ライフサイエンスコーパス: apically

1 Thus APC is essential for driving extrusion apically.

2 with little or no response to toxin applied apically.

3 ity proteins that then travel and accumulate apically.

4 f cells through which the rudiment elongates apically.

5 solaterally, whereas bile acids are secreted apically.

6 , whereas Notch2 and Delta1 were distributed apically.

7 mutated to alanine and targets both proteins apically.

8 re (18 degrees C) redistributes the receptor apically.

9 sin II prevents determinants from localizing apically.

10 cant changes in cytokine levels when exposed apically.

11 virus to filter between the cells and emerge apically.

12 ptide and both repeats A and B were secreted apically.

13 cant changes in gene expression of 190 genes apically, 84 genes anterolaterally, 126 genes posteriorl

14 hat species deploy different combinations of apically and basally driven mechanisms to convert a two-

15 t the nuclei of Muller glia and NPCs migrate apically and basally in phase with the cell cycle.

16 s in mid-cochlear regions and falls off both apically and basally, whereas the LOC innervation peaks

17 fferentially affects the surface delivery of apically and basolaterally destined proteins in polarize

18 Characterization of isolated apically and basolaterally released EVs revealed enrichm

19 We present the first endothelial apically and basolaterally secreted proteomes, demonstra

20 Proper function of epithelia depends on apically and basolaterally situated ion channels as well

21 ed level of intracellular appearance of both apically and basolaterally targeted SVCTs in the absence

22 goblet cells in the colon, is released both apically and basolaterally, and is hence found in both t

23 layer by peripheral basal cells that extend apically and centripetally while remaining attached to t

24 ot meristem away from the QC and then spread apically and circumferentially around the root.

25 g live imaging, we show that PAR-3 foci move apically and cluster, and that PAR-3 is required to asse

26 In epithelia, this complex localizes apically and defines the apical membrane, whereas Bazook

27 ression pattern in the papillary epithelium: apically and dorsally they are expressed in sparse clust

28 sters in mesoderm not only persist, but move apically and enhance in density and total intensity.

29 Roof-forming cells constrict apically and express high levels of Broad protein.

30 ing PAR-3 fail to localize their centrosomes apically and have aberrant localization of gamma-tubulin

31 pithelia lacking S1P(2) cannot extrude cells apically and instead form apoptotic-resistant masses, po

32 ethyldioxirane retain the cage and give both apically and medially substituted homodiamantanes.

33 ti (BmRON2) and show that they are localized apically and that anti-BdRON2 antibodies are significant

34 nificant (P</= 0.05) displacement of all PMs apically and the septal PM and posterior PM away from th

35 Moe and Crumbs proteins colocalize apically and this apical localization requires reciproca

36 protein (TRAP) adhesins, which are secreted apically and translocated to the posterior end of the pa

37 and zonal occludens-1 mRNA are co-localized apically and zonal occludens-1 3' untranslated region-bi

38 rations, 299 of which were uniquely released apically, and 94 uniquely released basolaterally.

39 While LECs are migrating they also constrict apically, and changes in activity of the small GTPase Rh

40 eir association with the basal lamina, shift apically, and differentiate into sustentacular cells.

41 rowth, which predicts bulk secretion, occurs apically, and is compensated by subapical endocytosis, h

42 tially enters the cells basolaterally, exits apically, and maintains epithelial integrity by stimulat

43 The ventricles were paced apically, and uniform-field, truncated-exponential, mono

44 s are resistant to the inhibitory effects of apically applied auxin, indicating that MAX4 is required

45 alization insulates cells at the center from apically applied ligands while maintaining response to b

46 ry function (by tracking the surface flow of apically applied microbeads).

47 Thus, we investigated the effects of apically applied occludin peptide on the paracellular pe

48 Our data showed that apically applied occludin peptide significantly reduced

49 monolayers (day 1) efficiently internalized apically applied P. aeruginosa via a pathway that requir

50 d the polarized epithelial cell responses to apically applied soluble LT and LT-containing vesicles (

51 ral surface did not increase transduction of apically applied virus, indicating that transduction was

52 solaterally as quasi-enveloped particles and apically as naked virions, recapitulating essential step

53 sk), a MAPK transport factor, is sequestered apically at a time when lateral inhibition is required f

54 face of the outer epithelium but only insert apically at the vertices where multiple outer cells make

55 aced 0.8+/-0.9 mm laterally and 0.9+/-0.6 mm apically away from the anterolateral scallop; such displ

56 red across the tissue, each nucleus migrates apically before undergoing mitosis.

