ライフサイエンスコーパス: apicomplexan

1 t the first genome-wide genetic screen of an apicomplexan.

2 assified as a chytrid fungus, is actually an apicomplexan.

3 sis and salvage of vitamins and cofactors in apicomplexans.

4 elopment of therapeutic intervention against apicomplexans.

5 large diversity of alveolates, in particular apicomplexans.

6 ora nuclei but not to more distantly related apicomplexans.

7 ight into a divergent mRNA export pathway in apicomplexans.

8 n ancestral mechanism for parasitism used by apicomplexans.

9 itic photosynthetic algae closely related to apicomplexans.

10 he apicoplast, an indispensable organelle in apicomplexans.

11 a nonphotosynthetic plastid present in most apicomplexans.

12 ly, fosmidomycin has no effect on most other apicomplexans.

13 r chemotherapy against T. gondii and related apicomplexans.

14 in restructuring the evolutionary history of apicomplexans.

15 lution of the PMTs in plants, nematodes, and apicomplexans.

16 for Gram-negative bacteria, mycobacteria and apicomplexans(2,3).

17 ites, explaining the inherent instability of apicomplexan actin filaments.

18 Apicomplexan actin is important during the parasite's li

19 ther members of the ADF/cofilin (AC) family, apicomplexan ADFs lack key F-actin binding sites.

20 id biosynthesis, predating the divergence of apicomplexan and dinoflagellates.

21 We show that apicomplexan and perkinsid AP2 domains cluster distinctl

22 glycan binding mode is distinct from that of apicomplexan and viral cell surface recognition ligands

23 TgCDPK1 is conserved among apicomplexans and belongs to a family of kinases shared

24 nto the early evolution of parasitism in the apicomplexans and illustrate the important contributions

25 with particular emphasis on the situation in apicomplexans and other alveolates.

26 asites and consider how this varies in other apicomplexans and related organisms, while discussing ho

27 ade of P-type ATPases that are restricted to apicomplexans and their closest relatives.

28 in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and sha

29 dies, although gregarines are the most basal apicomplexans and therefore key players in the understan

30 rids and colpodellids as the sister group to apicomplexans, and a complex distribution of retention v

31 and stramenopiles) and alveolates (ciliates, apicomplexans, and dinoflagellates) share a common ances

32 the context of host manipulation by related apicomplexans, and propose key directions for future res

33 yzoite development that encode proteins with apicomplexan AP2 (ApiAP2) DNA binding domains.

34 exes and is particularly enriched within the Apicomplexan AP2 (ApiAP2) DNA-binding protein family.

35 Orthologous Apicomplexan AP2 (ApiAP2) expression has been rearranged

36 show that PbAP2-G, a conserved member of the apicomplexan AP2 (ApiAP2) family of DNA-binding proteins

37 es of two members of the recently identified Apicomplexan AP2 (ApiAP2) family of putative transcripti

38 anscription factor PfAP2-I, belonging to the Apicomplexan AP2 (ApiAP2) family, that is responsible fo

39 n AP2 DNA-binding domain from a prototypical Apicomplexan AP2 protein, PF14_0633 from Plasmodium falc

40 he major family of regulators comprising the Apicomplexan Apetala2 (AP2) proteins.

41 Apicomplexans are a major lineage of parasites, includin

42 Apicomplexans are a phylum of intracellular parasites th

43 Gregarine apicomplexans are closely related to parasites such as P

44 sly unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the m

45 Malaria parasites and related Apicomplexans are the causative agents of the some of th

46 The intraerythrocytic apicomplexan Babesia microti, the primary causative agen

47 rom piroplasm, coccidian, and haemosporidian apicomplexans but differs from all other currently known

48 Furthermore, how apicomplexan CAPs, which lack many domains present in ye

49 and deciphers the principle behind flexible apicomplexan cell division modes.

50 The evolution of unique apicomplexan cellular compartments is concomitant with v

51 The apicomplexan centrosome has a unique bipartite structure

52 ein kinases of mammals, and the CDPK1 of the apicomplexan Cryptosporidium lack side chains that typic

53 arasite Plasmodium falciparum, the parasitic Apicomplexan Cryptosporidium parvum, the yeast Saccharom

54 eins related to protist P/U-type cyclins and apicomplexan cyclins.

