ライフサイエンスコーパス: apical dendrite

1 te, which differ mainly on the extent of the apical dendrite.

2 g translocation of the soma into an existing apical dendrite.

3 perpolarizing injections in the soma or main apical dendrite.

4 of the recording probe with the axis of the apical dendrite.

5 topped close to the junction of the soma and apical dendrite.

6 Ca2+ spike (LTS) throughout the granule cell apical dendrite.

7 these neurons comes from studies of the main apical dendrite.

8 f action potentials backpropagating into the apical dendrite.

9 one of which supported Ca(2+) spikes in the apical dendrite.

10 al cells with paler cytoplasm, often with an apical dendrite.

11 esting [Ca(2+)] was 32-59 nM in the proximal apical dendrite.

12 leading to spike generation in the proximal apical dendrite.

13 granule cells (DGCs) have a single, complex, apical dendrite.

14 ominantly within their soma, rather than the apical dendrite.

15 e of these neurons is the axon origin at the apical dendrite.

16 educed dendritic complexity and thinner main apical dendrite.

17 ansformation of the leading process into the apical dendrite.

18 rly from the soma, and leveled at the distal apical dendrite.

19 ated K(+) channel was uniform throughout the apical dendrite.

20 ing the number of inhibitory synapses on the apical dendrites.

21 kinetics as they undergo strong filtering by apical dendrites.

22 (2)(+) influx and regenerative potentials in apical dendrites.

23 d strong PIST-labeling, extending into their apical dendrites.

24 the soma and proximal portion of tufted cell apical dendrites.

25 lucifer yellow to visualize their basal and apical dendrites.

26 dendrite formation in vivo without affecting apical dendrites.

27 are preferentially established on basal vs. apical dendrites.

28 mice show a pronounced shift toward shorter apical dendrites.

29 reduced, as was electrical coupling between apical dendrites.

30 voked a localized Ca(2+) wave in the primary apical dendrites.

31 ic lengths and field sizes, and identifiable apical dendrites.

32 d this horizontal spread was due to off-axis apical dendrites.

33 hrough dendodendritic inputs on their distal apical dendrites.

34 of these pyramidal neurons or along layer 5 apical dendrites.

35 k and strong inputs were both located in the apical dendrites.

36 targeted progressively higher regions of the apical dendrites.

37 nitiates degenerative signaling generally in apical dendrites.

38 and highly reliable property of neocortical apical dendrites.

39 ls mediating this current are located in the apical dendrites.

40 cal in the soma and the first 300 mum of the apical dendrites.

41 ns of DA can be attributed to effects in the apical dendrites.

42 ces in the extension and complexity of their apical dendrites.

43 vident age-related differences in LTP in the apical dendrites.

44 ersus young adult slices and in basal versus apical dendrites.

45 of Schaffer-collateral synapses in the upper apical dendrites.

46 eceive stronger synaptic inhibition on their apical dendrites.

47 s in the series, durably inhibits the distal apical dendrites.

48 and shifted their initiation site along the apical dendrites.

49 bition rapidly shifts from their soma to the apical dendrites.

50 perisomatic membrane of PNs, and not on the apical dendrites.

51 K(+) current uniformly distributed along the apical dendrites.

52 ex and developed misoriented, often inverted apical dendrites.

53 larization observed at the tips of basal and apical dendrites.

54 ns) elicited by stimulations of the soma and apical dendrites.

55 controlling electrogenesis in pyramidal cell apical dendrites.

56 emonstrating coincidence detection along the apical dendrites.

57 ned within the region circumscribed by their apical dendrites.

58 that often displayed infoldings and thicker apical dendrites.

59 nd superficial cells short or absent primary apical dendrites.

60 rs and structural abnormalities of subicular apical dendrites.

61 tory synaptic contacts with the proximal CA3 apical dendrites.

62 mislocalization and development of multiple apical dendrites.

63 aglomerular lateral inhibition between their apical dendrites.

64 eral and temporoammonic inputs at the distal apical dendrites.

65 uced excitability is correlated with shorter apical dendrites.

66 feliforms) exhibiting bifurcating, V-shaped apical dendrites.

67 l pyramidal neurons receive input onto their apical dendrites.

