ライフサイエンスコーパス: apical-basal

1 ented relative to two axes: longitudinal and apical-basal.

2 eeded to sense mechanical stresses along the apical-basal (A-B) axis, especially in a thick pseudostr

3 he ubiquitous epithelial polarization in the Apical-Basal (A/B) axis, many epithelia (and associated

4 ens junctions, tight junctions and by intact apical-basal (A/B) polarity.

5 rate epithelia and is perpendicular to their apical/basal (A/B) polarity axis.

6 zed cytoskeletal structures that pattern the apical, basal and longitudinal planes of the epithelium.

7 ression of a small number of genes along the apical-basal and dorsal-ventral axes in the globular emb

8 encoding components of the highly conserved apical-basal and planar cell polarity pathways, suggesti

9 t did disrupt spatial patterning in both the apical-basal and planar dimensions of the retinal epithe

10 that division orientation in different axes-apical-basal and planar-is controlled by distinct, indep

11 ophyte develops morphogenetic defects in the apical-basal and radial axes.

12 lecular marker for the establishment of both apical-basal and radial patterns during plant embryogene

13 ased on HD-ZIP III repression, mediates both apical-basal and radial polarity in the embryo and later

14 consequence, increases are observed in both apical-basal and right-left ventricular gradients of rep

15 Maintaining the correct ratio of apical, basal, and lateral membrane domains is important

16 ouples cytokinesis with the establishment of apical, basal, and lateral membrane domains that are sep

17 e, for example, changes in relative sizes of apical, basal, and lateral membranes, is a key mechanism

18 Depending on the relative tension of the apical, basal, and lateral sides of the cells, tissue th

19 prostate glands with marked staining of the apical, basal, and lateral surfaces.

20 anar cell polarity (PCP) orthogonal to their apical-basal axes.

21 ave polarized microtubules (MTs) along their apical-basal axes.

22 thin the plane of a tissue orthogonal to the apical basal axis.

23 sis and is required for establishment of the apical-basal axis and bilateral symmetry.

24 thelial cells, which are polarized along the apical-basal axis and divide symmetrically along the pla

25 , which controls division orientation in the apical-basal axis and planar division orientation in oth

26 und that both the cell lengthening along the apical-basal axis and the movement of the nucleus to the

27 ristems show a functional zonation along the apical-basal axis and the radial axis.

28 numerous neighbour intercalations along the apical-basal axis as well as over time.

29 rce generation occurring across the observed apical-basal axis in a pulsed fashion, while the conserv

30 the CLV3 domain and does not shift along the apical-basal axis in clv3 mutants.

31 Blood vessel polarization in the apical-basal axis is important for directed secretion of

32 and corticocortical (CC) synapses along the apical-basal axis of layer five pyramidal neurons as mod

33 and Rac1-dependent pathway markers over the apical-basal axis of lens pit cells showed that in RhoA

34 The role of protein localization along the apical-basal axis of polarized cells is difficult to inv

35 control cell-type patterning throughout the apical-basal axis of the Arabidopsis seedling.

36 cell surface affect changes along the entire apical-basal axis of the cell remains elusive.

37 ic site of localization of the RNA along the apical-basal axis of the cell.

38 Comparison of material along the apical-basal axis of the frond demonstrates that structu

39 the patterning of spatial domains along the apical-basal axis of the gynoecium.

40 symmetric cell division that establishes the apical-basal axis of the plant.

41 growth, promoting cell elongation along the apical-basal axis of the tissue, and basal surface contr

42 urface contraction and cell growth along the apical-basal axis of the tissue.

43 coordinated cell polarization and subsequent apical-basal axis orientation during embryogenesis and,

44 In some species it is graded along the apical-basal axis with a maximum in the basal tissue of

45 eir spindles by 90 degrees to align with the apical-basal axis, and divide asymmetrically in a stem c

46 ize asymmetry, spindle orientation along the apical-basal axis, basal Numb localization, and requirem

47 larity (PCP) in epithelia, orthogonal to the apical-basal axis, is essential for numerous development

48 n three dimensions, including especially the apical-basal axis, is unclear.

49 ay asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (

50 e cytoskeleton, and helps define each cell's apical-basal axis.

