ライフサイエンスコーパス: antiport

1 re opening by lowering the matrix pH (Pi/OH- antiport).

2 fied that inhibits CAX1-mediated Ca(2+)/H(+) antiport.

3 feature involved in regulation of Ca(2+)/H+ antiport.

4 r fully protonated malate)/Na(+)-lactate(-1) antiport.

5 es a simultaneous Na(+)/H(+) and malolactate antiport.

6 es that are responsible for proton/multidrug antiport.

7 e impairment in the activity of the Na(+)-H+ antiport.

8 dversely affect the activity of the Na(+)-H+ antiport.

9 of TetA(L) in mediating electrogenic NA+/H+ antiport.

10 ates erythrocyte sugar uniport but not sugar antiport.

11 acellular K(+) binding, which precluded K(+) antiport.

12 mono-, di-, and triphosphates by uniport and antiport.

13 two states would result in rapid Na(+)/H(+) antiport.

14 MdtM to catalyse electrogenic bile salt/H(+) antiport.

15 from the thylakoid lumen by proton/potassium antiport.

16 nd transport required for alternating access antiport.

17 pointing to electrogenic 3H(+)/propidium(2+) antiport.

18 nsistent with electrogenic 2H(+)/ethidium(+) antiport.

19 lecular movements that underlie CLC-mediated antiport.

20 iport, whereas both AmhT and AmhMT exhibited antiport.

21 ), with the latter being due to a Na(+)/H(+) antiport.

22 h), all of which exhibited Na(+)(Li(+))/H(+) antiport.

23 g on the exact conditions, reversed Na+-Ca2+ antiport.

24 rules generally deemed essential for coupled antiport.

25 which are inhibitors of the sodium-hydrogen antiport.

26 condary carriers catalyzing substrate/cation antiport.

27 to be facilitated by a putative H+/arginine antiport.

28 n their concentration gradients, protons are antiported.

29 Electroneutral monovalent cation/proton antiport across the chloroplast envelope has been shown

30 K(+)/H(+) antiport across the thylakoid membrane via K+ EXCHANGE A

31 at both yeast and fish CAXs have Ca(2+)/H(+) antiport activities.

32 er that also exhibits monovalent cation/H(+) antiport activity and a net K(+) uptake mode.

33 can essentially ablate this lysosomal Cl-/H+ antiport activity and can strongly diminish the ability

34 aCl-induced increases in V-ATPase and Na+/H+ antiport activity are independent of plant age.

35 strated increased tonoplast-enriched Ca2+/H+ antiport activity as well as increased Ca2+ accumulation

36 onent of the relatively high affinity Na+/H+ antiport activity available to extrude the Na+ and to co

37 H increases beyond the optimum, electrogenic antiport activity ceases, and cytoplasm acidification is

38 runcated VCAX1 had approximately 70% greater antiport activity compared with full-length VCAX1.

39 -borne tetA(L) and related tet(K) genes; the antiport activity conferred by the tet(K) gene had an ap

40 +-translocating ATPase (V-ATPase) and Na+/H+ antiport activity in Mesembryanthemum crystallinum, lead

41 , H(+)-PPase, and (ADP-dependent) H(+)/Na(+) antiport activity in the same compartment.

42 a significant amount of the Na(+),K(+)/H(+) antiport activity in tonoplast vesicles.

43 ize that regulated expression of Ca(2+)/H(+) antiport activity is critical for normal growth and adap

44 Ca(2+)/H(+) antiport activity measured from vacuolar-enriched membra

45 o be an integral membrane protein and has no antiport activity of its own.

46 ode of the electrogenic monovalent cation/H+ antiport activity of TetA(L) and TetK in which K+ takes

47 However, here we show that we can switch the antiport activity of the bacterial Na(+)/H(+) antiporter

48 , leading to the inhibition of the K(+)/H(+) antiport activity of YcgO.