55 emerging of the assembly and maintenance of apicomplexan cytoskeletons, illuminating how they templa

56 ion of the four selected genes: Actin (Act), Apicomplexan DNA-binding protein (Ap2), Rhomboid protein

57 enzymes involved in these pathways, and all apicomplexans express one or both of fructose 1,6-bispho

58 recycling and organellar positioning and an apicomplexan family.

59 s and progress in the tools available to the Apicomplexan field will allow for a closer look at the i

60 a describe an F-actin dependent mechanism in apicomplexans for transport and recycling of maternal or

61 ty with observations in other eukaryotes: an apicomplexan fountain-flow-model for parasite motility.

62 of interest, we generated three knockouts of apicomplexan genes considered essential for host-cell in

63 has been learned about the evolution of the apicomplexan genome as well as the significance and impa

64 CLAMP is present throughout sequenced apicomplexan genomes and is essential during the asexual

65 A number of apicomplexan genomes have been sequenced, but the accura

66 and naming protein phosphatases in available apicomplexan genomes, and summarizing the progress of th

67 me-associated connector (GAC), that mediates apicomplexan gliding motility, invasion, and egress by c

68 ted single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data.

69 Apicomplexans harbor a mitochondrion that is essential f

70 Furthermore, while no other apicomplexan has been found to possess retrotransposons,

71 ndii and Plasmodium spp. as the best studied apicomplexans; however, many cytoskeletal adaptations ar

72 hitecture of the cytoskeletal network of the apicomplexan IMC.

73 complex of Toxoplasma gondii and some other apicomplexans includes a cone-shaped assembly, the conoi

74 , but is thought to have been lost from some apicomplexans including the malaria-causing genus Plasmo

75 The apicomplexan intestinal parasites of the genus Cryptospo

76 in-2 is the primary F-actin nucleator during apicomplexan intracellular growth, mediating multiple es

77 Apicomplexans invade a variety of metazoan host cells th

78 Apicomplexans invade host cells by a multistep process i

79 ironmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-reg

80 argeting a broad range of AMA-RON2 pairs and apicomplexan invasive stages.

81 for efficient control of infection by these Apicomplexans involves the induction of potent T cell re

82 This apicomplexan is the causative agent of toxoplasmosis, a

83 icuous feature of the apical complex in many apicomplexans is the conoid, a hollow tapered barrel str

84 Our work validates apicomplexan KRSs as promising targets for the developme

85 ation of a series of selective inhibitors of apicomplexan KRSs.

86 During the evolution of the apicomplexan LDH, however, specificity switched via an i

87 rection, we find that specificity evolved in apicomplexan LDHs by classic neofunctionalization charac

88 or how cell cycle flexibility is achieved in apicomplexan life cycles.

89 Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their s

90 NA data are further supported by the several apicomplexan-like structural features in Nephromyces, in

91 solic Prx1a and mitochondrial Prx1m from the apicomplexan malaria parasite Plasmodium falciparum (Pf)

92 Motility of the apicomplexan malaria parasite Plasmodium falciparum is e

93 The Library of Apicomplexan Metabolic Pathways is a web database that p

94 ntify as an invasion factor the claudin-like apicomplexan microneme protein (CLAMP), which resembles

95 y the absence of functional assays to detect apicomplexan mitochondrial translation, a lack of knowle

96 Our work lays a foundation for the study of apicomplexan mitochondrial translation.

97 The apicomplexan mitochondrion shows striking differences fr

98 s, and provide evidence suggesting these are apicomplexan mitoribosomal subunits, detected here for t

99 adhesins, challenging the current model for apicomplexan motility and invasion.

100 and challenges of current methods applied to apicomplexan noncoding RNA study and discuss future dire

101 sequencing of many new eukaryotic parasite (apicomplexan or kinetoplastid) species or strains.

