ライフサイエンスコーパス: anxiogenic

1 cts, but ablating AT(2)R(s) from the CeA was anxiogenic.

2 nin, in knockout mice during EZM testing was anxiogenic.

3 However, OT can also be anxiogenic.

4 by stress and activation of this pathway in anxiogenic.

5 The anxiogenic action of mecamylamine (30 and 100 ng) was mo

6 els of social investigation, thus indicating anxiogenic actions in the social interaction test.

7 signaling within the BNST and the CeA in the anxiogenic actions of cocaine.

8 ial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently em

9 environments paired with the drug's delayed/anxiogenic actions.

10 ot exhibit the convulsant, proconvulsant, or anxiogenic activity associated with nonselective GABA(A)

11 Intravenous administration of the anxiogenic agent sodium lactate elicited robust increase

12 of CRF2 receptor knock-out mice suggest both anxiogenic and anxiolytic effects of CRF2 receptor activ

13 gnition-enhancing effects in animals but are anxiogenic and can precipitate convulsions.

14 treatment of cognitive disorders because of anxiogenic and convulsant side effects.

15 ease activity, while higher doses tend to be anxiogenic and decrease activity.

16 onist treatment was effective in alleviating anxiogenic and depressive affective-like behaviors in bo

17 testing in adult mice revealed a persistent anxiogenic and despair-like phenotype.

18 CUS for 3 wk in adult mice induced anxiogenic and helpless-like behavior and decreased memo

19 tide corticotropin releasing factor (CRF) is anxiogenic and is produced by subpopulations of neurons

20 The anxiogenic and panicogenic effects of peripheral adminis

21 fied the mechanism by which PACAP exerts its anxiogenic and pro-depressant effects, via the recruitme

22 imbic neuronal circuit, RGS6 exerts powerful anxiogenic and prodepressant actions.

23 R, but its acute hypolocomotor, hypothermic, anxiogenic, and antinociceptive effects are not.

24 selective activation of GR within the CeA is anxiogenic, and peripheral administration of an ERbeta a

25 reas CCK administration into mPFC mimics the anxiogenic- and depressant-like effects of social stress

26 ural paradigm to motivate rats to explore an anxiogenic area.

27 hippocampal activity in mice exposed to two anxiogenic arenas.

28 e general syndrome, by altering reactions to anxiogenic, aversive, and nociceptive stimuli as well.

29 However, there were no changes in anxiogenic behavior using the elevated plus maze (p>0.05

30 ll neuronal subpopulation capable of driving anxiogenic behavioral responses in rodents.

31 in the BLA, but not CeA, has been implicated anxiogenic behaviors and anxiety disorders.

32 -17 receptor A (IL-17RA) antibodies, promote anxiogenic behaviors by increasing the excitability of I

33 , infusions of mCPP into the CeA produced no anxiogenic behaviors suggesting that 5-HT(2C) receptors

34 mice (39,XO), and found that they exhibited anxiogenic behaviour relative to normal females (40,XX).

35 atergic projections resulted in aversive and anxiogenic behavioural phenotypes.

36 The anxiogenic benzodiazepine inverse agonist FG7142 increas

37 The anxiogenic beta-carboline, FG 7142 (20 mg/kg) significan

38 ine system by mild stress can be mimicked by anxiogenic beta-carbolines such as FG7142.

39 es the complexity of the dendritic extent of anxiogenic BLA principal neurons, making them less excit

40 ) has been recently revealed as an origin of anxiogenic brain signals, suggesting a target for anxiet

41 and planning and to target depressogenic and anxiogenic cognitions that undermine effective self-mana

42 g and successive remapping of neurons to the anxiogenic compartment.

43 These findings indicate that anxiogenic compounds produce an effect similar to physic

44 eful assay for detecting both anxiolytic and anxiogenic compounds, and suggests that the high affinit

45 adaptive fulfillment of vital needs despite anxiogenic conditions, both in healthy and pathological

46 LH) neurons enabled adaptive responses under anxiogenic conditions-exploration of new terrain, eating

47 timuli but inhibited in conditioned fear and anxiogenic conditions.

48 nal orofacial behaviors and is influenced by anxiogenic conditions.

49 Consistent with data demonstrating the anxiogenic consequences of 5-HT(2C)R activation in human

50 nses of dmPFC and VTA during the learning of anxiogenic contingencies are independent from the punish

51 These same marmosets displayed an anxiogenic, dose-dependent response to the human intrude

52 duced hyperthermia, and a challenge with the anxiogenic drug metachlorophenylpiperazine (mCPP).

