ライフサイエンスコーパス: antiviral defense

1 alled Cascade (CRISPR-associated complex for antiviral defense).

2 alled Cascade (CRISPR-associated complex for antiviral defense).

3 alled Cascade (CRISPR-associated complex for antiviral defense).

4 effector system, which plays a major role in antiviral defense.

5 gene expression and the RNA silencing-based antiviral defense.

6 Three vsRNA pathways are implicated in antiviral defense.

7 ransgenerational RNAi did not have a role in antiviral defense.

8 on response, a powerful branch of the innate antiviral defense.

9 ranscription of interferon genes and promote antiviral defense.

10 or effector arm of interferon (IFN)-mediated antiviral defense.

11 urvive in infected hosts with a multifaceted antiviral defense.

12 ochondrial apoptosis as a strategy of innate antiviral defense.

13 in eukaryotic cells and be programmed as an antiviral defense.

14 viral M protein, which is a new paradigm in antiviral defense.

15 Cs (pDCs) are typically thought to be key in antiviral defense.

16 hat DRB3 is involved in methylation-mediated antiviral defense.

17 as general transcriptional enhancers of the antiviral defense.

18 d Argonaute 4 (AGO4) in methylation-mediated antiviral defense.

19 ble for cytopathic effects and subversion of antiviral defense.

20 w viruses counter this apparently ubiquitous antiviral defense.

21 lindromic repeats (CRISPR) systems mediating antiviral defense.

22 red by the type I interferon is critical for antiviral defense.

23 re a critical component of the first line of antiviral defense.

24 disruption and underlines the role of SGs in antiviral defense.

25 bacterial defenses and reduced investment in antiviral defense.

26 infected cells is an important mechanism of antiviral defense.

27 ted the role of caspase-1 in epithelial cell antiviral defense.

28 n essential component of this host intrinsic antiviral defense.

29 s, the role of NbAGO2 might be primarily for antiviral defense.

30 role and mechanism of ISG15 modification in antiviral defense.

31 hagy in the homeostatic regulation of innate antiviral defense.

32 kinase R (PKR) is an important component of antiviral defense.

33 atterning, hematopoietic differentiation and antiviral defense.

34 d dendritic cells (pDCs) are key elements of antiviral defense.

35 nding miRNAs are a part of the host's innate antiviral defense.

36 c regulation of gene expression and mount an antiviral defense.

37 highlight the importance of type III IFNs in antiviral defense.

38 by increasing inflammation and compromising antiviral defense.

39 by infection and plays a key role in innate antiviral defense.

40 ransgenes, but it is seemingly redundant for antiviral defense.

41 ession of proteins involved in intracellular antiviral defense.

42 -encoded function to block the RNA silencing antiviral defense.

43 sion that play a critical role in the innate antiviral defense.

44 important indication of their relevance for antiviral defense.

45 rent understanding of viral counters to host antiviral defense.

46 sizing a critical role for NK cells in human antiviral defense.

47 clc prevented autoimmune disease but blocked antiviral defense.

48 ly controlled to ensure timely activation of antiviral defense.

49 , RNA interference (RNAi) is responsible for antiviral defense.

50 s to airway hyper-responsiveness and reduced antiviral defense.

51 e I IFNs are a cytokine family essential for antiviral defense.

52 e important effectors in interferon-mediated antiviral defense.

53 Autophagy functions as an intrinsic antiviral defense.

54 e increased, supporting their involvement in antiviral defense.

55 ry but do express many genes associated with antiviral defense.

56 ytosolic DNA sensing plays a pivotal role in antiviral defense.

57 indispensible for interferon production and antiviral defense.

58 st, typified by interferon (IFN), is a major antiviral defense.

59 een studied in a few proteins specialized in antiviral defense.

60 Type I interferon (IFN) is crucial in host antiviral defense.

61 es in CRISPR-Cas9 technology as a eukaryotic antiviral defense.

62 RNA silencing pathway comprises its primary antiviral defense.

63 tive roles of the IFN mediators in amphibian antiviral defenses.