102 Malaria parasites belong to the diverse apicomplexan order Haemospororida and use a variety of v

103 cal and structural analyses demonstrated the apicomplexan orthologue to be a functional, homodimeric

104 The apicomplexan parasite Cryptosporidium causes significant

105 The apicomplexan parasite Cryptosporidium is a leading globa

106 The apicomplexan parasite Cryptosporidium is a leading globa

107 p in TgPRF with the homologous loop from the apicomplexan parasite Cryptosporidium parvum does not af

108 an cells to infection with the intracellular apicomplexan parasite Cryptosporidium parvum, infected a

109 Cryptosporidiosis, caused by the apicomplexan parasite Cryptosporidium parvum, is a diarr

110 actin filament disassembly is essential for apicomplexan parasite development but not for motility,

111 nal inflammation driven by the intracellular apicomplexan parasite Eimeria falciformis.

112 We show that Eimeria falciformis, an apicomplexan parasite infecting the mouse caecum, induce

113 Apicomplexan parasite invasion of host cells is a multis

114 t in cells infected with the closely related apicomplexan parasite Neospora caninum.

115 iding motility and host cell invasion by the apicomplexan parasite Plasmodium falciparum (Pf), the ca

116 The apicomplexan parasite Plasmodium falciparum causes malig

117 Malaria caused by the apicomplexan parasite Plasmodium falciparum has served a

118 Severe malaria is caused by the Apicomplexan parasite Plasmodium falciparum, and results

119 he beta subunit, the CP alpha subunit of the apicomplexan parasite Plasmodium is refractory to target

120 Toxoplasma gondii, an apicomplexan parasite prevalent in developed nations, in

121 Neospora caninum is an Apicomplexan parasite related to important losses in liv

122 Neospora caninum is an apicomplexan parasite responsible for major economic los

123 Toxoplasma gondii (T. gondii) is an apicomplexan parasite that can cause eye disease, brain

124 Toxoplasma gondii is a ubiquitous apicomplexan parasite that can cause severe disease in f

125 Toxoplasma gondii is an apicomplexan parasite that causes morbidity and mortalit

126 Chronic infection with the apicomplexan parasite Toxoplasma correlates with certain

127 The apicomplexan parasite Toxoplasma gondii can cause severe

128 The apicomplexan parasite Toxoplasma gondii causes macrophag

129 As an obligate intracellular pathogen, the apicomplexan parasite Toxoplasma gondii evades immune sy

130 The apicomplexan parasite Toxoplasma gondii expands during a

131 (ABA) controls calcium signalling within the apicomplexan parasite Toxoplasma gondii, an opportunisti

132 simultaneously within the globally prevalent apicomplexan parasite Toxoplasma gondii.

133 te infection with the obligate intracellular apicomplexan parasite Toxoplasma gondii.

134 re recombinase-mediated recombination in the apicomplexan parasite Toxoplasma gondii.

135 smodium falciparum, the mosquito-transmitted Apicomplexan parasite, causes the most severe form of hu

136 nternalization of the obligate intracellular apicomplexan parasite, Cryptosporidium parvum, results i

137 ngly, Toxoplasma gondii, a highly successful apicomplexan parasite, expresses F16BP aldolase (TgALD1)

138 Neospora caninum, a cyst-forming apicomplexan parasite, is a leading cause of neuromuscul

139 Apicomplexan parasites (including Plasmodium spp. and To

140 xocytosis is essential to the lytic cycle of apicomplexan parasites and required for the pathogenesis

141 dence of an intracellular purine permease in apicomplexan parasites and suggests a novel biological f

142 These results suggest that apicomplexan parasites appropriated polyspecific I domai

143 Calcium-dependent protein kinases (CDPKs) of Apicomplexan parasites are crucial for the survival of t

144 Plasmodium and other apicomplexan parasites are deficient in purine biosynthe

145 Apicomplexan parasites are leading causes of human and l

146 ry complexes I and III, whereas Vitrella and apicomplexan parasites are missing only complex I.

147 Apicomplexan parasites are motile and invade host cells.

148 Apicomplexan parasites are responsible for high impact h

149 Apicomplexan parasites are typified by an apical complex

150 for chemotherapy against T. gondii and other apicomplexan parasites as well.