53 system to pharmacological challenge with the anxiogenic drug, N-methyl-beta-carboline-3-carboxamide (

54 Moreover, intra-BLA injection of anxiogenic drugs is sufficient to bias rats towards the

55 ve or habit learning, intra-BLA infusions of anxiogenic drugs result in a behavioral profile indicati

56 erexpression of endogenous antagonist has an anxiogenic effect mediated by serotonergic transmission.

57 phosphodiesterase inhibitor antagonized the anxiogenic effect of 15% N2O and enhanced the anxiolytic

58 Evidence that the anxiogenic effect of 8-OH-DPAT (50 ng) was due to activa

59 ffect basal anxiety, but fully prevented the anxiogenic effect of acute stress.

60 However, 1.4 g/kg ethanol blocked the anxiogenic effect of caffeine.

61 n of corticoamygdala projections blocked the anxiogenic effect of CCK, although no effect was observe

62 al anxiolytic response, opposing the general anxiogenic effect of Crh mediated by Crhr1.

63 alteration in 5-HT systems, we examined the anxiogenic effect of mCPP in exercising and nonexercisin

64 This suggests that tolerance to the anxiogenic effect of nicotine administered into the dors

65 ediating the development of tolerance to the anxiogenic effect of nicotine in the social interaction

66 urons, and Gal OX mice were resistant to the anxiogenic effect of optogenetic LC activation.

67 In the social interaction test, the anxiogenic effect of pirenzepine (30-100 ng) provided ev

68 The cellular mechanism for the anxiogenic effect of psychosocial stress is largely uncl

69 ely, vehicle injection failed to prevent the anxiogenic effect of stress in bilaterally adrenalectomi

70 enalectomized rats by injection, the delayed anxiogenic effect of stress was once again blocked.

71 However, this anxiogenic effect was blunted in exercising mice.

72 n in vehicle pre-treated rats, indicating an anxiogenic effect, but tolerance to this effect was seen

73 e; a higher dose of 5 micrograms produced an anxiogenic effect.

74 behavior, while E reduced this HFD-dependent anxiogenic effect.

75 on of idazoxan did not reproduce yohimbine's anxiogenic effects and anxiety was not reduced by periph

76 ther NCAM peptide mimetic, FGL(L), had acute anxiogenic effects and chronic antidepressant effects in

77 lated fish were more sensitive to caffeine's anxiogenic effects and less sensitive to caffeine's stim

78 l hippocampus, nicotine (0.1-8.0 microg) had anxiogenic effects in conditions of moderate anxiety; me

79 CART peptide ((55-102)) into the DRN-induced anxiogenic effects in male C57BL/6J mice, while central

80 e plus-maze pirenzepine and mecamylamine had anxiogenic effects in the dose range of 30-300 ng; galla

81 sal hippocampus is one area that can mediate anxiogenic effects in the social interaction test, but t

82 NE-deficient mice were resistant to the anxiogenic effects of acute stress and optogenetic LC st

83 lular and molecular mechanism to explain the anxiogenic effects of AVP in the amygdala.

84 th panic disorder were more sensitive to the anxiogenic effects of CO2 than were normal subjects, and

85 ratory physiology by several mechanisms: the anxiogenic effects of hyperventilation, the catastrophic

86 rons causes resilience to a stressor and the anxiogenic effects of optogenetic LC activation.

87 leus of the stria terminalis (BNST) mediates anxiogenic effects of OT.

88 f fear extinction memories and attenuate the anxiogenic effects of stress, in a direct translation of

89 tes fear extinction and protects against the anxiogenic effects of stress.

90 ral malaise contributes to the stressful and anxiogenic effects of systemic YO and that YO recruits b

91 the mouse brain, dramatically reduced acute anxiogenic effects of the glucocorticoid hormone cortico

92 Male mice were more vulnerable to the anxiogenic effects of the high fat diet, and obese male

93 or and olfactory function, as well as on the anxiogenic effects of this amine.

94 selective antagonist antalarmin, blocked the anxiogenic effects of urocortin 2.

95 Conversely, the anxiogenic effects of withdrawal after long-term ethanol

96 In contrast, MTIP dose-dependently reversed anxiogenic effects of withdrawal from a 3 g/kg alcohol d

97 cted exposure to a cat produces long-lasting anxiogenic effects on behavior which are NMDA receptor-d

98 well studied, the mechanisms underlying its anxiogenic effects remain unclear.

99 that Asn (60 pmoles) was able to reverse the anxiogenic effects seen during acute administration of U

100 scape, the elevated plus maze for anxiolytic/anxiogenic effects, place preference conditioning for re

101 olateral nucleus of the amygdala may produce anxiogenic effects, while agonist activation of BDZ rece

102 lation of carbon dioxide (CO2) may blunt its anxiogenic effects.

