ライフサイエンスコーパス: antioxidant response element

1 of a vast number of genes by binding to the antioxidant response element.

2 ygenase 1, markers for the activation of the antioxidant response element.

3 ss stimulated HO-1 promoter activity via the antioxidant response element.

4 e redox-sensitive metal response element and antioxidant response element.

5 of Nrf2 and the binding of Nrf2 to the HO-1 antioxidant response element.

6 g phase II drug-metabolizing enzymes via the antioxidant response element.

7 ctive oxygen species (ROS) via a presumptive antioxidant response element.

8 enzymes via a electrophilic response element/antioxidant response element.

9 he composite major late transcription factor/antioxidant response element.

10 porter expression from a promoter containing antioxidant response element.

11 assays demonstrated binding of Nrf2 to Bcl-2 antioxidant response element.

12 pathways influencing genes controlled by the antioxidant response element.

13 ulated through cis-acting sequences known as antioxidant response elements.

14 ressing a luciferase reporter gene driven by antioxidant response elements.

15 with emphasis on Nrf2-mediated activation of antioxidant response elements.

16 nuclear proteins to activating protein-1 and antioxidant response elements.

17 irected mutagenesis assays demonstrated that antioxidant response element 1 is activated upon infecti

18 ted by NFE2-related factor 2 (Nrf2)-mediated antioxidant response element activation.

19 2, a transcription factor known to bind the antioxidant response element and activate antioxidant de

20 sic-region leucine zipper protein(s), to the antioxidant response element and consequently in gene tr

21 cated into the nucleus where it binds to the antioxidant response element and coordinately activates

22 rf2 in the nucleus of a cell upregulates the antioxidant response element and induces the expression

23 Nrf2 binds to the antioxidant response element and regulates expression an

24 T cells, as evidenced by Nrf2 binding to the antioxidant response element and the subsequent upregula

25 Cys506 impede binding of Nrf2 to endogenous antioxidant response element and to coactivator cAMP res

26 Analyses of antioxidant response elements and carbohydrate response

27 transcriptional regulator BACH1 binds HMOX1 antioxidant response elements and represses transcriptio

28 ion of phase II enzymes through induction of antioxidant response elements and support the approach o

29 The antioxidant response elements are regulatory sequences f

30 on of Txnip by high glucose by binding to an antioxidant response element (ARE) (-1286 to -1276) of t

31 ent to elicit the pharmaceutically important antioxidant response element (ARE) activation, and the r

32 riptional up-regulation of both subunits are antioxidant response element (ARE) and activator protein

33 lated factor 2 (Nrf2), where it binds to the antioxidant response element (ARE) and induces up-regula

34 The antioxidant response element (ARE) and Nrf2 are known to

35 Antioxidant response element (ARE) and nuclear transcrip

36 The antioxidant response element (ARE) and transcription fac

37 Nrf2 acts through the regulation of antioxidant response element (ARE) binding motifs in tar

38 Transcriptional regulation of the antioxidant response element (ARE) by Nrf2 is important

39 are induced occurs through activation of the antioxidant response element (ARE) by the oxidative-stre

40 factor NRF2, which in turn binds cis-acting antioxidant response element (ARE) enhancers and induces

41 say revealed that NRF2 directly binds to one antioxidant response element (ARE) found in the -230-bp

42 s is mediated, at least in part, through the antioxidant response element (ARE) found in the regulato

43 ranscription factor Nrf2, which binds to the antioxidant response element (ARE) found in the upstream

44 Amongst these were a group of antioxidant response element (ARE) genes encoding phase

45 ear factor E2-related factor 2 (Nrf2) to the antioxidant response element (ARE) in neural cells resul

46 gets because of their role in regulating the antioxidant response element (ARE) in response to oxidat

47 ctrophilic stress, Nrf1 is displaced from an antioxidant response element (ARE) in the gene promoter

48 cription factor that binds and activates the antioxidant response element (ARE) in the promoters of m

49 gulates cytoprotective genes that contain an antioxidant response element (ARE) in their promoters.

50 The antioxidant response element (ARE) is a cis-acting regul

51 The antioxidant response element (ARE) is known to regulate

52 putative USF binding site which overlaps an antioxidant response element (ARE) located at -101 bp re

53 deacetylases (HDACs) HDAC1 and HDAC3 to the antioxidant response element (ARE) located in the Slc40a

54 2 in the cytosol prevents Nrf2 activation of antioxidant response element (ARE) mediated gene express

55 The antioxidant response element (ARE) mediates the transcri

56 r levels and binding activity of MafG to the antioxidant response element (ARE) of GCLC but lower Nrf

57 ine zipper transcription factor Nrf2 and the antioxidant response element (ARE) of Nqo1.

