ライフサイエンスコーパス: anxious

1 t down-regulating fears were also less trait-anxious.

2 1 patients (24.0%) as depressed and 40.3% as anxious.

3 ive stimuli and a propensity to worry and be anxious.

4 ymic, dysthymic, cyclothymic, irritable, and anxious.

5 hallenge (P = 0.007), but children were less anxious.

6 Are you feeling anxious?

7 - about which they have every right to feel anxious?

8 ed MRI scans were acquired in 151 youths (75 anxious, 76 HV; ages 8-18).

9 Not infrequently, patients are anxious about a scheduled imaging procedure because of a

10 addition, more than 60% of participants were anxious about applying topical corticosteroids to certai

11 h affected persons who may understandably be anxious about having a mutation in their blood that pred

12 acy, did not engage in drunken sex, and were anxious about infection.

13 ly for children whose parents are habitually anxious about math.

14 m scores, especially for students habitually anxious about test taking.

15 stmortem and patients are often confused and anxious about the most likely cause of their post-trauma

16 likely to report feeling "worried, tense, or anxious" about repaying, were 54 percent more likely to

17 d more fear than the healthy groups, but the anxious adolescent and adult groups did not differ on ph

18 During imaging, both anxious adolescents and adults exhibited lower activatio

19 ontal cortex when appraising threat, whereas anxious adolescents exhibited a U-shaped pattern of acti

20 n the ventromedial prefrontal cortex in many anxious adolescents may reflect heightened sensitivity t

21 Anxious adolescents showed greater amygdala activation t

22 anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening.

23 d with their age-matched counterpart groups, anxious adults exhibited reduced activation in the ventr

24 PD had shorter telomeres than those with no anxious affect (beta: -0.07, P<0.01), but there was no r

25 sorder (PD), as well as depressed affect and anxious affect, were assessed using the Composite Intern

26 Ghr-/- mice are more anxious after acute restraint stress, compared with wild

27 Fifty-four anxious alcohol-dependent participants were admitted to

28 Anxious, alcohol-dependent women (age 21-65 years, n=39)

29 em was suggested in aetiology of depressive, anxious and anorexiolytic symptoms in OSA.

30 substance abuse, prior suicide attempts, and anxious and atypical symptom features.

31 blation of these dopaminergic neurons led to anxious and depressed behavior, phenocopying performance

32 ore knowledgeable, better informed, and less anxious and depressed patients, with a better mental wel

33 Orexins are altered in anxious and depressed patients.

34 e concerned (medical, work/family), and more anxious and depressed than all other ethnic groups.

35 dult neurogenesis and behavior indicative of anxious and depressive-like mood states.

36 Anxious and healthy adolescents and adults (N=114) compl

37 thors compared prefrontal cortex function in anxious and healthy adolescents and adults following con

38 gdala and vlPFC engagement differentially in anxious and healthy adolescents.

39 Socially anxious and healthy children and adolescents learnt asso

40 on recall, brain activation patterns between anxious and healthy individuals differed.

41 may mediate emotion dysregulation when very anxious and irritable youth process threat-related faces

42 ressant treatment outcomes for patients with anxious and nonanxious major depression in Levels 1 and

43 More anxious and pain-attentive individuals display weaker de

44 their ability to perceive when patients were anxious and stressed than when they were depressed.

45 IBS patients often are anxious and stressed, and stress accelerates small bowel

46 haracterizing the extent to which people are anxious and tense.

47 field showed that males were generally more anxious and that stress increased male, but decreased, f

48 on and none of the 13 subjects were severely anxious and/or depressed.

