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1 ive feedback mechanism requiring the protein antizyme.
2 llular polyamine uptake through induction of antizyme.
3 tion with a specific protein factor known as antizyme.
4 y its association with the inducible protein antizyme.
5 ine biosynthesis, is promoted by the protein antizyme.
6 o and sequestering the cell cycle suppressor antizyme.
7  of AZIN1 lacking this variant to neutralize antizyme.
8 al genetic background but express endogenous antizyme.
9 ntly upregulated after ectopic expression of antizyme.
10  cancer cells that do not express endogenous antizyme.
11 paralog of mammalian ornithine decarboxylase antizymes.
12 hifting are similar in the mRNAs for the two antizymes.
13 olled by biosynthetic, catabolic enzymes and antizymes.
14 system utilizing rabbit reticulocyte lysate, antizyme 1 (AZ1) accelerates proteasomal ornithine decar
15 feedback loop that employs a second protein, antizyme 1 (AZ1).
16 ith the polyamine-induced regulatory protein antizyme 1 (AZ1).
17 ited, homology to its evolutionarily distant antizyme 1 and 2 counterparts.
18  gene, HuAZ2, and make a comparison with its antizyme 1 homologue.
19                      Ornithine decarboxylase antizyme 1, a negative regulator of polyamine levels, ac
20 work has shown that the coding sequences for antizymes 1 and 2 are in two different, partially overla
21  Like its previously described counterparts, antizymes 1 and 2, it inhibits ornithine decarboxylase,
22                               In contrast to antizymes 1 and 2, which are widely expressed throughout
23                                  Asn reduced antizyme-1 (AZ1) mRNA and protein.
24 e partners, of which ornithine decarboxylase antizyme-1, NEEP21 (NSG1), and ADAM10 were validated by
25 nithine decarboxylase (ODC) degradation, but antizyme 2 (AZ2) does not.
26                                              Antizyme 3 cDNA has the same arrangement of reading fram
27                The potential significance of antizyme 3 expression during spermatogenesis is discusse
28                                              Antizyme 3 is a paralog of mammalian ornithine decarboxy
29 ch are widely expressed throughout the body, antizyme 3 transcription is restricted to testis germ ce
30 ression of mammalian ornithine decarboxylase antizyme, a protein involved in the regulation of intrac
31 olysis, we appended to p53 the N terminus of antizyme, a protein that binds to and induces degradatio
32  of one ODC allele or elevated expression of antizyme, a protein that stimulates ODC degradation.
33 ribosomal frameshifting, the existence of an antizyme and an antizyme inhibitor, ubiquitin-independen
34                                              Antizyme and antizyme inhibitor have a central role in m
35                                           As antizyme and antizyme inhibitor proteins are functionall
36                       We show here that both antizyme and AZI concentrate at centrosomes and that ant
37               The potential tumor suppressor antizyme and its endogenous inhibitor (antizyme inhibito
38                                              Antizyme and its isoforms are members of an unusual yet
39  from the non-covalent association of native antizyme and ODC.
40 RF) which encodes the amino-terminal part of antizyme and overlaps the +1 frame (ORF2) that encodes t
41 ing functions of the ornithine decarboxylase antizyme and the proteasome beta subunit HsN3.
42 ved features among the various homologues of antizyme and their isoforms.
43 aining proteins and does so independently of antizyme/antizyme inhibitor regulation.
44 role of ODC in BCC tumorigenesis, we used an antizyme (AZ) approach to inhibit ODC activity in the Pt
45                                              Antizyme (AZ) is known to be a regulator of polyamine me
46 romoter elements to direct the expression of antizyme (AZ) to specific skin cell populations.
47  by the 26S proteasome in collaboration with antizyme (AZ).
48                                          The antizymes (AZ) are proteins that regulate cellular polya
49  results demonstrate that alterations in the antizyme/AZI balance cause numerical centrosomal defects
50 found that like many PPIs, the energy of the antizyme-AZIN binding interaction is distributed across
51  problem, we developed and validated a novel antizyme-AZIN intramolecular FRET sensor using clover an
52 f this FRET sensor for probing intracellular antizyme-AZIN PPI.
53            Despite the important role of the antizyme-AZIN protein-protein interaction (PPI) in cell
54  degraded in vivo or, by cooperating with an antizyme binding domain of ODC, to confer polyamine-depe
55 monstrated to independently collaborate with antizyme binding to target ODC for degradation by the 26
56                                              Antizyme binds directly to ODC, targeting ODC for ubiqui
57                                Both forms of antizyme can therefore function as negative regulators o
58                                      The ODC-antizyme complex bound to the 26 S protease but not the
59  NeissLock using the Ornithine Decarboxylase/Antizyme complex.
60 ino acids 130-145 were exchanged between the antizymes confirmed the critical nature of this region.
61                                          The antizymes constitute a conserved gene family with at lea
62 These results suggest that failure to induce antizyme correlates with spermine resistance in prostate
63 ogy of this coding sequence to its mammalian antizyme counterpart also extends to a 5' open reading f
64 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP.