51 ll populations occurs at opposite ends of an apical-basal axis.

52 r that epithelial cells elongate along their apical-basal axis.

53 of seed plant embryos is polarized along the apical-basal axis.

54 y along an axis orthogonal to the epithelial apical-basal axis.

55 f proteins and junctional complexes along an apical-basal axis.

56 ng prevail and cells divide along their long apical-basal axis.

57 that localize to defined positions along the apical-basal axis.

58 in which cells exchange neighbors along the apical-basal axis.

59 ll division is oriented perpendicular to the apical-basal axis.

60 is of elongation, and orthogonal to the cell apical-basal axis.

61 ial polarity axis but jointly to pattern the apical-basal axis.

62 auxin response that specifies the embryonic apical-basal axis.

63 ical complex that orients spindles along the apical-basal axis.

64 nesis initiates with the establishment of an apical-basal axis; however, the molecular mechanisms acc

65 Establishment and maintenance of apical basal cell polarity are essential for epithelial

66 of afadin in vivo leads to misorientation of apical-basal cell division in nephron tubules.

67 Defects in apical-basal cell polarity and abnormal expression of ce

68 eir epithelial characteristics, for instance apical-basal cell polarity and cell-cell contact, and ga

69 s involving genes encoding components of the apical-basal cell polarity complexes.

70 Establishment of apical-basal cell polarity has emerged as an important p

71 The roles of Scrib and Lgl1 in apical-basal cell polarity have been studied extensively

72 The establishment and maintenance of apical-basal cell polarity is critical for assembling ep

73 Only in outer cells, the apical-basal cell polarity is established, and Hippo sig

74 in a conserved molecular pathway that links apical-basal cell polarity to Notch signaling and cell f

75 ikely due to abnormalities in development of apical-basal cell polarity, as well as in laminin-511 an

76 , Discs large (dlg) plays a critical role in apical-basal cell polarity, cell adhesion and cell proli

77 ired for the establishment or maintenance of apical-basal cell polarity, suggesting different functio

78 At the morula stage, outer cells acquire an apical-basal cell polarity, with expression of atypical

79 yers in the establishment and maintenance of apical-basal cell polarity.

80 alization and cortical signaling are tied to apical-basal cell restructuring and discover that a Notc

81 requirement for Cdc42 in establishing proper apical/basal cell polarity and cell-cell adhesions.

82 sophila Abl (dAbl) causes loss of epithelial apical/basal cell polarity and secretion of matrix metal

83 tant imaginal disc epithelia have defects in apical/basal cell polarity and tissue morphology.

84 at Moesin1 contributes to the maintenance of apical/basal cell polarity of the ISVs as defined by adh

85 in different aspects of the formation of the apical-basal cellular architecture.

86 blasts undergo asymmetric division along the apical-basal cellular axis.

87 ar cell polarity core protein Vangl2 and the apical-basal complex component aPKC.

88 ent manner then lead to rapid and pronounced apical-basal contractions of the neuroepithelium.

89 tors are correctly specified and show normal apical-basal cortical polarity, they can dedifferentiate

90 ila neuroblasts align their spindle along an apical/basal cortical polarity axis to self-renew an api

91 nal modifications including acetylation, and apical-basal cytoskeletal polarization to control the de

92 In Drosophila, abnormal expression of apical-basal determinants can cause neoplastic phenotype

93 mponents initiate the planar polarization of apical-basal determinants, ensuring asymmetric division

94 We conclude that the ratio of apical/basal determinants specifies neuroblast/GMC ident

95 road hypothesis that integrins contribute to apical-basal differences in dendrites and that the integ

96 r these effects was supported by the lack of apical/basal directionality of the dilution potentials,

97 sophila embryos, microtubules oriented along apical-basal directions support saltatory vesicle moveme

98 he basal cytonemes and formed characteristic apical-basal distributions in the anterior compartment c

99 betagamma signaling in progenitors regulates apical-basal division and asymmetric cell-fate decisions

100 s causes a shift in spindle orientation from apical-basal divisions to planar divisions.

