ライフサイエンスコーパス: antisense strand

1 while the intron-encoded protein cleaves the antisense strand.

2 originating from two different places in the antisense strand.

3 ereas the intron-encoded protein cleaves the antisense strand.

4 for a substrate that contained a 2'-methoxy antisense strand.

5 r activity than a siRNA with a 23-nucleotide antisense strand.

6 d using 'click' chemistry was annealed to an antisense strand.

7 e strand, but only at a few positions in the antisense strand.

8 base 10 and 11 relative to the 5' end of the antisense strand.

9 A precursors, rasiRNAs arise mainly from the antisense strand.

10 ethylation of the Ets site (5'CCGGAG) on the antisense strand.

11 oop and a U1-4 3' overhang at the end of the antisense strand.

12 lement C3 gene locus which is encoded on the antisense strand.

13 porated at the tested positions of sense and antisense strands.

14 aracteristically different between sense and antisense strands.

15 equence, and the first intron start sites on antisense strands.

16 and a slow elongation rate to both sense and antisense strands.

17 yme (class I aaRS homolog) via its sense and antisense strands.

18 at are different for the converted sense and antisense strands.

19 A sequence with high identity to the 736 antisense strand (17 of 19 bases) is present within the

20 anscriptional products of both the sense and antisense strands across the IIa-IIx-IIb MHC gene locus.

21 iRAPs encoded in the antisense strand also promote gene expression by reducin

22 ghest potential to form strong duplexes with antisense strands also have the greatest tendency to be

23 ApoE AS1 is transcribed from the antisense strand and is complementary to exon 4 of ApoE

24 (NUDT6) protein is encoded from FGF2 gene's antisense strand and its role in the regulation of affec

25 With the exceptions of position 2 of the antisense strand and position 11 of the sense strand, th

26 RAPs coordinate Rho activity at the antisense strand and terminate antisense transcripts.

27 r occurred in untranslated leader sequences, antisense strands, and intergenic regions.

28 found only at the expected frequency on the antisense strands, and they are underrepresented within

29 The antisense strands are isolated and hybridised with a sen

30 ly generated from the sense strand at Map2b, antisense strand at Nefl, and both strands at Vim were i

31 Modification in the seed region of the antisense strand at position 6 or 7 resulted in an activ

32 Additionally, placement of the antisense strand at position 7 mitigated seed-based off-

33 been directed to the genomic features of the antisense strand at the HD locus, though the presence of

34 It is probably generated in the antisense strand between the consensus bases 3'-AA and T

35 ch silencer function of 5'SHS is mediated by antisense strand binding proteins, possibly by stabilizi

36 predominantly dissociated into the sense and antisense strands by collisional activation.

37 Antisense-strand cleavage requires additional interactio

38 Antisense-strand cleavage requires additional interactio

39 hich cDNAs are incorporated at a nick at the antisense-strand cleavage site.

40 artial or complete reverse splicing, and the antisense strand cleaved by the intron-encoded protein.

41 evaluation of siRNAs with the 3' termini of antisense strands conjugated to GalNAc for the first tim

42 Computational models of siRNA antisense strands containing TNA bound to Argonaute 2 su

43 at relatively low temperatures, whereas the antisense strand, d(AGAAT)9, does not form a structure e

44 s can act directly to mediate RNAi, with the antisense strand determining mRNA target specificity.

45 s C virus replicon RNA dissociates, and only antisense strand distributes in the cytoplasm of the cel

46 We demonstrate that the sense and antisense strand DNA mutagenesis at the immunoglobulin h

47 The distribution of sense and antisense strand DNA mutations on transcribed duplex DNA

48 e of a single 5'p-rN1-(2'-5')-N2 unit in the antisense strand does not alter the 'clover leaf' bend a

49 racteristically interacted with the unwound, antisense strand E7 siRNA.

50 The antisense strand encodes miR-214, which is transcribed b

51 lecule selected to target ICAM-1 through its antisense strand exhibited broad anti-TNF activities.

52 The HTLV genome antisense-strand genes hbz and aph-2 are often the only

53 ne might produce functional species from its antisense strand has not been examined.