65                        Although knockdown of antizyme did not affect the lifespan of C. elegans, knoc
66    Plasmid end-joining assays confirmed that antizyme enhances the ability of UM1 cells to repair DNA
67 in of known structure, and results show that antizyme exhibits a novel arrangement of its strands and
68           Polyamine-independent induction of antizyme expression was found to be negatively regulated
69                               Interestingly, antizyme expression was found to drastically increase in
70 ual review of genes for three members of the antizyme family and two members of the antizyme inhibito
71                                          The antizyme family consists of closely homologous proteins
72 y, additional novel conserved members of the antizyme family have been described.
73                        A cassette containing antizyme frameshift signals is found to direct high-leve
74 applying a novel GFP-based method to monitor antizyme frameshifting in vivo, we show that the inducti
75 utant, a polyamine-independent regulation of antizyme frameshifting is suggested.
76 human, mouse and rat ornithine decarboxylase antizyme gene (ODC-Az).
77                     As shown here, the yeast antizyme gene and several newly identified antizyme gene
78                       A zinc-inducible human antizyme gene expression vector was transfected into UM1
79  within one of the introns of the Drosophila antizyme gene, the gene for snRNP Sm D3 is located.
80                                              Antizyme genes from different evolutionary branches have
81 t antizyme gene and several newly identified antizyme genes from different nematodes also require a r
82 nterparts, is now shown to be encoded by the antizyme genes of distantly related invertebrates.
83                 The expression of eukaryotic antizyme genes requires +1 translational frameshifting.
84                  The expression of mammalian antizyme genes requires a specific +1 translational fram
85 e decarboxylase (ODC) regulatory protein ODC-antizyme has been shown to correlate with cell growth in
86                                              Antizyme has the ability to bind and inhibit the enzyme
87 ted with other eukaryotic cells, no specific antizyme homologue has been detected either in in vitro
88 dependent inhibitory activity by either anti-antizyme IgG or antizyme inhibitor.
89                                 Depletion of antizyme in various cell lines and primary cells leads t
90                        Ectopic expression of antizyme increased radio-resistance of UM1 cells and res
91 nto vesicles was a saturable and an ATP- and antizyme-independent process.
92 ins basal degradation elements necessary for antizyme-induced proteolysis, is not buried by the struc
93                             We now show that antizyme induction also leads to degradation of the cell
94 is progression in chronic HCV, an SNP in the antizyme inhibitor (AzI) gene is most strongly associate
95              Both protein and mRNA levels of antizyme inhibitor (AZI) were increased in alveolar macr
96                                              Antizyme inhibitor (AZIN) stimulates cell proliferation
97 latory proteins antizyme isoform 1 (Az1) and antizyme inhibitor (AzIN).
98              We found that A-to-I editing of antizyme inhibitor 1 (AZIN1), a positive regulator of po
99  different genes, such as hyperedited AZIN1 (antizyme inhibitor 1) and FLNB (filamin B, beta) and hyp
100 he exosomes, promoting RNA-editing in AZIN1 (Antizyme Inhibitor 1) and GLI1 (Glioma-Associated Oncoge
101 d, and we found that ornithine decarboxylase antizyme inhibitor 2 (AZIN2) increased to the greatest e
102 f the antizyme family and two members of the antizyme inhibitor family in 91 vertebrate organisms res
103  are functionally connected, we also curated antizyme inhibitor genes to more fully represent the ele
104                                 Antizyme and antizyme inhibitor have a central role in maintaining ce
105 the lifespan of C. elegans, knockdown of the antizyme inhibitor led to a significant reduction in lif
106 ransport of polyamines and interact with the antizyme inhibitor protein (AZI), as well as the cell-cy
107                              As antizyme and antizyme inhibitor proteins are functionally connected,
108 s elegans antizyme was investigated, and the antizyme inhibitor was identified.
109 essor antizyme and its endogenous inhibitor (antizyme inhibitor, AZI) have been implicated in the ubi
110                 Conversely, silencing of the antizyme inhibitor, AZI, results in a decrease of numeri
111 hifting, the existence of an antizyme and an antizyme inhibitor, ubiquitin-independent proteasomal de
112 tory activity by either anti-antizyme IgG or antizyme inhibitor.
113 tizyme itself is negatively regulated by the antizyme inhibitor.
114                                  The protein antizyme is a negative regulator of cellular polyamine c
115 geting it for degradation at the proteasome; antizyme is also known to affect the transport of polyam
116                          We demonstrate that antizyme is capable of specific, noncovalent association
117           The capacity of agmatine to induce antizyme is demonstrated by: (a) an agmatine-dependent t
118            At the level of primary sequence, antizyme is not similar to any protein of known structur
119                                Expression of antizyme is positively regulated by rising polyamine con
120          Interestingly, however, the fold of antizyme is similar to that found in a family of acetyl
121                                              Antizyme is unique in that it is expressed via a novel p
122 ocally controlled by the regulatory proteins antizyme isoform 1 (Az1) and antizyme inhibitor (AzIN).
