ライフサイエンスコーパス: apoptotic body

1 lasma membrane (microvesicles, oncosomes and apoptotic bodies).

2 ompetent cell fragments (matrix vesicles and apoptotic bodies).

3 untingtin generated the most cell fragments (apoptotic bodies).

4 uring apoptosis to catalyze the formation of apoptotic body.

5 suggest that it may derive from an engulfed apoptotic body.

6 is, chromatin condensation, and formation of apoptotic bodies.

7 marker for assessing apoptosis or detecting apoptotic bodies.

8 ted with particles of a size consistent with apoptotic bodies.

9 RA on VSMCs and blocks phagocytic removal of apoptotic bodies.

10 contain abnormal microtubule arrangement and apoptotic bodies.

11 mmunogen expression before the generation of apoptotic bodies.

12 and increased the subsequent level of total apoptotic bodies.

13 d [3H]-membrane lipid release and release of apoptotic bodies.

14 pases arrested the maturation and release of apoptotic bodies.

15 rmation by constructing "blebbishields" from apoptotic bodies.

16 functional properties of chondrocyte-derived apoptotic bodies.

17 ntation, membrane blebbing, and formation of apoptotic bodies.

18 uclear DNA, and the subsequent appearance of apoptotic bodies.

19 the presence of cytoplasmic nucleosomes and apoptotic bodies.

20 udies demonstrate the ubiquitous presence of apoptotic bodies.

21 in the form of exosomes, microvesicles, and apoptotic bodies.

22 are composed of exosomes, microvesicles, and apoptotic bodies.

23 edema, stromal inflammation, and epithelial apoptotic bodies.

24 d presence of GFAP+ fragments reminiscent of apoptotic bodies.

25 CAR-induced efferocytosis against tumor cell apoptotic bodies.

26 f chromatin condensation, cell shrinkage and apoptotic bodies.

27 frequently sheared off the 'string' to form apoptotic bodies.

28 ts in the exclusion of nuclear contents from apoptotic bodies.

29 ation of 'beads-on-a-string' protrusions and apoptotic bodies.

30 teins that were specifically absent in HiBEC apoptotic bodies.

31 res were also obtained from intact cells and apoptotic bodies.

32 loid P component (SAP)-mediated clearance of apoptotic bodies.

33 f its contents into membrane vesicles called apoptotic bodies.

34 These nucleosomal units are then included in apoptotic bodies.

35 phosphatidylserine exposed on the surface of apoptotic bodies.

36 present at the surface of apoptotic cells or apoptotic bodies.

37 de did not alter the rate of newly generated apoptotic bodies.

38 fragmentation, and the deposition of B cell apoptotic bodies.

39 rovesicles (MVs), but not exosomes (Exos) or apoptotic bodies (Abs), are the main type of EVs found i

40 secretes all three general subtypes of EV - apoptotic bodies (ABs), microvesicles (MVs), and exosome

41 he accumulation of apoptotic cells (ACs) and apoptotic bodies (ABs), resulting in accelerated leukemi

42 normally surrounds the cells is degraded and apoptotic bodies accumulate within and in the vicinity o

43 Basal stem cells engulf apoptotic bodies, activate Wnt signaling, and are stimul

44 llowing apoptosis and, furthermore, that the apoptotic body-adjuvant complexes are readily transferre

45 d in a significant increase in the number of apoptotic bodies after 4-6 hours.

46 ytosis is also required for the clearance of apoptotic bodies, an essential aspect of tissue homeosta

47 on, orally applied OTP reduced the number of apoptotic bodies and activated caspase-3-positive cells

48 o dehydration from that due to detachment of apoptotic bodies and can be used on samples where cell v

49 studies showing the formation and release of apoptotic bodies and cell death, and both processes are

50 ors have been implicated in the clearance of apoptotic bodies and could compensate for the TIM-4 defi

51 translocate immunologically intact PDC-E2 to apoptotic bodies and create an apotope.

52 ectable at 24 h postinfection as revealed by apoptotic bodies and DNA fragmentation, indicating that

53 reased cell viability and marked decrease of apoptotic bodies and DNA laddering.

54 oside, WT or NRKvector exhibited significant apoptotic bodies and DNA laddering; in contrast, NRKproH

55 and internalization of sialic acid decorated apoptotic bodies and exosomes derived from tumors.

56 proteins or lipids or in vesicles, including apoptotic bodies and exosomes.

