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1 hickened epithelial structure similar to the apical ectodermal ridge.
2 ced by the underlying mesenchyme to form the apical ectodermal ridge.
3 and is essential for proper formation of the apical ectodermal ridge.
4 on of Msx1 and a decrease in Fgf4 within the apical ectodermal ridge.
5 ing activity (ZPA) and Fgfs in the overlying apical ectodermal ridge.
6 A expression of sonic hedgehog (Shh) and the apical ectodermal ridge.
7 the posterior region of the limb bud and the apical ectodermal ridge.
8 parameters and the duration of the overlying apical ectodermal ridge.
9 ponse to FGF4, which mimics extension of the apical ectodermal ridge.
10 nsistent with reduced FGF signaling from the apical ectodermal ridge.
11 s with Fgf4, but not Fgf8, expression by the apical ectodermal ridge.
12 ich fail both to express Fgf8 and to form an apical ectodermal ridge.
13 iate into a specialized structure termed the apical ectodermal ridge.
14 also required for normal organization of the apical ectodermal ridge, a signaling center that directs
16 cations are due to a failure to maintain the apical ectodermal ridge, a stratified epithelium, essent
19 n carried out to investigate the role of the apical ectodermal ridge (AER) and FGF-4 on the control o
20 buds, Msx2 transcripts are expressed in the apical ectodermal ridge (AER) and in various regions of
21 is maintained by two signaling centers, the apical ectodermal ridge (AER) and the zone of polarizing
22 m along their distal tips that resembles the apical ectodermal ridge (AER) and this thickened distal
23 d in the reciprocal interactions between the apical ectodermal ridge (AER) and underlying mesoderm re
24 he developing limb, Bmp4 is expressed in the apical ectodermal ridge (AER) and underlying mesoderm.
25 entral (DV) border ectoderm exclusive of the apical ectodermal ridge (AER) as a new signaling center
26 st growth factor 8 (Fgf8) is produced by the apical ectodermal ridge (AER) at the distal tip of the l
28 esults in the formation of a second, ventral apical ectodermal ridge (AER) at the junction between Wn
29 m control dorso-ventral patterning while the apical ectodermal ridge (AER) controls bud outgrowth and
30 gous Dac embryos, the central segment of the apical ectodermal ridge (AER) degenerates, leaving the a
34 activation of the Lbx1 and Btrc genes in the apical ectodermal ridge (AER) in an Fgf8-like pattern in
43 f the developing limb bud in response to the apical ectodermal ridge (AER) is mediated at least in pa
46 Ectrodactyly is linked to defects of the apical ectodermal ridge (AER) of the developing limb bud
47 hat chick Ptc2 is expressed in the posterior apical ectodermal ridge (AER) of the limb bud in a patte
51 ive apoptotic cell death was observed in the apical ectodermal ridge (AER) of the newly forming forel
52 imb, delayed elevation and compaction of the apical ectodermal ridge (AER) produces a ridge that is a
53 t growth factors (FGFs) are signals from the apical ectodermal ridge (AER) that are essential for lim
54 ng posterior mesodermal cells underneath the apical ectodermal ridge (AER) that give rise to the skel
55 te embryonic limb requires signalling by the apical ectodermal ridge (AER) to the progress zone (PZ),
57 rom the expression pattern of Jagged2 in the apical ectodermal ridge (AER) whether the ectodermal or
58 genetic proteins (BMPs) are expressed in the apical ectodermal ridge (AER), a critical signaling cent
60 tor gene Bmpr1a specifically in the limb bud apical ectodermal ridge (AER), a source of FGF activity.