57 of the OsO(4)-catalyzed hydroxylation of an apically brominated lactam, 7-bromo-2-azabicyclo[2.2.1]h

58 recursor cells polarize and enrich myosin II apically but fail to contract their apical surfaces.

59 educed the response of ARPE-19 cells to VEGF apically but not basolaterally, suggesting polarized exp

60 ce of IgG, FcRn is distributed predominantly apically, but redistributes to basolateral locations upo

61 netic nuclear migration (INM) that is driven apically by cytoplasmic dynein and basally by the kinesi

62 We show that centrosomes localize apically by first moving toward lateral foci of the cons

63 ereas wild-type cells preferentially extrude apically, cells lacking APC or expressing an oncogenic A

64 Mechanistically, we show that to become apically clustered, Cdc42 requires the interaction betwe

65 onse to Fz/PCP signaling, they are uniformly apically colocalized.

66 ted from the basal nuclear region and became apically concentrated.

67 eased density and Ca(2+) storage capacity of apically confined endoplasmic reticulum (ER) Ca(2+) stor

68 nflammation triggers an up-regulation of the apically confined ER Ca(2+) stores, normal airway epithe

69 Supernatant treatment expanded the apically confined ER, resulting in larger apical P2Y(2)-

70 -molecular-weight VWF predominantly occurred apically, consistent with a role in localized platelet c

71 ind that emerging NSCs remain epithelial and apically constrict before dividing asymmetrically to pro

72 This myosin loss enabled nonmitotic cells to apically constrict through mitotic cell stretching.

73 euroepithelial cells in both mutants fail to apically constrict, leading to craniorachischisis.

74 Drosophila mesoderm, linked epithelial cells apically constrict, without cell extrusion or intercalat

75 al follicle cells (FC) from a columnar to an apically constricted shape.

76 lens placode cells are both longer and less apically constricted than control cells, thereby reducin

77 elongate and change from a cylindrical to an apically constricted, conical shape.

78 e highly enriched at the apical junctions of apically constricting cells and that MRCK-1 and myosin a

79 e novel data that confirm that the volume of apically constricting cells is conserved throughout the

80 elson (Abl) tyrosine kinase depletion causes apically constricting cells to undergo aberrant basal ce

81 external, cell-cell contact-free surfaces of apically constricting cells, downstream of cell fate det

82 In apically deficient embryos, JNK signalling is activated

83 pancreas, threshold stimulation generated an apically delimited [Ca(2+)](c) signal, while a stronger

84 tion of TGF-beta receptors I and II deprives apically delivered TGF-beta of access to its receptors.

85 growing SAM to suggest the plausibility that apically derived cytokinin and CLV signaling, together,

86 Sorting signals for apically destined proteins are highly diverse and can be

87 ice in which this polarity is disrupted, the apically directed collagen offset is no longer observed.

88 e "classical" cell (type I), containing only apically directed dendrites with large spines, and a pre

89 l neuroblast cortex, necessary to trigger an apically directed flow, removing Actomyosin from the bas

90 relies on balancing counteracting forces: an apically directed force exerted by F-actin/myosin-2 via

91 knockdown of Cx43 (connexin 43) retards the apically directed interkinetic nuclear migration accompa

92 DOCK7 influences neurogenesis by controlling apically directed interkinetic nuclear migration of RGCs

93 llagen fibrils are oriented radially with an apically directed slant - a feature considered crucial f

94 implies: (1) a clathrin/AP-1 function on an apically directed transport route; and (2) the convergen

95 CG release from the placenta is apically directed, whereas LH is released from the basal

96 TLR2 is apically displayed on airway cells, making it a likely t

97 including signals derived from clustering of apically disposed intercellular adhesion molecule 1 and

98 including signals derived from clustering of apically disposed intercellular adhesion molecule-1 and

99 d Rho-kinase/myosin II signaling and loss of apically distributed actin.

100 l as human embryos, cells undergoing mitosis apically do not express INSM1.