57 ed at the outer membrane surface to resemble apoptotic bodies and phosphatidic acid (PA) at the inner

58 with increased frequency of hepatocytes with apoptotic bodies and positivity for proliferating cell n

59 ndividuals rescued TIM-4 expression, cleared apoptotic bodies and restored a macrophage resolution ph

60 play an important role in the generation of apoptotic bodies and their recognition by phagocytosing

61 lar mechanisms followed by the generation of apoptotic bodies and their subsequent rapid elimination

62 eleased was proteinaceous in nature, free of apoptotic bodies, and had an apparent m.w. much larger t

63 ere detected in the cells with intracellular apoptotic bodies, and immunohistochemistry documented tr

64 Increased numbers of mitotic cells, apoptotic bodies, and polyploid keratinocytes were evide

65 atin condensation, PARP cleavage, release of apoptotic bodies, and release of labeled lipid, DEVD-tre

66 ion of microbial pathogens, senescent cells, apoptotic bodies, and retinal outer segment fragments.

67 This study tested whether resulting apoptotic bodies (ApoBods) containing virally modified d

68 The levels of pyrophosphate produced by apoptotic bodies are increased by pretreatment of the ch

69 el cell cleavage process in which developing apoptotic bodies are rescued by the virus and differenti

70 at encompasses microparticles, exosomes, and apoptotic bodies) are emerging as a novel mean of cell-t

71 lular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circu

72 (EVs), including exosomes, microvesicles and apoptotic bodies, are lipid-bound vesicles secreted by c

73 mbrane and nuclear blebbing and formation of apoptotic bodies, are not observed in dying aleurone cel

74 ith a threefold increase in the frequency of apoptotic bodies as detected by terminal deoxynucleotidy

75 s and epithelial cells were found to contain apoptotic bodies at 3 times the rate of nonexpressing ce

76 erine macrophages resulting in a build up of apoptotic bodies at the uteroplacental interface that el

77 -based vaccine outperforms both exosome- and apoptotic-body-based vaccines in inhibiting tumour recur

78 Several Kupffer cells were seen containing apoptotic bodies but did not show evidence of apoptosis.

79 ese cells show neither DNA fragmentation nor apoptotic bodies, but display lethal damage of the cell

80 re resistant to the Fas-induced formation of apoptotic bodies, but had an enhanced externalization of

81 Engulfment of the apoptotic bodies, but not latex beads, stimulated Kupffe

82 ic process, the induction of phagocytosis of apoptotic bodies by hepatic stellate cells.

83 r aim was to ascertain whether engulfment of apoptotic bodies by Kupffer cells promotes hepatic infla

84 The disposal of apoptotic bodies by professional phagocytes is crucial t

85 Our ability to improve the disposal of apoptotic bodies by professional phagocytes is impaired

86 e have previously shown that phagocytosis of apoptotic bodies by stellate cells induces procollagen a

87 ly we have demonstrated that phagocytosis of apoptotic bodies by stellate cells is profibrogenic.

88 th EM studies we showed that phagocytosis of apoptotic bodies by stellate cells occurs in vivo.

89 drug delivery by phagocytosis of drug-loaded apoptotic bodies by the tumor cells and by increased dru

90 Alcohol-induced hepatocyte apoptotic bodies can be phagocytosed by HSCs and Kupffer

91 Apoptotic bodies can be used to target delivery of DNA-e

92 Apoptotic bodies can readily be ingested, with their nut

93 Because apoptotic bodies can serve as nucleation sites for calci

94 ents (a form of extracellular vesicle called apoptotic bodies) can facilitate removal of apoptotic de

95 Apoptotic bodies contain alkaline phosphatase and NTP py

96 r vesicles (EVs; exosomes, microvesicles and apoptotic bodies) containing proteins, lipids and RNAs i

97 animal model that virally modified dsDNA in apoptotic bodies could break tolerance to self dsDNA and

98 Here we show that antigen-laden apoptotic bodies created by vectors co-expressing influe

99 optosis precedes VSMC calcification and that apoptotic bodies derived from VSMCs may act as nucleatin

100 uding cell shrinkage, rounding, formation of apoptotic bodies, detachment and nuclear condensation an

101 asma membrane blebbing, and the formation of apoptotic bodies do not occur when aleurone cells die.

