ライフサイエンスコーパス: apical constriction

1 nt cells, causing impaired nucleokinesis and apical constriction.

2 d elevated DE-cadherin is thought to promote apical constriction.

3 tchet-like stabilization of cell shape drive apical constriction.

4 d that microridge morphogenesis is linked to apical constriction.

5 ocytosis nor GTP-shifted Dyn2 mutants induce apical constriction.

6 the neural plate driven largely by cellular apical constriction.

7 t not dynamic, microtubules are required for apical constriction.

8 hat actomyosin contractility is required for apical constriction.

9 and unpredicted role for microtubules during apical constriction.

10 pithelial markers and do not undergo ectopic apical constriction.

11 as found to be expressed in cells engaged in apical constriction.

12 with the polarization that establishes this apical constriction.

13 tion (Fog) activates Rho1 signaling to drive apical constriction.

14 oss of apical-medial actomyosin and impaired apical constriction.

15 ces of neighboring ectoderm cells undergoing apical constriction.

16 tures are used in animal cells to accomplish apical constriction.

17 oses aPKC function and supports Yurt-induced apical constriction.

18 n, activates Rho-associated kinase to induce apical constriction.

19 al Arp2/3 makes an important contribution to apical constriction.

20 I recruitment is essential for Lmo7-mediated apical constriction.

21 otubule tails, which are known to facilitate apical constriction.

22 d invagination without affecting the rate of apical constriction.

23 omplex genes that regulate cell adhesion and apical constriction.

24 e and non-muscle myosin II, which coordinate apical constriction.

25 enriches junctional components to facilitate apical constriction.

26 contractility during Drosophila melanogaster apical constriction.

27 bly and thus dynamics also play key roles in apical constriction.

28 nitor proliferation, neural tube closure and apical constriction.

29 portant to generate contractile force during apical constriction.

30 active force generation required other than apical constriction.

31 undergo continuous, rather than incremental, apical constriction.

32 in Shot, and disruption of Shot also impairs apical constriction.

33 proceeded stepwise and were correlated with apical constriction.

34 s in the contractile cytoskeleton underlying apical constriction.

35 ell shape changes driven by myosin-dependent apical constriction.

36 e different morphogenetic movement, mesoderm apical constriction.

37 gh processes such as convergent extension or apical constriction(1,2).

38 tional actin populations in cells engaged in apical constriction.(14)(,)(15) In the context of Xenopu

39 During apical constriction, a microtubule-organizing center (MT

40 tes polarization of epiblast cells and their apical constriction, a prerequisite for lumenogenesis.

41 Coordinated apical constriction (AC) in epithelial sheets drives tis

42 Apical constriction (AC) is a widely utilized mechanism

43 To test whether the physical forces from apical constriction alone are sufficient to drive the fo

44 IM is required for neural fold elevation and apical constriction along with cell polarization and elo

45 ition of non-muscle myosin II (NM II)-driven apical constriction altered ISC shape and reduced niche

46 ered apical junctions, with perturbations in apical constriction and actin accumulation.

47 ting cells and prevents them from undergoing apical constriction and apicobasal contraction.

48 in vivo 4D microscopy, I show that, besides apical constriction and apoptosis, the LECs undergo exte

49 nhibiting actomyosin contractility prevented apical constriction and blocked branch initiation.

50 o signals through Rho-kinase (Rok) to induce apical constriction and cell shape change during invagin

51 s morphogenetic event, including anisotropic apical constriction and coordinated cell movements.

52 activated actomyosin contraction that drives apical constriction and ingression.

53 loss of both together leads to a failure of apical constriction and ingression.

54 ellular events such as convergent extension, apical constriction and interkinetic nuclear migration,

55 , we show that disruption of Rho1 suppresses apical constriction and invagination in APC null cells.

56 We find that apical constriction and invagination of APC null tissue

57 rminant Dlg1 disrupts the transition between apical constriction and invagination without affecting t

58 A major driver of apical constriction and junctional disassembly are perio

59 segmentation, we visualize cells undergoing apical constriction and large-scale actin structures suc

60 achieved through an interplay between local apical constriction and mechanical bistability of the ep

61 tomyosin cortex, and inhibiting NMII blocked apical constriction and microridge formation.

62 s of the WERDS complex results in defects of apical constriction and neural tube closure.

