ライフサイエンスコーパス: antiviral effect

1 into the immune mechanisms that mediate this antiviral effect.

2 osbuvir and ribavirin results in an additive antiviral effect.

3 GTPase activity, which was critical for its antiviral effect.

4 ith these lipoproteins further increased the antiviral effect.

5 on-alpha, which was essential for the innate antiviral effect.

6 agy promoted viral replication dampening the antiviral effect.

7 nation with pIFN-alpha, it has a synergistic antiviral effect.

8 oblasts indicated that host YB-1 mediates an antiviral effect.

9 ng HCV replication and mediating IFN-induced antiviral effect.

10 promote ZIKV infection while HuR exhibits an antiviral effect.

11 terferon protein has increased the protein's antiviral effect.

12 ical GFP-MxA condensates in cells showing an antiviral effect.

13 , suggesting host species specificity of the antiviral effect.

14 a and anti-TNF Abs significantly blocked the antiviral effect.

15 antagonizes the GTPase activity and thus the antiviral effect.

16 amma) are produced by immune cells to elicit antiviral effects.

17 iR-122 and a DAA had additive or synergistic antiviral effects.

18 tion of type I interferons with the expected antiviral effects.

19 biogenesis pathway to subvert miRNA-induced antiviral effects.

20 ect) and reduced NK cell-mediated (indirect) antiviral effects.

21 wnstream of TNFR1 and -2 with known pro- and antiviral effects.

22 and impaired promoter activity and displayed antiviral effects.

23 properties, but nothing is known about their antiviral effects.

24 ny of which have been investigated for their antiviral effects.

25 lso possess pleiotropic anti-inflammatory or antiviral effects.

26 es have developed strategies to overcome its antiviral effects.

27 ferons (IFNalpha/beta), which mediate potent antiviral effects.

28 is an interferon-stimulated gene that exerts antiviral effects.

29 ron stimulated genes (ISGs) that have direct antiviral effects.

30 IFN-alpha and increases the efficacy of its antiviral effects.

31 used in the treatment of HIV-1, exert their antiviral effects.

32 host defenses, including mucus and paracrine antiviral effects.

33 ducible genes and generation of IFN-mediated antiviral effects.

34 icating that the drug is not exerting direct antiviral effects.

35 ns, and different stimuli can activate these antiviral effects.

36 , IFITM3 packaging is not sufficient for the antiviral effects.

37 HCV-specific CD8 T cells and the downstream antiviral effects.

38 cts of TNF must be considered along with its antiviral effects.

39 virus infection, as it has both proviral and antiviral effects.

40 ed to induce both therapeutic and preventive antiviral effects.

41 e of T-cell immunity in mediating protective antiviral effects.

42 ly identified form of cell death with potent antiviral effects.

43 This conveys antiviral effects, activates other immune cells (NK cell

44 f pigs' innate immune defenses allows potent antiviral effects after Ad5-poIF7/3(5D) administration.

45 Overall, PCZ showed a previously unknown antiviral effect against DENV infection, and D2R may pla

46 r activity against PI4KB as well as profound antiviral effect against hepatitis C virus, human rhinov

47 the mechanism behind the type I IFN-mediated antiviral effect against HEV remains unclear.

48 FITM2 and IFITM3 have been described to have antiviral effects against a broad range of RNA viruses.

49 IL-12-polarized Th1 cells, displayed potent antiviral effects against a variety of viruses.

50 s, suggesting that such reagents may possess antiviral effects against both viral assembly and uncoat

51 2 (also known as Viperin)) that mediated the antiviral effects against different neurotropic viruses.

52 Cyclosporine, but not tacrolimus, has potent antiviral effects against HCV replication in cell cultur

53 evealing a network of host factors mediating antiviral effects against HCV, we identified EFTUD2 as a

54 stimulated genes (ISGs) and determined their antiviral effects against HCV.