58 igrate to the nucleus where it activates the antioxidant response element (ARE) of phase 2 genes and

59 In addition, BTG2 is detectable at the antioxidant response element (ARE) of several NFE2L2-res

60 These genes contain an antioxidant response element (ARE) or ARE-like transcrip

61 egulated by a cis-acting element, called the antioxidant response element (ARE) or electrophile-respo

62 usions, and increased expression of the NRF2-antioxidant response element (ARE) pathway.

63 or nuclear factor E2-related factor 2 (Nrf2)-antioxidant response element (ARE) regulates intracellul

64 Antioxidant response element (ARE) regulates the inducti

65 in Keap1 is required for termination of Nrf2-antioxidant response element (ARE) signaling by escortin

66 hich the Nrf2 transcription factor-dependent antioxidant response element (ARE) signaling is activate

67 r factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway is

68 The antioxidant response element (ARE) signaling pathway pla

69 ered proteins and transcripts (228) included antioxidant response element (ARE) target genes, such as

70 nalysis of the human Trx1 gene identified an antioxidant response element (ARE) that is required for

71 Mutation of an antioxidant response element (ARE) that maps at -84/-76

72 tor NF-E2-related factor (Nrf2) binds to the antioxidant response element (ARE) to induce antioxidant

73 factor NF-E2-related factor (Nrf2) binds to antioxidant response element (ARE) to induce antioxidant

74 ated antioxidant response as measured by the antioxidant response element (ARE) using a luciferase re

75 kinase (HSV-TK/GCV) under the regulation of antioxidant response element (ARE), a cis-acting enhance

76 to identify functional polymorphisms in the antioxidant response element (ARE), a cis-acting enhance

77 -1 promoter by the triterpenoids requires an antioxidant response element (ARE), a cyclic AMP respons

78 anslocates into the nucleus and binds to the antioxidant response element (ARE), activating defensive

79 anscription of antioxidant enzymes under the antioxidant response element (ARE), and HCMV suppression

80 duction of these enzymes is regulated by the antioxidant response element (ARE), as demonstrated in r

81 everal important cis-elements, including the antioxidant response element (ARE), the xenobiotic respo

82 ble GCLC and GCLM expression by means of the antioxidant response element (ARE), we hypothesized that

83 rans-activates gene expression by way of the antioxidant response element (ARE), which controls the e

84 otein from HepG2 cells (YABP) that binds the antioxidant response element (ARE), which is required fo

85 s regulated by NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE), which play an import

86 enetic response pathway linked to PAH is the antioxidant response element (ARE), which regulates expr

87 nuclear translocation and activation of the antioxidant response element (ARE), which regulates phas

88 ement revealed that it contained a consensus antioxidant response element (ARE), which was confirmed

89 Both IAB and tBHQ induced antioxidant response element (ARE)-directed green fluore

90 Using two well-characterized antioxidant response element (ARE)-driven gene promoters

91 2, modulates the transcriptional activity of antioxidant response element (ARE)-driven genes.

92 eductase, a phase II detoxifying enzyme, and antioxidant response element (ARE)-linked reporter gene

93 Antioxidant response element (ARE)-mediated expression a

94 (Nrf2) is a CNC/b-zip protein that regulates antioxidant response element (ARE)-mediated expression,

95 f Nrf2, a transcription factor essential for antioxidant response element (ARE)-mediated gene express

96 Nrf2 activates antioxidant response element (ARE)-mediated gene express

97 or) as well as subsequent induction of GSTA1 antioxidant response element (ARE)-mediated GST activity

98 CA activated the DNA-binding of NRF2 and the antioxidant response element (ARE)-mediated transcriptio

99 scription of p66Shc is activated through the antioxidant response element (ARE)-nuclear factor erythr

100 o malonate and 3NP and demonstrate increased antioxidant response element (ARE)-regulated transcripti

101 These compounds induce the expression of the antioxidant response element (ARE)-related genes and cau

102 sfection of reporter plasmids containing the antioxidant response element (ARE).

103 oxidative stress response genes through the antioxidant response element (ARE).

104 and antioxidant proteins via its binding to antioxidant response element (ARE).

105 transcriptionally activate genes through the antioxidant response element (ARE).

106 zymes through the regulatory sequence termed antioxidant response element (ARE).

107 700 and -683; this 20-bp region contains the antioxidant response element (ARE).

108 ation via a cis-acting sequence known as the antioxidant response element (ARE).

109 AD(P)H: quinone oxidoreductase 1 (NQO1) gene antioxidant response element (ARE).

110 -lactamase reporter under the control of the antioxidant response element (ARE).

111 fection of a reporter plasmid containing the antioxidant response element (ARE).

112 gulates gene expression through the promoter antioxidant response element (ARE).

113 sfection of reporter plasmids containing the antioxidant response element (ARE).