63 he airway epithelium and used it to simulate apical constriction and proliferation in the primary bro

64 oduces balanced activities of RhoA-generated apical constriction and Rac1-dependent cell elongation t

65 l-autonomous Ras-MAPK signal is required for apical constriction and Rock2a localization.

66 activating the actomyosin network to promote apical constriction and rosette formation in the pLLp.

67 ntracellular Ras-MAPK, which is required for apical constriction and rosette formation in the pLLp.

68 tein signaling to drive actomyosin-dependent apical constriction and subsequent bending of the neural

69 of mcf2lb mutant pLLP cells showed disrupted apical constriction and subsequent rosette organization.

70 -polarized dynamic actomyosin networks drive apical constriction and the anisotropic loss of cell con

71 e longitudinal microtubule array crucial for apical constriction and tube formation.

72 Affected cells also undergo progressive apical constriction and, frequently, delamination.

73 mediating events as diverse as cytokinesis, apical constriction, and cell migration.

74 ts of the contractile complexes required for apical constriction, and for the apical localization of

75 APC loss leads to segregation, apical constriction, and invagination that result from t

76 sential roles in both endogenous and ectopic apical constriction, and might be involved in Vangl2 tra

77 retina leads to increased cortical tension, apical constriction, and Yki-mediated hyperplasia, spect

78 Thus, apical constriction appears to be triggered not by a cha

79 ell biological processes that together drive apical constriction are coordinated.

80 The forces driving apical constriction are primarily generated through the

81 myosin-driven anisotropic junction loss and apical constriction are the main drivers of this process

82 ons or how they contribute to DAPLE-mediated apical constriction are unknown.

83 invasive basal ends rather than depending on apical constriction as do the corresponding "bottle cell

84 elial cells, Apxl and KIAA1202 do not induce apical constriction as Shroom does, but have the capacit

85 Loss of Lrp2 severely affected apical constriction as well as proper localization of th

86 helial rupture requires a global increase of apical constriction, as it is prevented by the presence

87 tes endocytic membrane removal for efficient apical constriction, as well as PCP component traffickin

88 tance, involves apicobasal cell heightening, apical constriction at hingepoints, convergent extension

89 molecular bases of such cell behaviors (e.g. apical constriction, basal nuclear migration) are poorly

90 x (medioapical) can change cell shape (e.g., apical constriction) but can also result in force transm

91 nvagination are thought to be facilitated by apical constriction, but the mechanism by which changes

92 he Galpha12/13 pathway coordinate collective apical constriction, but the mechanism of coordination i

93 We find that artificially inducing apical constriction by activating myosin contraction is

94 ithelium, and each non-autonomously prevents apical constriction by an average of five Vangl2-replete

95 al force-producing actomyosin networks drive apical constriction by contracting while connected to ce

96 ression of the fog signaling protein induces apical constriction by interacting with a receptor whose

97 We conclude that apical constriction can function to position blastomeres

98 Apical constriction changes cell shapes, driving critica

99 is process involves a tissue-wide pattern of apical constriction controlled by Sonic hedgehog (Shh) s

100 morphogenetic events common to most animals: apical constriction, convergent extension and collective

101 Epithelial folding mediated by apical constriction converts flat epithelial sheets into

102 yos expressing activated Smoothened, display apical constriction defects in lateral cells.

103 Apical constriction depends on a Rho GTPase signaling pa

104 sistent with a role for Shroom in organizing apical constriction, disrupting Shroom function resulted

105 Apical constriction driven by actin and non-muscle myosi

106 larization of Rab11 is essential for ectopic apical constriction driven by the actin-binding protein

107 Apical constriction drives tissue folding or cell extrus

108 ral cells are taller and undergo synchronous apical constriction, driving neural fold elevation.

109 uggest that Vangl2 affects Rab11 to regulate apical constriction during blastopore formation.

110 disassembly, or pulses, are associated with apical constriction during Drosophila melanogaster gastr

111 the airway epithelium is driven primarily by apical constriction during monopodial branching of the a

112 room3, a molecule previously associated with apical constriction during morphogenesis of the neural p

113 ate that Shroom is an essential regulator of apical constriction during neurulation.

114 n the medioapical region of cells to control apical constriction during SG invagination.

115 between Wnt5a and Lgl that is essential for apical constriction during vertebrate gastrulation.

116 e a role for PCP signaling in the process of apical constriction during Xenopus gastrulation.