101 Moreover, cell volume lost apically due to constriction largely balanced the volume

102 examine the role of the polarity components, apically enriched aPKC and basolateral Lgl2, in primary

103 At the morula stage, rafts were also apically enriched in each blastomere.

104 t atypical protein kinase C (aPKC), which is apically enriched, inhibits neurogenesis and acts as a n

105 telliform lesions corresponded to regions of apically expelled RPE organelles.

106 Here, we report that Xenopus 2F3 cells apically express the cysteine protease cathepsin B, as i

107 vE1 revealed selective induction of CD55, an apically expressed antiadhesive molecule.

108 transport modeling supports the notion that apically expressed BK channels are part of an apical loo

109 id (ASL) volume that is in part regulated by apically expressed cystic fibrosis transmembrane conduct

110 nly regulated through Na(+) transport by the apically expressed epithelial sodium channel (ENaC) and

111 nce is regulated by Na(+) uptake through the apically expressed epithelial sodium channel (ENaC) and

112 type 5 (AAV5) and adenovirus targeted to an apically expressed glycosylphosphatidylinositol-modified

113 Inflammation reduces the activity of apically expressed large-conductance Ca(2+)-activated an

114 on studies (short hairpin RNA) revealed that apically expressed PAFr is central to the induction of t

115 As glycans on apically expressed proteins have been identified as targ

116 nofluorescence revealed the GM35 Ag to be an apically expressed v6 variant exon-containing form of hu

117 Apically expressed, large-conductance, Ca(2+)- and volta

118 hin epithelia, the harmful or dead cells are apically extruded from tissues to maintain epithelial ho

119 nstead many horizonal cell neurites extended apically, forming ectopic synapses with photoreceptors a

120 of the implants were displaced lingually and apically from the bony indentations that were created du

121 vides the predominant mechanism transmitting apically generated forces deep into the tissue and that

122 ediatric cardiopulmonary assist systems, (4) apically implanted axial-flow ventricular assist devices

123 s 12 copies of protein A arranged basally to apically in an N-to-C orientation.

124 pithelium-derived factor (PEDF) was directed apically in both cultures, but fhRPE cells exhibited sec

125 F-actin and activated myosin accumulate apically in bottle cells, and actin and myosin inhibitor

126 Cad87A is strongly enriched apically in epithelia and in neuronal dendrites.

127 s elegans PAR-6 and PKC-3/aPKC also localize apically in epithelial cells, but a role for these prote

128 Both proteins also accumulate apically in epithelial cells, where they are required fo

129 aPKC (an atypical protein kinase C) localize apically in fly and mammalian epithelial cells and are i

130 ow that the HA receptor layilin is expressed apically in human airway epithelium and that cells infec

131 CA XII protein was localized apically in human bronchiolar epithelia and basolaterall

132 insc mRNA transcripts also localize apically in neuroblasts, yet the mechanism underpinning

133 ocalize the polarity proteins PATJ and PALS1 apically in NPCs, whereas the formation and maintenance

134 F-actin and WAVE/SCAR proteins are enriched apically in one epithelial tissue and basolaterally in a

135 nd exogenously expressed TRPC3 was localized apically in polarized Madin-Darby canine kidney cells (M

136 Ano1, ezrin, and moesin/radixin colocalize apically in salivary gland epithelial cells, and overexp

137 ted via activation of Y2 receptors localized apically in taste cells.

138 nvade polarized gallbladder epithelial cells apically in the absence and presence of bile in a Salmon

139 cells missorted vesicular stomatitis virus G apically in the biosynthetic route.

140 re heavily in NRC cells but was concentrated apically in these cells as well.

141 ictyostelium discoideum, myosin II localizes apically in tip epithelial cells that surround the stalk

142 Second, gamma-tubulin fails to accumulate apically in wild-type cells following laser ablation of

143 s predominantly extrude basally, rather than apically, in a cell-autonomous manner and can survive an

144 Apically, in the absence of CFL1 myosin light chain does

145 rprisingly, junction proteins still localize apically, indicating that PAR-6 and asymmetric PKC-3 are

146 STEC clinical isolates applied apically induced PMN transmigration across and interleuk

147 teral media of model epithelia that had been apically infected with Salmonella typhimurium for a shor

148 epithelial cells still sense the presence of apically infecting P. aeruginosa, but they may do so thr

149 Human ARPE-19 cells were apically inoculated with wild-type or quorum-sensing-def

150 ch other and from early endosomes labeled by apically internalized ligand.