101 results in loss of F-actin and expansion of apical-basal domains, which comes at the expense of late

102 Formation of the apical-basal embryonic pattern in P. abies proceeds thro

103 w roles for paxillin in the establishment of apical-basal epithelial cell polarity and lumen formatio

104 Establishing apical-basal epithelial cell polarity is fundamental for

105 Whereas Crumbs is implicated in apical-basal epithelial polarity and photoreceptor morph

106 lkb1 mutant clones also disrupt apical-basal epithelial polarity, suggesting a general r

107 ane protein Crumbs, a conserved regulator of apical-basal epithelial polarity.

108 ens, due to an inability to establish normal apical/basal epithelial polarity, as well as proper cell

109 istal cell polarity field in the leaf and an apical-basal field in the hypocotyl and root of Arabidop

110 We show that the main apical/basal functional differences can be accounted for

111 A model is proposed suggesting an apical-basal gradient of auxin during gynoecium developm

112 In addition, we report both an apical-basal gradient of these clusters in individual ha

113 thelial polarity and are expected to perform apical-basal interkinetic nuclear migration (INM)--a hal

114 r and fast forces propagate across different apical-basal layers, as well as where topological change

115 l resistance (TEER), and strongly polarised (apical:basal) localisation of transporters and receptors

116 ally, we show that TJ-mediated separation of apical-basal membrane domains is established prior to eq

117 where they are required for the formation of apical-basal microtubule arrays.

118 neural plate and for the formation of stable apical-basal microtubule arrays.

119 analyze interkinetic nuclear migration, the apical-basal movement of nuclei in phase with the cell c

120 uit fly Drosophila have a well-characterized apical-basal orientation (the Rabl configuration [4]).

121 RPE monolayers also retained proper apical-basal orientation and secreted multiple factors i

122 sis, Inscuteable is required for the correct apical-basal orientation of the mitotic spindle and for

123 slp embryos exhibit a normal apical-basal pattern and radial tissue organization, but

124 s are located more basally, forming a robust apical-basal pattern.

125 he YDA signaling pathway, and thus initiates apical-basal patterning as soon as SSP protein is transl

126 s in stamen number and anther formation, and apical-basal patterning defects in the gynoecium.

127 m to show that auxin plays a role during the apical-basal patterning of the embryo of brown algae.

128 tial for the stem cell specification and the apical-basal patterning of the SAMs.

129 suggest that auxin acts in the formation of apical basal patterns in F. distichus embryo development

130 termine the shape of epithelial cells in the apical-basal plane are not well-understood.

131 ramework to understand the less well-studied apical-basal plane of epithelial tissues.

132 We also found that, within their specific apical-basal plane, most nascent transcript foci could o

133 which act antagonistically to mediate their apical-basal polar delivery.

134 d associated with the requirement for normal apical basal polarity and adherens junctions for the acc

135 by redundant mechanisms, whereas it disrupts apical basal polarity and inhibits apoptosis using Tyr 1

136 scs large (dlg) act together to maintain the apical basal polarity of epithelial cells in the Drosoph

137 a complex with Crb/Sdt, is not essential for apical basal polarity or for the stability of the Crb/Sd

138 A key component of apical-basal polarity (A-BP) signaling, aPKC, also inhib

139 Apical-basal polarity (ABP) establishment and maintenanc

140 ominent characteristics of epithelial cells, apical-basal polarity and a highly ordered cytoskeleton,

141 pe observed for all three genes is a loss of apical-basal polarity and accumulation of follicular epi

142 1 (annotated as TRIM62) in the regulation of apical-basal polarity and acinar morphogenesis as well a

143 Loss of apical-basal polarity and activation of epithelial-mesen

144 abl depletion disrupted apical-basal polarity and adherens junction organization

145 The transitional cells exhibit a similar apical-basal polarity and antigenic phenotype as the ova

146 ated cell competition that is independent of apical-basal polarity and couples Xrp1 to protein turnov

147 exact in vivo function of Patj in regulating apical-basal polarity and development remains to be eluc

148 ssembly of the AJ, and finally, to a loss of apical-basal polarity and disruption of the tissue.

149 originally identified because of its role in apical-basal polarity and epithelial integrity in Drosop

150 ice and differentiation are coordinated with apical-basal polarity and epithelial morphogenesis.