68 classes for axons, dendrites, and pyramidal apical dendrites.

69 s PNs primarily innervate basal and proximal apical dendrites.

70 action potentials originate in the proximal apical dendrite, a region targeted by cortical feedback

71 tenin expression shifts primarily to nascent apical dendrites, a pattern that continues through adult

72 ablished dendrodendritic input to the distal apical dendrite and a novel pathway in which the cell bo

73 eurons appear pyramidal, growing a prominent apical dendrite and few small basal dendrites.

74 proximal, middle, and distal segments of the apical dendrite and measured boosting of subthreshold an

75 t, using dual whole-cell recordings from the apical dendrite and soma of layer 5 (L5) pyramidal neuro

76 ap junctions distributed uniformly along the apical dendrite and, on average, proximally with respect

77 es with heads increases by 162% on secondary apical dendrites and 113% on basal dendrites.

78 without heads) increases by 38% on secondary apical dendrites and 88% on basal dendrites and the numb

79 atory cells, preferentially targeting distal apical dendrites and apical dendritic tufts of pyramidal

80 found to have constitutive atrophy of distal apical dendrites and decrements in apically targeted exc

81 Axons of these bipolar cells arise from the apical dendrites and follow a course through the optic t

82 ted predominantly in CA2/CA3a pyramidal cell apical dendrites and in interneurons in CA1-3 stratum or

83 estricted dendritic localization of Npn-2 to apical dendrites and of Npn-1 (also known as Nrp1) to al

84 -40 min, a large Ca(2+) elevation appears in apical dendrites and propagates to the soma.

85 Dual recordings from the apical dendrites and somata of mitral cells show that LL

86 Ca(2+) waves that initiated in the proximal apical dendrites and spread over this region and in the

87 se in dendritic spine density selectively in apical dendrites and subtle changes in dendritic spine m

88 he cell layer giving deep cells long primary apical dendrites and superficial cells short or absent p

89 for the control of pyramidal cells at their apical dendrites and support differential computational

90 the size) in diameter than unlabeled, mature apical dendrites and that they had developing synapses o

91 hins increased the extent of only basal, not apical, dendrites and promoted greater elongation than w

92 s asymmetrically localized to the developing apical dendrite, and is required for the chemoattractive

93 ve described inhibitory synaptic contacts on apical dendrites, and an abundant number of GABAergic sy

94 ayer 4 spiny neurons failed to remodel their apical dendrites, and approximately 55% remained as pyra

95 l area CA1 are remarkably enriched in distal apical dendrites, and this unique distribution pattern i

96 A subset of cells, those with the largest apical dendrites, are plastic, but those with the smalle

97 most spine populations on basal and proximal apical dendrites, as well as firing rates and ocular dom

98 In contrast to apical dendrites, basal and oblique branches: (1) impose

99 Type 1 cells had apical dendrites bearing numerous dendritic spines with

100 ons of IP3 appear to be confined to the main apical dendrite because uncaging IP3 in the oblique dend

101 stacks of 15-19 somata with pyramidal cells apical dendrites being arranged into distinct vertically

102 They are clearest on the main apical dendrite but also have been detected in the finer

103 present on corticospinal neuronal somata and apical dendrites but were not detected on their projecti

104 preferentially innervated either L2 or L3/5 apical dendrites, but not both.

105 t mitral-mitral cell gap junctions on distal apical dendrites contain Cx36.

106 Our findings indicate apical dendrite degeneration as a novel cellular patholo

107 Alzheimer's disease (AD), and found profound apical dendrite degeneration of Betz cells in both fALS

108 as a potential intrinsic mechanism for CSMN apical dendrite degeneration.

109 reviously reported progressive CSMN loss and apical dendrite degeneration.

110 , AIS distance inversely correlates with the apical dendrite diameter, and model simulations confirme

111 ines from basal, proximal apical, and distal apical dendrites, differences that are more pronounced w

112 In proximal and distal apical dendrites, different calcium dynamics correlate w

113 show here that the excitability of terminal apical dendrites differs from that of the apical trunk.

114 ing to the cortical plate, neurons extend an apical dendrite directed toward the pial surface.

