to effective antimicrobials.

57 aureus strains that are resistant to various antimicrobials.

58 rategy for repurposing venoms into promising antimicrobials.

59 t roles in mediating bacterial resistance to antimicrobials.

60 the adaptation to growth in the presence of antimicrobials.

61 culture sample and injection of intravitreal antimicrobials.

62 immune effectors and systemically delivered antimicrobials.

63 tance to these novel and otherwise promising antimicrobials.

64 patients with plague have received effective antimicrobials.

65 ny language with terms related to plague and antimicrobials.

66 Test of cure was recommended 14-28 days post-antimicrobials.

67 ining glycerol monolaurate (GML) in place of antimicrobials.

68 necessitating the development of innovative antimicrobials.

69 industry can support the responsible use of antimicrobials.

70 in food systems vis-a-vis other conventional antimicrobials.

71 ublications with terms related to plague and antimicrobials.

72 residues arising from production inputs (75 antimicrobials, 10 coccidiostats and 121 pesticides) hav

73 was applied to the resistance profiles of 14 antimicrobials across three urgent threat pathogens enco

74 n vitro activities of 12 clinically relevant antimicrobials against clinical S. maltophilia isolates

75 provide a foundation for platforms to launch antimicrobials against gastrointestinal tract pathogens,

76 thelial cells influence the efficacy of most antimicrobials against P. aeruginosa biofilm formation,

77 cteria RNA polymerase (RNAP) is a target for antimicrobials against tuberculosis, motivating structur

78 e of pyuria increased, the odds of receiving antimicrobials also increased linearly (low pyuria, 14.7

79 e of pyuria increased, the odds of receiving antimicrobials also increased linearly (low, 14.7%; mode

80 egative pathogens to all empiric, first-line antimicrobials (ampicillin/penicillin, gentamicin, ceftr

81 uted to a combination of overprescription of antimicrobials and a lack of accessible diagnostic metho

82 tants are cross-resistant to fluoroquinolone antimicrobials and a siderophore-conjugated lactivicin a

83 ng and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as i

84 ategy to overcome resistance in antibiotics, antimicrobials and anticancer drugs.

85 try can lead to the release of unmetabolized antimicrobials and antimicrobial resistance genes (ARG)

86 DH-2 an attractive new target for developing antimicrobials and antiprotozoal agents.

87 o use of less effective and broader spectrum antimicrobials and are associated with antimicrobial res

88 ere is an urgent need for discovery of novel antimicrobials and carbohydrate-based anti-adhesive stra

89 e, increased contact with housing materials, antimicrobials and cleaning products, and increased expo

90 To promote the appropriate use of antimicrobials and combat antimicrobial resistance, the

91 urring role of Rgg/RNPP in the production of antimicrobials and designed a robust genetic screen to u

92 pidemic has fuelled the development of novel antimicrobials and diagnostics.

93 simultaneously detect AMR, novel therapeutic antimicrobials and gonococcal vaccine(s) in particular i

94 orms biofilms that enhance its resistance to antimicrobials and host defenses.

95 We reviewed use of specific antimicrobials and illness outcome among cases of plague

96 We also investigated the effect of pretest antimicrobials and interpretation of molecules of microb

97 for resistance to eleven clinically relevant antimicrobials and phenotypic occurrence of ESBLs as mod

98 Klebsiella pneumoniae resists penetration by antimicrobials and protects the bacteria from the innate

99 ity rates among septic patients, despite new antimicrobials and resuscitation agents.

100 tent intracellular reservoirs that can evade antimicrobials and the immune response.

101 -have the potential to reduce the overuse of antimicrobials and thereby reduce antimicrobial resistan

102 gation into potential overuse or underuse of antimicrobials and to evaluate the effectiveness of ASP

103 on of tolerance to otherwise lethal doses of antimicrobials and to other antimicrobial activities.