64 nnate immune signaling and type 1 interferon antiviral defenses.

65 , replication, and suppression of the host's antiviral defenses.

66 interacts with its mammalian hosts to evade antiviral defenses.

67 vivo while avoiding triggering their hosts' antiviral defenses.

68 e developed to counteract these early innate antiviral defenses.

69 tem and DNA methylation are also critical to antiviral defenses.

70 pecific cellular factors to evade the host's antiviral defenses.

71 d make SARS-CoV more susceptible to the host antiviral defenses.

72 s the frontline in the arsenal of the host's antiviral defenses.

73 of the ICP0 protein in countering intrinsic antiviral defenses.

74 d reduction allows poxvirus to overcome host antiviral defenses.

75 the presence of viral molecules and inducing antiviral defenses.

76 ha and -beta]) constitutes the first line of antiviral defenses.

77 his AGO protein has evolved to specialize in antiviral defenses.

78 n, a modification known to mediate host cell antiviral defenses.

79 ly of the Toll pathway and the RNAi-mediated antiviral defenses.

80 d TLR3, which contribute to the induction of antiviral defenses.

81 n and evasion of the host's rapidly deployed antiviral defenses.

82 to disrupt RIG-I signaling and impede innate antiviral defenses.

83 iption factors controlling a multiplicity of antiviral defenses.

84 duced signaling pathways activating cellular antiviral defenses.

85 utes to the ability of HCV to control innate antiviral defenses.

86 e functions critical for effective localized antiviral defenses.

87 this suppression and restored intracellular antiviral defenses.

88 to facilitate viral replication and inhibit antiviral defenses.

89 exert effects on the host cell that promote antiviral defenses.

90 in HIV-1 and other RNA viruses to evade host antiviral defenses.

91 n response to IFN, potentially to antagonize antiviral defenses.

92 proteins have specialized, modular roles in antiviral defense across different tissues, and demonstr

93 gether, our data indicate that RNAi provides antiviral defense against dsDNA viruses in animals.

94 criptional gene silencing (TGS) is a natural antiviral defense against geminiviruses.

95 ll signalling, suggesting that Toll mediates antiviral defense against Kallithea virus infection but

96 milarity to Arabidopsis AGO2, is involved in antiviral defense against TBSV.

97 In the present study, we examined the innate antiviral defenses against mouse (m) and human (h) CMVs

98 interferons (IFNs), which were discovered as antiviral defense agents but were revealed to be compone

99 cascade that initiates innate intracellular antiviral defenses aimed at restricting the replication

100 nts are detected on Cas proteins involved in antiviral defense, an aspect of Cas biochemistry not con

101 Type I interferons (IFN-I) are a major antiviral defense and are critical for the activation of

102 ons (IFNs) are important mediators of innate antiviral defense and function by activating a signaling

103 the C. parasitica dicer gene responsible for antiviral defense and generation of virus-derived small

104 E4 (DCL4) performs dual functions, acting in antiviral defense and in development via the biogenesis

105 n (NS1A) plays a key role in countering host antiviral defense and in virulence.

106 on provides mechanistic insights into innate antiviral defense and potential antiviral prevention str

107 iously unrecognized mechanism for optimizing antiviral defense and set the stage for the discovery of

108 are influenced by type 1 interferon-mediated antiviral defenses and by viral countermeasures to these

109 a kinases, which are critically important in antiviral defenses and protection against environmental

110 connect epithelial cells, evading immune and antiviral defenses and provide an explanation for the in

111 stinctly altered immune responses in monocot antiviral defenses and provide insights into monocot vir

112 les the virus to counteract the human innate antiviral defenses and that NSs is one of the major dete

113 N-induced apoptosis, cell growth inhibition, antiviral defense, and chemotaxis.

114 Our data identify a role for neutrophils in antiviral defense, and establish a functional link betwe

115 assembly, suppression of RNA silencing-based antiviral defense, and long-distance movement in infecte

116 N) response is an important aspect of innate antiviral defense, and the transcription factor IRF3 pla

117 ry air impairs mucociliary clearance, innate antiviral defense, and tissue repair.