61 proximodistal (PD) axis is controlled by the apical ectodermal ridge (AER), a specialized epithelium
63 migration, and patterning in response to the apical ectodermal ridge (AER), and has the functional po
64 he zone of polarizing activity (ZPA) and the apical ectodermal ridge (AER), are known to cause limb m
65 cular from the specialized epithelium of the apical ectodermal ridge (AER), including three members o
66 in a specialized epithelial compartment, the Apical Ectodermal Ridge (AER), is a conserved feature of
68 cant growth defect associated with a smaller apical ectodermal ridge (AER), referred to here as an ap
69 xpressed during embryogenesis in the forming apical ectodermal ridge (AER), restricted regions of the
70 r, Jagged2 and Notch1 are coexpressed in the apical ectodermal ridge (AER), suggesting a role for thi
71 ion also results in ventral expansion of the apical ectodermal ridge (AER), suggesting that En-1 is a
72 arent as early as embryonic day 9.5 when the apical ectodermal ridge (AER), the principal site of Meg
73 last growth factor (FGF) signalling from the apical ectodermal ridge (AER), we inactivated Fgf4 and F
74 ent control posterior fin development via an apical ectodermal ridge (AER), whereas an alternative Ho
75 the vertebrate limb bud is regulated by the apical ectodermal ridge (AER), which forms at an invaria
76 The proximal-distal axis is specified by the apical ectodermal ridge (AER), which forms from limb ect
77 10 in the mesenchyme to activate Fgf8 in the apical ectodermal ridge (AER), which in turn promotes me
78 roposed to mediate critical functions of the apical ectodermal ridge (AER), which is required for pro
79 limb development depends on signals from the apical ectodermal ridge (AER), which rims the distal tip
80 ive limb-forming mesoderm and in prospective apical ectodermal ridge (AER)-forming ectoderm, but is n
81 Although the initiation of the expression of apical ectodermal ridge (AER)-specific genes, including
91 novel cell state, but a re-deployment of the apical-ectodermal-ridge (AER) programme underlying limb
92 atenin in the developing chick embryo elicit apical ectodermal ridge and limb regeneration in an orga
93 s expanded in the dorsal-ventral axis of the apical ectodermal ridge and shortened in the anterior-po
94 ave been proposed to direct Fgf8 in the limb apical ectodermal ridge and the midbrain-hindbrain bound
95 Fgf8 and Shh orthologs are expressed in the apical ectodermal ridge and zone of polarizing activity,
96 to the distal ventral limb ectoderm and the apical ectodermal ridge, and overlaps in these ectoderma
98 re dependent on a posterior extension of the apical ectodermal ridge, and this also allows the additi
99 ented epithelium, nephrogenic mesenchyme and apical ectodermal ridge are distributed across the appro
100 on is inhibited distally by signals from the apical ectodermal ridge, both Fgfs and Bmps, and proxima
101 derm, and to a specialized region of it, the apical ectodermal ridge, controls the distribution of ce
102 F/MAPK signaling pathway, emanating from the apical ectodermal ridge, does not regulate cell orientat
103 derm (e.g. Bone Morphogenetic Protein-2) and apical ectodermal ridge (e.g. Fibroblast Growth Factor-4
105 gf-4 was induced in the anterior part of the apical ectodermal ridge, followed later by ectopic expre
106 mb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the
107 expression of epiprofin mRNA in cells of the apical ectodermal ridge in developing limbs and the post
110 over time, including focused analyses of the apical ectodermal ridge, limb mesenchyme and skeletal mu
111 ic transgenic overexpression of Dlx5, in the apical ectodermal ridge of Dlx5/6 null mice can fully re
112 m1 is expressed at significant levels in the apical ectodermal ridge of the limb buds during embryoge
115 y co-grafting either a retinoic acid-exposed apical ectodermal ridge or ectoderm from the wing region
117 ity but inclusion of a retinoic acid-exposed apical ectodermal ridge or of prospective wing bud ectod
118 t the midbrain/hindbrain boundary and in the apical ectodermal ridge, regions where FGF signalling is
119 ructive extrinsic signals from the trunk and apical ectodermal ridge specify the stylopod and zeugopo
120 field ectoderm prior to the formation of the apical ectodermal ridge, structures required for limb in
121 ng limb, it is specifically expressed in the apical ectodermal ridge, suggesting a role in epithelial
123 nge genes play roles in the formation of the apical ectodermal ridge, the dorsal/ventral border in th
124 veloping brain, the developing limb buds and apical ectodermal ridge, the lateral and nasal processes
125 development of median fins occurs beneath an apical ectodermal ridge, the structure that controls out
127 Moreover, we show that FGF-8 can replace the apical ectodermal ridge to maintain Shh expression and o
129 impaired response to FGF signaling from the apical ectodermal ridge, which disrupts the feedback loo
130 athway induces functional alterations of the apical ectodermal ridge, which mediates limb outgrowth.
131 protein; FGF, fibroblast growth factor; AER, apical ectodermal ridge; ZPA, zone of polarizing activit