55 Silymarin had antiviral effects against hepatitis C virus cell culture

56 of cancer and leukemia cell lines as well as antiviral effects against hepatitis C virus in the repli

57 (AuNP-PT) exhibit substantially more potent antiviral effects against HIV-1 than corresponding pepti

58 Lambda interferon (IFN-lambda) has potent antiviral effects against multiple enteric viral pathoge

59 se, and we show that miR-342-5p exerts broad antiviral effects against multiple, unrelated pathogenic

60 All samples were tested for antiviral effects against the human immunodeficiency vir

61 IFN-gamma and TNF-alpha also exerted antiviral effects against vesicular stomatitis virus inf

62 antiviral activity against VV by (1) direct antiviral effects against VV; and (2) stimulating the ex

63 n for all genotypes and showed the strongest antiviral effect among the retinoids tested.

64 contrast, miR-122 antagonism shows extensive antiviral effects among all HCV genotypes and a high bar

65 Consistent with its antiviral effect, AMPK activation potentiated the expres

66 lower level, the loss of interferon-induced antiviral effect and an increased availability of target

67 The combination exerted an additive antiviral effect and reduced heart pathology.

68 In addition to a direct antiviral effect and synergism with IFN, the SOCS antago

69 ding potential protective mechanisms such as antiviral effects and enhanced steroid responsiveness.

70 ingle treatments had additive or synergistic antiviral effects and helped to efficiently suppress HCV

71 n vivo treatment with histones did not yield antiviral effects and instead exacerbated lung pathology

72 determinants for the observed differences in antiviral effects and other biological functions.

73 y blocks NF-kappaB, likely to counteract its antiviral effects and promote efficient viral replicatio

74 jects were monitored for 58 days for safety, antiviral effects, and PRO 140 serum concentrations.

75 jects were monitored for 58 days for safety, antiviral effects, and serum concentrations of PRO 140.

76 that Silymarin exerts anti-inflammatory and antiviral effects, and suggest that complementary and al

77 In the present study, we investigated the antiviral effect as well as the potential immunomodulato

78 This antiviral effect, as well as the protective effect again

79 eta, which may play a role in the antagonist antiviral effect at the cellular level.

80 IFN-gamma mimetic to exert a multiplicative antiviral effect at the level of transcription, the cell

81 cytokines in signaling via IFNLR to mediate antiviral effects at mucosal surfaces.

82 into assembling virions, where it exerts its antiviral effect by deaminating viral cDNA cytosines dur

83 but significant reversal of the PIC-mediated antiviral effect by IDO RNA interference and/or tryptoph

84 C/C genotype at IL28B rs12979860 exerts its antiviral effect by increasing the infected hepatocyte d

85 that as an RNase, MCPIP1 has broad-spectrum antiviral effects by targeting viral RNA.

86 ations indicate that the TRIM5alpha-mediated antiviral effects can be orchestrated by the conventiona

87 of pregnancy-acceptable drugs with potential antiviral effects can be the key to better addressing th

88 Thus, in addition to their direct antiviral effect, CD4-mimetic compounds dramatically enh

89 mbination of both antibodies had no additive antiviral effect compared to a single dose of PGT121, po

90 ng drugs may achieve synergistic or additive antiviral effects compared with single drug therapy.

91 wo is more important than finger one for the antiviral effect, demonstrating a correlation between de

92 sm by which ATRA exerts either a proviral or antiviral effect, depending on how it engages cellular r

93 ock NS5A dimerization, suggesting that their antiviral effects do not involve the disruption of NS5A-

94 s suggest that MCPIP1 may be involved in the antiviral effect downstream of IL-1beta.

95 ng in an increase in the type I IFN-mediated antiviral effect during HEV replication.

96 69 muM against NS5B polymerase and selective antiviral effect (EC50 = 3.03 muM) coupled with the abse

97 IC50 of 7.9 muM against NS5B polymerase and antiviral effect (EC50 = 8.1 muM; EC90 = 23.3 muM) coupl

98 in IDO-expressing cells, indicating that the antiviral effect elicited by IDO is mediated by tryptoph

99 ms produce ROS that provide vital protective antiviral effects for the host.

100 This antiviral effect further requires active signaling in NK

101 potency translated in vivo to a substantial antiviral effect in a single-ascending dose study and a

102 tic benefit over Tamiflu and has an additive antiviral effect in combination with Tamiflu.

103 f SOCS-1, pJAK2(1001-1013), that had both an antiviral effect in keratinocytes against HSV-1 as well

104 ce, although TNF-alpha did not have a direct antiviral effect in primary neuron cultures.