49 use of habit memory that can be produced by anxious and/or stressful emotional states may have impli

50 he the post-MA administration timecourse of 'anxious' and increased ratings of 'bad drug effects,' as

51 rated monkeys displayed heightened avoidant, anxious, and aggressive behaviors, those with hippocampa

52 aggressive faces when they are feeling more anxious, and this bias leads to increased negative arous

53 s exhibit more dominant behaviours, are less anxious, and, for males only, spend more time in play at

54 ous depression, moderate anxious depression, anxious anhedonia, pure anhedonia, and resolved depressi

55 Together, these findings indicate that anxious animals and those with the greatest EtOH-induced

56 Responses among anxious animals can be confounded further by neophobia t

57 Highly anxious animals showed increased depression-like behavio

58 High-anxious animals that are prone to become subordinate dur

59 Low- and high-anxious animals were identified by behavioral responses

60 bability to become dominant observed in high-anxious animals.

61 Entering a state of anxious anticipation triggers widespread changes across

62 hopathology, key neural activity involved in anxious anticipation, and resulting aversive emotional s

63 nization unfolds with time during periods of anxious anticipation.

64 neural signatures and uniquely contribute to anxious anticipation.

65 ar-provoking situations but rather increased anxious apprehension and went along with increased anxie

66 sorder distinguishes between acute panic and anxious apprehension as distinct emotional states.

67 While 31.6% of the patients showed strong anxious apprehension during this task (as indexed by inc

68 tients is dynamically organized ranging from anxious apprehension to panic with increasing proximity

69 predominant generalization of fear and hence anxious apprehension.

70 y positively associated with the severity of anxious arousal (ie, hypervigilance) symptoms (r = 0.52)

71 dimensional factors of general distress and anxious arousal as well as a diagnosis of MDD explained

72 regulate their worries and reinterpret their anxious arousal before their tests.

73 ion is associated with increased severity of anxious arousal symptoms in individuals with PTSD.

74 nxiety and depression, and anxiety-specific (anxious arousal) or depression-specific (anhedonia) symp

75 released from the program also appeared more anxious, as indicated by a short latency to vocalize whe

76 avoids a reference to anger which transforms anxious avoidance into collective and unified action.

77 ith neuroticism being strongly related to an anxious, avoidant style and affective instability relate

78 to examine the role of endogenous ghrelin in anxious behavior and hypothalamic-pituitary-adrenal axis

79 or anterior orbitofrontal cortex (antOFC) on anxious behavior and Pavlovian conditioned autonomic and

80 ble individuals exhibit social avoidance and anxious behavior and ultimately develop depression, wher

81 Anxious behavior in the mouse is a complex quantitative

82 from MS-induced PVB loss and exhibited less anxious behavior than those infused with control peptide

83 No change in anxious behavior was observed with gap junction blockade

84 e-loxP recombination system, we investigated anxious behavior, spatial memory, and metabolic function

85 l learning/memory and demonstrated increased anxious behavior.

86 anding of network-related aspects underlying anxious behavior.

87 lir in brain areas implicated in fearful and anxious behavior.

88 coustic preferences in mPFC, which mitigates anxious behavior.

89 ggesting that children and adolescents learn anxious behaviors from their parents through a number of

90 tes, while inhibition suppresses, persistent anxious behaviors.

91 F2 decreased anxiety-like behavior in highly anxious bLRs without altering other behaviors and withou

92 ring fearful versus happy face processing in anxious, but not healthy, participants.

93 d with each other, namely, patients who were anxious by nature experienced higher levels of state anx

94 Three groups were analyzed: anxious children and adolescents who requested that thei

95 frontal cortex were significantly reduced in anxious children and adolescents who requested that thei

96 Mean activity in these regions in anxious children and adolescents with their caregiver in

97 aregiver accompany them in the scanner room, anxious children and adolescents without their caregiver

98 trategies aimed at reducing the suffering of anxious children and preventing them from developing fur

99 High math-anxious children showed a significant reduction in math

100 ased study found elevated cortisol levels in anxious children susceptible to CO(2)-induced panic, but

101 order, good vocational record, absence of an anxious cluster personality disorder, low neuroticism, a

102 romes, reaching statistical significance for Anxious/Depressed (0.75 times as high; 95% CI: 0.57, 0.9

103 gression (P<.001); 9%, 14%, 16%, and 27% for anxious/depressed (P<.001); and 7%, 12%, 15%, and 19% fo

104 , was positively associated with symptoms of Anxious/Depressed and Attention Problems (p </= 0.05).

