ライフサイエンスコーパス: antitumor effect

1 nanosheets, showing a promising and enhanced antitumor effect.

2 F mutation rather than showing a synergistic antitumor effect.

3 ligands are more permissive of mAb-mediated antitumor effect.

4 es and thereby produces a strong and durable antitumor effect.

5 t an immune mechanism mediating the observed antitumor effect.

6 eficient mice, confirming a B-cell-dependent antitumor effect.

7 re cell transfer was required to mediate the antitumor effect.

8 on are potential mechanisms for the observed antitumor effect.

9 and CK2 inhibitor enhances 1,25D(3)-mediated antitumor effect.

10 secreted GM-CSF to have an immune-associated antitumor effect.

11 ctivation in established tumors has a potent antitumor effect.

12 ounding tumor tissue resulting in a vigorous antitumor effect.

13 ion to the tumor cells, resulting in a local antitumor effect.

14 the prodrug were sufficient, showed the best antitumor effect.

15 paclitaxel, thereby resulting in a profound antitumor effect.

16 h pathway cross-talk and display synergistic antitumor effects.

17 -2, can activate T and NK cells resulting in antitumor effects.

18 ggers lethal replication stress and profound antitumor effects.

19 ntly been shown to lead to both protumor and antitumor effects.

20 ulatory CARs in an effort to improve durable antitumor effects.

21 ted every 2 mo patients experienced additive antitumor effects.

22 ring mice also showed strong immune-mediated antitumor effects.

23 el, compound 3 had statistically significant antitumor effects.

24 BPTES nanoparticle monotherapy led to modest antitumor effects.

25 iple myeloma, which correlates with clinical antitumor effects.

26 PI3K inhibitors but does induce substantial antitumor effects.

27 sly unrecognized role of PLP binding in Pfn1 antitumor effects.

28 TLA-4 immune checkpoints leads to remarkable antitumor effects.

29 y or intraperitoneal) at levels that yielded antitumor effects.

30 hirsutinolide-mediated mechanisms to induce antitumor effects.

31 ified Bifidobacterium as associated with the antitumor effects.

32 ss broad-reaching effects in vivo, including antitumor effects.

33 unotherapy resulted in significantly greater antitumor effects.

34 /IL-24-driven autocrine loop, culminating in antitumor effects.

35 terial l-Met-degrading enzymes exerts potent antitumor effects.

36 ibition of its enzymatic activity could have antitumor effects.

37 escuing p53 pathway deficiency and promoting antitumor effects.

38 vated CD8 T cells, resulting in the observed antitumor effects.

39 suppression of ERK signaling and significant antitumor effects.

40 ion of the other population and compensatory antitumor effects.

41 utralization of IL-23 causes IL-12-dependent antitumor effects.

42 gramming in pyruvate impaired glycolysis and antitumor effects.

43 SARI expression is necessary for mda-7/IL-24 antitumor effects.

44 s broad range of physiological functions and antitumor effects.

45 is necessary and sufficient for progesterone antitumor effects.

46 eased beta-carotene consumption is linked to antitumor effects.

47 ion, which results in potent immune-mediated antitumor effects.

48 umors and may work with radiation to enhance antitumor effects.

49 immunotherapy still resulted in significant antitumor effects.

50 and developed by us have demonstrated potent antitumor effects.

51 bination of these 2 therapies might increase antitumor effects.

52 depletion of CD8(+) T cells abrogated these antitumor effects.

53 tanib concentration in tumor led to stronger antitumor effects.

54 reduced the occurrence of irAEs and enhanced antitumor effects.

55 ynamic (PK/PD) model to investigate observed antitumor effects.

56 of SHH-subtype medulloblastoma exerts potent antitumor effects.

57 alone, the combination exhibited a superior antitumor effect against trastuzumab-resistant tumor xen

58 s and inhibit colony formation with superior antitumor effects against aggressive and drug-resistant

59 ntricularly or intratumorally mediate potent antitumor effects against cerebral ATRT xenografts in mi

60 coumarin (5, SS5020), has been reported with antitumor effects against chemically induced mammary tum

61 d T-replete CBT may provide superior Tc1-Th1 antitumor effects against high-risk hematologic malignan

62 ning a CD28 signaling domain mediated potent antitumor effects against primary AML and MM while spari

63 B13 exerted its anti-invasive and antitumor effects against prostate cancer cells, with mi

64 eptor consensus half-site was found to exert antitumor effects against prostate cancer xenografts.