115 contained complex pyramidal cells with dual apical dendrites displaying nonaccommodating discharge p

116 ging of developing mouse cortex reveals that apical dendrites emerge by direct transformation of the

117 Whether the apical dendrite emerges by transformation of the leading

118 ype, the "dentate" CA3 pyramidal cell, whose apical dendrites extend into and ramify within the hilus

119 By 96 h after BrdU injection, these apical dendrites extended into the middle of the molecul

120 he majority of neurons in all mice have long apical dendrites extending into cortical layer I.

121 tified these neurons as pyramidal cells with apical dendrites extending into superficial cortical lay

122 in secondary branches and distal segments on apical dendrites following sleep deprivation.

123 eeper layers of MEC in view of the extensive apical dendrites from deeper cells reaching layers II an

124 neously recorded long-term spine dynamics in apical dendrites from layer 5 pyramidal cells and blood

125 ysis of caged glutamate, individual terminal apical dendrites generated cadmium-sensitive all-or-none

126 in malformed cortex identified as having an apical dendrite had firing patterns similar to control p

127 We find that truncated GCs with long apical dendrites had active properties that were indisti

128 y, the sADP occurred along the extent of the apical dendrite in CPn and COM neurons.

129 Cells presenting a tufted apical dendrite in layer I have dense terminal fields in

130 ce correlated with density of thin spines on apical dendrites in CA1, although not with mushroom spin

131 eurogenesis led to atrophy of pyramidal cell apical dendrites in dorsal CA3 and to neuronal reorganiz

132 drite inputs, suggesting a dominant role for apical dendrites in integrating feedback in visual infor

133 urons occurs in the distal branches of their apical dendrites in L1 but not in the perisomatic dendri

134 Monitoring layer 5 neurons' apical dendrites in layer 1, we show that one cellular e

135 diate a specific developmental retraction of apical dendrites in layer VI neurons.

136 the soma and throughout the entire length of apical dendrites in resting pyramidal neurons.

137 lized to layer V pyramidal neurons and their apical dendrites in the cortex, and to pyramidal neurons

138 ations in the morphology of pyramidal neuron apical dendrites in the prelimbic area of the medial pre

139 pplication of a hyperosmotic solution to the apical dendrites in the vicinity of the dendritic whole-

140 campal pyramidal neurons in vitro and toward apical dendrites in vivo.

141 groups of pyramidal neurons (twin and single apical dendrites) in the CA1 region.

142 re recurrent mossy fiber input through their apical dendrites, indicating that these cells are robust

143 Furthermore, apical dendrite inputs have larger receptive fields and

144 The oriented growth of the apical dendrite is regulated by Sema3A, which acts as a

145 the modulation of dendritic excitability by apical dendrite length and show that the operational rep

146 rence in output mode between single and twin apical dendrite morphologies, which was consistent with

147 s are generated in the distal portion of the apical dendrite, most likely in the glomerulus.

148 on an outside-out patch was excised from the apical dendrite near the point of stimulation and satura

149 ted microglia closely apposed and ensheathed apical dendrites, neurites, and neuronal perikarya.

150 g uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were obser

151 these L1-3 interneurons inhibited the distal apical dendrite of >60% of L5 pyramidal neurons across m

152 The apical dendrite of 86% of the biocytin-labeled HEGCs ext

153 patch-electrode recordings from the soma and apical dendrite of CA1 pyramidal neurons in hippocampal

154 many experimental results recorded from the apical dendrite of L5 pyramidal neurons, the model valid

155 ded the membrane potential from the soma and apical dendrite of layer 5 (L5) pyramidal neurons of the

156 The integration of synaptic inputs to the apical dendrite of layer 5 neocortical pyramidal cells w

157 The apical dendrite of layer V pyramidal neurons in the mPFC

158 l-D-aspartate receptor transmission onto the apical dendrite of layer V pyramidal neurons undergoes l

159 pendent synaptic modification vary along the apical dendrite of rat cortical layer 2/3 pyramidal neur

160 eous whole-cell recordings from the soma and apical dendrite of rat neocortical pyramidal neurons.