105 ith clinically relevant phenotypes including anxious depression and episodic recurrence.

106 response were compared between patients with anxious depression and those with nonanxious depression.

107 stigated in the clinic for schizophrenia and anxious depression disorders.

108 Similarly, in Level 2, patients with anxious depression fared significantly worse in both the

109 se events, were significantly greater in the anxious depression group.

110 Patients were designated as having anxious depression if their anxiety/somatization factor

111 Anxious depression is associated with poorer acute outco

112 ression: severe anxious depression, moderate anxious depression, anxious anhedonia, pure anhedonia, a

113 res expected of a mouse model of melancholic anxious depression, including reduced survival of adult-

114 nct subtypes of perinatal depression: severe anxious depression, moderate anxious depression, anxious

115 nt in work productivity and higher levels of anxious depression.

116 In Level 1 of STAR*D, 53.2% of patients had anxious depression.

117 In fact, for the sensation seeking trait and anxious-depression factor, higher scores were associated

118 or depressive disorder (MDD) in general, and anxious-depression in particular, are characterized by p

119 met criteria for melancholic, atypical, and anxious depressive subtypes, as well as subtype combinat

120 these tests in adulthood, reminiscent of the anxious-depressive phenotype previously described for gl

121 with high VS-low amygdala reactivity, and by anxious/depressive symptomatology for those with the opp

122 improvement in positive (weight = 0.62) and anxious/depressive symptoms (weight = 0.49).

123 and behavioral changes characteristic of an anxious/depressive-like phenotype.

124 oral changes, which are the expression of an anxious/depressive-like phenotype.

125 as exaggerated among individuals with a more anxious disposition.

126 Depressed mothers with high anxious distress and irritability may require medication

127 of intra-ICU anxiety were significantly more anxious during recovery over 6 months.

128 that socially isolated females possessed an anxious, fearful, and vigilant phenotype.

129 Sham rats exhibit a continuum of anxious/fearful behaviors.

130 These anxious feelings can paradoxically co-occur with positiv

131 ith high levels of self-rated depressive and anxious feelings in first grade were more likely to expe

132 e subscale of neuroticism that reflected the anxious form of neuroticism (N1) explained a greater pro

133 During conditioning and extinction, the anxious groups reported more fear than the healthy group

134 oups were matched for age and, among the two anxious groups, for diagnosis (mean age 9.5).

135 alker according to 5 target emotions: angry, anxious, happy, sad, and neutral.

136 The fourth group, anxious high responders (n = 5; 9%), was characterized b

137 y aversive cues disrupt learning in socially anxious human individuals.

138 ariations in fear responding with clinically anxious humans exhibiting a tendency to generalize learn

139 sorder (ruling out effects merely reflecting anxious hyperarousal), motivating new interventions targ

140 Anxious hypervigilance is marked by sensitized sensory-p

141 function and response regulation as well as anxious-impulsive personality traits may represent endop

142 s and their siblings also exhibited elevated anxious-impulsive personality traits relative to healthy

143 However, PA mice were more anxious in open field, and showed reduced activity of sy

144 pment, but not adult-treated rats, were less anxious in the open field and less immobile in the force

145 recovery and proportion of days depressed or anxious in the preceding year were significantly associa

146 to precisely quantify the process deficit in anxious individuals and determine the degree to which th

147 creasing the proportion of bold, active, and anxious individuals and in-turn affecting the potential

148 We show that when the math-anxious individuals are female elementary school teacher

149 Overall, the data suggest that anxious individuals are quicker to update their behaviou

150 However, up to 50% of clinically anxious individuals do not respond to current evidence-b

151 Anxious individuals exhibit heightened sensitivity towar

152 ng context evoked by an angry face, socially anxious individuals fail to benefit from a stable learni

153 s in healthy individuals, whereas clinically anxious individuals fail to discriminate.