65 Moreover, the antitumor effects against U251 were significantly greate

66 ressing antitumor cytokines induces a potent antitumor effect and antitumor immunity by ameliorating

67 On their own, HDPDL1 exhibited no antitumor effect and CAd-VECPDL1 alone reduced tumors on

68 point inhibitor alpha-PD-1 provides the best antitumor effect and longest overall survival, and may b

69 However, its antitumor effect and mechanisms are context dependent an

70 The secondary endpoints were antitumor effect and safety (UMIN000009446).

71 fy H1.0 as a major mediator of Quisinostat's antitumor effect and suggest that sequential administrat

72 body titers, as well as partially diminished antitumor effects and altered carrier activities.

73 l studies, pomalidomide mediated both direct antitumor effects and immune activation by binding cereb

74 mmunosuppressive responses could augment the antitumor effects and induce an abscopal response.

75 iety of subcutaneous tumors mediated limited antitumor effects and induced significant cachexia and l

76 therapies are needed to achieve synergistic antitumor effects and provide much needed treatment pers

77 ed stimuli can offer improved, site-specific antitumor effects, and can improve the efficacy of conve

78 h neuroprotective, pro-neurogenic as well as antitumor effects, and in the current study we introduce

79 posed antitumor mechanisms, in vivo reported antitumor effects, and possible mechanisms that may expl

80 hough SPIR is an aldosterone antagonist, its antitumor effects are independent of the mineralocortico

81 euroendocrine tumors; however, data on their antitumor effects are limited.

82 However, the mechanisms underlying TIMP-2 antitumor effects are not fully characterized.

83 ion of SPIO-DOX and IRE demonstrate enhanced antitumor effect as compared with individual treatments

84 Antitumor effects, as assessed by tumor growth delay wer

85 Therefore, the antitumor effect associated to SHH deprivation, usually

86 l leaky tumor vascular system may have large antitumor effects at the tumor vascular level, and their

87 transcription factors, TiPARP exerts strong antitumor effects both in cell culture and in mouse xeno

88 pathway with an agent known to induce potent antitumor effects but now also appears to potently suppr

89 ed neuropathic pain without interfering with antitumor effects, but also reversed it once established

90 tivity was sufficient to induce the striking antitumor effect by activating the neuronal signaling an

91 upported by the fact that compound 10 exerts antitumor effect by inducing cell apoptosis through acti

92 rated that CB T cells mediated this enhanced antitumor effect by rapid infiltration of the tumor with

93 Moreover, anti-CTLA4 DVD induced potent antitumor effects by decreasing tumor-infiltrating Tregs

94 he Phoneutria nigriventer spider venom (PnV) antitumor effects by our group has shown that the venom

95 /RLX-PCDP-treated hMSCs elicited more potent antitumor effect compared to naked oAd/RLX or oAd/RLX-tr

96 ion of these 2 agents significantly enhanced antitumor effects compared with single-agent administrat

97 and prevented metastatic disease in vivo The antitumor effect correlates with the fact that pioglitaz

98 wn as an immunosuppressive cytokine, induces antitumor effects depending on CD8(+) T cells.

99 antimetastatic activity but lost its direct antitumor effects due to kinome reprogramming, which res

100 nges in tumor lesions and the improvement of antitumor effects from HBS-Fc-lv immunization were depen

101 Given that antitumor effects have correlated with increased host im

102 small clinical trials has yielded promising antitumor effects, highlighting the need of systematic a

103 lines and primary specimens and had a robust antitumor effect in a disseminated MM mouse model.

104 AT using (225)Ac-PSMA-I&T showed a promising antitumor effect in advanced metastatic castration-resis

105 immunodeficient mice and induced a superior antitumor effect in intrafemural multiple myeloma-bearin

106 together, Stattic inhibit Stat3 and display antitumor effect in NPC, and enhanced chemosensitivity a

107 However, rapamycin did not induce antitumor effect in the majority of tumors with activate

108 nvolvement of additional mechanisms in their antitumor effect in vivo.