104 velops and markets both human and veterinary antimicrobials and vaccines is used as a case study for

105 early has a leading role in developing novel antimicrobials and vaccines, it is also active in many a

106 sks for AKI and CDI across individual target antimicrobials and vancomycin combination therapies, inc

107 e, 22-80 months), 8 have ceased prophylactic antimicrobials, and 5 have ceased immunoglobulin replace

108 tionship between antimicrobial use, residual antimicrobials, and ARG prevalence within manure is not

109 ), nonbacterial infections, use of redundant antimicrobials, and continuation of empirical broad-spec

110 asmid maintenance, confer resensitization to antimicrobials, and have specific mechanisms of action.

111 e susceptibility of Neisseria gonorrhoeae to antimicrobials, and the reasons for this are largely une

112 hnology could facilitate timely selection of antimicrobials, and therapeutic drug monitoring would pr

113 enge after drug-induced liver injury (DILI): antimicrobials; and central nervous system, cardiovascul

114 4); risk was higher in patients who received antimicrobials (aOR 2.4; 1.7-3.4).

115 4); risk was higher in patients who received antimicrobials (aOR, 2.4; 1.7-3.4).

116 Antimicrobials are a class of drugs of particular concer

117 interactions via aqueous diffusion, volatile antimicrobials are able to act at a distance and diffuse

118 Numerous antimicrobials are considered effective for treating pla

119 Although water-soluble antimicrobials are limited to proximal interactions via

120 ficult due to antibiotic resistance, and new antimicrobials are needed to treat infections.

121 ents similar to the building blocks existing antimicrobials are overrepresented in them.

122 he approaches for the loading and release of antimicrobials are presented.

123 Novel antimicrobials are urgently needed to combat drug-resist

124 Large amounts of antimicrobials are used in salmonid aquaculture in Chile

125 arch suggests that many clinically important antimicrobials are used indiscriminately.

126 floxacin and levofloxacin, 2 fluoroquinolone antimicrobials, are >=90% effective for the treatment of

127 with suspected plague with highly effective antimicrobials as quickly as possible.

128 the unique features of FAs that function as antimicrobials at high doses and biofilm inhibitors at l

129 MS was used to visualize the distribution of antimicrobials at the inhibition zone between bacteria a

130 ng in healthcare settings, and there are few antimicrobials available to treat infections from these

131 Among the antimicrobials, B-lactam with B-lactamase inhibitors (OR

132 is a promising target for the development of antimicrobials because a loss of its activity is detrime

133 ritical priority" for the development of new antimicrobials because of the risk to human health posed

134 ercentage of each physician's patients whose antimicrobials began within 3 hours of emergency departm

135 cell wall deconstruction, biofilm formation, antimicrobials biosynthesis, and metabolism of diverse n

136 es, two of which were largely susceptible to antimicrobials but showed sporadic antimicrobial resista

137 Biofilms are often extremely tolerant to antimicrobials but their reliance on shared EPS may also

138 o reduce adverse effects of orally delivered antimicrobials, but has potential for other therapeutics

139 led that adjunctive use of local delivery of antimicrobials, but not systemic antibiotic usage, with

140 The use of antimicrobials by the livestock industry can lead to the

141 icrobial resistance of two major therapeutic antimicrobials, clarithromycin and amikacin.

142 o-amoxiclav and resistance to the same three antimicrobials/classes among community-associated colifo

143 n upon exposure to three clinically relevant antimicrobials (colistin, imipenem or ciprofloxacin) by

144 bases for primary sources on the safety of 9 antimicrobials considered for plague during pregnancy (a

145 ween patients treated with 1 vs 2 classes of antimicrobials considered to be effective for plague.

146 for determining selective concentrations of antimicrobials currently exist, preventing appropriate e

147 The efficacy of both antimicrobials declined as treatment initiation was furt

148 rom concomitant treatment with QT-prolonging antimicrobials, direct effects of inflammatory cytokines

149 results were further reviewed for changes in antimicrobials due to the additional organism(s) identif

150 e yield in large-scale production of natural antimicrobials due to the ease of application and the ro

151 reated with a median of one (1-22) course of antimicrobials, during 34 (28-730) days.