117 In our recent paper we observed that apical constrictions during the initial phase of ventral

118 cluding remodeling of the basement membrane, apical constriction, epithelial de-adhesion, directed mo

119 Apical constriction facilitates epithelial sheet bending

120 myosin mutants with in vivo measurements of apical constriction for the same mutants, we show that i

121 Work on apical constriction from multiple systems including Dros

122 constrict isotropically, which suggests that apical constriction generates anisotropic epithelial ten

123 reveal a morphogenetic program of patterned apical constriction governed by Shh signaling that gener

124 Most studies of tissue folding, including apical constriction, have focused on how RhoA is activat

125 tomyosin complexes play an essential role in apical constriction; however, the detailed analysis of m

126 ve posterior endoderm, which still undergoes apical constriction in acellular embryos as in wildtype.

127 iscent of similar requirements of Cap during apical constriction in Drosophila development, suggestin

128 ssion of constitutively active Mrtfa induced apical constriction in ectodermal cells via remodeling o

129 Yurt overexpression thus induces apical constriction in epithelial cells.

130 nts, that there is no role for columnar cell apical constriction in FC morphogenesis, and that squamo

131 imaging shows that aPKC perturbation induces apical constriction in non-mitotic cells within minutes,

132 microtubule cytoskeleton leads to failure of apical constriction in placodal cells fated to invaginat

133 lations by formation of smooth boundaries or apical constriction in small groups of cells.

134 ing Rab11-mediated trafficking in regulating apical constriction in the Drosophila embryo.

135 n ventral floor plate expansion and mediated apical constriction in the lateral midbrain neural folds

136 uckling-like deformation jointly mediated by apical constriction in the mesoderm and in-plane compres

137 ockdown reduced F-actin levels and inhibited apical constriction in the neural and non-neural ectoder

138 We show that in C. elegans morphogenesis, apical constriction in the retracting pharynx drives inv

139 that there are two crucial preconditions for apical constriction in the ventral furrow: myosin stabil

140 domain adaptor at apical junctions, promotes apical constriction in the Xenopus superficial ectoderm,

141 pression of Shroom is sufficient to organize apical constriction in transcriptionally quiescent, naiv

142 Our results suggest a new model for apical constriction in which a cortical actin-myosin cyt

143 networks previously shown to underlie pulsed apical constrictions in the amnioserosa are apparently a

144 pectrin and integrins as novel regulators of apical constriction-independent cell elongation, as alph

145 mechanism involving volume conservation and apical constriction-induced basal movement of cytoplasm

146 This inhibition of apical constriction involves diminished myosin-II locali

147 Apical constriction is a cell shape change critical to v

148 Apical constriction is a cell shape change that drives k

149 Apical constriction is a cell shape change that promotes

150 Apical constriction is a cell shape change that promotes

151 Apical constriction is a change in cell shape that drive

152 Apical constriction is a critical cell shape change that

153 Apical constriction is a widely utilized cell shape chan

154 Apical constriction is associated with contractile myosi

155 Apical constriction is conventionally thought to be driv

156 When apical constriction is disrupted, compressing force gene

157 Although it has been well documented that apical constriction is necessary for VF formation, the m

158 It remains unclear how apical constriction is regulated spatiotemporally during

159 t, consistent with the experimental results, apical constriction is sufficient to drive the early sta

160 Apical constriction is thought to be triggered by contra

161 We propose that apical constriction leading to endoderm invagination is

162 triction of cells in the MF, with a stronger apical constriction leading to less frequent and more pr

163 both the common themes and the variations in apical constriction mechanisms promises to provide insig

164 s is topologically analogous to well-studied apical constriction mechanisms, but very different from

165 dditional mechanical inputs are required for apical constriction-mediated folding.

166 ement of the microtubule cytoskeleton during apical constriction: medioapical Patronin (CAMSAP) foci

167 ibits mesoderm invagination, which relies on apical constriction, mitotic entry in an artificially co

168 pressing cells flanking the boundary undergo apical constriction, move inwards and adopt a bottle mor

169 e that neither loss of spatially coordinated apical constriction nor its complete blockage prevent in

170 to spatially restrict where actomyosin-based apical constriction occurs across the invaginating Droso

171 tial and temporal differences in the rate of apical constriction of AS cells.