151 wn in low calcium, although these cells lack apical-basal polarity and exhibit loss of plasma membran

152 ane microdomains, but fail to develop normal apical-basal polarity and generate a continuous lumen.

153 tumor-suppressor gene scribble (scrib) lose apical-basal polarity and have the potential to form lar

154 f Nck signaling included loss of endothelial apical-basal polarity and impaired lumenization.

155 ty Alix plays a role in the establishment of apical-basal polarity and in the maintenance of the epit

156 Drosophila Crumbs (Crb) is required for apical-basal polarity and is an apical determinant in em

157 membrane microdomains, thereby establishing apical-basal polarity and lumen formation/elongation dur

158 building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled compl

159 hich targets RhoA for degradation to control apical-basal polarity and tight junction dissolution.

160 t factors on the cell surface by maintaining apical-basal polarity and tight junction integrity.IMPOR

161 e acetylation in controlling epithelial cell apical-basal polarity and tissue branching morphogenesis

162 ulation and provide a molecular link between apical-basal polarity and tissue growth.

163 licle-cell differentiation and follicle cell apical-basal polarity are unaffected in the lanA mutant

164 cal cell membrane, although other aspects of apical-basal polarity are unaffected.

165 y, but not sufficient, for the disruption of apical-basal polarity associated with loss of lethal gia

166 ovel, redundant activity in establishing the apical-basal polarity axis of the gynoecium, indicating

167 In contrast, PAR-1 directly modulates apical-basal polarity between border cells and epithelia

168 t, in contrast, plays a more limited role in apical-basal polarity but is essential for the proper lo

169 emonstrate that activation of ErbB2 disrupts apical-basal polarity by associating with Par6-aPKC, com

170 Conversely, ULT1 and KAN1 together establish apical-basal polarity by promoting basal cell fate in th

171 In neuroblasts, establishment of apical-basal polarity by the protein Inscuteable is cruc

172 However, how factors that organize apical-basal polarity contribute to ingression is unknow

173 Atypical protein kinase C (aPKC) is a key apical-basal polarity determinant and Par complex compon

174 However, the pathways through which apical-basal polarity determinants affect growth are poo

175 model, we found that distinct alterations in apical-basal polarity dictate airway epithelial differen

176 n of Arabidopsis, which is known to maintain apical-basal polarity during embryogenesis.

177 s complex is also required for disruption of apical-basal polarity during the oncogene ErbB2-induced

178 zzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3).

179 Our results demonstrate that apical-basal polarity functions as a critical checkpoint

180 Lethal giant larvae (Lgl) is an apical-basal polarity gene identified in Drosophila, whe

181 in Crumbs (Crb), a determinant of epithelial apical-basal polarity in Drosophila embryos, as an upstr

182 as not per se crucial for the maintenance of apical-basal polarity in Drosophila melanogaster epithel

183 Lethal (2) giant larvae (Lgl) regulates the apical-basal polarity in epithelia and asymmetric cell d

184 etric cell division, or the establishment of apical-basal polarity in epithelia, this review will foc

185 e uncover the role of retromer in regulating apical-basal polarity in epithelial cells and identify r

186 role in the establishment and maintenance of apical-basal polarity in epithelial cells in various org

187 proteins that regulate the establishment of apical-basal polarity in epithelial cells(1,2).

188 ite for the establishment and maintenance of apical-basal polarity in epithelial cells.

189 role in the establishment and maintenance of apical-basal polarity in forming epithelia, the Cdc42-Pa

190 Cdc42 does not prevent the establishment of apical-basal polarity in individual cells but rather dis

191 Apical-basal polarity in many cells is established by co

192 essential to better understand the roles of apical-basal polarity in morphogenesis and how defects i

193 Apical adherens junctions also establish the apical-basal polarity in neural progenitors, which in tu

194 erly specified and appear to display correct apical-basal polarity in sax-7(eq1);hmr-1(RNAi) embryos.

195 which form an epithelium in WT embryos, lose apical-basal polarity in sec61al1(c163) mutants.