54 encing complex (RISC) assembly the guide (or antisense) strand has to separate from its complementary

55 subject to non-coding transcription of their antisense strand; however the genome-wide role for antis

56 pelling hairpin structures on both sense and antisense strands; however, the possibility that a miRNA

57 tion depends on the presence of a functional antisense strand in the siRNA duplex, suggesting that vi

58 d 4,000 predicted ORFs was observed from the antisense strand, indicating that most of the genome is

59 are well tolerated on the sense, but not the antisense, strand, indicating that the two trigger stran

60 nucleic acid interactions and loading of the antisense strand into the RNA-induced silencing complex

61 tebrates are endogenously processed on their antisense strands into mature miRNAs with distinct seeds

62 ctive than native siRNA if the center of the antisense strand is not modified.

63 5' hydroxyl termini of antisense strands isolated from human cells were phospho

64 y associated with ANA modification of the 5'-antisense strand may be due to reduced phosphorylation a

65 The addition of a G at 5' end of the antisense strand may enhance the efficacy of gene silenc

66 Introducing an additional mismatch in the antisense strand may improve the selectivity.

67 vestigate 3' exonuclease activity toward the antisense strand metabolism.

68 Extensive modification of the antisense strand minimally affected 5'-phosphorylation o

69 A siRNA with a GalNAc-conjugated antisense strand of 22 nucleotides had better activity t

70 Southwestern blot analysis revealed that the antisense strand of 5'SHS binds to nuclear proteins of m

71 study identified 45 321 tags that match the antisense strand of 9804 known mRNA sequences, 6606 of w

72 tron (e.g. mirtrons in animals), or from the antisense strand of a protein coding gene (natural antis

73 e (COIN module) that lies inertly within the antisense strand of a resident gene.

74 he status of the 5' hydroxyl terminus of the antisense strand of a siRNA determines RNAi activity, wh

75 Finally, we show that on the antisense strand of Alus, a non-CpG site just downstream

76 chromosome-wide effects of ASAR6 map to the antisense strand of an L1 retrotransposon within ASAR6 R

77 ng RNA (lncRNA) that is transcribed from the antisense strand of homeobox C gene locus in chromosome

78 A basic leucine zipper region located in the antisense strand of HTLV-1, believed to play a role in v

79 eveal a new open reading frame, ORF0, on the antisense strand of human LINE-1 encoding a small regula

80 HTLV-1 encodes a protein from the antisense strand of its proviral genome, the HTLV-1 basi

81 the antisense SAGE tags originated from the antisense strand of known mRNA sequences included in the

82 d2 (Per2) locus that is transcribed from the antisense strand of Per2 This transcript, Per2AS, is exp

83 ), a recombinant protein translated from the antisense strand of PR3 cDNA.

84 ous screens missed small RNAs encoded on the antisense strand of protein-coding genes and small RNAs

85 The study of the antisense strand of siRNAs demonstrated that activity de

86 the mismatches were centrally placed in the antisense strand of small interfering RNAs.

87 non-coding RNA (lncRNA) that arises from the antisense strand of SMN, SMN-AS1, which is enriched in n

88 The antisense strand of such a mismatched RNA requires a 5'-

89 using a cryptic polyadenylation site in the antisense strand of the adjacent MPP1 gene, normally loc

90 erated transgenic Arabidopsis expressing the antisense strand of the AtRanBP1c gene to understand the

91 were detected by their hybridization to the antisense strand of the complementary promoter-directed

92 n 50 makes contacts with two guanines on the antisense strand of the DNA, adjacent to the TAAT core D

93 The antisense strand of the dsRNA determined target specific

94 on nucleotide modifications in the sense or antisense strand of the dsRNA in insects and demonstrate

95 A novel 2986-base transcript encoded by the antisense strand of the HRES-1 human endogenous retrovir

96 The antisense strand of the HTLV-1 genome encodes HBZ, a nov

97 The antisense strand of the HTLV-1 genome encodes HTLV-1 bas

98 PH-2), whose messenger RNA is encoded by the antisense strand of the HTLV-2 genome.

99 The antisense strand of the HTLV-2 proviral genome also enco

100 Targeting the antisense strand of the L1 within ectopically expressed

101 of a validated novel miRNA derived from the antisense strand of the miR-203 locus, which plays a rol