154 Under those circumstances, socially anxious individuals failed to use their dorsal anterior

155 h the everyday decision-making of clinically anxious individuals is clearly influenced by their exces

156 y which uncertainty changes the behaviour of anxious individuals is unclear.

157 Previous studies have shown that anxious individuals may not appropriately differentiate

158 As a result, anxious individuals often make decisions that favor harm

159 on of both reward and threat, explaining why anxious individuals show stronger potentiation of incent

160 Anxious individuals showed persistent, long-term fearful

161 High trait-anxious individuals showed reduced prefrontal activity a

162 that presents in clinical populations where anxious individuals tend to adopt a more pessimistic-lik

163 High math-anxious individuals tend to avoid situations involving m

164 Anxious individuals tend to experience more worry under

165 may therefore be more fruitful to encourage anxious individuals to integrate information over longer

166 We predicted that anxious individuals under stress would learn faster abou

167 High trait socially anxious individuals used a less-dynamic strategy for adj

168 n analyses provided compelling evidence that anxious individuals' tendency to mis-allocate WM resourc

169 tion is implicated in biased attention among anxious individuals, no work has examined the neural cor

170 development of a subordinate status in high-anxious individuals.

171 om those that generate attentional biases in anxious individuals.

172 g competitors for attention, particularly in anxious individuals.

173 When chronic and extreme, this anxious, inhibited phenotype is an important early-life

174 bsequent uptake was dysregulated in the more anxious Lewis rats.

175 The BAG1 TG mice showed less anxious-like behavior on the elevated plus maze test and

176 p glutamate reduced anxiety levels in highly anxious marmosets in two uncertainty-based tests of anxi

177 Neurally, high-anxious marmosets showed reduced amygdala serotonin leve

178 l as four orthogonal dimensions of symptoms: anxious-misery (mood and anxiety), behavioral disturbanc

179 In contrast, anxious-misery symptoms were associated with widespread

180 erview, which delineated four factors (fear, anxious-misery, psychosis and behavioral symptoms) plus

181 hippocampal glutamate release in high-trait-anxious monkeys normalizes the aberrant behavioral and c

182 appears to be driven by positive effects on anxious mood and night-time sleep problems.

183 Depressed mood and anxious mood represent two different quadrants of this s

184 In a sample of patients who were clinically anxious (n = 70), we applied a well-validated form of co

185 ess severely and chronically depressed, less anxious, not experiencing complicated grief symptoms, di

186 e matter differences in persons featuring an anxious or a nonanxious personality, taking into account

187 12 studies), including negative self-esteem, anxious or avoidant behavior, poor emotional knowledge,

188 ic' cognitive bias that is characteristic of anxious or depressed humans and other vertebrates in put

189 cellular DA is high and the generation of an anxious or depressed state when DA is relatively low.

190 dence that the intervention resulted in more anxious or depressive symptoms.

191 sttraumatic stress disorders; social phobia; anxious or melancholic features; or more severe depressi

192 Patients reporting pain were more anxious (OR, 3.53; 95% CI, 1.38-9.03) and depressed (OR,

193 R=5.24, P=0.001), GAD-2 items predicted GAD (anxious: OR=4.09, P=0.003; unable to control worrying: O

194 e onset of anxiety disorders in offspring of anxious parents.

195 ence of anxiety disorders among offspring of anxious parents.

196 nd the results will be helpful in reassuring anxious parents.

197 In each trial, more or less socially anxious participants chose between an interaction with a

198 to healthy control subjects, pathologically anxious participants exhibited enhanced risk aversion bu

199 l) face location, especially in highly trait anxious participants.