109 This compound demonstrates robust antitumor effects in a Karpas-422 xenograft model when d

110 city (GI50 0.55 +/- 0.04 microM) and in vivo antitumor effects in a MIA PaCa-2 xenograft mouse model.

111 amatically potentiated the drugs' individual antitumor effects in a mouse model of breast cancer.

112 int molecules, such as CTLA4, provide robust antitumor effects in a subset of patients.

113 receptors (CARs) demonstrate potent clinical antitumor effects in a variety of blood cancers.

114 bilizing effects, and T-epoxide demonstrated antitumor effects in a xenograft model of breast cancer.

115 patients and importantly it exhibits strong antitumor effects in a xenograft model of neuroblastoma.

116 ce in vitro and was associated with enhanced antitumor effects in an in vivo xenograft model.

117 ur in vitro results suggest that MLN9708 has antitumor effects in breast cancer and can sensitize bre

118 HLA-restricted T cell responses can induce antitumor effects in cancer patients.

119 s, which contrast strongly with the powerful antitumor effects in conventional mouse models.

120 from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin in myeloi

121 ckade, CmAb-(IL10)(2) significantly improves antitumor effects in mice with advanced tumors.

122 IRB) cells, which displayed superior in vivo antitumor effects in mice.

123 SY-1365 demonstrated substantial antitumor effects in multiple AML xenograft models as a

124 ated T cells showed enhanced persistence and antitumor effects in murine T cell receptor and chimeric

125 ated for their tumor-targeting potential and antitumor effects in nude mice with tumors that were sen

126 ring a preclinical rationale to evaluate its antitumor effects in other cancers.

127 LX4032-resistant tumors and displayed potent antitumor effects in ovarian and prostate cancers.

128 Targeting CD73 results in favorable antitumor effects in pre-clinical models and combined tr

129 e examined the generation of immune-mediated antitumor effects in response to treatment by bortezomib

130 umoral immune response and their nonspecific antitumor effects in the B16F10 melanoma model, we found

131 or programmed death receptor-1 (PD-1) showed antitumor effects in treatment-naive tumors in orthotopi

132 anscription also correlates with significant antitumor effects in vitro and in vivo, including the re

133 e (to induce mitotic arrest) had synergistic antitumor effects in vitro, with minimal effect on norma

134 ibitors with HDAC inhibitors had synergistic antitumor effects in vitro.

135 Importantly, IL-36gamma exerted profound antitumor effects in vivo and transformed the tumor micr

136 astoma: PlGF/Nrp1 blockade results in direct antitumor effects in vivo, resulting in medulloblastoma

137 a potent induction of apoptosis in vitro and antitumor effects in vivo.

138 proliferation, induced apoptosis, and showed antitumor effects in vivo.

139 OM-trastuzumab (DAR 4) showed dose-dependent antitumor effects, including complete tumor eradications

140 nt with an anti-PD-L1 mAb had no significant antitumor effect, indicating that early, self-activating

141 nhanced targeted accumulation, and effective antitumor effects, indicating their potential as an anti

142 duced cytotoxicity in MM cell lines, and its antitumor effect is associated with suppression of the A

143 s provide new insights into endostatin whose antitumor effect is not limited to inhibiting angiogenes

144 etastases can occasionally elicit a systemic antitumor effect, known as the abscopal effect, but hist

145 thaferin A (WFA) is a steroidal lactone with antitumor effects manifested at multiple levels that are

146 Of these, copanlisib exerts the most potent antitumor effects, markedly inhibiting cell proliferatio

147 cisplatin/Nutlin-3 combination and enhanced antitumor effects more than either agent alone.

148 o the immune cell subset responsible for the antitumor effects observed.

149 The antitumor effect of 15-PGDH is mediated through its enzy

150 On the basis of our finding that the antitumor effect of 5-{4-[(1-methylcyclohexyl)methoxy]be

151 In the present study, we investigated the antitumor effect of a small molecule GSK-3beta inhibitor

152 ver, the molecular mechanisms underlying the antitumor effect of ailanthone on HCC have not been exam

153 Also, the therapeutic antitumor effect of an AnxA5-peptide fusion can be furth

154 Although the antitumor effect of anti-CD40/CpG did not require T cell

155 The SFK inhibitor dasatinib enhanced the antitumor effect of BKM120 and fulvestrant against estro

156 n or TNFalpha neutralization can restore the antitumor effect of BRAF inhibition in mice receiving Cp

157 STING-deficiency dramatically reduced the antitumor effect of cGAMP.

158 ockout mice, lumican significantly increased antitumor effect of chemotherapy.