102 We also found transcripts from the antisense strand of the mudrA gene in all cell types in

103 This putative protein is encoded on the antisense strand of the provirus genome and entirely ove

104 rough RNAPII promoters are recognized by the antisense strand of the siRNA and function as a recognit

105 ology study, TNA placed at position 7 of the antisense strand of the siRNA mitigated off-target effec

106 er seed region (positions 2-7 or 2-8) of the antisense strand of the siRNA.

107 It is not clear whether the antisense strand of the siRNAs bind directly to DNA or t

108 e-specific long noncoding RNA encoded by the antisense strand of the triadin gene, between exons 9 an

109 class that is processed from both sense and antisense strands of approximately 130 endogenous transc

110 Both sense and antisense strands of CRM and CentC, but not small interf

111 sequenced unambiguously using the sense and antisense strands of DNA.

112 ipelines that allow the mapping of sense and antisense strands of mitochondrial and RefSeq genes, the

113 a-sensitive quantification of both sense and antisense strands of siRNA independent of structural mod

114 sfection into mammalian cells, the sense and antisense strands of the duplex are transcribed by these

115 leotide tiling arrays representing sense and antisense strands of the entire nonrepetitive sequence o

116 sequence is obtained from both the sense and antisense strands of the insert region.

117 Sense and antisense strands of the parent duplex were synthesized

118 1 from class II, as complementary sense and antisense strands of the same ancestral gene.

119 RNAs (siRNAs) derive from both the sense and antisense strands of their double-stranded RNA precursor

120 n affinity-enhancing nucleoside, LNA, on the antisense strand, offers optimal duplex melting temperat

121 The activity did not bind to the antisense strand or to an RNA with three mutations in th

122 tation studies reveal that the 5' end of the antisense strand, or "seed" sequence, is critical for ac

123 nds, while modification at the 5' end of the antisense strand resulted in complete loss of activity.

124 5'-(E)-vinylphosphonate modification of the antisense strand resulted in GalNAc-sciRNAs that are pot

125 The 2'-O-MOE modification in the antisense strand resulted in less active siRNA construct

126 ediated transcription and translation of the antisense strand resulted in production of a 18.5-kDa pr

127 the dissociation of the individual sense and antisense strand siRNA anions was studied using ion trap

128 iated up-regulation of MALAT1 as well as its antisense strand TALAM1 occurs in breast cancer cells, b

129 rs were integrated at position 7 of an siRNA antisense strand, targeting transthyretin messenger RNA.

130 y exert their activities exclusively via the antisense strand that binds and silences designated targ

131 sidues were detrimental at the 5' end of the antisense strand, the siRNAs with ANA at position 6 or 7

132 This is followed by removal of antisense strands to generate an ssDNA pool for subseque

133 s approach is complicated by the presence of antisense strand transcription of expanded GGCCCC repeat

134 In addition, we detected previously unknown antisense strand transcription that produced natural ant

135 ral C4'alpha-epimer monomers in the sense or antisense strands triggered RNAi-mediated gene silencing

136 rotein gene (VSV-GFP) and one expressing the antisense strand (VSV-PFG).

137 odified ribonucleotides at the 5'-end of the antisense strand were less active relative to the 3'-mod

138 Both the sense and antisense strands were analyzed independently, and sever

139 the modified UNAs facilitate kinking of the antisense strand when incorporated at position 7.

140 -F sugar was generally well-tolerated on the antisense strand, whereas the 2'-O-Me showed significant

141 ense strand to the reverse complement of the antisense strand, which is protected from conversion by

142 ations at or near the 3' end of the sense or antisense strands, while modification at the 5' end of t

143 gene, ZNF127AS, that is transcribed from the antisense strand with a different transcript size and pa

144 ences derive from a template on the sense or antisense strand with similar frequency.

145 modeling of a complex of a GalNAc-conjugated antisense strand with the PAZ domain of Ago2 rationalize