118 ted that La was required for efficient RNAi, antiviral defense, and transposon silencing in vivo.

119 RNA silencing in plants is a multivalent antiviral defense, and viruses respond by elaborating mu

120 nism that viruses use to suppress endogenous antiviral defenses, and provide potential targets for fu

121 eve one or more cellular outcomes, including antiviral defense, antiproliferative activities, and sti

122 hway activation, but their relative roles in antiviral defense are not well understood.

123 ighest viral loads and initial engagement of antiviral defenses are expected.

124 Innate cellular antiviral defenses are likely to influence the outcome o

125 rons (IFNs) play an important role in direct antiviral defense as well as linking the innate and adap

126 cytoid dendritic cells (PDCs) are central in antiviral defense because of their superior capacity to

127 r characterize the mechanism(s) of honey bee antiviral defense, bees were infected with a model virus

128 interferons (IFNs) are principal elements of antiviral defense but can cause autoimmunity if misregul

129 detection of nucleic acids is important for antiviral defense but is also associated with specific a

130 Both STAT1 and STAT2 are important for antiviral defense, but STAT1 has a unique role in protec

131 interferons (IFNs) are critical mediators of antiviral defense, but their elicitation by bacterial pa

132 viral mRNAs and helps combat cellular innate antiviral defenses, but little is known about its struct

133 cture (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition,

134 FNs play critical roles in orchestrating the antiviral defense by inducing direct antiviral activitie

135 ic CD4 T cells have the potential to mediate antiviral defense by multiple effector mechanisms in viv

136 oplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of viru

137 ve important implications for DCL4's role in antiviral defense by reducing the selective constraints

138 ) in plants and animals initiates a specific antiviral defense by RNA interference (RNAi).

139 ot enhanced, suggesting prevention of innate antiviral defense by ZIKV.

140 Type 1 interferons (IFN1) elicit antiviral defenses by activating the cognate receptor co

141 ing human cytomegalovirus (HCMV), blunt host antiviral defenses by limiting ISG expression, the overa

142 ode proteins that counteract PML NB-mediated antiviral defenses by multiple mechanisms.

143 st that regulation of IRF-3-dependent innate antiviral defenses by PLpro may contribute to the establ

144 V has evolved a mechanism to limit host cell antiviral defenses by sequestering NF-kappaB proteins in

145 chia coli, the CRISPR-associated complex for antiviral defense (Cascade) utilizes these RNAs to targe

146 ns that form a CRISPR-associated complex for antiviral defense (Cascade)-like complex are needed for

147 herichia coli "CRISPR-associated complex for antiviral defense" (CASCADE) is central in targeting inv

148 ese same cells showed that engagement of the antiviral defenses compromised ectoderm and endoderm for

149 that IL-6, although critical to establishing antiviral defense, contributes to pathogenesis when rele

150 g in insects and adversely affects honey bee antiviral defenses controlled by this transcription fact

151 We propose that reduced innate antiviral defenses coupled with exuberant inflammatory c

152 te MCMV infection to determine whether liver antiviral defense depends on signaling through these mol

153 macytoid dendritic cells (pDCs) are vital to antiviral defense, directing immune responses via secret

154 -beta in response to VSV plays a key role in antiviral defense during infection.

155 c acid-sensing TLRs in promoting early liver antiviral defense during MCMV infection.

156 t evidence for Gal-9 functioning as a potent antiviral defense effector molecule against HCMV infecti

157 al, nondegradative role in IFNgamma-mediated antiviral defense, establishing that multicellular organ

158 Highlighting its role in antiviral defense, fly Ago2 dissociates so slowly from e

159 the mode of target interference and role in antiviral defense for two CRISPR-Cas systems in Marinomo

160 B activation, attenuating expression of host antiviral defense genes and interrupting an IFN amplific

161 interferon-mediated response and hundreds of antiviral defense genes not observed following immunosti

162 orks of host resistance genes, RNA silencing/antiviral defense genes, and crucial transcriptional and

163 A possible role in C-to-U RNA editing or in antiviral defense has been discussed for other members.

164 cific TRIMs that contribute to TLR3-mediated antiviral defense have not been identified.

