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1 hickened epithelial structure similar to the apical ectodermal ridge.
2 ced by the underlying mesenchyme to form the apical ectodermal ridge.
3 and is essential for proper formation of the apical ectodermal ridge.
4 on of Msx1 and a decrease in Fgf4 within the apical ectodermal ridge.
5 ing activity (ZPA) and Fgfs in the overlying apical ectodermal ridge.
6 A expression of sonic hedgehog (Shh) and the apical ectodermal ridge.
7 the posterior region of the limb bud and the apical ectodermal ridge.
8 parameters and the duration of the overlying apical ectodermal ridge.
9 ponse to FGF4, which mimics extension of the apical ectodermal ridge.
10 nsistent with reduced FGF signaling from the apical ectodermal ridge.
11 s with Fgf4, but not Fgf8, expression by the apical ectodermal ridge.
12 ich fail both to express Fgf8 and to form an apical ectodermal ridge.
13 iate into a specialized structure termed the apical ectodermal ridge.
14 also required for normal organization of the apical ectodermal ridge, a signaling center that directs
15                                          The apical ectodermal ridge, a specialized epithelial struct
16 cations are due to a failure to maintain the apical ectodermal ridge, a stratified epithelium, essent
17               Complex signalling between the apical ectodermal ridge (AER - a thickening of the dista
18                          Lack of Fgf8 in the apical ectodermal ridge (AER) alters expression of other
19 n carried out to investigate the role of the apical ectodermal ridge (AER) and FGF-4 on the control o
20  buds, Msx2 transcripts are expressed in the apical ectodermal ridge (AER) and in various regions of
21  is maintained by two signaling centers, the apical ectodermal ridge (AER) and the zone of polarizing
22 m along their distal tips that resembles the apical ectodermal ridge (AER) and this thickened distal
23 d in the reciprocal interactions between the apical ectodermal ridge (AER) and underlying mesoderm re
24 he developing limb, Bmp4 is expressed in the apical ectodermal ridge (AER) and underlying mesoderm.
25 entral (DV) border ectoderm exclusive of the apical ectodermal ridge (AER) as a new signaling center
26 st growth factor 8 (Fgf8) is produced by the apical ectodermal ridge (AER) at the distal tip of the l
27                      Half a century ago, the apical ectodermal ridge (AER) at the distal tip of the t
28 esults in the formation of a second, ventral apical ectodermal ridge (AER) at the junction between Wn
29 m control dorso-ventral patterning while the apical ectodermal ridge (AER) controls bud outgrowth and
30 gous Dac embryos, the central segment of the apical ectodermal ridge (AER) degenerates, leaving the a
31 rizing Activity (ZPA) and the Fgf-expressing Apical Ectodermal Ridge (AER) ectoderm.
32                      Fgf-10 is necessary for apical ectodermal ridge (AER) formation and acts epistat
33                   By surgically removing the apical ectodermal ridge (AER) from either wing or leg bu
34 activation of the Lbx1 and Btrc genes in the apical ectodermal ridge (AER) in an Fgf8-like pattern in
35                                          The apical ectodermal ridge (AER) in the vertebrate limb is
36                                          The apical ectodermal ridge (AER) is a critical signaling ce
37                          In vertebrates, the apical ectodermal ridge (AER) is a specialized epitheliu
38                                          The apical ectodermal ridge (AER) is a transient embryonic s
39                                          The apical ectodermal ridge (AER) is an essential structure
40                         The formation of the apical ectodermal ridge (AER) is critical for the distal
41                       In sm homozygotes, the apical ectodermal ridge (AER) is hyperplastic by embryon
42                                          The apical ectodermal ridge (AER) is induced in the Shh(-/-)
43 f the developing limb bud in response to the apical ectodermal ridge (AER) is mediated at least in pa
44             A major function of the limb bud apical ectodermal ridge (AER) is to produce fibroblast g
45                The extra digits and expanded apical ectodermal ridge (AER) of Dkk1-deficient mice clo
46     Ectrodactyly is linked to defects of the apical ectodermal ridge (AER) of the developing limb bud
47 hat chick Ptc2 is expressed in the posterior apical ectodermal ridge (AER) of the limb bud in a patte
48 n the hair follicle placode, but also at the apical ectodermal ridge (AER) of the limb bud.