151 Malaria in humans is caused by apicomplexan parasites belonging to 5 species of the gen

152 Apicomplexan parasites can change fundamental features o

153 ations and biochemical studies indicate that apicomplexan parasites can synthesize fatty acids via a

154 Apicomplexan parasites cause diseases such as malaria an

155 cine against any human parasitic disease and apicomplexan parasites cause enormous human suffering; t

156 Apicomplexan parasites cause major human disease and foo

157 Apicomplexan parasites cause numerous important human di

158 Apicomplexan parasites contain a conserved protein CelTO

159 Apicomplexan parasites contain a relict chloroplast, the

160 Gliding motility and host-cell invasion by apicomplexan parasites depend on cell-surface adhesins t

161 Apicomplexan parasites exhibit an unusual mechanism of h

162 e point of divergence of dinoflagellates and apicomplexan parasites from ciliates and may have accomp

163 the malaria-causing Plasmodium spp., and in Apicomplexan parasites generally, remain poorly understo

164 Most apicomplexan parasites harbor a relict chloroplast, the

165 Apicomplexan parasites harbor a secondary plastid that h

166 The nature of energy metabolism in apicomplexan parasites has been closely investigated in

167 To invade red blood cells (RBCs), apicomplexan parasites have to adhere with their apex to

168 Apicomplexan parasites have unique apical rhoptry and mi

169 t deploy their contents at the apical tip of apicomplexan parasites in a regulated manner.

170 Apicomplexan parasites include those of the genera Plasm

171 Apicomplexan parasites invade host cells in an active pr

172 One defining feature of apicomplexan parasites is their special ability to activ

173 Apicomplexan parasites like Toxoplasma gondii have a spe

174 The obligate intracellular lifestyle of apicomplexan parasites necessitates an invasive phase un

175 Cryptosporidium spp. are apicomplexan parasites of global importance that cause h

176 he genus Theileria includes tick-transmitted apicomplexan parasites of ruminants with substantial eco

177 Following intracellular replication, the apicomplexan parasites Plasmodium falciparum and Toxopla

178 The life cycles of apicomplexan parasites progress in accordance with fluxe

179 Apicomplexan parasites rely on actin-based gliding motil

180 Apicomplexan parasites replicate within a protective org

181 the enzymes required for their synthesis in apicomplexan parasites represent a large repertoire of p

182 K-lysin, have antimicrobial activity against apicomplexan parasites such as Eimeria spp., via membran

183 Apicomplexan parasites such as Toxoplasma gondii possess

184 Apicomplexan parasites such as Toxoplasma gondii rely on

185 In apicomplexan parasites such as Toxoplasma gondii, the ap

186 on of Ca(2+)-related phenotypes in these two apicomplexan parasites suggests that depletion of intrac

187 Cryptosporidium species are waterborne apicomplexan parasites that cause diarrheal disease worl

188 Plasmodium and Toxoplasma are genera of apicomplexan parasites that infect millions of people ea

189 MA1) is a conserved transmembrane adhesin of apicomplexan parasites that plays an important role in h

190 s caused by protozoans of the genus Babesia, apicomplexan parasites that replicate within erythrocyte

191 Apicomplexan parasites Toxoplasma gondii and Plasmodium

192 Apicomplexan parasites use a specialized cilium structur

193 Apicomplexan parasites utilize a unique form of 'gliding

194 Gene regulation in apicomplexan parasites, a phylum containing important pr

195 Apicomplexan parasites, an ancient protozoan clade that

196 ns, including Mycobacterium tuberculosis and apicomplexan parasites, and differs from the classical m

197 itochondrial function, host cell invasion by apicomplexan parasites, and protein translocation across

198 ced in free-living phototrophic ancestors of apicomplexan parasites, and such reduction is not associ

199 Unlike other apicomplexan parasites, B. microti lacks a canonical lac

200 diosis is caused primarily by two species of apicomplexan parasites, Cryptosporidium parvum and C. ho