114 l 3-kinase (PI3-K) activity, which represses antioxidant response element (ARE)/NF-E2 related factor

115 NRF2 binds to antioxidant response elements (ARE) and up-regulates pro

116 phase II detoxifying enzymes are induced via antioxidant response elements (ARE) in their promoters o

117 -responsive element binding protein (CBP) at antioxidant response elements (ARE) located in the promo

118 Many phase 2 genes are regulated by upstream antioxidant response elements (ARE) that are targets of

119 n part through cis-active sequences known as antioxidant response elements (ARE).

120 Antioxidant-response element (ARE) and nuclear factor Nr

121 ession of key protective enzymes through the antioxidant-response element (ARE).

122 ents in this region, including two potential antioxidant response elements (ARE3 and ARE4), separated

123 using a luciferase reporter regulated by the antioxidant response element ARE4.

124 pounds are attributed to their activation of antioxidant response elements (AREs) by reacting with th

125 r factor-erythroid 2-related factor 2 (NRF2) antioxidant response elements (AREs) depletes it.

126 expression of NDP52, which we show has three antioxidant response elements (AREs) in its promoter reg

127 rf2 nuclear translocation and occupancy of 4 antioxidant response elements (AREs) in the NRF-1 promot

128 lular proteins by recognizing and binding to antioxidant response elements (AREs) in their gene promo

129 efects result from impaired Nrf2 activity on antioxidant response elements (AREs) localized to a micr

130 he nucleus, and increased binding of Nrf2 to antioxidant response elements (AREs) or electrophile res

131 t defenses by activating gene expression via antioxidant response elements (AREs), but their roles in

132 f2 dose-responsive miRNAs harboring proximal antioxidant response elements (AREs), implicating these

133 ers for both GCLC and GCLM contain consensus antioxidant response elements (AREs).

134 often involves protein binding to cis-acting antioxidant response elements (AREs).

135 ay leading to the induction of genes through antioxidant response elements (AREs).

136 regulate the expression of genes containing antioxidant-response elements (AREs) in their promoter r

137 tional activating pathway involving Nrf2 and antioxidant-response elements (AREs), the mechanism of p

138 hat regulate the expression of genes bearing antioxidant-response elements (AREs).

139 eriments demonstrated that p65Nrf1 binds the antioxidant response element as a heterodimer with small

140 ys used to screen potential toxicants is the antioxidant response element beta lactamase reporter gen

141 enesis and transfection assays identified an antioxidant response element between nucleotides -3148 a

142 a gene that also contains a maf recognition/antioxidant response element but is less studied, respon

143 activity in cells transfected with the GSTA2 antioxidant response element-chloramphenicol acetyl tran

144 xposure increased Nrf2 binding to a putative antioxidant response element consensus sequence in the s

145 ctor critical for the expression of multiple antioxidant response element-dependent genes, plays an i

146 cellular and in vivo activity, upregulating antioxidant response element-dependent target genes, the

147 The ability of BRCA1 to stimulate antioxidant response element-dependent transcription and

148 1 (Kelch-like ECH-associated protein 1)/ARE (antioxidant response element)-driven target gene system

149 In this study, we observed a decrease in the antioxidant response element-driven antioxidants in FECD

150 pression of Fbw7 leads to down-regulation of antioxidant response element-driven gene activation, whe

151 d destabilization of Nrf1 leads to increased antioxidant response element-driven gene expression.

152 means of selective induction of one or more antioxidant response element-driven genes.

153 ro-15d-PGJ2 abolishes the inducibility in an antioxidant response element-driven luciferase assay.

154 lso impaired Nrf2-induced transactivation of antioxidant response element-driven reporter gene expres

155 Finally, BRCA1 stimulated antioxidant response element-driven transcriptional acti

156 human QR gene promoter with its electrophile/antioxidant response element (EpRE/ARE) or deleted or mu

157 , is known to be mediated by an electrophile/antioxidant response element (EpRE/ARE), we examined the

158 n is known to be mediated by an electrophile/antioxidant response element (EpRE/ARE).

159 Twenty-four base pairs of the human antioxidant response element (hARE) are required for hig

160 Mediated via the electrophile or human antioxidant response element (hARE), induction of the ex

161 Ethanol-induced HO-1 transcription involved antioxidant response elements, hypoxia-response elements

162 arity between the NF-E2/AP-1 element and the antioxidant response element identified in a number of p

163 nd 4, but no xenobiotic response elements or antioxidant response elements, implicated in the regulat

164 anscription factor NFE2L2 (NRF2) through the antioxidant response element in a BRCA1-dependent manner

165 t OA-NO2 increased the binding of Nrf2 to an antioxidant response element in the enhancer region of t

166 s and transfection experiments identified an antioxidant response element in the forward and reverse

167 Jun proteins bound to the antioxidant response element in the HS-2 region in vitro

168 ated factor 2 (NRF2) by direct binding to an antioxidant response element in the p62 promoter.