123 ture of a stable, folded domain of mammalian antizyme isoform-1 (AZ-1), consisting of amino acid resi
124                                              Antizyme itself is negatively regulated by the antizyme
125                      Ornithine decarboxylase antizyme levels, measured by Western blotting, were elev
126 ults indicate that S. cerevisiae contains an antizyme-like mechanism for the control of the level of
127                             GUF is the first antizyme-like protein identified in invertebrates.
128           Increasing evidence suggested that antizyme may also have ODC-independent functions.
129                              We propose that antizyme-mediated degradation of cyclin D1 by the protea
130 This is most likely caused by an increase in antizyme-mediated degradation of ornithine decarboxylase
131                                          The antizyme-mediated pathway for cyclin D1 degradation is i
132 ogrammed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circui
133  Prior and new multiple alignments of fungal antizyme mRNA sequences from the Agaricomycetes class of
134 matine-dependent translational frameshift of antizyme mRNA to produce a full-length protein and (b) s
135                                              Antizyme mRNA translation depends upon a polyamine-stimu
136 ODC activity by enhancing the translation of antizyme mRNA, resulting in subsequent binding of antizy
137          Except for Saccharomyces cerevisiae antizyme mRNA, the frameshift site alone only supports l
138   The frameshift in decoding most vertebrate antizyme mRNAs is stimulated by an RNA pseudoknot 3' of
139  3' RNA pseudoknot was known in invertebrate antizyme mRNAs.
140 ined the interaction between Clover-AZIN and antizyme-mRuby2 in cells.
141 a direct interaction between Clover-AZIN and antizyme-mRuby2 was observed within cells, validating th
142 ed in S-adenosylmethionine-decarboxylase and antizyme mutants, as well as in the wild-type genetic ba
143                            The N terminus of antizyme (NAZ), although unneeded for the interaction wi
144 endent pathway, as it neither interacts with antizyme nor affects the ability of AZIN1 lacking this v
145                                              Antizyme (OAZ), a mediator of ubiquitin-independent degr
146 ity to the mammalian ornithine decarboxylase antizyme (OAZ).
147                                          The antizyme (OAZ1)-mediated downregulation of ODC and inhib
148    Stress-dependent expression of C. elegans antizyme occurred morely slowly than expression in respo
149          The hamster ornithine decarboxylase antizyme (ODC-Az) cDNA was transfected into the hamster
150 own, it has been attributed to the effect of antizyme on polyamine metabolism.
151  shows that defects in either snRNP Sm D3 or antizyme, or both, are likely causes of the phenotype.
152  high homology to the sequence for mammalian antizyme (ornithine decarboxylase antizyme) was reported
153 duced either by the polyamine spermine or by antizyme overexpression causes reduction of intracellula
154  understanding of how the different parts of antizyme play their roles in polyamine regulation.
155                         Here, we report that antizyme plays a role in DNA double-strand break repairs
156  and AZI concentrate at centrosomes and that antizyme preferentially associates with the maternal cen
157                                          The antizyme protein, Oaz1, regulates synthesis of the polya
158 e overduplication, whereas overexpression of antizyme reduces numerical centrosome abnormalities.
159                      Synthesis of functional antizyme requires programmed +1 ribosomal frameshifting
160 MEU1(+) cells, which we show is caused by an antizyme-requiring degradation system.
161              Functional distinctions between antizymes seem likely, but no distinction in the tissue
162          To examine the relationship between antizyme structure and function, we further characterize
163 were found to be located on a single face of antizyme, suggesting this surface is a possible site of
164 n ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradatio
165                Ornithine decarboxylase (ODC) antizyme targets ODC for ubiquitin-independent proteosom
166 or directly measuring the binding of AZIN to antizyme that are amenable to high throughput screening.
167 yme mRNA, resulting in subsequent binding of antizyme to ODC monomers which targets ODC for proteolys
168 ated Reference Sequence (RefSeq) data set of antizyme transcript and protein records across a broad t
169 ed frameshift, resulting in misannotation of antizyme transcripts and proteins on transcript and geno
170                                     In vivo, antizyme up-regulation induced either by the polyamine s
171 nd ubiquitination-dependent pathway, because antizyme up-regulation induces the degradation of a cycl
172  for the repression of cell growth following antizyme up-regulation.
173                 Recently, a second mammalian antizyme was discovered.
174   A second mammalian ornithine decarboxylase antizyme was discovered.
175 dy, the regulation of Caenorhabditis elegans antizyme was investigated, and the antizyme inhibitor wa
176  mammalian antizyme (ornithine decarboxylase antizyme) was reported.
177 rosophila homolog of Ornithine Decarboxylase Antizyme, was isolated.
178 n system in cultured Sf21 insect cells, both antizymes were found to accelerate ornithine decarboxyla
179 mines are autoregulated through induction of antizyme, which represses both the rate-limiting polyami

 
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