49                                          The apical ectodermal ridge (AER) of the limb buds of the mu
50 m, which contrasts with the situation in the apical ectodermal ridge (AER) of the limb.
51 ive apoptotic cell death was observed in the apical ectodermal ridge (AER) of the newly forming forel
52 imb, delayed elevation and compaction of the apical ectodermal ridge (AER) produces a ridge that is a
53 t growth factors (FGFs) are signals from the apical ectodermal ridge (AER) that are essential for lim
54 ng posterior mesodermal cells underneath the apical ectodermal ridge (AER) that give rise to the skel
55 te embryonic limb requires signalling by the apical ectodermal ridge (AER) to the progress zone (PZ),
56                      FGF4 is produced in the apical ectodermal ridge (AER) where it is hypothesized t
57 rom the expression pattern of Jagged2 in the apical ectodermal ridge (AER) whether the ectodermal or
58 genetic proteins (BMPs) are expressed in the apical ectodermal ridge (AER), a critical signaling cent
59                                          The apical ectodermal ridge (AER), a rim of thickened ectode
60 tor gene Bmpr1a specifically in the limb bud apical ectodermal ridge (AER), a source of FGF activity.
61 proximodistal (PD) axis is controlled by the apical ectodermal ridge (AER), a specialized epithelium
62                                          The apical ectodermal ridge (AER), a transient specialized e
63 migration, and patterning in response to the apical ectodermal ridge (AER), and has the functional po
64 he zone of polarizing activity (ZPA) and the apical ectodermal ridge (AER), are known to cause limb m
65 cular from the specialized epithelium of the apical ectodermal ridge (AER), including three members o
66 in a specialized epithelial compartment, the Apical Ectodermal Ridge (AER), is a conserved feature of
67                            One of these, the apical ectodermal ridge (AER), is critical for proximodi
68 cant growth defect associated with a smaller apical ectodermal ridge (AER), referred to here as an ap
69 xpressed during embryogenesis in the forming apical ectodermal ridge (AER), restricted regions of the
70 r, Jagged2 and Notch1 are coexpressed in the apical ectodermal ridge (AER), suggesting a role for thi
71 ion also results in ventral expansion of the apical ectodermal ridge (AER), suggesting that En-1 is a
72 arent as early as embryonic day 9.5 when the apical ectodermal ridge (AER), the principal site of Meg
73 last growth factor (FGF) signalling from the apical ectodermal ridge (AER), we inactivated Fgf4 and F
74 ent control posterior fin development via an apical ectodermal ridge (AER), whereas an alternative Ho
75  the vertebrate limb bud is regulated by the apical ectodermal ridge (AER), which forms at an invaria
76 The proximal-distal axis is specified by the apical ectodermal ridge (AER), which forms from limb ect
77 10 in the mesenchyme to activate Fgf8 in the apical ectodermal ridge (AER), which in turn promotes me
78 roposed to mediate critical functions of the apical ectodermal ridge (AER), which is required for pro
79 limb development depends on signals from the apical ectodermal ridge (AER), which rims the distal tip
80 ive limb-forming mesoderm and in prospective apical ectodermal ridge (AER)-forming ectoderm, but is n
81 Although the initiation of the expression of apical ectodermal ridge (AER)-specific genes, including
82 limb buds, SPC4 mRNA is most abundant in the apical ectodermal ridge (AER).
83 ponent of the Hh signaling pathway, from the apical ectodermal ridge (AER).
84 associated with a loss of signaling from the apical ectodermal ridge (AER).
85 Factor 8 (FGF8) produced by the newly formed apical ectodermal ridge (AER).
86 eletal differentiation and do not develop an apical ectodermal ridge (AER).
87 he zone of polarizing activity (ZPA) and the apical ectodermal ridge (AER).
88 e blastocyst, the myotomes, and the limb bud apical ectodermal ridge (AER).
89 he zone of polarizing activity (ZPA) and the apical ectodermal ridge (AER).