169 d xenobiotic transporters by binding the cis-antioxidant response element in the promoter regions of

170 T, is dependent on the activity of a genetic antioxidant response element in their promoters.

171 on with small-Maf protein and binding to the antioxidant response element in vivo.

172 es coordinately regulated by maf recognition/antioxidant response elements in iron/oxygen/antioxidant

173 r-reporter assays revealed the importance of antioxidant response elements in Nrf1-mediated upregulat

174 2 antibodies revealed the binding of Nrf2 to antioxidant response elements in the promoter regions of

175 Tandem antioxidant response elements in the proximal promoter o

176 tin immunoprecipitation assays identified an antioxidant-response element in the reverse strand of th

177 ression) of phase 2 genes by binding to the "antioxidant response element" in their promoters.

178 tor [erythroid-derived 2]-like 2) to 2 AREs (antioxidant response elements) in the proximal IL1B prom

179 Transcriptional activation through the antioxidant response elements involves members of the CN

180 t transcriptional activation by means of the antioxidant response element is known to coordinate the

181 ccumulation and subsequent activation of the antioxidant response element is regulated by the proteas

182 DEPs induced activity of the antioxidant response element located in the NQO1 gene pr

183 nd binds to a cis-acting enhancer called the antioxidant response element located in the promoters of

184 se elements, major late transcription factor/antioxidant response element (MLTF/ARE), the STAT3 bindi

185 Because BACH1 is thought to interact with antioxidant response element motifs, we further examined

186 eporter cell lines driven by functional ROS (antioxidant response elements), NFkappaB, and mothers ag

187 ly activated TGFbeta1 signaling through ROS (antioxidant response elements), NFkappaB, and SMAD3 in b

188 cts of tumor suppressor P53, and inhibit the antioxidant response element Nrf-2, resulting in deplete

189 d phase 2 inducers, the TP analogues use the antioxidant response element-Nrf2-Keap1 signaling pathwa

190 ead to stabilization of Nrf2 to activate the antioxidant response element of phase 2 enzymes.

191 se inhibitor 1 (p21(Cip1)) and Nrf2 bound to antioxidant response elements of the Slc7a11 promoter an

192 ve transcription factor Nrf2, which binds to antioxidant response elements of various promoters.

193 nzymes via an electrophilic response element/antioxidant response element PAH o-quinones represent a

194 xygen species generation, activates the Nrf2/antioxidant response element pathway, inducing reactive

195 scription factors that bind NF-kappaB and/or antioxidant response elements play an activating role in

196 nce in ferritin genes is the maf recognition/antioxidant response element present in several other ge

197 The binding activities of Nrf2 on the antioxidant response element promoter regions of p62/Bcl

198 ted diminished Nfe2l2 protein binding to the antioxidant response element promoter site proximal to t

199 ne of the genes expressed in response to the antioxidant response element promoter.

200 ional inducers is mediated indirectly via an antioxidant response element rather than a xenobiotic re

201 KPEV activated Keap1/Nrf2 pathway leading to Antioxidant Response Element-regulated enzymes upregulat

202 atotoxicity caused by oxidative stress using antioxidant response element reporter gene assay models

203 failed to interact with Keap1 or activate an antioxidant response element reporter gene due to the ab

204 lination appear normal, when crossed with an antioxidant response element reporter line, the mutant m

205 lity that Nrf1 plays a role in mediating the antioxidant response element response.

206 leading to transcription of genes under the antioxidant response element, resulting in HCMV inhibiti

207 r factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element signaling and decreased act

208 ectrophilic stress is activation of the Nrf2-antioxidant response element signaling pathway, which co

209 resses including unfolded protein responses, antioxidant response element signaling, autophagy, mitop

210 f2 (nuclear factor E2-related factor 2)/ARE (antioxidant response element) signaling system.

211 S-transferase) functions via the stress- or antioxidant-response elements (StRE/ARE).

212 ref(2)P promoter also contains a functional antioxidant response element that is directly bound by t

213 The NF-E2 binding site is a subset of the antioxidant response elements that have the sequence GCN

214 The HO-1 promoter region contains antioxidant-response elements that can bind the transcri

215 While higher exposures trigger cellular antioxidant response elements, the released ROS induce o

216 whereas deacetylation disengages it from the antioxidant response element, thereby resulting in trans

217 d Nrf2, a transcription factor that binds to antioxidant response elements, thus activating them.

218 o lycopene, focusing on the induction of the antioxidant response element transcription system and th

219 (K-Loop) of mVP24 leading to upregulation of antioxidant response element transcription, which is dis

220 In addition, a possible role of the Nrf2-antioxidant response element transcriptional pathway in

221 lex distinct from AP-1, but specific for the antioxidant response element, were detected.

222 wn transcription factors albumin binds to an antioxidant response element, which controls the express