105 In this issue of Blood, Tebas et al report antiviral effects in a clinical trial of multiple infusi

106 e data suggest that IFN-gamma production has antiviral effects in rabies, largely due to the inductio

107 elminth infection can have remote protective antiviral effects in the lung through induction of a mic

108 Hydroxychloroquine and chloroquine have antiviral effects in vitro against severe acute respirat

109 and FK778, have been reported to exert broad antiviral effects, in addition to their immunosuppressiv

110 a cell culture system, we found TNF to have antiviral effects independently of, as well as in combin

111 he blood-brain barrier to achieve its direct antiviral effect, intrathecal administration of IFN is w

112 ies are required to assess whether a similar antiviral effect is achievable in humans without toxic e

113 ents with IFN-gamma, the establishment of an antiviral effect is demonstrated to occur within the fir

114 ike membrane-binding photosensitizers: their antiviral effect is dependent on light and the generatio

115 FN-gamma induced the type I IFN pathway, its antiviral effect is likely to be partially induced via c

116 Recent data suggest that the antiviral effect is mediated by inhibition of cyclophili

117 Although significant, clemizole's antiviral effect is moderate (50% effective concentratio

118 l(s) upon which IFN-lambda acts to exert its antiviral effects is unclear.

119 enium status or selenium supplementation has antiviral effects, is essential for successful male and

120 iated with the production of IFN-gamma, with antiviral effects likely mediated through the enhanced e

121 These results suggest that Ifit2 exerts its antiviral effect mainly at the level of viral replicatio

122 on (IFN-gamma) secretion likely mediated the antiviral effect needed to control virus infectivity in

123 However, the strong antiviral effect observed suggests that with further dev

124 rion production in human cells and that this antiviral effect occurred early during infection at the

125 fety and tolerability, pharmacokinetics, and antiviral effect of a single dose of RG-101, a hepatocyt

126 A modest antiviral effect of alisporivir against contemporary (Ma

127 mmunomodulatory properties which augment the antiviral effect of antiviral agents and offer the poten

128 The antiviral effect of CD40L required activation of c-Jun N

129 We found that the antiviral effect of CpGs was not correlated with their a

130 However, this antiviral effect of CRABP2 was abrogated due to the func

131 d to SM-dependent genes, indicating that the antiviral effect of DHX9 was not mediated through its ef

132 e EGFR inhibitor, erlotinib, potentiates the antiviral effect of each compound in a highly synergisti

133 efective Huh7.5.1 cells, indicating that the antiviral effect of EFTUD2 is dependent on RIG-I.

134 nor knockdown of STAT1 diminished the early antiviral effect of exogenous IL-6.

135 the Ebola glycoprotein (GP) antagonized the antiviral effect of human and murine tetherin and facili

136 The antiviral effect of IDO, the enzyme that catalyzes the f

137 other viruses, much less is known about the antiviral effect of IFITM3 on alphaviruses.

138 The synergistic antiviral effect of IFN-alpha and RBV combination treatm

139 In this study we investigated the potential antiviral effect of IFN-beta-induced Sp100.

140 s an important role in the inhibition of the antiviral effect of IFN-gamma in keratinocytes infected

141 ally induced genes that are required for the antiviral effect of IFNalpha.

142 d to in vivo studies to explore the possible antiviral effect of immunostimulation with ZOL in this c

143 cal study suggested that NTZ can augment the antiviral effect of interferon (IFN), although the molec

144 However, the antiviral effect of MAb treatment during acute HIV-1 inf

145 hese observations could explain the clinical antiviral effect of NTZ.

146 ion to being relatively insusceptible to the antiviral effect of oseltamivir, might confer an additio

147 and mutational analyses established that the antiviral effect of P56 was mediated by its direct inter

148 The translation inhibition and antiviral effect of PARP12L appear to be mediated by mor

149 eater sensitivity of mG versus wt RSV to the antiviral effect of passively transferred RSV antibodies

150 (FRG) mouse model was used to determine the antiviral effect of PLK1 inhibitor BI-2536 on HBV infect

151 Here, we demonstrate a unique antiviral effect of prodigiosin (PG), a natural secondar

152 We examined the antiviral effect of ribavirin in a cohort of nine AGMs b

153 agy promoted viral replication, reducing the antiviral effect of RNase L.