151 ative IgG transport studies demonstrate that apically-internalized IgG recycles to the apical surface

152 epithelial cells express and release leptin apically into the intestinal lumen.

153 Cells can extrude apically into the lumen or basally into the tissue the e

154 Although predominantly secreted apically into the urine, where it becomes highly polymer

155 trate that RhoA, when activated and targeted apically, is sufficient to induce AC and that RhoA plays

156 ed Baz recruits adherens junction components apically, leading to a loss of the apical domain and an

157 Apically linked rhombuses, which are formed by the bridg

158 We also detected very rapid apically localised Ca2+ signalling events with an approx

159 ll, either in the form of a whole cell or an apically localised increase, indicating that [Ca2+](cyt)

160 but also fail to elongate due to the loss of apically localised N-cadherin and N-CAM.

161 erfering RNA, we observe that stimulation of apically localized A1 adenosine receptors (A1ARs) trigge

162 epithelial cells, a process that requires an apically localized actin cytoskeleton.

163 nstriction was associated with enrichment of apically localized actin filaments and required the smal

164 The Hippo pathway component Expanded, an apically localized adaptor protein, is mislocalized in b

165 but where basolateral proteins (LGL) become apically localized and apical junctional proteins (PAR3,

166 ol 1,4,5-trisphosphate receptor (InsP3R3) is apically localized and triggers Ca(2+) waves and secreti

167 In this process, apically localized Bazooka recruits Inscuteable and othe

168 MRCK-1 is apically localized by active Cdc42 at the external, cell

169 pithelial cells and has been associated with apically localized Ca2+-signaling proteins.

170 Most cell divisions are restricted to apically localized cells with mitotic spindles oriented

171 eable (Insc) protein functions as part of an apically localized complex to coordinate orientation of

172 migration to the apical epithelial surface, apically localized epithelial proteins may serve to reta

173 ity despite a relatively intact, albeit more apically localized F-actin and BTB tight junctional prot

174 The apically localized Four-point-one, Ezrin, Radixin, Moesi

175 Our previous data have shown that apically localized growth factors segregate from their b

176 for several aspects of cytokinesis, remains apically localized in each of these tissues after intern

177 nt with a role in polarized growth, For2 are apically localized in growing cells.

178 a membrane, and with high specificity by the apically localized kinase LOK.

179 Similar to its function in epidermis, apically localized LGN directs perpendicular divisions t

180 geting signal by its ability to redirect the apically localized P75 neurotrophin receptor to the baso

181 features are thought to be controlled by an apically localized protein complex comprising of two sig

182 Among several apically localized protein complexes, the Crumbs and Par

183 We show that loss of the apically localized protocadherin Cad99C rescues the SG d

184 EF reduces levels of apically localized Rab11 and indirectly blocks vesicle f

185 Inhibiting Fgfr-Ras-MAPK leads to loss of apically localized Rho-associated kinase (Rock) 2a, whic

186 We show that the apically localized serine/threonine kinase aPKC directly

187 in FUS1 is required for adhesion between the apically localized sites on the plasma membranes of plus

188 hesis these proteins act together to form an apically localized spectrin-based membrane skeleton (SBM

189 ultured cells with loss of Expanded (Ex), an apically localized SWH component that inhibits Yki.

190 tine and excretory systems and that ACT-5 is apically localized within intestinal cells.

191 s, whereas KCC1, IK(Ca)1, CFTR, and ClC3 are apically localized.

192 tablishment of epithelial cell polarity: the apically-localized proteins of the Par (Par3-Par6-aPKC-C

193 aryngeal pouch endoderm have an abundance of apically located actin fibres that are networked within

194 During formation of the apically located cellular cementum, some cementoblasts b

195 These data suggest a role for an apically located Duox-based NADPH oxidase during intrace

196 teral direction, indicating dependence on an apically located efflux transporter.