161 ic Ca(2+) spikes as prominently found in the apical dendrite of S1 (somatosensory cortex) pyramidal n

162 the activation of Ca(2+) channels along the apical dendrite of the CA1 hippocampal pyramidal neuron

163 subunits were primarily distributed on large apical dendrites of a subset of pyramidal cells from dee

164 Apical dendrites of Betz cells are important sites for t

165 al slices revealed increased staining in the apical dendrites of CA1 neurons.

166 reases with distance from the soma along the apical dendrites of CA1 PCs.

167 Kv4.2-mediated A-type K(+) current along the apical dendrites of CA1 pyramidal cells (CA1 PCs) is res

168 hic factor (BDNF) increased spine density in apical dendrites of CA1 pyramidal neurones in organotypi

169 Voltage-dependent K(+) channels in the apical dendrites of CA1 pyramidal neurones play importan

170 ich are constitutively active at rest in the apical dendrites of CA1 pyramidal neurons and can be fur

171 e asymmetric (excitatory) synapses formed on apical dendrites of CA1 pyramidal neurons at 2 months po

172 stimulation (48 h) reduces spine density in apical dendrites of CA1 pyramidal neurons in organotypic

173 Moreover, the average spine density on the apical dendrites of CA1 pyramidal neurons is significant

174 tics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neurons using dual who

175 e elimination of A-type K+ currents from the apical dendrites of CA1 pyramidal neurons.

176 ing by making whole-cell recordings from the apical dendrites of CA1 pyramidal neurons.

177 maturity without affecting spine density in apical dendrites of CA1 pyramidal neurons.

178 kainate receptors located mainly on proximal apical dendrites of CA3 pyramidal cells may be compensat

179 the cell bodies and proximal portion of the apical dendrites of CA3 pyramidal neurons of the postnat

180 and was generated by a current source in the apical dendrites of CA3.

181 We investigated the synaptic innervation of apical dendrites of cortical pyramidal cells in a region

182 HCN1 shows a high level of expression in apical dendrites of cortical pyramidal neurons and in pr

183 covering the dentate gyrus, CA3c/hilus, and apical dendrites of field CA1, but not for the remainder

184 al extension of the Golgi apparatus into the apical dendrites of hippocampal and neocortical pyramida

185 results in altered spine morphologies along apical dendrites of hippocampal CA1 neurons in vivo.

186 To do so, we recorded from the apical dendrites of hippocampal CA1 pyramidal neurons in

187 From the apical dendrites of hippocampal CA1 pyramidal neurons, w

188 ent (Ih), are selectively targeted to distal apical dendrites of hippocampal CA1 pyramidal neurons.

189 okes large amplitude Ca2+ waves in the thick apical dendrites of hippocampal CA1 pyramidal neurons.

190 at produces retraction and simplification of apical dendrites of hippocampal CA3 pyramidal neurons, a

191 e enhanced dendritic arborization within the apical dendrites of hippocampal cornu ammonis 1 and gran

192 ptic sites and colocalizes with the NMDAR in apical dendrites of hippocampal neurons.

193 r long-term potentiation (LTP) in the distal apical dendrites of hippocampal pyramidal neurons.

194 se is specific to L2/3 neurons and absent on apical dendrites of L5 neurons, and is dependent on expr

195 uitry, layer 4-3 (L4-L3) synapses, or in the apical dendrites of L5 neurons- but a broad-scale analys

196 NDNF+ cells also inhibit the apical dendrites of L5 pyramidal tract (PT) cells to sup

197 eled neurons revealed microglia fused to the apical dendrites of labeled pyramidal neurons.

198 clustered loss of dendritic spines along the apical dendrites of layer (L) 5 pyramidal neurons (PNs)

199 inergic inhibition of NGFCs disinhibited the apical dendrites of layer 2/3 pyramidal neurons by silen

200 Spines on apical dendrites of layer 3 neurons were then characteri

201 py and determined the spine turnover rate of apical dendrites of layer 5 (L5) and L2/3 pyramidal neur

202 The motility of spines on apical dendrites of layer 5 neurons was assayed by time-

203 nscranial two-photon microscopy, we followed apical dendrites of layer 5 pyramidal neurons in the mot

204 eases the elimination of dendritic spines on apical dendrites of layer 5 pyramidal neurons in the mot

205 ere, we report reduction of spine density in apical dendrites of layer 5 pyramidal neurons of several

206 we repeatedly imaged dendritic spines on the apical dendrites of layer 5 pyramidal neurons.