103 and high doses (0.5 and 1.0 mg/kg i.p.) had anxiogenic effects.

104 reduction in oICSS and Delta(9)-THC-induced anxiogenic effects.

105 ectopic G9a overexpression leads to lasting anxiogenic effects.

106 o produce both initial rewarding and delayed anxiogenic effects.

107 s-exploration of new terrain, eating despite anxiogenic environment and limiting maladaptive excessiv

108 DG neurons were highly active in response to anxiogenic environment but had lower excitability and fe

109 als in the dBNST reduces anxiety in a highly anxiogenic environment.

110 s into the dBNST increases anxiety in a less anxiogenic environment.

111 n the medial prefrontal cortex (mPFC) encode anxiogenic environmental cues in freely behaving mice.

112 ing by integrating both external cues (e.g., anxiogenic environmental cues) and internal drives (e.g.

113 yperactivity (PD45), enhanced sensitivity to anxiogenic environments (PD46), and sensory maladaptatio

114 t has been proposed to regulate responses to anxiogenic environments in humans and rodents.

115 does not solely depend on the exploration of anxiogenic environments, but also on intentions to explo

116 s increase their firing when animals explore anxiogenic environments.

117 al BNST neurons that differentiated safe and anxiogenic environments.

118 line, and this correlation increased in both anxiogenic environments.

119 tion-dependent firing was homogenised by the anxiogenic experience.

120 We found that anxiogenic experiences activated the vH and that this ac

121 both D1 and D2 neurons are recruited during anxiogenic exploration, yet with distinct profiles relat

122 We demonstrate that the anxiogenic impact of sleep loss is linked to impaired me

123 te the basic brain mechanisms underlying the anxiogenic impact of sleep loss.

124 macological activation of the 5-HT system is anxiogenic in animal models and also in humans.

125 nts were anxiolytic in proestrus females but anxiogenic in males as determined by time spent in the o

126 ehavioural phenotype with beta-carboline, an anxiogenic inverse benzodiazepine receptor agonist, norm

127 mice also exhibit a significant increase in anxiogenic-like behavior as assessed by the elevated plu

128 The increased anorectic and anxiogenic-like behavior most likely is caused by increa

129 deficits to obtain less palatable food, and anxiogenic-like behavior.

130 sible inhibitor of the SERCA pump, exhibited anxiogenic-like behaviors and increased Ih, similar to t

131 ressful situations, provoking depressive and anxiogenic-like behaviors, even more intense than the av

132 However, only short-term activation induces anxiogenic-like behaviors.

133 ncy to emerge into the light compartment, an anxiogenic-like effect.

134 Overall, d-amphetamine (5 and 10mg/L) evokes anxiogenic-like effects in zebrafish acutely, but not 7

135 t not in nondependent, rats and reversed the anxiogenic-like effects of ethanol abstinence using an a

136 lock the potentiation of nicotine CPP or the anxiogenic-like effects of kappa-receptor activation.

137 ance and sucrose preference deficits but not anxiogenic-like effects.

138 In vivo, ABM300 did not elicit anxiogenic-like or cannabimimetic effects, but it decrea

139 havioral models, the NPY KO mice may have an anxiogenic-like phenotype, and appear to be hypoalgesic

140 administration (30 and 50 mg/L) produces an anxiogenic-like reduction of top swimming, paralleled wi

141 enetic models, mice over-expressing CRF show anxiogenic-like responses compared to wild-type mice, an

142 noradrenergic-derived galanin, alone, alters anxiogenic-like responses to stress.

143 y induces or restricts the exploration of an anxiogenic location remains unexplained.

144 emoved in parts of the track to introduce an anxiogenic location.

145 s predicted the extent of exploration of the anxiogenic location.

146 ited remapping of activity, overrepresenting anxiogenic locations.

147 f activity, overly aggressive treatment with anxiogenic medications, and more prolonged and frequent

148 hypercapnia or hyperventilation, the use of anxiogenic medications, and the stress of coping with ch

149 Here, we confirm that 6% CCM is a tolerable anxiogenic model in the MRI setting.

150 proposed anxiolytic networks or suppressing anxiogenic networks.

151 anxiety and is a key site of action for the anxiogenic neuromodulator, corticotropin releasing facto

152 corticotropin-releasing hormone (CRH) is an anxiogenic neuropeptide that may mediate the stressor-li

153 An anxiogenic odor potentiated their abnormal repetitive le

154 projection neurons during exploration of the anxiogenic open arms.

155 d that enhances cognition in animals without anxiogenic or convulsant effects.

156 primates (object retrieval), without showing anxiogenic or proconvulsant effects in rats.