201 The obligate intracellular apicomplexan parasites, e.g. Toxoplasma gondii and Plasm

202 dent protein kinases (CDPKs) are expanded in apicomplexan parasites, especially in Toxoplasma gondii

203 Certain apicomplexan parasites, including Pf, have an IMP-specif

204 Apicomplexan parasites, including Plasmodium falciparum

205 ) is a micronemal protein conserved in other apicomplexan parasites, including Plasmodium, Neospora,

206 ique group of myosin motor proteins found in apicomplexan parasites, including those that cause malar

207 us vacuole is a unique replicative niche for apicomplexan parasites, including Toxoplasma gondii.

208 ted adhesins and for host infection in other apicomplexan parasites, loss of TgPOFUT2 in T. gondii ha

209 vel molecular insight into cell traversal by apicomplexan parasites, our work facilitates the design

210 ry organelles unique to Toxoplasma and other apicomplexan parasites, play critical roles in parasite

211 Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global c

212 During their life cycle, apicomplexan parasites, such as the malaria parasite Pla

213 Cryptosporidium is a genus of apicomplexan parasites, the causative agents of cryptosp

214 transcriptome data for an enigmatic group of apicomplexan parasites, the gregarines.

215 nner two membranes of the apicoplasts of the apicomplexan parasites, Toxoplasma gondii and Plasmodium

216 Toxoplasma gondii, like all apicomplexan parasites, uses Ca(2+) signaling pathways t

217 roadly explore artemisinin susceptibility in apicomplexan parasites, we employ genome-scale CRISPR sc

218 c aspects of cell biology in early-diverging Apicomplexan parasites, which do not divide by canonical

219 bundant mRNA-binding domains are enriched in apicomplexan parasites, while strong depletion of mRNA-b

220 centrate on serine/threonine phosphatases in apicomplexan parasites, with the focus on comprehensivel

221 nates motility, cell invasion, and egress by apicomplexan parasites, yet the key mediators that trans

222 eukaryotic cells and is poorly understood in apicomplexan parasites.

223 features of mitochondrial protein import in apicomplexan parasites.

224 proteins are conserved across the phylum of apicomplexan parasites.

225 whose homologs have been identified in many apicomplexan parasites.

226 t roles in protein trafficking mechanisms of apicomplexan parasites.

227 Calcium flux is essential for entry in apicomplexan parasites.

228 te the ever important CD8 T cell response to apicomplexan parasites.

229 domain) that is almost exclusively found in apicomplexan parasites.

230 ential for motility, invasion, and egress in apicomplexan parasites.

231 trolling stage and life cycle transitions of apicomplexan parasites.

232 be crucial for the motility and survival of apicomplexan parasites.

233 que glimpse into the evolutionary history of apicomplexan parasites.

234 ife cycle of Plasmodium falciparum and other apicomplexan parasites.

235 stence of an alternative invasion pathway in apicomplexan parasites.

236 , being present in organisms from mammals to apicomplexan parasites.

237 y conserved function of CAPs from mammals to apicomplexan parasites.

238 an important experimental model for studying apicomplexan parasites.

239 ed for gliding motility and cell invasion by apicomplexan parasites.

240 the few actin-binding proteins conserved in apicomplexan parasites.

241 ing, mitochondrial dynamics, and invasion by apicomplexan parasites.

242 cess for the completion of the life cycle of apicomplexan parasites.

243 a shared but tailored invasion pathway among apicomplexan parasites.

244 lity, secretion, cell invasion and egress by apicomplexan parasites.

245 a key conserved role in Na(+) regulation in apicomplexan parasites.

246 for five Plasmodium species and two related apicomplexan parasites.

247 ntly become the focus of research within the apicomplexan parasites.

248 protein hub 1 (CPH1), which is conserved in apicomplexan parasites.

249 nction in motility and host cell invasion of apicomplexan parasites.

250 tal transitions, biology and pathogenesis of apicomplexan parasites.

251 s observed between these two closely related apicomplexan parasites.

252 in metazoans and recently identified also in apicomplexan parasites.