165 n development, differentiation and host cell antiviral defenses; however, roles in cancer biology are

166 ell as effects on the host cell that enhance antiviral defenses.IMPORTANCE Kaposi's sarcoma-associate

167 piRNA pathway does not play a major role in antiviral defense in adult Drosophila and demonstrates t

168 clease Argonaute 2 (Ago-2), is essential for antiviral defense in adult Drosophila melanogaster.

169 nt to which the piRNA pathway contributes to antiviral defense in adult flies.

170 topic expression of Lck/Hck/Fgr dampened the antiviral defense in cells and zebrafish.

171 pathways that generate them are also used in antiviral defense in higher eukaryotes, as they are in p

172 have established a novel role of miR-128 in antiviral defense in human cells, namely inhibiting HIV-

173 be an important early factor for the host's antiviral defense in Lepidoptera.

174 er, the importance of the RNAi pathway as an antiviral defense in mammals is unclear.

175 ent antimicrobial mechanism, but its role in antiviral defense in mammals is unclear.

176 The induction of the intrinsic antiviral defense in mammals relies on the accumulation

177 I interferon response, a major component of antiviral defense in mammals.

178 e, PKR, which plays a major role in cellular antiviral defense in mammals.

179 (piRNA) pathway also has been implicated in antiviral defense in mosquitoes infected with arboviruse

180 raising questions about its importance as an antiviral defense in mosquitoes.

181 RNA silencing is a potent means of antiviral defense in plants and animals.

182 st that BIR1 acts as a negative regulator of antiviral defense in plants, and indicate that RNA silen

183 While RNA silencing is a potent antiviral defense in plants, well-adapted plant viruses

184 RdDM components to counter RdDM-mediated TGS antiviral defense in plants, which extends our current u

185 ting that these proteins might contribute to antiviral defense in prokaryotes.

186 Innate inflammatory events promoting antiviral defense in the liver against murine cytomegalo

187 Antiviral defense in the liver during acute infection wi

188 mbdas therefore constitute the front line of antiviral defense in the lung without compromising host

189 tiviral pathway, plays no detectable role in antiviral defense in the midgut but only protects later

190 al regions in ICP0 involved in altering ND10 antiviral defenses in a cell culture model of HSV-1 infe

191 representative cell lines, supporting robust antiviral defenses in bat cells that correlated with hig

192 viruses is important in understanding innate antiviral defenses in birds.IMPORTANCE Birds are importa

193 Here, we examined antiviral defenses in CD4+ cells during virus infection

194 the robustness and redundancy of the innate antiviral defenses in fish.

195 Germ line encoded antiviral defenses in vertebrate cells tend to be either

196 atic activities not previously implicated in antiviral defense, including RNA editing and retron sate

197 clei of infected cells and inhibits multiple antiviral defenses, including a DNA damage response (DDR

198 earance and expression of genes required for antiviral defenses, including MDA5, RIG-I, TLR3, IRF7/9,

199 E4orf3, which functions to disrupt cellular antiviral defenses, including the DNA damage response pa

200 ions induce complex host responses linked to antiviral defense, inflammation, and tissue damage and r

201 llers, NK cells are also key helper cells in antiviral defense, influencing adaptive immune responses

202 During antiviral defense, interferon (IFN) signaling triggers n

203 nal signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladde

204 role played by many in RNA silencing-related antiviral defense is largely unknown, except for reports

205 This intrinsic antiviral defense is normally counteracted by ICP0, whic

206 Another important mechanism of host innate antiviral defense is represented by virus-induced mitoch

207 The major mechanism of antiviral defense is the small, interfering RNA pathway

208 lymphocytes and neutralizing antibodies for antiviral defense is well known, the antiviral mechanism

209 emonstrates that a potent antagonist of host antiviral defenses is encoded by multiple and diverse vi

210 coli, Cascade (CRISPR-associated complex for antiviral defense) is an RNA-guided surveillance complex

211 DNA methylation (RdDM) pathway is a natural antiviral defense mechanism against geminiviruses.

212 ever, the impact of silencing as a mammalian antiviral defense mechanism and the ability of mammalian

213 ce of RNA interference (RNAi) as a mammalian antiviral defense mechanism has been controversial.