154 in the viral Env glycoprotein gp120, and the antiviral effect of SERINC5 is counteracted by the viral

155 and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib (in addition

156 of chronic WHV carriers that counteracts the antiviral effect of the treatment.

157 and this occurrence correlated with a modest antiviral effect of TNF-alpha on primary macrophages but

158 xpress IFN-stimulated genes, and mediate the antiviral effect of type I IFNs against La Crosse virus

159 The antiviral effect of WJ379 was also synergistic with osel

160 Our findings reveal antiviral effects of acetate involving IFN-beta in lung

161 virus type 1 (HTLV-1) were resistant to the antiviral effects of all three lectins.

162 us virus is cleared from neurons through the antiviral effects of antibody and interferon-gamma (IFNg

163 infected cell surface, and LIF enhanced the antiviral effects of antibody.

164 pox virus (FWPV), is highly resistant to the antiviral effects of avian IFN.

165 We evaluated the potential antiviral effects of azithromycin on the nasopharyngeal

166 The antiviral effects of bat IFNs appeared not to correlate

167 Consistent with this, the antiviral effects of BPIFB3 depletion can be reversed by

168 A clear understanding of the antiviral effects of CD8(+) T cells in the context of ch

169 Taken together, the observed antiviral effects of CDots on noroviruses were mainly th

170 Although the antiviral effects of CpAMs are acknowledged, the mechani

171 icroscopic analyses reveal that the pro- and antiviral effects of CRABPs are mediated by modulation o

172 nhibit IKKe was much more susceptible to the antiviral effects of double-stranded RNA than the wild-t

173 CV replication assays were used to study the antiviral effects of drug combinations that included cle

174 n decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes.

175 The antiviral effects of hepatitis C virus (HCV)-specific CD

176 They also provide new information on antiviral effects of HSV-bacterial metabolite interactio

177 ese antifusogenic effects and the beneficial antiviral effects of IFITMs in virus infections during p

178 Inhibition of the antiviral effects of IFN by the capsid appears to occur

179 ng principles highlighting unique aspects of antiviral effects of IFN protection following neurotropi

180 of the cells to IFN-alpha and to compare the antiviral effects of IFN-alpha and IFN-lambda.

181 ntify the cellular proteins that mediate the antiviral effects of IFN-alpha, we created a HEK293-base

182 in mouse cells, as assessed by assays of the antiviral effects of IFN-alpha/beta and the IFN-alpha/be

183 dendritic cells, and are dispensable for the antiviral effects of IFN-alpha/beta that block MNV repli

184 a cell-type-dependent ability to resist the antiviral effects of IFN-alpha/beta.

185 ls, suggests that PML acts as an effector of antiviral effects of IFN-beta.

186 rategies used by flavivirus NS5 to evade the antiviral effects of IFN-I and how this information can

187 re often targeted by viruses to suppress the antiviral effects of IFN-I.

188 fected fibroblasts but instead modulated the antiviral effects of IFN-induced proteins with tetratric

189 antagonize STAT1 signaling to counteract the antiviral effects of IFN.

190 of potentiating and recapitulating important antiviral effects of IFN.

191 PTP1B inhibitors robustly augmented the antiviral effects of IFN1 against vesicular stomatitis a

192 ntiviral miRNAs with anti-miRNAs reduces the antiviral effects of IFNbeta against HCV.

193 these IFNbeta-induced miRNAs reproduces the antiviral effects of IFNbeta on HCV replication and infe

194 Although the antiviral effects of IFNs are well characterized, their

195 ed with TNF before infection, the subsequent antiviral effects of IFNs were increased.

196 e JAK/STAT pathway that is necessary for the antiviral effects of IFNs.

197 ssion and to the protection of EEEV from the antiviral effects of IFNs.

198 green fluorescent protein (NDV-GFP) from the antiviral effects of interferon (IFN).

199 ls, SAMe increased induction of ISGs and the antiviral effects of interferon by increasing STAT1 meth

200 havior can be explained by incorporating the antiviral effects of interferon into the model.

201 4 promoted viral replication and blocked the antiviral effects of interferon-gamma (IFNgamma) by indu

202 To determine the extent to which antiviral effects of IRF-1 are B cell intrinsic, we gene

203 however, the mechanisms responsible for the antiviral effects of IRF-1 are still poorly understood.