207 Both cell types targeted the distal apical dendrites of layer II principal neurons.

208 SF increased the mushroom-type spines on the apical dendrites of layer V pyramidal neurons adjacent t

209 (the NO receptor) was at high levels in the apical dendrites of layer V pyramidal neurons and in par

210 The apical dendrites of many neurons contain proximal and di

211 also unexpectedly found them ubiquitously in apical dendrites of mature hippocampal CA1 and cortical

212 glomerular (PG) cell types interact with the apical dendrites of mitral and tufted cells inside glome

213 In the olfactory bulb, gap junctions between apical dendrites of mitral cells increase excitability a

214 terminals in the upper layers impinge on the apical dendrites of neurons in other layers, suggesting

215 yer were significantly reduced compared with apical dendrites of normotopic granule cells.

216 Incertocortical axons contact the distal apical dendrites of postmigratory cortical pyramidal cel

217 interneurons were shown to synapse on distal apical dendrites of pyramidal cells and to spike prefere

218 genic reporter line, we demonstrate that the apical dendrites of pyramidal cells are abnormally organ

219 (-ir) was particularly dense within primary apical dendrites of pyramidal cells in both hippocampus

220 cells, gate top down input by inhibiting the apical dendrites of pyramidal cells in layers 2/3 and 5,

221 t an excitatory feedback mechanism acting on apical dendrites of pyramidal cells in V1 and other area

222 In analyses restricted to the apical dendrites of pyramidal cells, greater spine densi

223 4 subunit mRNAs were highly localized to the apical dendrites of pyramidal cells, whereas in interneu

224 The apical dendrites of pyramidal neurons integrate inputs f

225 llations (field potentials) generated in the apical dendrites of pyramidal neurons.

226 perpolarization in the outer portions of the apical dendrites of pyramidal neurons.

227 mice resulted in elevated spine densities on apical dendrites of star pyramidal cells at both postnat

228 Spine density on apical dendrites of subicular pyramidal cells was determ

229 s undergoes retraction and simplification of apical dendrites of the CA3 pyramidal neurons and synapt

230 stent with a distribution in cell bodies and apical dendrites of the sensory neurons.

231 , S-SDS increases arborization and spines of apical dendrites of these neurons in a D1 receptor-depen

232 led accumulation of autophagosomes along the apical dendrites of vulnerable CSMN at P60, early sympto

233 ema3F-Fc protein induced spine retraction on apical dendrites of wild-type, but not NrCAM-null cortic

234 Basal, but not apical, dendrites of neurons from SNI rats are longer an

235 lude reduced spine density on basal, but not apical, dendrites of pyramidal neurons in the binocular

236 ino acids mediate a reversible remodeling of apical dendrites on CA3 pyramidal cell neurons of the hi

237 Changes did not occur on their apical dendrites or on cells in the dentate gyrus or som

238 rve terminals (input) and mitral/tufted cell apical dendrites (output).

239 end into the stratum oriens-alveus while the apical dendrites project deep into the stratum lacunosum

240 LLDs occur synchronously only in cells whose apical dendrites ramify in the same glomerulus.

241 Only the largest pyramidal cell apical dendrites reached the supragranular layers, and t

242 ptic glutamate receptors across the range of apical dendrites receiving Schaffer collateral input.

243 odel with five crucial ionic currents in the apical dendrites reproduces all features of these neuron

244 fields are generated in or near the soma and apical dendrites, respectively.

245 In addition, pyramidal apical dendrites reveal a distinct motif profile.

246 Classic pyramidal cells had a long apical dendrite, robust basal arbors, and an axon with b

247 e found the relative inhibitory input at the apical dendrite's main bifurcation to be more than 2-fol

248 ical properties of rat (either sex) GCs with apical dendrites severed at different locations.

249 timulus preference, while feedback inputs to apical dendrites sharpen selectivity.