159 ctivated type II NKT cells contribute to the antitumor effect of CpG in the B16 melanoma model.

160 Accordingly, a significantly decreased antitumor effect of dFdC was observed in mice bearing M.

161 In vitro studies investigated the antitumor effect of ErPC3 in 9L rat gliosarcoma cells.

162 Our findings demonstrate a potent antitumor effect of ErPC3 in vitro, in vivo, and ex vivo

163 bition of SCD1 significantly potentiated the antitumor effect of ferroptosis inducers in both ovarian

164 derstanding of the mechanisms underlying the antitumor effect of hormonal treatment and the rational

165 f anti-CD40/CpG did not require T cells, the antitumor effect of IC/anti-CTLA-4 was dependent on T ce

166 The antitumor effect of imiquimod is multifactorial, althoug

167 e we show that cGAS is indispensable for the antitumor effect of immune checkpoint blockade in mice.

168 high molecular weight poly I:C improved the antitumor effect of IR.

169 notherapy, with an unanticipated cooperative antitumor effect of LDH inhibition and IL-21.

170 The antitumor effect of lymphodepletion/anti-PD-L1 therapy w

171 In most mice, the antitumor effect of MCMV was transient.

172 Similar antitumor effect of N6L has been observed in a highly an

173 This significantly enhanced antitumor effect of oAd/DCN/LRP-PEG-NT was mediated by a

174 We hypothesized that the potent antitumor effect of ONC201/TIC10 in colorectal cancer in

175 ation-generated neoantigens, potentiated the antitumor effect of PD-1 antibody or Flt3 ligand, and in

176 and that this activation is critical for the antitumor effect of PG545.

177 The antitumor effect of SNA vaccination is dependent on the

178 This potent antitumor effect of systemically administered oAd/RLX-PC

179 lls along with CD4 T cells further maximized antitumor effect of T cells in 2 different murine tumor

180 Most importantly, it could potentiate the antitumor effect of the anticancer drug paclitaxel.

181 The antitumor effect of the aptamer was nearly twofold stron

182 enesis, and was associated with an increased antitumor effect of the chemotherapy.

183 In mice, the antitumor effect of the Kit inhibitor imatinib is partia

184 These data suggest that the long-lasting antitumor effect of the prodrug is due to a combination

185 CD4(+) T cells were essential to the optimal antitumor effect of this combination treatment in an IFN

186 cation of CD4 T cells significantly enhanced antitumor effect of unmodified CD8 T cells.

187 The antitumor effects of 15a were also demonstrated in GIST4

188 ophagy inhibitor chloroquine potentiated the antitumor effects of 9-ING-41 when tested in combination

189 One implication of these results is that the antitumor effects of A(2A)R blockade that can be mediate

190 Similarly, inhibition of IL6R enhanced the antitumor effects of aflibercept in DU145 prostate tumor

191 1 (IRS-1), and IRS-1 knockdown enhances the antitumor effects of ALK inhibitors.

192 f the FAP(+) stromal cell also uncovered the antitumor effects of alpha-CTLA-4 and alpha-PD-L1, indic

193 bitor pictilisib (GDC-0941) can increase the antitumor effects of anastrozole in primary breast cance

194 activating and inhibitory FcgammaRs for the antitumor effects of antibodies targeting the TNFR gluco

195 colonic cells might be less sensitive to the antitumor effects of aspirin than BRAF-wild-type neoplas

196 cer and provide a mechanism for the proposed antitumor effects of beta-carotene.

197 immunologic mechanisms subtending the potent antitumor effects of bromodomain blockers.

198 The antitumor effects of calcineurin inhibitors are associat

199 human cancers, potentially neutralizing the antitumor effects of calcitriol, the active form of vita

200 ults provide biological explanations for the antitumor effects of CD19 CARs and for the observations

201 In addition, the antitumor effects of CD47 blockade required expression o

202 be an additional strategy to potentiate the antitumor effects of CDK4/6 inhibitors.