214 In contrast, no general inducible antiviral defense mechanism has been reported in any inv

215 The role of RNA silencing as an antiviral defense mechanism in fungi was examined by tes

216 ted by siRNAs is an evolutionarily conserved antiviral defense mechanism in higher plants and inverte

217 Thus, RNAi is the predominant antiviral defense mechanism in insects that provides pro

218 ed regulatory process that has evolved as an antiviral defense mechanism in plants and animals.

219 RNA interference (RNAi) is an established antiviral defense mechanism in plants and invertebrates.

220 RNA silencing is a major antiviral defense mechanism in plants and invertebrates.

221 riptional gene silencing (PTGS), which is an antiviral defense mechanism in plants.

222 RNA silencing in plants serves as a potent antiviral defense mechanism through the action of small

223 g with other pathogenic stimuli, triggers an antiviral defense mechanism through the induction of IFN

224 > A hypermutation is an innate antiviral defense mechanism, mediated by host enzymes, w

225 Autophagy is a well-known cell-intrinsic antiviral defense mechanism.

226 IFNbeta induces cellular antiviral defense mechanisms and thereby contributes to

227 Among the multiple antiviral defense mechanisms found in prokaryotes, CRISP

228 mechanisms by which viral pathogens activate antiviral defense mechanisms in IECs are largely unknown

229 ssembly, and the ability to inhibit cellular antiviral defense mechanisms play an especially importan

230 ights the important function of Nod2 in host antiviral defense mechanisms.

231 as well as HIV-1 Vif-resistant intracellular antiviral defense mechanisms.

232 antiviral protein and provide insights into antiviral defense mechanisms.

233 enhance virus replication and to antagonize antiviral defense mechanisms.

234 ich is a key regulator of autophagy-mediated antiviral defense mediated by TANK-binding kinase 1 (TBK

235 ceptor-binding protein and a potential novel antiviral defense modulator are derived from dsRNA virus

236 ther viruses, VZV must subvert the intrinsic antiviral defenses of differentiated human cells to prod

237 interferons (IFNs), which are central to the antiviral defenses of other vertebrates.

238 RF-3-dependent signaling pathways and innate antiviral defenses of the host cell.

239 r, whether autophagy is a cell-type-specific antiviral defense or broadly restricts HSV-1 reproductio

240 sults further our understanding of honey bee antiviral defense, particularly the role of a non-sequen

241 protein that inhibits RNA silencing, a major antiviral defense pathway in insects.

242 R (PKR) is a key component of the interferon antiviral defense pathway.

243 KR) is a central component of the interferon antiviral defense pathway.

244 Innate antiviral defense pathways are altered in the asthmatic

245 vivo in recognizing viral RNA and activating antiviral defense pathways has remained controversial.

246 Important antiviral defense pathways that result in type I IFN pro

247 ediated activities that antagonize host cell antiviral defense pathways, such as host cell translatio

248 contributes to the evasion of intracellular antiviral defense programs.

249 st frequently in humans with a defect in the antiviral defense protein RNase L, suggesting a role for

250 revious assumptions, tadpoles possess intact antiviral defenses reliant on type III IFNs, which are o

251 as a tumor suppressor gene, but its role in antiviral defense remains unclear.