200 "Low-anxious" participants showed a reduced amygdala response

201 ded versus attended fearful faces, but "high-anxious" participants showed no such reduction, having a

202 ssfully used to facilitate weaning in a very anxious patient, possibly secondary to anxiolysis or dir

203 from prolonged mechanical ventilation in an anxious patient.

204 They must manage anxious patients and family members who may be waiting f

205 ok a multicentre, randomised trial on health anxious patients attending cardiac, endocrine, gastroent

206 Anxious patients demonstrated hyperactive prefrontal cor

207 Highly anxious patients reported more pain prior to the procedu

208 Eligible articles contrasted either anxious patients to control subjects or an unpredictable

209 The less dentally fearful and anxious patients were in general and the more they trust

210 hypotheses about neurocircuit dysfunction in anxious patients, and 5) evaluate treatment mechanisms a

211 nxiety disorder diagnosis still tended to be anxious, perfectionistic, and harm avoidant.

212 is typified by a remarkable hypersocial but anxious personality and offers a unique opportunity to i

213 pecific microstructure is associated with an anxious personality, a different structure subserves emo

214 nd OFC, indexing weaker connections in trait-anxious persons.

215 msPs display an anxious phenotype accompanied by elevations in amygdalar

216 ter expression contributes to the high trait anxious phenotype and suggest that reduction of threat r

217 cause children and young monkeys express the anxious phenotype in similar ways and have similar neuro

218 at CRH signaling in the amygdala promotes an anxious phenotype that is prevented by FAAH inhibition.

219 A4 repeat region may contribute to the trait anxious phenotype via neurochemical changes in brain are

220 ease in the ventral hippocampus correct the "anxious phenotype" caused by early life stress.

221 l role in two key features of the high trait anxious phenotype: high responsivity to anxiety-provokin

222 1A)AR mice exhibited antidepressant and less anxious phenotypes in several behavioral tests compared

223 ework for understanding the pathways linking anxious phenotypes to the development of internalizing p

224 al construction) and behavioral (hypersocial/anxious) phenotypes, offers a unique opportunity to stud

225 entially stressful situation in a clinically anxious population of youths.

226 Childhood behavioral and depressive/anxious problems may influence the risk for PTSD directl

227 rdinate during a social encounter with a low-anxious rat exhibit reduced mitochondrial complex I and

228 d novelty-induced locomotor reactivity, high anxious rats (HA) based on the propensity to avoid open

229 A was more strongly related to task-specific anxious reactivity during shock anticipation.

230 authors tested the hypothesis that elevated anxious reactivity, specifically toward unpredictable av

231 e relationship between PNA and task-specific anxious reactivity.

232 Anxious relative to healthy youths exhibited thicker cor

233 effect was driven to a greater extent by the anxious relative to the depressive characteristics of ne

234 Current measures of anxious responding to threats are limited because they l

235 , objective, within-subject 'stress-test' of anxious responding.

236 se as a non-subjective measure of individual anxious responding.

237 ate cortex, a network involved in regulating anxious responses to aversive stimuli.

238 Startle was used to assess anxious responses to cues and contexts.

239 ability to predict aversive events mitigates anxious responses.

240 ith AN displayed increased activation during anxious rumination in the dorsal mid-insula, and activat

241 Participants also performed an anxious rumination task while in the scanner.

242 is, pain, tired, short of breath, restless, anxious, sad, hungry, scared, thirsty, confused).

243 .g., heightened reactivity to safety cues in anxious samples), the extant literature suffers from key

244 no-pressure condition, both groups were more anxious, showed adaptations in movement kinematics relat

245 ereas predator-exposed mothers produced more anxious sons and daughters.

246 phine dependence and social isolation in non-anxious Sprague Dawley (SD) rats, and a depression model

247 temporal aspects of this transition into an anxious state are poorly understood.

248 l BNST activity promoted several independent anxious state features, whereas anterodorsal BNST-associ

249 Behavioural states in mammals, such as the anxious state, are characterized by several features tha

250 election of features for the assembly of the anxious state.