203 Here, we report the cellular and antitumor effects of CFI-402257, a potent (Mps1 Ki = 0.0

204 The antitumor effects of chemotherapies can in part be due t

205 Our results demonstrated potent antitumor effects of CmAb-(IL10)(2) with reduced toxicit

206 Here, we examined the antitumor effects of CMLD-2 in four thyroid cancer cell

207 We examined the antitumor effects of combined inhibition of these pathwa

208 RAF) signaling pathways, we investigated the antitumor effects of combining phenformin with a BRAF in

209 ibitor, indicated that microglia mediate the antitumor effects of CpG-C.

210 We find that the antitumor effects of CTLA-4 blockade depend on distinct

211 stimulator (ICOS) as a crucial player in the antitumor effects of CTLA-4 blockade.

212 ally deficient mice were used to dissect the antitumor effects of developmentally different NK cell s

213 -associated dendritic cells (DCs) attenuates antitumor effects of DNA vaccines.

214 mycin inhibitor BEZ235 (BEZ) potentiates the antitumor effects of doxorubicin (DOX) against pancreati

215 r heterogeneity, in order to interrogate the antitumor effects of EGFR-targeted drugs in mCRC (n = 40

216 Notably, DCA potentiated the antitumor effects of elesclomol, a pro-oxidative drug cu

217 The mechanism of action (MOA) underlying the antitumor effects of FL118 remains to be fully elucidate

218 Antitumor effects of HER3 and PI3K inhibitors alone and

219 ed induction of MCP-1, implicating it in the antitumor effects of IgE.

220 Overall, our findings clearly indicate that antitumor effects of IH may be mediated through modulati

221 stemness properties drastically improved the antitumor effects of IL1beta-cultured Th17 cells.

222 S-mediated inflammation is essential for the antitumor effects of immune checkpoint blockade.

223 ced DCs in mouse tumors enhanced the in vivo antitumor effects of immunostimulatory CpG DNA; however,

224 In the present study, we investigated the antitumor effects of inhibiting mTORC2 plus HSP90 in mou

225 -gamma plays a pivotal role in mediating the antitumor effects of IR therapy.

226 The local and systemic antitumor effects of IT-IC were inhibited by depletion o

227 on of tumor stroma, we evaluated the in vivo antitumor effects of MEDI-575 in tumor-bearing severe co

228 Its overexpression can overcome the antitumor effects of miR-1 and promote androgen-independ

229 was attenuated, exhibited resistance to the antitumor effects of nab-paclitaxel therapy.

230 We report the antitumor effects of nitric oxide (NO) releasing derivat

231 Here, we evaluated the antitumor effects of NK cell-based immunotherapy by seri

232 The antitumor effects of NT-7-16 were evaluated in an MDA-MB

233 ophils have an important role to play in the antitumor effects of oncolytic MV.

234 possible combination strategy to enhance the antitumor effects of OV in clinics.

235 ylation in uterine epithelial cells, and the antitumor effects of P4 are mediated by the endometrial

236 The antitumor effects of paclitaxel are generally attributed

237 s, and, notably, does not interfere with the antitumor effects of paclitaxel.

238 e or antibiotic-treated mice ameliorated the antitumor effects of PD-1 blockade, whereas FMT from non

239 e models of lymphoma, we determined that the antitumor effects of PG545 are critically dependent on N

240 ced immune activation and cereblon/ikaros in antitumor effects of pomalidomide in vivo is unknown.

241 The potent antitumor effects of PPD/polyIC should spur its developm

242 MyD88, is required for type I IFN-dependent antitumor effects of radiation.

243 However, studies comparing the therapeutic antitumor effects of radiolabeled SSTR agonists versus a

244 latory molecules CD137 and CD40 enhanced the antitumor effects of radiotherapy and promoted the rejec

245 osphorylation of certain RTKs, restoring the antitumor effects of sunitinib in models of acquired or

246 In this study, we assessed the antitumor effects of synthetic LXR agonist TO901317 in a

247 T-oligo can form a G-quadruplex and that the antitumor effects of T-oligo may be mediated through POT

248 The antitumor effects of targeting Dll4 were augmented signi

249 ion, and p300 inhibition similarly augmented antitumor effects of the adoptively transferred T cells.