90 al organizer of the developing limb bud, the apical ectodermal ridge (AER).
91 novel cell state, but a re-deployment of the apical-ectodermal-ridge (AER) programme underlying limb
92 atenin in the developing chick embryo elicit apical ectodermal ridge and limb regeneration in an orga
93 s expanded in the dorsal-ventral axis of the apical ectodermal ridge and shortened in the anterior-po
94 ave been proposed to direct Fgf8 in the limb apical ectodermal ridge and the midbrain-hindbrain bound
95  Fgf8 and Shh orthologs are expressed in the apical ectodermal ridge and zone of polarizing activity,
96  to the distal ventral limb ectoderm and the apical ectodermal ridge, and overlaps in these ectoderma
97 served on the muscle masses of the limb, the apical ectodermal ridge, and the developing liver.
98 re dependent on a posterior extension of the apical ectodermal ridge, and this also allows the additi
99 ented epithelium, nephrogenic mesenchyme and apical ectodermal ridge are distributed across the appro
100 on is inhibited distally by signals from the apical ectodermal ridge, both Fgfs and Bmps, and proxima
101 derm, and to a specialized region of it, the apical ectodermal ridge, controls the distribution of ce
102 F/MAPK signaling pathway, emanating from the apical ectodermal ridge, does not regulate cell orientat
103 derm (e.g. Bone Morphogenetic Protein-2) and apical ectodermal ridge (e.g. Fibroblast Growth Factor-4
104               Similarly, limb mesenchyme and apical ectodermal ridge expression are governed by separ
105 gf-4 was induced in the anterior part of the apical ectodermal ridge, followed later by ectopic expre
106 mb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the
107 expression of epiprofin mRNA in cells of the apical ectodermal ridge in developing limbs and the post
108            Although Fgf9 is expressed in the apical ectodermal ridge in the limb bud, we demonstrate
109  reform; nevertheless Fgf4 expression in the apical ectodermal ridge is maintained.
110 over time, including focused analyses of the apical ectodermal ridge, limb mesenchyme and skeletal mu
111 ic transgenic overexpression of Dlx5, in the apical ectodermal ridge of Dlx5/6 null mice can fully re
112 m1 is expressed at significant levels in the apical ectodermal ridge of the limb buds during embryoge
113 ral neural tube, the developing eye, and the apical ectodermal ridge of the limb.
114                                          The apical ectodermal ridge of the vertebrate limb bud lies
115 y co-grafting either a retinoic acid-exposed apical ectodermal ridge or ectoderm from the wing region
116                        In the absence of the apical ectodermal ridge or in wingless or limbless mutan
117 ity but inclusion of a retinoic acid-exposed apical ectodermal ridge or of prospective wing bud ectod
118 t the midbrain/hindbrain boundary and in the apical ectodermal ridge, regions where FGF signalling is
119 ructive extrinsic signals from the trunk and apical ectodermal ridge specify the stylopod and zeugopo
120 field ectoderm prior to the formation of the apical ectodermal ridge, structures required for limb in
121 ng limb, it is specifically expressed in the apical ectodermal ridge, suggesting a role in epithelial
122                                       In the apical ectodermal ridge, the control of Fgf8 expression
123 nge genes play roles in the formation of the apical ectodermal ridge, the dorsal/ventral border in th
124 veloping brain, the developing limb buds and apical ectodermal ridge, the lateral and nasal processes
125 development of median fins occurs beneath an apical ectodermal ridge, the structure that controls out
126  defects that are caused by a failure of the apical ectodermal ridge to differentiate.
127 Moreover, we show that FGF-8 can replace the apical ectodermal ridge to maintain Shh expression and o
128                    Integrity of the forelimb apical ectodermal ridge was abnormal as determined by ex
129  impaired response to FGF signaling from the apical ectodermal ridge, which disrupts the feedback loo
130 athway induces functional alterations of the apical ectodermal ridge, which mediates limb outgrowth.
131 protein; FGF, fibroblast growth factor; AER, apical ectodermal ridge; ZPA, zone of polarizing activit

 
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