152 The antimicrobials, either singly or in combination, can be

153 Veterinary and human antimicrobials enrofloxacin, clarithromycin, roxithromyc

154 their active profile as radical scavengers, antimicrobials, estrogen-like activators and acetylcholi

155 The antimicrobials examined were vancomycin, cefepime, piper

156 though not statistically significant) to all antimicrobials except nitrofurantoin (NIT) were higher i

157 We propose a revaluation of empirical antimicrobials for dysenteric diarrhea and endorse the u

158 assays needed to ensure optimal selection of antimicrobials for M. genitalium.

159 d lead discovery with efforts to develop new antimicrobials for mycobacterial infections.

160 ker, clinicians may consider more aggressive antimicrobials for rapid bacterial load reduction in hig

161 f these organisms when administering empiric antimicrobials for sepsis.

162 Antimicrobials for suspected typhoid might therefore be

163 Novel antimicrobials for treatment of Mycobacterium tuberculos

164 cases of disease, we sought FDA approval of antimicrobials for treatment under the Animal Efficacy R

165 roquinolone prophylaxis/clinically-indicated antimicrobials for up to 40 days.

166 recent meeting on the evaluation process for antimicrobials for urogenital gonorrhea treatment and en

167 stems, where subinhibitory concentrations of antimicrobials frequently occur.

168 validated an HPLC-MS/MS method to detect 29 antimicrobials from eight classes and applied it to 43 a

169 In vitro, these antimicrobials had expressed antiviral activity against

170 ine ants acts as a microbial filter and that antimicrobials have a potentially widespread but so far

171 ance is a global health crisis and few novel antimicrobials have been discovered in recent decades.

172 Antimicrobials have unique adsorption and clearance prof

173 e (AMR), and lack of new classes of licensed antimicrobials, have made alternative treatment options

174 Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of bacterial resi

175 promising lead compounds for developing new antimicrobials; however, their narrow spectrum of action

176 Producing antimicrobials imposes a fitness cost on burying beetles

177 organisms were sensitive to the administered antimicrobials in 93%.

178 hen compare an EPS inhibitor to conventional antimicrobials in an evolutionary experiment.

179 he pharmacokinetics of commonly administered antimicrobials in an ex vivo continuous renal replacemen

180 The determination of antimicrobials in aquaculture fish is important to ensur

181 l and human health posed by excessive use of antimicrobials in aquaculture.

182 gs highlight the need for the prudent use of antimicrobials in chickens to minimize the development o

183 The use of antimicrobials in contrast media was associated with a s

184 In India, the use of antimicrobials in food animal production is unregulated.

185 he nontherapeutic use of medically important antimicrobials in food animal production.

186 as been published about algae ingredients as antimicrobials in food.

187 pathway is a potential target for evaluating antimicrobials in gram-positive bacteria.

188 nterventions to reduce misuse and overuse of antimicrobials in high-consumption populations and core

189 The use of antimicrobials in human and veterinary medicine has coin

190 that unregulated use of clinically relevant antimicrobials in Indian broiler and layer farms may con

191 ut limited potential therapeutic efficacy as antimicrobials in nasal applications, as concentrations

192 ent prescription of broad-spectrum empirical antimicrobials in patients with coronavirus-associated r

193 nd practical challenges in the management of antimicrobials in patients with sepsis.

194 Agricultural use of antimicrobials in subtherapeutic concentrations is incre

195 Adult patients treated with antimicrobials in the emergency department between 2009

196 with severe sepsis or septic shock receiving antimicrobials in the emergency department, door-to-anti

197 and pharmacodynamics for current and future antimicrobials in the treatment of urogenital and extrag

198 Empiric prescribing of antimicrobials in typhoid-endemic settings has increased

199 ddition to aminoglycosides, other classes of antimicrobials including tetracyclines, fluoroquinolones

200 n overcome the barriers faced by traditional antimicrobials, including antibiotic resistance.

201 e dwindling due to resistance to several key antimicrobials, including the fluoroquinolones.

202 Among those <=60 days, AMR to all first-line antimicrobials increased from 7.0% to 67.7% (P < .001).

203 developments suggest that local delivery of antimicrobials into periodontal pockets improve periodon

204 that attempts to improve the penetration of antimicrobials into S. maltophilia by conjugating them w

205 ve neutrophil recruitment and the release of antimicrobials into the tears and protected the eye from

206 whether the population-level consumption of antimicrobials is a contributory factor.