204 echanism that is likely to contribute to the antiviral effects of IRF-1 in other virus systems.

205 n primary macrophages and contributed to the antiviral effects of IRF-1.

206 upport a role for protein conjugation in the antiviral effects of ISG15.

207 XRalpha-deficient hosts, indicating that the antiviral effects of LXRalpha are independent of lipogen

208 s apparently evolved to partially resist the antiviral effects of mA3 and to totally resist the abili

209 Potent antiviral effects of MPA at clinically relevant concentr

210 The antiviral effects of NDGA resulted in reduced HCV replic

211 Control monocytes increased the antiviral effects of NK cells from patients with chronic

212 in mice seems to be resistant to any direct antiviral effects of NK cells.

213 s, in this contribution we have analyzed the antiviral effects of peptides derived from the membrane-

214 Here, we show that Vpr mitigates the antiviral effects of REAF, a protein highly expressed in

215 This study aimed to evaluate the antiviral effects of sorbifolin (1) and pedalitin (2), t

216 Unexpectedly, we found that the antiviral effects of statins are counteracted by type I

217 type I interferon signaling counteracts the antiviral effects of statins.

218 In contrast to the direct antiviral effects of Tetherin, which are dependent on ce

219 es have evolved mechanisms to antagonize the antiviral effects of the autophagy pathway, others subve

220 evolved a remarkable strategy to thwart the antiviral effects of the cellular cytidine deaminase APO

221 Antiviral effects of the extract were attributable in pa

222 that the proviral effect of ROS overcame the antiviral effects of the interferon (IFN) response.

223 ated the role of type I IFN induction in the antiviral effects of the miR-34 family and confirmed tha

224 evaluated the pharmacokinetics, safety, and antiviral effects of the respiratory syncytial virus (RS

225 Antiviral effects of the type III IFN family have previo

226 The potent antiviral effects of these cells make them important com

227 Here, we describe the antiviral effects of two molecules that alter polyamine

228 pe 5 E1B 55-kDa protein protects against the antiviral effects of type 1 interferon (IFN), we examine

229 ts required to induce ISGs and the potential antiviral effects of type I IFN on JCV replication in hu

230 N-inducible HIV-1 attachment factor, offsets antiviral effects of type I IFN.

231 and CD4(+) T cells in trans and thus offset antiviral effects of type I IFN.

232 and its replication space is limited by the antiviral effects of type I interferon in the chronicall

233 avian cells, DTMUV was more sensitive to the antiviral effects of type I interferon than other known

234 UN) exhibited an enhanced sensitivity to the antiviral effects of type I interferon.

235 FN receptor and IRF-1 expression potentiated antiviral effects of type II IFN to restrict gammaherpes

236 IMPORTANCE It is generally accepted that the antiviral effects of vaccine-induced classical CD8(+) T-

237 In contrast, the antiviral effects of Xrn2 were limited to JFH1 and H77D

238 immunomodulatory role and can have a direct antiviral effect on a wide spectrum of virus families.

239 component of human lipid metabolism with an antiviral effect on HCV.

240 e components of the ATR pathway may exert an antiviral effect on infection.

241 ntiviral efficacy for pathogenicity, and the antiviral effect on infectiousness.

242 hat the human cathelicidin LL-37 mediates an antiviral effect on RSV by inducing direct damage to the

243 egulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection.

244 rall, we identified 34 ISGs that elicited an antiviral effect on the replication of either one or bot

245 s provided further evidence that AMPK has an antiviral effect on ZIKV replication.

246 f hepatitis C virus inhibitors had different antiviral effects on genotypes 4a vs 1b.

247 n enzymatic activity, can also have profound antiviral effects on HCV-infected subjects.

248 sing group of drugs that could have profound antiviral effects on herpesviruses.

249 que immune stimulation by poly(I:C) with its antiviral effects on imDCs marked by the expression of I

250 ique ISGs that have either broad or specific antiviral effects on these viruses.