172 1 and Rho-associated kinase (Rock), regulate apical constriction of bottle cells at the blastopore an

173 Xenopus laevis gastrulation is marked by the apical constriction of bottle cells in the dorsal margin

174 contractile actomyosin network that triggers apical constriction of cells and thereby tissue folding.

175 s are found to depend on the strength of the apical constriction of cells in the MF, with a stronger

176 urrow in the Drosophila embryo relies on the apical constriction of cells in the ventral region to pr

177 MPDZ depletion also blunted DAPLE--mediated apical constriction of cultured cells.

178 Shroom regulates this process by causing apical constriction of epithelial cells via a pathway in

179 osophila ventral furrow and other epithelia, apical constriction of hundreds of epithelial cells fold

180 precursor cells in a process that depends on apical constriction of ingressing cells.

181 We show that the apical constriction of lens epithelial cells that accomp

182 Apical constriction of mesodermal cells initiates but is

183 g neurulation in Xenopus and is required for apical constriction of neuroepithelial cells and subsequ

184 We suggest that apical constriction of the actin cytoskeleton may provid

185 ow that monopodial branching is initiated by apical constriction of the airway epithelium, and not by

186 ile behavior in wild-type embryos drives the apical constriction of the cells.

187 n, DE-cadherin and Armadillo associated with apical constriction of the centripetal FC.

188 on of beta(H) by the karst mutation prevents apical constriction of the follicle cells during mid-oog

189 ession of individual cells, but is driven by apical constriction of the kind that promotes migration

190 nalysis of Drosophila gastrulation, that the apical constriction of ventral furrow cells is pulsed.

191 by a columnar-to-conical cell shape change (apical constriction or AC) and is known to be dependent

192 contacts induces cell shape changes, such as apical constriction or polarized junction remodeling, dr

193 Apical constriction, or a reduction in size of the apica

194 al constriction, the diversity of roles that apical constriction plays in development, and the common

195 uperficial epithelial enveloping layer by an apical constriction process of cell delamination.

196 Strikingly, apical constriction produces similar flow patterns in mu

197 e in lateral surface area of ISCs induced by apical constriction promotes interactions between neighb

198 r actomyosin network, and a reduction in the apical constriction rate.

199 e epithelial gaps that result from increased apical constriction, rather than loss of apical-basal po

200 cisely localized actomyosin regulators drive apical constriction remains poorly understood.

201 Epithelial folding mediated by apical constriction serves as a fundamental mechanism to

202 The requirement of Cap1 for a cellular apical constriction step is reminiscent of similar requi

203 ws that Wnt signaling directly regulates the apical constriction that drives gastrulation movements i

204 losure and appears pivotal in regulating the apical constrictions that drive epithelial foldings in v

205 esumptive mesoderm cells exhibit coordinated apical constrictions that mediate invagination [5, 6].

206 rt to explore the diversity of mechanisms of apical constriction, the diversity of roles that apical

207 partner the RhoGEF Cysts support myosin and apical constriction to ensure robust ingression dynamics

208 n of the PAR-3 protein complex, then undergo apical constriction to form a cylindrical cyst.

209 by actomyosin cortical networks, which drive apical constriction to position the first inner cells of

210 l cells change shape, undergoing synchronous apical constriction, to create the ventral furrow (VF).

211 of cortical actin is sufficient to delay the apical constriction-to-invagination transition.

212 ary for VF formation, the mechanism by which apical constriction transmits forces throughout the bulk

213 Consistently, in ectoderm, cell-autonomous apical constriction was accompanied by neighbor expansio

214 Shroom-induced apical constriction was associated with enrichment of ap

215 Surprisingly, apical constriction was inhibited in the presence of noc

216 broadly conserved actin architecture driving apical constriction, we examined actomyosin architecture

217 nerate invagination as a passive response to apical constriction when it is combined with region-spec

218 ical and molecular changes characteristic of apical constriction, whereas depletion of their function

219 s the extracellular matrix and folds through apical constriction, whereas the transit amplifying zone

220 basal polarity and undergo actomyosin-driven apical constriction, which are processes that require Ga

221 rmed into the ciliated dendritic tip through apical constriction, which is followed by axonal outgrow

222 ty and adhesion in unique ways, resulting in apical constriction with varying dynamics and subcellula

223 in the shape of the neural plate as well as apical constriction within the neural plate are perturbe

224 non-GTP state, by contrast, causes dramatic apical constriction without disrupting polarity.