197 s and demonstrates the dynamic regulation of apically located ENaC by recycling, which is facilitated

198 The apically located ErbB2 is phosphorylated on tyrosines 11

199 hereas intracellular [Na] is regulated by an apically located H(Na)-K ATPase and not by the tradition

200 inly governed by vectorial salt movement via apically located rate-limiting Na(+) channels (ENaC) and

201 e;Wnt10a(flox/flox)) led to an absence of or apically located root furcation in molars of mice, a phe

202 canals that is dependent on the presence of apically located voltage-gated cation channels in a popu

203 -5.4) and PEA (basolaterally, logEC50 -4.9; apically logEC50 -5.3) increased Caco-2 resistance by 20

204 OEA (applied apically, logEC50 -5.4) and PEA (basolaterally, logEC50

205 f ankyrin binding, prevented transcytosis of apically mis-sorted E-cadherin to the lateral membrane.

206 at the lateral membrane and transcytosis of apically mis-sorted protein to the lateral membrane.

207 -Darby canine kidney cells stably expressing apically mistrafficked EREG form significantly larger, h

208 thermore, we demonstrate that once localized apically, myosin continues to contract.

209 ria are small and fragmented and translocate apically on microtubules and distribute progressively al

210 t an air-liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists.

211 When MV-eGFP was applied apically or basolaterally to primary cultures of airway

212 SA-independent rotaviruses applied apically or basolaterally were capable of efficiently in

213 whereas JNK is activated by TLR9 ligand both apically or basolaterally, NF-kappaB is activated only v

214 ding edge creating an axis of migration with apically oriented (+) ends.

215 Guanylate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is express

216 own in endothelial cells arrests neutrophils apically over the junction, similar to when PECAM is blo

217 present throughout the cell, it accumulates apically, particularly at sites of cadherin-based adhere

218 Studies of apically permeabilised cells showed that a small rise in

219 localized and physically segregated from its apically placed ligand.

220 olarized outside cells, Angiomotin localizes apically, pointing to the importance of cell polarity in

221 ted by cAMP/CREB activation and occurs in an apically polarized fashion.

222 t the monocarboxylate transporter (MCT-1) is apically polarized in model human intestinal epithelia a

223 We show that secretion of Fog protein is apically polarized, making this the earliest polarized c

224 d concentrates in close association with the apically positioned basal body of neural target cells, f

225 In the current view, apically positioned Bazooka/Par3 is the initial polarity

226 oach to increase PSP, either bilaminar or an apically positioned flap (APF) technique.

227 ular construct [LCC], in combination with an apically positioned flap [APF]), resulted in significant

228 iodontal treatment was provided, followed by apically positioned flap surgery in the maxillary right

229 riodontal treatment was provided followed by apically positioned flap surgery in the maxillary right

230 conventional scaling and root planing (SRP), apically positioned flaps, root amputations, root resect

231 result from vertical divisions in either the apically positioned luminal epithelial cells or the basa

232 tion through analogous vertical divisions of apically positioned luminal epithelial cells.

233 ens placode AC may be partially dependent on apically positioned myosin-containing filaments associat

234 the MT (-) end protein CAMSAP1 fused to the apically positioned Par6 protein, we have artificially r

235 These procedures rely on the transfer of apically positioned stem cells, including stem cells of

236 er, under shear stress, T cells encountering apically presented CXCL12 were primed to undergo robust

237 The primary cilium is an apically projecting solitary organelle that is generated

238 Apically restricted [Ca2+]i signals were never observed

239 ensures the formation and maintenance of the apically restricted actomyosin-tight junction complex.

240 In Drosophila neuroblasts, apically restricted aPKC is required for segregation of

241 llen tubes) are generated through continuous apically restricted growth (tip growth), which universal

242 tant lens placode cells are shorter and more apically restricted than controls, resulting in increase

243 e ventricular surface for DNA synthesis, and apically return to the surface for mitotic division; a p

244 zed and secreted from endothelial cells; the apically secreted ADAMTS13 from endothelial cells may co

245 The novel mitogen "lacritin" is apically secreted by several nongermative epithelia.

246 totic and anti-inflammatory activity that is apically secreted in exosomes by polarized human retinal

247 ding is powered by rearward translocation of apically secreted transmembrane adhesins via their inter

248 Granules containing MUC5AC were apically secreted via Ca(2+)-regulated exocytosis as dem

249 terning of the Drosophila wing disc, wherein apically secreted Wingless (Wg) encounters its receptor,

250 ynamic ranges, sharper frequency tuning, and apically shifted positions of peak vibration.