157 ne induced a depression-like effect, but not anxiogenic- or anxiolytic-like effects; promoted hyperal

158 sed on GABAergic interneurons containing the anxiogenic peptide cholecystokinin (CCK), we also examin

159 icotropin releasing factor (CRF), a putative anxiogenic peptide, inhibit maternal defense behavior.

160 that central infusion of urocortin 1 and 3, anxiogenic peptides that bind to CRF receptors, reduce m

161 pecifically into the mPFC displayed the same anxiogenic phenotype as the CSDS mice, whereas overexpre

162 gnificant role of PVT astrocytic GLT1 in the anxiogenic phenotype in adulthood induced by adolescent

163 We conclude that the anxiogenic phenotype in female LXRbeta(-/-) mice is caus

164 blocking FGF-21 activity did not rescue the anxiogenic phenotype of UCP-1 KO mice.

165 f dorsal raphe GluD1(R)-channels produces an anxiogenic phenotype.

166 FKBP51(mut) BLA-overexpression, reduced the anxiogenic phenotype.

167 tore cognitive function without altering the anxiogenic phenotype.

168 striatum alone was sufficient to produce an anxiogenic phenotype.

169 GABAA current, a possible mechanism for its anxiogenic, proconvulsant sequelae.

170 xhibited novelty-induced hyperlocomotion, an anxiogenic profile in the elevated plus-maze and open fi

171 27 rats and Sprague-Dawley rats reversed the anxiogenic profile of the TGR (mREN2)27 rat on the eleva

172 maze the TGR (mREN2)27 rat showed a greater 'anxiogenic' profile (fewer open arm entries) than the co

173 than the control Sprague-Dawley rats, this 'anxiogenic' profile increased further during a second ex

174 iod of fluid-deprivation (3 h) reversed the 'anxiogenic' profile of the TGR (mREN2)27 on the elevated

175 ch conditioned effects may be related to the anxiogenic properties of cocaine.

176 Consistent with its anxiogenic properties, mCPP produced a dose-dependent in

177 ive allosteric modulator with convulsant and anxiogenic properties.

178 s of these events that are depressogenic and anxiogenic remain uncertain.

179 (BLA) in male Wistar rats would result in an anxiogenic response as measured in the social interactio

180 he AMY, but not into the HIPP, abolished the anxiogenic response elicited by acute stress.

181 tive PPARgamma antagonist, elicited a marked anxiogenic response in PPARgamma wild-type (WT), but not

182 ol consumption and plays a major role in the anxiogenic response to ethanol withdrawal.

183 inforcing effects effects of ethanol and the anxiogenic response to ethanol withdrawal.

184 we found that Rcan1 KO mice lacked the early anxiogenic response to the selective serotonin reuptake

185 haplotype AC/C/G exhibited a dose-dependent, anxiogenic response, individuals homozygous for the low

186 de or genetic deletion of PPARgamma enhanced anxiogenic responses and increased vulnerability to stre

187 orticotropin-releasing factor (CRF) mediates anxiogenic responses by activating CRF type 1 (CRF1) rec

188 Furthermore, Asn has no effect on anxiogenic responses due to sodium lactate infusions in

189 from dopamine neurons enhances neuronal and anxiogenic responses to restraint stress.

190 Our data also reveal an unanticipated anxiogenic role for this particular DOR subpopulation, w

191 al responses, DORs exert dual anxiolytic and anxiogenic roles, both of which may have implications in

192 neously as a dominant behavioral strategy in anxiogenic situations.

193 ateral septum attenuates active avoidance of anxiogenic stimuli (i.e., decreased burying behavior), b

194 al DG (dDG) neurons, which were activated by anxiogenic stimuli and specifically express osteocalcin

195 LepR(LH) neurons differentiated poorly among anxiogenic stimuli and were inhibited by input from the

196 eral hypothalamus (LH; LepR(LH)) that encode anxiogenic stimuli.

197 and was specific to both the presence of the anxiogenic stimulus and the familiar social partner.

198 s to reflect an unconditioned response to an anxiogenic stimulus, whereas fear-potentiated startle re

199 ety-like behaviors induced by an ethological anxiogenic stimulus.

200 in the maze, regardless of the nature of the anxiogenic stimulus.

201 Here, we report that anxiogenic stressors elicit acute and prolonged response

202 Anxiogenic threats and other stressors robustly activate

203 tributes to multiple behavioral responses to anxiogenic threats, yet also serves to limit the plasma

204 We used a clinically substantiated anxiogenic treatment to induce sustained anxiety in rats

205 an-20-one (3alpha, 5alpha-THP) that produces anxiogenic withdrawal symptoms.

206 wo opposing circuits, one anxiolytic and one anxiogenic, within the BNST, the relative strength of wh