49 transformants was detected after the H+/Ca2+-antiport activity was eliminated with bafilomycin A1 and

50 No Orf9-dependent K+(Na+)/H+ antiport activity was found in membrane vesicles.

51 Na+/H+ antiport activity was induced in both juvenile and adult

52 bit a 50% reduction in tonoplast Ca(2+)/H(+) antiport activity, a 40% reduction in tonoplast V-type H

53 vesicles from hum1 mutants lack all Ca2+/H+ antiport activity, demonstrating that Hum1p catalyzes th

54 S1cl7 had greater H(+)-PPiase and Na(+)/H(+) antiport activity, respectively, than the WT.

55 tionally lacks vacuolar membrane Zn(2+)/H(+) antiport activity.

56 logical phenotypes or alterations in Ca2+/H+ antiport activity.

57 kalinization being driven by the Ca(2+)/H(+) antiporting activity of the plasma membrane Ca(2+)-ATPas

58 chloride/nitrate and a chloride/bicarbonate antiport agent for lipid bilayer transmembrane anion tra

59 very of H+ and HCO3- to Na+/H+ and Cl-/HCO3- antiports, also reduced IOP by 2.9 +/- 0.6 mm Hg.

60 Tet(L)-12 catalyzed Na+/H+ antiport and antiport with K+ as a coupling ion as well

61 of TVP1 and TNHXS1 increased both Na(+)/H(+) antiport and H(+)-PPiase activities and induced the H(+)

62 arply, and recovery required both Na(+)/H(+) antiport and proton current.

63 that LmrP mediates selective calcium/proton antiport and raise interesting questions about the funct

64 s of both transporters catalyze electrogenic antiport and that demonstration of electrogenicity depen

65 Mrp catalyzes secondary Na+/H+ antiport and was hypothesized to have an additional prim

66 al transporters, including reversed Na+-Mg2+ antiport and, depending on the exact conditions, reverse

67 es exhibited a reduction in vacuolar Mn2+/H+ antiport and, like cax1 mutants, reduced V-type H+ -ATPa

68 ey are energized and regulated by symported, antiported and allosteric ions on both sides of the memb

69 possibly by both paired Na+/H+ and Cl-/HCO3- antiports and a bumetanide-sensitive Na+-K+-2Cl- symport

70 mediating either calcium or potassium/proton antiport, and facilitating mitochondrial translation.

71 ing K(+)/H(+) (KHA1), Na(+)/H(+)-K(+) (GerN) antiport, and ligand-gated ion channel (KefC).

72 K(m)(app) for 3-O-methylglucose uniport and antiport are unaffected by metabolic poisoning.

73 abbit ciliary epithelium indicating that the antiports are the dominant mechanism.

74 rescent-based assays confirm the Cl(-)/anion antiport as the operational mechanism of the ion transpo

75 Antiport blockade is known to decrease the internal pH o

76 ot only act as carriers for Cl(-) /NO(3) (-) antiport but can also perform the cotransport of PrNH(3)

77 isolated from the mutant showed high H+/Ca2+-antiport but no Ca2+-pump activity.

78 t was consistent with a secondary Na(+)/H(+) antiport, but YqkI-dependent Na(+) uptake depended on in

79 (2+), and Mg(2+) did not support significant antiport by any of the test antiporters.

80 ires VMAT function and results from net H(+) antiport by VMAT out of the vesicle lumen coupled to inw

81 Here a K(+)/H(+) antiport capacity was demonstrated for YhaTU, AmhMT, and

82 6-phosphates is mediated by the P(i)-linked antiport carrier, UhpT, a member of the major facilitato

83 pressing ClC-3 (Ad-ClC-3) induces Cl(-)/H(+) antiport current (I(ClC-3)) in HEK293 cells.

84 ing that it translocates only one proton per antiport cycle.

85 t of a virtual proton from the cytoplasm per antiport cycle.