207 pathogen, for which the development of novel antimicrobials is desperately needed.

208 to hypothesize that resistance to intestinal antimicrobials is essential for long-term GIT colonizati

209 Delayed initiation of appropriate antimicrobials is linked to higher sepsis mortality.

210 ar diffusion is commonly performed for other antimicrobials, its use for polymyxins is discouraged du

211 Some but not all physicians started antimicrobials later for patients who were normotensive

212 aecalis tolerates high concentrations of GIT antimicrobials, like cholate and lysozyme, leading us to

213 This study was aimed to develop antimicrobials loaded hydrogels composed of cellulose na

214 A) associated with resistance to beta-lactam antimicrobials, macrolides, or fluoroquinolones.

215 Among cases treated with antimicrobials, maternal mortality and fetal fatality we

216 EP of plague during pregnancy; the choice of antimicrobials may be influenced by these data as well a

217 n of resistance through judicious use of new antimicrobials may be more effective than trying to reve

218 e population-level consumption of particular antimicrobials may contribute to variations in the level

219 ermine the disposition of five commonly used antimicrobials (meropenem, piperacillin, liposomal ampho

220 pancreatic factors, such as the excretion of antimicrobials, might have a substantial impact on the c

221 sponsible for their formidable resistance to antimicrobials, mycobacteria synthesize rare intracellul

222 h reduced susceptibility to recommended oral antimicrobials: namely, azithromycin, trimethoprim-sulfa

223 Polymyxins are antimicrobials of last resort for the treatment of carba

224 st the development of oligonucleotides-based antimicrobials of superior efficacy.

225 satile carriers to host, protect and release antimicrobials, offering a strong tool to tackle antimic

226 These data demonstrate that few antimicrobials, old or new, maintain reliable activity a

227 typhoidal Salmonella and the dearth of novel antimicrobials on the horizon, we risk losing our primar

228 Given the lack of new antimicrobials or a vaccine, understanding the evolution

229 result in exposure to host-derived, secreted antimicrobials or force direct interactions with immune

230 Rather than targeting antimicrobials or inhibitors of individual inflammatory

231 myces strains as a promising source of novel antimicrobials, particularly the strain Streptomyces fil

232 ic regulation, resistance to antibiotics and antimicrobials, pathogenesis, and adhesion to the mucosa

233 Patients who were transferred, received antimicrobials prior to emergency department arrival, or

234 cic ultrasonography and early treatment with antimicrobials prior to the development of clinical sign

235 Attine ants use antimicrobials produced by commensal bacteria to inhibit

236 view also includes recent information on new antimicrobials proposed for the treatment of NTM but not

237 d and validated for the quantification of 14 antimicrobials (quinolones and tetracyclines) in fish.

238 Circuit adsorption of antimicrobials ranged between 13% and 27%.

239 While resistance against conventional antimicrobials rapidly evolves, we see no evolution of r

240 Resistance to targeted antimicrobials reduced by 3.5 years postintervention com

241 Both antimicrobials reduced overall prevalence of Salmonella;

242 For most antimicrobials reviewed, adverse maternal/fetal/neonatal

243 his, the administration and exposure of such antimicrobials should be restricted until required in or

244 Antimicrobials should be used for treatment and PEP of p

245 From 2000 to 2018, the proportion of antimicrobials showing resistance above 50% increased fr

246 selection and administration of appropriate antimicrobials, significant physiological alterations th

247 Limited data for new investigational antimicrobials such as the ketolide solithromycin sugges

248 study demonstrated that mixtures of natural antimicrobials, such AuraShield L, can prevent in vitro

249 and was hypersusceptible to cell wall-acting antimicrobials suggesting defective cell wall biosynthes

250 Curing infections increasingly requires antimicrobials that are broader spectrum, more toxic, an

251 rtunity to create programmable gene-specific antimicrobials that are far less likely to drive resista

252 ts the paths of discovery for new classes of antimicrobials that could potentially mitigate the urgen

253 physiology and growth, and demonstrate that antimicrobials that depolarize cell membranes can benefi

254 latory complexities of bacterial response to antimicrobials that involve multiple riboregulators.