251 muscle tips in 6 adult sheep were retracted apically short of producing mitral regurgitation to repl

252 During normal development, apically situated prestalk cells express the ecmB gene j

253 t, containing the LTAxxVAxxR element, to the apically sorted influenza hemagglutinin (HA) protein was

254 able to direct basolateral expression of the apically sorted nerve growth factor receptor (NGFR, p75;

255 chondrial staining pattern in HEp2 cells and apically stained the biliary epithelial cells (BECs) in

256 When intact mammalian taste buds are apically stimulated with umami tastants, their functiona

257 host cells through a process that depends on apically stored adhesins that are strategically released

258 RasV12 cells are eliminated apically, suggesting that extrusion may be a tumor-suppr

259 ant membranes (DRMs) but still are delivered apically, suggesting that GPI-AP association with DRMs i

260 absence of stimuli, and occurs predominantly apically, suggesting this could be the main source of ci

261 nhibits model basolaterally targeted but not apically targeted cargo delivery, for both PM-destined a

262 c atrophy results in diminished responses to apically targeted excitatory inputs and (ii) corticoster

263 of distal apical dendrites and decrements in apically targeted excitatory postsynaptic currents in la

264 ugation indicated that, unlike several other apically targeted membrane and soluble proteins, apical

265 lycans, but not poly-N-acetyllactosamine, in apically targeted MUC1 and chimeras when compared with T

266 epithelial cells, where it colocalized with apically targeted NHERF2.

267 nteracting region (Sp151-483) by fusion with apically targeted p75NTR extended the half-life of alpha

268 Finally, coexpression of apically targeted type I and type II TGF-beta receptors

269 Because an apically targeted VSV-G mutant behaved similarly, these

270 In one, reproductive organs form apically, terminating growth of the primary shoot (gamet

271 with the apical cortex, but expression of an apically tethered aPKC rescues normal lumen formation.

272 ositioning the papillary muscles that become apically tethered in MR.

273 Myosin activity was higher apically than basally in wild-type cells, but upon trans

274 As most cells extrude apically, they are typically eliminated through the lume

275 Methyl-beta-cyclodextrin added apically to (MPK)CCD(14) cells resulted in a slow declin

276 naptic contacts with nerve fibers, and taper apically to a single, large microvillus.

277 Monolayers were exposed apically to Alexa 488-labeled albumin (Alexa 488-BSA) in

278 nthesize DNA near the basal surface and move apically to divide.

279 When added apically to epithelial cells, TFV/TAF was released basol

280 phate leaving group of GTPalphaS is oriented apically to His404 with the epsilon-nitrogen poised for

281 uteable/Baz/Par-6/aPKC complex recruits Pins apically to induce vertical spindle orientation, whereas

282 70-kD FITC-dextran added apically to Myo5b KO intestinal explants accumulated in

283 illary muscle tips in 6 sheep were retracted apically to replicate tethering, short of producing MR (

284 We find that Abl acts apically to suppress the accumulation of both Enabled (E

285 chniques-suturing the vestibular flap margin apically to the base of the recipient bed versus leaving

286 st group the mucosal flap margin was sutured apically to the periosteum at the base of the graft; whe

287 The apically trafficked pool colocalized with the early endo

288 RGP nuclei migrate basally during G1, apically using cytoplasmic dynein during G2, and undergo

289 Failure to restrict PHB and PHV expression apically via a microRNA-dependent pathway prevents corre

290 monolayers, about half of the PGE2 taken up apically was oxidized to 13, 14-dihydro, 15-keto-PGE2, w

291 Protein kinase C epsilon, normally localized apically, was found in the cytoplasm where it can lead t

292 Although most apoptotic cells extrude apically, we find that some exit basally.

293 -exon isoform of CAR, CAR(Ex8), is localized apically where it can support viral infection from the a

294 demonstrated that the M(2) subtype is sorted apically, whereas M(3) is targeted basolaterally.

295 onfluent cells, latent TGF-beta1 is secreted apically, whereas TbetaR-I and integrin alphaVbeta3 are

296 rm at the protein level and was concentrated apically, whereas the type I and type II isoforms were e

297 arized epithelial cell cultures were treated apically with live or heat-killed Escherichia coli or La

298 The TER of cells infected apically with SA-dependent rotaviruses decreased earlier

299 ike structures, endogenous NUAK2 colocalized apically with the actomyosin network, which was disrupte

300 n the basal region of the cochlea and spread apically with time, leading to permanent threshold shift