86 nal domain of 550 residues that precedes the antiport domain appears to tether the full-length AtKEA2

87 lectrogenic and do not result from secondary antiport effects.

88 etailed mechanism of CLC-mediated Cl(-)/H(+) antiport, especially for mammalian isoforms.

89 al/H+ antiport for both proteins; Na+(K+)/H+ antiport for both proteins; and an electrical potential-

90 These include: tetracycline (Tc)-metal/H+ antiport for both proteins; Na+(K+)/H+ antiport for both

91 hosphate into vesicles by H(2)PO(4)(-)/Cl(-) antiport, H(2)PO(4)(-) uniport, and Cs(+)/H(2)PO(4)(-) s

92 pal mechanistic elements of proton/substrate antiport have been described, the structural record is l

93 f tetracycline-cobalt/H+, Na+/ H+, and K+/H+ antiport in an assay in which an outwardly directed prot

94 This impaired activity of Na(+)-H+ antiport in CRF was observed in all external concentrati

95 aA can still support electrogenic Na(+)/H(+) antiport in EcNhaA, but has reduced thermal stability.

96 led to catalyze either Tc-metal/H+ or Na+/H+ antiport in energized everted vesicles.

97 Tet(L) but exhibited no tetracycline-Me2+/H+ antiport in Escherichia coli vesicles.

98 d with reduction in the activity of Na(+)-H+ antiport in hepatocytes; (2) this defect is due to the s

99 Standard fluorescence-based assays of Mrp antiport in membrane vesicles from Escherichia coli tran

100 stent with the presence of an active Ca2+/H+ antiport in the thylakoid membrane.

101 ling chambers that coordinate Cl(-) and H(+) antiport in the transporters-are contained wholly within

102 ificantly inhibited KefFC-mediated K(+)/H(+) antiport in vesicles.

103 we examined the possible role of Na(+)/H(+) antiport in Yersinia pestis virulence and found that Y.

104 This study examines the activity of Na(+)-H+ antiport, intracellular pH (pHi), and buffering capacity

105 y unobserved lowering of IOP when the Na+/H+ antiport is also inhibited substantiates a dominant anti

106 bility, that is, proton hopping, hole/proton antiport is identified to account for long-distance char

107 data strongly suggest that intact Na(+)/H(+) antiport is indispensable for the survival of Y. pestis

108 plants, high capacity tonoplast cation/H(+) antiport is mediated in part by a family of cation excha

109 plants, high capacity tonoplast cation/H(+) antiport is mediated in part by a family of CAX (cation

110 best understood model system for Na(+)/H(+) antiport is NhaA from Escherichia coli, for which both e

111 ty of both tetracycline-cobalt/H+ and Na+/H+ antiports is presented.

112 tration, mediated by the V-ATPase and Na+/H+ antiport, is regulated through ABA-independent pathways.

113 SERT, however, antiports K(+) and achieves voltage-independent transpor

114 trong enough signals for characterization of antiport kinetics.

115 The antiport mechanism accounts for the H(+) uptake involved

116 acilitate the transport of ADP and ATP by an antiport mechanism across the inner mitochondrial membra

117 Selective transport of chloride ions via an antiport mechanism and channel formation in the lipid bi

118 deoxy)nucleoside di- and triphosphates by an antiport mechanism and SLC25A36 cytosine and uracil (deo

119 Uptake activity showed latency, exhibited an antiport mechanism of transport with GMP, and was suscep

120 s a specific transporter that act through an antiport mechanism with PAP as the returning ligand, the

121 ic transporter of PAPS which acts through an antiport mechanism with PAP as the returning ligand.

122 This scenario is distinct from the canonical antiport mechanism, in which both substrate and counteri

123 ollapses the proton motive force by a proton antiport mechanism, in which extracellular protons are e

124 t is also inhibited substantiates a dominant antiport mechanism.

125 ntrations of PAP supports the function of an antiport mechanism.