196 As cells acquire apical-basal polarity in the blastula the protein become

197 s the establishment of endothelial cell (EC) apical-basal polarity in three-dimensional (3D) extracel

198 Here, we report that apical-basal polarity inhibits EMT to suppress metastati

199 Apical-basal polarity is a fundamental property of anima

200 Apical-basal polarity is an essential epithelial trait c

201 In the absence of Baz, the apical-basal polarity is compromised in early pupal phot

202 irect regulation of Rbl2 and Cdkn1a, whereas apical-basal polarity is controlled by regulation of Tia

203 Apical-basal polarity is essential for epithelial cell f

204 nstrate that the EGFR-mediated regulation of apical-basal polarity is essential for the segregation o

205 Disruption of apical-basal polarity is implicated in developmental dis

206 Establishing apical-basal polarity is instrumental in the functional

207 Apical-basal polarity is maintained by distinct protein

208 We conclude that PAR-1-dependent apical-basal polarity is required for proper detachment

209 The development of apical-basal polarity is the earliest visible difference

210 PTEN, although proliferation, patterning and apical-basal polarity markers are normal in the mutants.

211 Disruption of epithelial cell apical-basal polarity occurs in early cancer development

212 rity characteristic of cell migration to the apical-basal polarity of an epithelium.

213 d collaborates with ROCK signaling to set up apical-basal polarity of ductal progenitors and further

214 r, ectopically expressed PON responds to the apical-basal polarity of epithelial cells and is suffici

215 , a neoplastic tumor suppressor that defines apical-basal polarity of epithelial cells.

216 The signaling pathway that establishes this apical-basal polarity of NE is not completely understood

217 n of ciliary Arl13b led to a reversal of the apical-basal polarity of radial progenitors and aberrant

218 ision of the zygote is the first hallmark of apical-basal polarity of the embryo and is controlled by

219 42 has an essential role in establishing the apical-basal polarity of the telencephalic NE, which is

220 hat both Lgl and Dsh are required for normal apical-basal polarity of Xenopus ectodermal cells.

221 In epithelia, apical-basal polarity often coexists, and sometimes inte

222 In addition to the apical-basal polarity pathway operating in epithelial ce

223 ponents of both the planar cell polarity and apical-basal polarity pathways, but their roles are not

224 Loss of apical-basal polarity prevents aPKC-mediated SNAI1 phosp

225 during lung development Dlg5 functions as an apical-basal polarity protein, which is necessary for th

226 clusters requires a rapid reorganization of apical-basal polarity that depends on Lulu/Epb4.1l5.

227 uroepithelium (NE) of mammalian brain has an apical-basal polarity that is marked by the positioning

228 two distinct processes: the establishment of apical-basal polarity that requires Bazooka (Baz), and t

229 Lethal giant larvae (Lgl) functions in apical-basal polarity through phosphorylation-dependent

230 tially polarized state of the FSC, establish apical-basal polarity throughout the lineage, and promot

231 ndent mechanism that links the regulation of apical-basal polarity to tissue morphogenesis.

232 However, apical-basal polarity was not compromised, transmembrane

233 The establishment of apical-basal polarity within a single cell and throughou

234 ear how cells disperse from clusters lacking apical-basal polarity, a hallmark of advanced epithelial

235 orting and non-essential roles in regulating apical-basal polarity, although such a supporting role m

236 lial de-adhesion, directed motility, loss of apical-basal polarity, and acquisition of mesenchymal ad

237 ell death and/or cell proliferation, loss of apical-basal polarity, and appearance of epithelial-to-m

238 al properties, including tight junctions and apical-basal polarity, and develop in a manner resemblin

239 tip cells, following stalk cells exhibiting apical-basal polarity, and lumens and branches connectin

240 Epithelial cells display apical-basal polarity, and the apical surface is segrega

241 Under intact apical-basal polarity, aPKC kinases phosphorylate S249 o

242 terior-posterior polarity, while maintaining apical-basal polarity, but how this is achieved at the m

243 lycan null mutant follicle cells have normal apical-basal polarity, but lose the planar polarity of t

244 sepithelial barrier but is not necessary for apical-basal polarity, epithelial integrity, or cytoskel

245 ly active atypical PKC results in defects in apical-basal polarity, increased Cyclin E protein expres

246 cinar cells changed phenotypes, establishing apical-basal polarity, increasing the size of zymogen gr

247 Cells loose their apical-basal polarity, mislocalize DE-cadherin, and dela

248 icient acinar cells in mice do not establish apical-basal polarity, properly position zymogen granule

249 Markers of apical-basal polarity, such as ZO-1, were mislocalized a

250 ntation during mitosis, the establishment of apical-basal polarity, the formation of apical cell-cell

251 attachment and a resultant disruption in MC apical-basal polarity, which culminated in retinal dyspl

252 ells resemble a columnar epithelium and have apical-basal polarity, with microvilli along the apical

253 gh its regulation of cellular metabolism and apical-basal polarity.