102 In particular, the clearance of apoptotic bodies (efferocytosis) is enabled by externali

103 ese results suggest that chondrocyte-derived apoptotic bodies express functional properties that may

104 ed (BDL) mice were phenotypically similar to apoptotic body-"fed" Kupffer cells with enhanced death l

105 levels [Ca(2+)](i), cell membrane integrity, apoptotic body formation and DNA fragmentation in cultur

106 These data uncover a new mechanism of apoptotic body formation in monocytes and also compounds

107 vealed a block in chromatin condensation and apoptotic body formation when nuclei from HeLa cells exp

108 uding membrane blebbing, cell shrinkage, and apoptotic body formation.

109 ladder formation, cell surface blebbing, and apoptotic body formation.

110 ladder formation, cell surface blebbing, and apoptotic body formation.

111 plasmic vacuolization, DNA condensation, and apoptotic body formation.

112 ular DNA into oligonucleosomal fragments and apoptotic body formation.

113 gamma-H2AX formation, DNA fragmentation, and apoptotic body formation.

114 5% loss in cell volume, DNA degradation, and apoptotic body formation.

115 ude cell contraction, membrane blebbing, and apoptotic body formation.

116 rogenase complex immunologically intact into apoptotic bodies, forming an apotope.

117 at macrophages have a function in scavenging apoptotic bodies from cells undergoing programmed cell d

118 ntation of the 19-kDa lipoprotein as well as apoptotic bodies from M. tuberculosis-infected cells.

119 Apoptotic bodies from tumor cells induces programmed cel

120 Apoptotic bodies generated by recombinant MVA (rMVA)-Ag8

121 ed murine Kupffer cells efficiently engulfed apoptotic bodies generated from UV-treated mouse hepatoc

122 hagocytic cell activity was maintained after apoptotic bodies had been removed.

123 hagocytic uptake and lysosomal fusion of the apoptotic body harboring the bacterium.

124 detection of apoptosis by directly detecting apoptotic bodies in a label-free manner.

125 s platform for proteomic characterization of apoptotic bodies in an effort to define the complex prot

126 significantly greater numbers of glomerular apoptotic bodies in C1q-deficient mice compared with con

127 istribution and association with well-formed apoptotic bodies in Cux-1(C)-infected cells.

128 ycotoxin induced cell death, DNA ladders, or apoptotic bodies in CV-1 cells expressing simian virus 4

129 of VP3 and a general lack of VP3-associated apoptotic bodies in infections of CIA-1 and chimeras con

130 Phagocytosis of apoptotic bodies in LX-1 cells significantly increased s

131 ntration-induced activation of caspase-3 and apoptotic bodies in mIMCD3 cells.

132 Apoptotic bodies in the mammary tumor were higher by abo

133 plement split products were deposited on the apoptotic bodies in the platelet pack.

134 MDMphis from PBC patients cultured with BEC apoptotic bodies in the presence of AMAs markedly increa

135 ages and B-1 cells do not efficiently engulf apoptotic bodies in vitro, or clear apoptotic bodies in

136 that TIM-4 is critical for the clearance of apoptotic bodies in vivo, and that lack of TIM-4 results

137 y engulf apoptotic bodies in vitro, or clear apoptotic bodies in vivo.

138 duced by lymphoid radiation, suggesting that apoptotic body ingestion by CD8(+) DCs initiates toleran

139 ther we demonstrate that the phagocytosis of apoptotic bodies inhibits both spontanous and UV-irradia

140 The presence of apoptotic bodies is considered important for the generat

141 Functional analysis shows that apoptotic bodies isolated from NO-treated chondrocytes o

142 of TIM-4 results in aberrant persistence of apoptotic bodies leading to dysregulated lymphocyte acti

143 re nuclear shrinkage and disintegration into apoptotic body-like fragments.

144 Results show that these apoptotic body-like liposomes carrying PA (ABL/PA) (i) a

145 Apoptotic body-like liposomes loaded with phosphatidylin

146 Altogether, these results suggest that apoptotic body-like liposomes may be used as a Janus-fac

147 RECENT FINDINGS: Microvesicles, exosomes, apoptotic bodies, lipoproteins, and large microparticles

148 nfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macropha

149 ystem opsonin which binds nuclear debris and apoptotic bodies, may protect against autoimmunity.

150 three types of extracellular vesicles (EVs): apoptotic bodies, microvesicles and exosomes.

151 extracellular vesicles (EVs), which include apoptotic bodies, microvesicles, and exosomes, have emer

152 mechanisms could include antigens present in apoptotic bodies, necrotic debris, exosomes or even rele

153 generated from CD14+ precursors, pulsed with apoptotic bodies of an allogeneic NSCLC cell line that o

154 cells as well as dendritic cells pulsed with apoptotic bodies of CLL cells to generate autologous and

155 re 11 proteins that localize specifically to apoptotic bodies of HiBEC and eight proteins that were s

156 uming milk cell membrane components, such as apoptotic bodies or extracellular vesicles (EVs).