250 ct subset of layer 10 bipolar neurons, whose apical dendrites show a complex transverse arborization

251 addition, electron microscopy of DCX-labeled apical dendrites showed that they were much thinner (1/4

252 y reduced in the first 150 micrometer of the apical dendrites, so that action potentials recorded far

253 imity of postsynaptic densities expressed in apical dendrite spines, which include also the alpha(3)

254 rease in spine density on CA3 pyramidal cell apical dendrites (stratum radiatum) and an increase in t

255 rease in spine density, both on basal and on apical dendrites, suggesting a possible substrate for th

256 layers and were substantially larger in the apical dendrites than in cell body layers or basal dendr

257 nel activity was significantly larger in the apical dendrites than in the soma.

258 with burst capability had less well-branched apical dendrites than nonbursting HEGCs, their dendrites

259 of back-propagating action potentials in the apical dendrite that occurs in parallel with long-term p

260 tions in oblique radial branches of the main apical dendrite that were of similar amplitude than thos

261 hanges in the architecture and plasticity of apical dendrites that are particularly evident in the CA

262 ments of mammalian visual cortex, with thick apical dendrites that ascend to layer 1, "intrinsically

263 se in synapse number specifically on layer V apical dendrites that emerges during adolescence and per

264 Most of these neurons have apical dendrites that extend to the superficial layers a

265 The total length and branching of HEGC apical dendrites that penetrated the molecular layer wer

266 roup 1 includes large pyramidal neurons with apical dendrites that reach layer 1 with an apical tuft;

267 t amplitude (0.3-0.6 nA) in the range of CA1 apical dendrites that receive a uniform density of Schaf

268 a change in the relative extent of basal and apical dendrites that results in a gradual sculpting int

269 ayer III while deep pyramidal cells had long apical dendrites that spanned layers I and II.

270 hough boosting was maintained throughout the apical dendrite, the degree of boosting changed nonmonot

271 s pS857 dephosphorylation in distal areas of apical dendrites, the region forming synapses with the i

272 The polarization was biphasic in the mid-apical dendrites; there was a time-dependent shift in th

273 he cell body for variable distances into the apical dendrite; these spikes were found in only a few a

274 responsible for the ability of the proximal apical dendrite to control the coupling between the axon

275 the sets of mitral cells that project their apical dendrite to the same glomerulus represent unique

276 DA spikes or trains of EPSPs from the distal apical dendrite to the soma in pyramidal neurons in the

277 lb, principal neurons (mitral cells) project apical dendrites to a common glomerulus where they recei

278 count for the enhanced responsiveness of CA3 apical dendrites to chronic stress and may either be pat

279 ons integrate synaptic inputs from basal and apical dendrites to generate stimulus-specific responses

280 widespread inhibition, which shifts from the apical dendrites to somata of pyramidal cells during bur

281 s into primary dendrites and shifts adjacent apical dendrites to the basal pole of the cell.

282 Here we show that the growth of apical dendrites towards the pial surface is regulated b

283 elayed-rectifier K(+) conductances, while an apical-dendrites/trunk compartment included persistent N

284 The gross structure and orientation of apical dendrite tufts remained stable over a two-month p

285 Three-dimensional analysis of labeled apical dendrites under an electron microscope revealed t

286 hold Ca(2+) spike initiation in the proximal apical dendrite using two-photon Ca(2+) photometry and f

287 Direct stimulation of distal apical dendrites using focal photolysis of caged glutama

288 Branching patterns of apical dendrites varied as a function of the cell's soma

289 However, the apical dendrite was frequently branched while basal dend

290 ole-cell recordings from the soma and distal apical dendrites were performed and, following the injec

291 release events and spine density on primary apical dendrites were reduced.

292 Spine density and arborization of subicular apical dendrites were significantly related to diagnosti

293 has focused on defining properties of distal apical dendrites where these interneurons form reciproca

294 Ca(2+)-activated channel decreased along the apical dendrite, whereas the density of the large-conduc

295 develops into a DGC, consisting of a single apical dendrite with further branches, remains largely u

296 Type 2 cells possessed apical dendrites with greatly reduced spine densities an

297 We find that CSMN display vacuolated apical dendrites with increased autophagy, shrinkage of

298 s coordination, leading to retraction of the apical dendrite without altering basolateral dendrite dy

299 eptors to synaptically active regions of the apical dendrite without inducing any significant changes

300 matergic terminals, and postsynaptically, at apical dendrites, without inhibiting the soma.