250 t in LXR-deficient mice, indicating that the antitumor effects of the agonist depends on functional L

251 In this study, we report that the in vivo antitumor effects of the c-KIT inhibitor, dasatinib, on

252 The antitumor effects of the LIP-activated prodrug TRX-CBI,

253 Mechanistic studies showed that the antitumor effects of the tyrosine isomers were mediated

254 s on the molecular mechanisms underlying the antitumor effects of these drugs in CRC.

255 response is essential for the antiviral and antitumor effects of TLR activation, these findings are

256 ly, stable expression of CCL22 abrogated the antitumor effects of treatment with RLR or TLR ligands.

257 Additionally, CD4+ Th2 cells mediated the antitumor effects of TSLP, challenging the notion that T

258 nsplanted 4T1 tumors and had an even greater antitumor effect on lung metastases of the same mice, wh

259 ociated molecular pattern recognition exerts antitumor effects on peritoneal metastases by inducing c

260 ruit neutrophils that could have protumor or antitumor effects on tumor development.

261 As(2)O(3) exerted antitumor effects only in immunocompetent mice and enhan

262 t PD-1(FSY) exhibited strikingly more potent antitumor effect over the noncovalent wild-type PD-1, at

263 However, how PG545 exerts its antitumor effect remains incompletely defined.

264 These antitumor effects require host's effector T cells but no

265 Surprisingly, this combinatorial antitumor effect required an intact T-cell immune system

266 reatment of I-P@NPs@M + laser shows the best antitumor effect, resulting in 85.27 +/- 12.80% suppress

267 The antitumor effect stems from an induction of cell death i

268 that repeated MCMV injections sustained the antitumor effect, suggesting that active viral infection

269 ized macrophages are predicted to antagonize antitumor effects, targeting these cells may be importan

270 of cGAMP and PD-L1 antibody exerted stronger antitumor effects than did either treatment alone.

271 er is capable of inducing tumor immunity, an antitumor effect that results from enhanced function of

272 oirradiation of EA-BPS induces a synergistic antitumor effect that results from the combination of RO

273 Therefore, simvastatin possesses antitumor effects that are dependent upon the apoptotic

274 For long-term antitumor effects, this therapy altered the metabolism o

275 vity generated by the SMI MO-I-1100 leads to antitumor effects through inhibiting Notch signaling cas

276 own pleiotropic effects in vitro, including: antitumor effects through inhibition of lipogenesis; dec

277 bined with PD-1 blockade exerted synergistic antitumor effects through modifying TAMs in the TME and

278 other gene insertions that might enhance the antitumor effect, thus bringing the field closer to the

279 P-specific CD8 T cells, generating effective antitumor effect to prevent clinically relevant carcinog

280 FN system were absolute requirements for the antitumor effects to occur.

281 The mechanism(s) for this antitumor effect was associated with reduced activation

282 Mechanistically, the antitumor effect was due to an alteration in vascular fu

283 Finally, the antitumor effect was even more prominent when combined w

284 Antitumor effect was expressed as the tumor growth ratio

285 Molecular analysis revealed that the antitumor effect was linked to the reduction in molecula

286 eneic to the lymphoma demonstrated that this antitumor effect was mediated by alloreactive rather tha

287 Unexpectedly, an immune-independent antitumor effect was observed that depended on the ectop

288 The antitumor effect was transient in all tested groups.

289 tors of systemic immune responses, including antitumor effects, we hypothesized that components of th

290 These antitumor effects were reversed upon reconstitution with

291 These antitumor effects were significantly enhanced upon addit

292 ntrast, the same antiplatelet regimen had no antitumor effect when HCC was induced nonimmunologically

293 findings show that type I IFNs have a strong antitumor effect, which is at least in part explained by

294 , but not tissue-resident, Tregs, preserving antitumor effects while minimizing toxicity.

295 n (HCT) technology: balancing the beneficial antitumor effect with the harmful anti-host effect.

296 microenvironment, and demonstrated improved antitumor effects with a CAR T cell-intrinsic PD-1 block

297 Preclinical studies have suggested enhanced antitumor effects with combined mTOR and VEGF pathway-ta

298 linical models in mice and shows synergistic antitumor effects with current PCa drugs.

299 can be significantly increased, we observed antitumor effects with follow-up imaging, and single pat

300 t outcomes - considering tumor targeting vs. antitumor effect - with the goal to enable therapy custo