253 eristics previously linked to the origins of apicomplexan parasitism and find that virtually all are

254 Here, we examine the origin of apicomplexan parasitism by resolving the evolutionary di

255 Although most apicomplexans parasitize within the host cell cytosols,

256 The apicomplexan pathogen Cryptosporidium parvum poses major

257 a parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid orga

258 the survival of many important bacterial and apicomplexan pathogens.

259 cular, the C-terminal extension found in all apicomplexan PBGS enzymes forms an intersubunit beta-she

260 netic, enzymatic, and structural features of apicomplexan PBGS offer scope for developing selective i

261 el of conformity of RON2 proteins within the apicomplexan phylum, particularly that of the AMA1-RON2

262 tem disease caused by Babesia species of the apicomplexan phylum.

263 and cytosolic metabolic pathways related to apicomplexan plastid function revealed an ancient depend

264 we show that Plasmodium falciparum and other apicomplexans possess a unique heterodimeric glutamyl-tR

265 mbrane antigen 1 (AMA1) which is a conserved apicomplexan protein present in the micronemes and then

266 Consequently, half of apicomplexan proteins are unique and uncharacterized.

267 Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of th

268 Apicomplexan protozoa such as Toxoplasma gondii invade h

269 dii is an obligate, intracellular eukaryotic apicomplexan protozoan parasite that can cause fetal dam

270 l cell line (ARPE-19) and tachyzoites of the apicomplexan protozoan parasite Toxoplasma gondii (T. go

271 Diseases caused by the apicomplexan protozoans Toxoplasma gondii and Cryptospor

272 Our research suggests that the novel apicomplexan R2 subunit may be a promising candidate for

273 teins with an RNA-binding domain abundant in Apicomplexans (RAP domain) that is almost exclusively fo

274 (OPR) and an RNA-binding domain abundant in apicomplexans (RAP) domain.

275 Apicomplexan-related diseases may be controlled via inhi

276 nce data, we describe the diversity of these apicomplexan-related lineages and select five species th

277 amed RAP (for RNA-binding domain abundant in Apicomplexans), shared by all six members of the family.

278 apicoplast, a non-photosynthetic plastid of apicomplexan species, has an extremely reduced but highl

279 us proteins between phylogenetically distant Apicomplexan species.

280 We find that the Apicomplexan-specific ALBA4 RNA-binding protein acts to

281 fDHHC1 to be a member of a highly conserved, apicomplexan-specific clade of PATs.

282 not monophyletic and consistently placed the apicomplexan-specific clade sister to the remaining clas

283 Governing this balance is the apicomplexan-specific DAG-kinase-1, which interconverts

284 er, two recent studies have revealed that an apicomplexan-specific DNA-binding protein is essential f

285 a defect in secretion of the micronemes, an apicomplexan-specific organelle that contains adhesion p

286 Our analyses revealed that the apicomplexan-specific sequences share characteristics wi

287 semblance of Nephromyces infective stages to apicomplexan sporozoites.

288 and single subunit transmembrane proteins in apicomplexans such as TRAP in Plasmodium and MIC2 in Tox

289 Like most apicomplexans, T. gondii possesses several plant-like fe

290 iniaceae species were solely associated with apicomplexan taxa.

291 family in Cryptosporidium, a basal-branching apicomplexan that is the second leading cause of infant

292 tions for the many genera and life stages of apicomplexans that express SPATR.

293 We present here a report of a beneficial apicomplexan: the mutualistic marine endosymbiont Nephro

294 Here, we demonstrate that the apicomplexan Toxoplasma gondii harbors homologues of pro

295 that modulate Ca(2+) signaling in the model apicomplexan Toxoplasma gondii In doing so, we took adva

296 aches to investigate the ATP4 protein of the apicomplexan Toxoplasma gondii, TgATP4.

297 osomatids, but associated with the conoid in apicomplexan Toxoplasma.

298 may provide clues to the ancestral state of apicomplexan transcriptional regulation, pre-AP2 dominat

299 Apicomplexans utilize a multiprotein complex that includ

300 quired to maintain the shape and rigidity of apicomplexan zoites.