126 CPA2 subset may use a channel rather than an antiport mechanism.

127 ective and transports ions via an OH(-)/X(-) antiport mechanism.

128 export substrates using a monovalent cation antiport mechanism.

129 phonium (TPP(+)) out of the cell by a proton antiport mechanism.

130 availability of structures, the symport and antiport mechanisms still need to be clarified.

131 Antiport mechanisms then exchange decarboxylation produc

132 ry exchange (also referred to as uniport and antiport mechanisms, respectively).

133 xport diverse drug substrates, it can couple antiport of a drug to either one or two protons, perform

134 The activity of the Na(+)-H+ antiport of hepatocytes from CRF animals was significant

135 (dDAT), also couple substrate uptake to the antiport of K(+) by a largely undefined mechanism.

136 s thaliana revealed that PAPST2 mediates the antiport of PAP, PAPS, ATP, and ADP.

137 ion binding site is essential for both anion antiport of SLC26A4 and motor functions of SLC26A5, and

138 bonding networks and are essential for anion antiport of SLC26A4 but not for motor (SLC26A5) and unco

139 lyaromatic cations due to its proton-coupled antiport of these substrates.

140 the inter- play of different ions (symport, antiport) or by ATP consumption (ATPases).

141 , maintaining stoichiometric proton/chloride antiport over a wide range of proton and chloride concen

142 Of the six possible combinations of antiport partners, Glu(+)/GABA(0) results in proton infl

143 acid-efflux mechanisms, such as the Na(+)-H+ antiport pathway and the Na(+)-independent Cl(-)-HCO3- e

144 present a novel ATP and Na+-dependent Cl-/H+ antiport process that (1) may be directly mediated by th

145 a lesser extent an unusual chloride/sulfate antiport process.

146 n, leads to severe slowing of the Cl(-)/H(+) antiport rate.

147 es of the polar region have little effect on antiport rates.

148 also took up [3H]aspartate in a heterologous antiport reaction that was stimulated or inhibited by an

149 f the physiologically relevant G3P-phosphate antiport reaction were characterized at different temper

150 Despite long-standing dogma that Na(+)/H(+) antiport regulates pH during the phagocyte respiratory b

151 nature of this coupling and the mechanism of antiporting remain topics of debate.

152 dily understood in terms of alternating-site antiport schemes.

153 m antiporter Gdx, reproduce the 1H(+):2Cl(-) antiport stoichiometry of CLC-ec1, and confirm loose pro

154 nt in normoxic avian erythrocytes, but sugar antiport (sugar uptake coupled to sugar exit) is present

155 s mesophyll vacuoles through a specific H(+) antiport system and not by an ion-trap mechanism or ABC

156 higher levels of secondary Na(+)(Li(+))/H(+) antiport than previously reported.

157 We present a free-exchange model for EmrE antiport that is consistent with these results and recap

158 The antiport to uniport switch mechanism requires ATP hydrol

159 Harnessing proton antiport, VMATs enrich monoamines around 10,000-fold and

160 ctrical potential (DeltaPsi), Mrp Na(+)/H(+) antiport was shown to be DeltaPsi consuming, from which

161 ysis to explore possible mechanisms for this antiport, we propose that Cl(-)/H(+) exchange involves a

162 in was required for YhaU- and KefC-dependent antiport, whereas both AmhT and AmhMT exhibited antiport

163 be more efficient than the Cl(-) /NO(3) (-) antiport, which is not the case with receptors without a

164 lso imply that AmhMT catalyzes NH(4)(+)/H(+) antiport, which would prevent net cytoplasmic H(+) loss

165 We postulate that Thl may be exported in antiport with H(+) and that Lys may be a low-affinity ex

166 Tet(L)-12 catalyzed Na+/H+ antiport and antiport with K+ as a coupling ion as well as or better

167 substrate-loaded transporter, thus enabling antiport without dissipation of the proton gradient.