157 red TuNEP- specific proteins with those from apoptotic bodies or NETs from neutrophils.

158 wild-type mice affected either the number of apoptotic bodies or the number of live macrophages.

159 o exosomes, microvesicles/microparticles, or apoptotic bodies, originating from different subcellular

160 Histopathology studies revealed fewer apoptotic bodies (P<0.05) in both the normal (1.70+/-0.1

161 dular VSMCs was unaltered, but the number of apoptotic bodies per nodule increased approximately 3-fo

162 Both apoptotic body phagocytosis and death ligand generation

163 A count of all of the apoptotic bodies positively labeled for nuclear DNA frag

164 e a mechanistic link between phagocytosis of apoptotic bodies, production of oxidative radicals, and

165 iver injury where Kupffer cell engulfment of apoptotic bodies promotes inflammation and fibrogenesis.

166 eed to acidify immediately in order to clear apoptotic bodies rapidly and effectively.

167 We conclude that ingestion of apoptotic bodies represents a regulatory mechanism linki

168 sis of large extracellular particles such as apoptotic bodies requires delivery of the intracellular

169 Our apoptotic body segmentation yielded an IoU accuracy of 7

170 n macrophages that enables the engulfment of apoptotic bodies, so-called efferocytosis.

171 DCs cultured with apoptotic bodies stimulated significantly greater T-cell

172 ssion correlated with a dramatic increase in apoptotic bodies, suggesting that Xist-mediated X chromo

173 iruses encode caspases or form such modified apoptotic bodies, suggesting this caspase plays a direct

174 5 stimulated production of microvesicles and apoptotic bodies that were CD63-negative, while DeltaICP

175 toplasm, cell shrinkage, and budding-off of 'apoptotic bodies' that are engulfed by glia.

176 vesicles (EVs; exosomes, microvesicles, and apoptotic bodies) that differ in biogenesis, composition

177 response to the larger numbers of persistent apoptotic bodies, the number of live macrophages in thes

178 er" transcripts that originate from engulfed apoptotic bodies, thus obscuring the true transcriptiona

179 ase-dependent production of Wnt8a-containing apoptotic bodies to drive cellular turnover in living ep

180 ediated disintegration of tumor cell-derived apoptotic bodies to facilitate presentation of membrane-

181 inflammatory sites it can bind bacteria and apoptotic bodies to trigger alternative pathway (AP) act

182 nsistent with these observations, binding of apoptotic bodies to VSMCs was decreased in the presence

183 Generation of apoptotic bodies via this mechanism can facilitate a sor

184 s morphologically unaltered and formation of apoptotic bodies was evident.

185 HCC-derived cells, and the ultimate fate of apoptotic bodies was phagocytosis and degradation by nei

186 eutic HIV-1 vaccine based on DCs loaded with apoptotic bodies was safe and induced T-cell activation

187 hagocytosis model, engulfment of GFP-labeled apoptotic bodies was seen, and the expression of alpha-s

188 of mitochondria was thickening, and the cell apoptotic body was observed.

189 off of portions of cytoplasm and nucleus as "apoptotic bodies." We have combined our previously estab

190 Extensive apoptotic bodies were characteristic of c-Myc-induced tu

191 After exposure, B cell apoptotic bodies were deposited in the spleen, lymph nod

192 procedure revealed that approximately 70% of apoptotic bodies were GST-II positive.

193 Internucleosomal DNA fragmentation and apoptotic bodies were observed between 3 and 4 d after i

194 of decreased calreticulin, CDKN2B-deficient apoptotic bodies were resistant to efferocytosis and not

195 ed) exhibited a high incidence of apoptosis (apoptotic bodies were seen in 55-75% of cells; 67-73% ha

196 ably, macrophages, which readily phagocytose apoptotic bodies, were very inefficient at acquiring lab

197 virus infection, but disassemble into small apoptotic bodies when DFNA5 is deleted.

198 ng microvesicles (distinct from exosomes and apoptotic bodies), which induce proliferation in neighbo

199 Furthermore, incubation of VSMC-derived apoptotic bodies with (45)Ca demonstrated that, like mat

200 et50 network identified nanowells containing apoptotic bodies with 92% accuracy and predicted the ons

201 Confocal images confirm internalization of apoptotic bodies within KIM-1-expressing epithelial cell