251 tedly found to exert opposite effects on the anxious state: oval BNST activity promoted several indep

252 ency range (4-12 Hz) have been implicated in anxious states and derive in part from the activity of i

253 Anxious subjects' exaggerated response to uncertainty le

254 In both healthy and anxious subjects, the amount of scanning behavior correl

255 lf-reported allergy severity, depressive and anxious symptoms, and attitude toward illness in adolesc

256 (CATIS) as measures of depressive symptoms, anxious symptoms, and attitude toward illness, respectiv

257 ing correlated positively with self-reported anxious symptoms, providing evidence of a continuous cir

258 reported disease severity and depressive and anxious symptoms.

259 ul life events, and offspring depressive and anxious symptoms.

260 By the school year's end, however, the more anxious teachers were about math, the more likely girls

261 ociation between genetic variation in CRHR1, anxious temperament (AT) and brain metabolic activity.

262 Children with an anxious temperament (AT) are at a substantially increase

263 Children exhibiting extreme anxious temperament (AT) are at an increased risk for de

264 Children with an anxious temperament (AT) are at risk for developing psyc

265 Children with anxious temperament (AT) are particularly sensitive to n

266 When extreme, this anxious temperament (AT) confers elevated risk for the d

267 We established a nonhuman primate model of anxious temperament (AT) for studying the early-life ris

268 Anxious temperament (AT) in human and non-human primates

269 An early-life anxious temperament (AT) is a risk factor for the develo

270 Anxious temperament (AT) is an early-life heritable trai

271 Anxious temperament (AT) is identifiable early in life a

272 odel of behavioral inhibition, which we term anxious temperament (AT), reveals that it is trait-like.

273 Children with an anxious temperament are prone to heightened shyness and

274 learning, which is inversely associated with anxious temperament in mice and humans.

275 ly neural measures implicated in anxiety and anxious temperament may be incorporated with traditional

276 Individuals with extreme anxious temperament often show persistent distress in th

277 etween regional brain glucose metabolism and anxious temperament was previously established.

278 We focused on BI, a core component of anxious temperament, because it affords the moment-by-mo

279 a behavioral and neuroendocrine composite of anxious temperament.

280 TgR mice behaved as more anxious than controls, an effect normalized by long-term

281 Postpartum rats are less anxious than diestrous virgin females, a phenomenon requ

282 Women with relapsing-remitting MS were more anxious than men with this type (p<0.001), and than wome

283 istological change in the adrenals, are less anxious than mice without SCH.

284 motor coordination, and were generally more anxious than wild-type controls.

285 ta4-/- mice behaved as though they were less anxious than wild-type littermates on the elevated-plus

286 ale-majority and sex-parity groups felt less anxious than women in female-minority groups.

287 Within twin pairs, the more anxious twin exhibited decreased fractional anisotropy (

288 = 0.022) in the left UF compared to the less anxious twin, controlling for age and gender.

289 res indicated that women were not inherently anxious: usual care group, score of 44.63; relaxation gr

290 ion between amygdala and vlPFC activation in anxious vs healthy adolescents in response to these stim

291 ants reported feeling most positive and most anxious when choosing between similarly high-valued prod

292 gh anxiety sensitivity (AS) become extremely anxious with heart rate increases, palpitations, and sym

293 found that the female LXRbeta(-/-) mice were anxious with impaired behavioral responses but normal lo

294 y behaviorally inhibited and temperamentally anxious young children are at marked risk of developing

295 nd neurobiological studies of risk taking in anxious youth and conclude by identifying directions for

296 better response to SSRI and CBT treatment in anxious youth and that neuroimaging may be a useful tool

297 less consideration of the processes by which anxious youth make avoidant decisions and how these choi

298 ng throughout development, interventions for anxious youths are largely based on principles of extinc

299 al learning for optimizing interventions for anxious youths by targeting the biological state of the

300 Capitalizing on the ability of anxious youths to manifest low levels of anxiety-like in