255 Contrary to Cas9-based antimicrobials that lack bacterial killing capacity when

256 ors constitute a novel family of Hp-specific antimicrobials that may help fight the constant increase

257 y facilitate the creation of next-generation antimicrobials that slow resistance development and coul

258 gs lay the foundation for the development of antimicrobials that target this novel, essential pathway

259 We identified 10 antimicrobials that would have qualified for an exclusiv

260 We identified 10 antimicrobials that would have qualified for an exclusiv

261 Among those treated with antimicrobials, the most commonly used were sulfonamides

262 s of this serotype can acquire resistance to antimicrobials, the temporal dynamics of this acquisitio

263 e carcass, perhaps through the production of antimicrobials themselves.

264 y can provide health benefits and as natural antimicrobials they offer preservation of foods.

265 s from insect microbiomes as a source of new antimicrobials through large-scale isolations, bioactivi

266 erived compounds could become new-generation antimicrobials to combat antibiotic-resistant pathogens.

267 ood animal producers often employ the use of antimicrobials to improve the survival and growth of the

268 Antagonistic microorganisms produce antimicrobials to inhibit the growth of competitors.

269 udy provides insights to develop alternative antimicrobials to treat foodborne pathogens with antibio

270 e therapeutic efficacy of various repurposed antimicrobials undergoing testing against the virus, we

271 nts without typhoid disease are treated with antimicrobials unnecessarily, conservatively amounting t

272 The safety profile of antimicrobials used during pregnancy is one important co

273 d with the lowest case fatality rates of all antimicrobials used for treatment of plague.

274 levels of resistance genes against the main antimicrobials used, these compounds continue to control

275 0 birds were tested for susceptibility to 11 antimicrobials using the disk diffusion method and valid

276 ass method for the HPLC-MS/MS analysis of 29 antimicrobials, validated according to the Commission De

277 cedure, the association between receipt of 2 antimicrobials (vancomycin plus a beta-lactam) versus ei

278 887 (24.5%) pyuria patients received antimicrobials versus 1918 (5.1%) patients without pyuri

279 887 (24.5%) patients with pyuria received antimicrobials versus 1918 (5.1%) patients without pyuri

280 ative outcomes following administration of 2 antimicrobials versus a single agent for the prevention

281 pic AMR testing, and resistance to empirical antimicrobials was associated with a significantly longe

282 thogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of cir

283 Antimicrobials were a priori classified into high-effica

284 Antimicrobials were administered into a reservoir contai

285 Based on data in the AGM model, these antimicrobials were approved under the Food and Drug Adm

286 ditional organism(s) was identified by mNGS, antimicrobials were changed 26% of the time.

287 In total, 15 antimicrobials were evaluated, with 11 for P. aeruginosa

288 Antimicrobials were extracted with trichloroacetic acid

289 ts profiting most obviously from intraductal antimicrobials were those with secondary sclerosing chol

290 patients who initiated CAS, the most common antimicrobials were trimethoprim-sulfamethoxazole, penic

291 sis inhibited in low combined concentrations antimicrobials, while Aspergillus spp. and T. macrosporu

292 Initial management included intravitreal antimicrobials with aqueous tap in 46% of eyes, needle v

293 icity study of a library of 24 peptide-based antimicrobials with narrow spectrum activity towards vet

294 resistance has necessitated a search for new antimicrobials with potent activity against multidrug-re

295 activated quantum dots (QDs) are alternative antimicrobials, with efficient transport, low cost, and

296 present an untapped source of underexploited antimicrobials, with pleuromutilin-a diterpene produced

297 Among 421 eligible patients, 74% received antimicrobials within 3 hours of emergency department ar

298 s the issue of how long treatment with these antimicrobials would remain effective after fever onset.

299 ly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Stre

300 is one of the largest exposures of humans to antimicrobials, yet the effects of TB treatment on intes