252 t functions in suppressing the RNA silencing antiviral defense response and in viral RNA replication,

253 te gene in the induction of an RNA silencing antiviral defense response and the promotion of viral RN

254 bited a striking enrichment in expression of antiviral defense response genes at 37 degrees C relativ

255 share a common pathway to trigger the innate antiviral defense response in human cells, although dsDN

256 er gene dcl2, required for the RNA silencing antiviral defense response in the chestnut blight fungus

257 emperature due, in part, to a less efficient antiviral defense response of infected cells at cool tem

258 We now report that the antiviral defense response requires only one of the four

259 Apoptosis is a potential antiviral defense response that has been shown to be imp

260 tica Dicer gene dcl2-dependent RNA-silencing antiviral defense response.

261 rating that WSP- and LAIV-induced changes in antiviral defense responses in the nasal mucosa occur in

262 virus burden in the periphery and brain, and antiviral defense responses were analyzed.

263 ther plant- and animal-infecting viruses and antiviral defense responses.

264 ndent processes are critical for propagating antiviral defense signals during viral infection.

265 RNA-induced silencing is a potent innate antiviral defense strategy in plants, and suppression of

266 cancer while resulting in vitro in deficient antiviral defenses, suggesting that prostate cancer coul

267 , bacteria and archaea have evolved a unique antiviral defense system composed of clustered regularly

268 DNA damage response (DDR), which acts as an antiviral defense system.

269 We found that pUL103 interacts with cellular antiviral defense systems and proteins involved in organ

270 cleotide second messengers are implicated in antiviral defense systems in bacteria and archaea as wel

271 nteraction between HCV and hepatocyte innate antiviral defense systems is not understood.

272 Here, we describe prokaryotic antiviral defense systems, such as receptor masking or m

273 obile genetic elements and rely on dedicated antiviral defense systems, such as restriction endonucle

274 chanisms also evolved to circumvent the host antiviral defense systems.

275 Here, we show that TRIM69 is an antiviral defense that can potently and specifically blo

276 ore identifies a previously unknown layer of antiviral defense that exerts its action on epithelial s

277 ) of a host organism represents an effective antiviral defense that is frequently manipulated and exp

278 Intrinsic immunity is an aspect of antiviral defense that operates through diverse mechanis

279 interfering RNAs (siRNAs) represents a major antiviral defense that the invading viruses have to over

280 uclear bodies are part of the cell-intrinsic antiviral defenses that restrict viral gene expression u

281 Based on their crucial role in antiviral defense, these ISGs may play an important role

282 IFN response is a key component to a host's antiviral defenses, this study has investigated the role

283 of VZV genes and to disarm the IFN-dependent antiviral defense through a novel mechanism that prevent

284 RNA (dsRNA) of virus origins mediate potent antiviral defense through a process referred to as RNA i

285 ng elicits interferon production for primary antiviral defense through cascades controlled by protein

286 LH86 cells mount an intact innate antiviral defense through induction of interferon and tr

287 efore, advances the general concept of broad antiviral defense through multihit targeting of a single

288 RNA silencing functions as an antiviral defense through the action of DICER-like (DCL)

289 tributes to homeostatic regulation of innate antiviral defense through the clearance of dysfunctional

290 al infection by inducing IFNs, which trigger antiviral defenses through IFN-stimulated gene (ISG) exp

291 N(pro) of pestiviruses counteracts cellular antiviral defenses through inhibition of IRF3.

292 resulted in the successful reconstitution of antiviral defenses through the direct up-regulation of I

293 interferon (IFN-I) is crucial for promoting antiviral defenses through the induction of antiviral ef

294 tion, and egress as well as the avoidance of antiviral defenses through the sequestration of key cell

295 mplex Cascade (CRISPR-associated complex for antiviral defense) uses CRISPR RNA (crRNA) guides to bin

296 ion of host and pathogen shaped the cellular antiviral defenses we know today.

297 of N in eukaryotic hosts having multifaceted antiviral defense, we demonstrate its interaction with N

298 iviral genes and that augmentation of innate antiviral defenses with IFN-alpha is a more effective st

299 m of regulation of TGF-beta signaling by the antiviral defense, with evidence for its role in immune

300 d from the early region E4 act to neutralize antiviral defenses, with a particular focus on DNA damag