254 tions controlled by modulation of epithelial apical-basal polarity.

255 ls1 or Mpp5 in mammalian cells) to establish apical-basal polarity.

256 es and degraded, causing a disruption of the apical-basal polarity.

257 roliferation and differentiation, as well as apical-basal polarity.

258 Arg kinase leads to a striking inversion of apical-basal polarity.

259 including proliferation, differentiation and apical-basal polarity.

260 iary proteins TCF2/HNF1beta nor with loss of apical-basal polarity.

261 d paracellular barrier function, but not for apical-basal polarity.

262 sional plane lying orthogonal to the axis of apical-basal polarity.

263 ells and has been reported to play a role in apical-basal polarity.

264 ic three-dimensional acini without affecting apical-basal polarity.

265 d basal plasma membranes and preservation of apical-basal polarity.

266 tions to promote cortical actin assembly and apical-basal polarity.

267 participate in the progressive emergence of apical-basal polarity.

268 s and seedlings express molecular markers of apical-basal polarity.

269 tions, the cytoskeleton and the formation of apical-basal polarity.

270 ivation of Hippo signaling and disruption of apical-basal polarity.

271 We find that spindle alignment orthogonal to apical/basal polarity always segregates apical determina

272 s (neuroblasts) align their spindle along an apical/basal polarity axis to generate a self-renewed ap

273 d Moesin1 function to establish and maintain apical/basal polarity during multicellular lumen formati

274 se results indicate that cells need not lose apical/basal polarity in order to invade neighboring tis

275 However, whereas apical/basal polarity initiates, apical maturation is de

276 Furthermore, there are no obvious defects in apical/basal polarity within the neuroepithelium, sugges

277 wn for roles in asymmetric cell division and apical/basal polarity.

278 tor recycling and planar polarity but not in apical/basal polarity.

279 cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation.

280 For instance, coordinated apical-basal polarization of epithelial and endothelial

281 ng, proliferation, wound-edge migration, and apical-basal polarization of Madin-Darby canine kidney (

282 Similar abnormalities of Hippo signaling and apical-basal polarization were also observed in embryos

283 biosynthetic turnover rate of DE-Cad during apical-basal polarization, and such biosynthetically sta

284 and efficient wound-edge migration, but not apical-basal polarization.

285 Epithelial cells are characterized by an "apical-basal" polarization.

286 Epithelial remodeling, in which apical-basal polarized cells switch to a migratory pheno

287 gnaling and AMOT function are interlinked in apical-basal polarized cells.

288 of progenitors for cell cycle exit based on apical-basal polarized signals.

289 There was no correlation between the apical-basal position of the transcribed locus and the f

290 nt debris, hypo/hyperpigmented RPE, abnormal apical-basal RPE surfaces and BrM thickening.

291 velopment, such as in the development of the apical-basal (shoot-root) axis in the embryo, as well as

292 sym) isomer wherein both dppv ligands occupy apical-basal sites.

293 n, jagn-deficient embryos display defects in apical-basal spindle orientation in delaminated embryoni

294 adin determines lumen placement by directing apical-basal spindle orientation, resulting in a continu

295 specifies neuroblast/GMC identity, and that apical/basal spindle orientation is required for neurobl

296 generated a chimeric retina with alternating apical-basal stripes of wild-type and Rb-deficient tissu

297 s lysosomal degradation; this process allows apical-basal transcytosis of bound peptides.

298 nd this planar movement is distinct from the apical-basal transcytosis previously described in polari

299 This apical-basal transcytosis was indispensable for NOGGIN i

300 Cdx2, defective protein trafficking impairs apical-basal transport and induces ectopic lumen formati