251 with other anti-HCV agents can increase the antiviral effect over that achieved with each drug alone

252 showed ER-stress-dependent and -independent antiviral effects, preventing virus release in human LCL

253 dent protein kinase, PKR, exerted some early antiviral effects prior to IFN-alpha/beta signaling; how

254 To assess antiviral effects, RSV RNA viral load from nasal swabs w

255 expression of pairs of ISGs showed additive antiviral effects similar to those of moderate type I in

256 y complex internalization could result in an antiviral effect, since it may interfere with virus part

257 ntify and interrogate other host factors for antiviral effect starting from chemical matter of unknow

258 ry indicates that factors beyond tenofovir's antiviral effect substantially influence PrEP efficacy.

259 ells, combined with its previously described antiviral effect, suggests a possible mechanism of actio

260 ted with SARS-CoV-2, are thought to exert an antiviral effect, suppressing virus replication before p

261 self-complementary AAV vector showed better antiviral effects than single shRNA both in vitro and in

262 n of alisporivir and telbivudine had greater antiviral effects than those of telbivudine or alisporiv

263 ase inhibitor raltegravir showed an additive antiviral effect that is dependent on a block at the pos

264 chistosome-induced IFN-gamma had a prominent antiviral effect that outcompeted immunosuppressive effe

265 In addition to its direct antiviral effect, the mimetic also possessed adjuvant ef

266 tors that rely on SUMOylation to exert their antiviral effects, the enzymes that mediate these SUMOyl

267 ly inhibit PKR and several of its downstream antiviral effects, thereby enhancing virus survival.

268 ere that Favipiravir predominantly exerts an antiviral effect through lethal mutagenesis.

269 Type I interferons (IFN) mediate antiviral effects through different mechanisms than cART

270 uced virus-induced cytotoxicity and promoted antiviral effects through IFN-beta response.

271 ha/beta interferon (IFN-alpha/beta) produces antiviral effects through upregulation of many interfero

272 Analysis of the antiviral effects, toxicities, and pharmacodynamics of d

273 Therapeutic anti-Env Abs can also exert antiviral effects via Fc-mediated effector mechanisms or

274 acteristic of the PKR/RNase L/Mx-independent antiviral effect was a blockage of viral protein accumul

275 However, no antiviral effect was achieved and, instead, an enhanceme

276 The antiviral effect was dependent on the continued presence

277 No antiviral effect was detected by measuring the secreted

278 al analyses of HPV16 PsV determined that the antiviral effect was exerted at the level of endosomal p

279 Clemizole's antiviral effect was highly synergistic with the HCV pro

280 egression analysis showed that the ALN-RSV01 antiviral effect was independent of other factors, inclu

281 Interestingly, the EFTUD2-induced antiviral effect was independent of the classical IFN-in

282 A(H7N9) harboring HA2-Asp19Gly, although the antiviral effect was lessened.

283 velopment of these functional attributes, no antiviral effect was observed early during infection, ev

284 Conclusion: A synergistic antiviral effect was observed when R1626 was combined wi

285 s experimentally infected with RSV, a potent antiviral effect was observed with a mean 4.2 log10 redu

286 was measured in a biochemical assay, but no antiviral effect was observed.

287 This antiviral effect was predominantly mediated by tumor nec

288 their combination was synergistic, and their antiviral effect was reversed by either AAK1 or GAK over

289 fic CD8 T-cell activation with cytolytic and antiviral effects was blunted by PD-L1 expression on HCV

290 The enhanced antiviral effects were abrogated in the presence of a po

291 d with pulmonary surfactant protein D, their antiviral effects were additive.

292 In contrast, cooperative antiviral effects were noted in some instances when rela

293 the ribavirin treatment, moderately reversed antiviral effects were observed, suggesting that the rib

294 Nevertheless, for some compounds antiviral effects were specific to a block of ion channe

295 Antiviral effects were studied during analytic treatment

296 RBV and IFN alfa were highly synergistic for antiviral effect when administered as combination therap

297 Exogenous IFN-lambda treatment confers an antiviral effect when mice receive both estradiol and pr

298 TLR7 and TLR8 were identified as eliciting antiviral effects when stimulated by viral ssRNA.

299 Vehicle and 1 mg/kg GS-9688 had no antiviral effect, whereas 3 mg/kg GS-9688 induced a >5 l

300 of S1P-dependent GPC cleavage, the additive antiviral effect with ribavirin, and the low probability