ライフサイエンスコーパス: apparent affinity

1 S, but with an almost 1000-fold reduction in apparent affinity.

2 ith large internal loops or bulges with high apparent affinity.

3 the radical reductase activity but of lower apparent affinity.

4 an cooperate to bind bivalent AP-2 with good apparent affinity.

5 tude lower (0.1 microM), indicating a higher apparent affinity.

6 r DAT inhibitors, which exhibited no loss in apparent affinity.

7 ope accessibility, epitope conservation, and apparent affinity.

8 ed TRPM2 channel gating, albeit with reduced apparent affinity.

9 esence or in the absence of Ca(2+) with high apparent affinity.

10 ed Ca(2+)-dependent movements with different apparent affinities.

11 switch responds to both ligands with similar apparent affinities.

12 ctivator of hAChE, when analyzed in terms of apparent affinity (1/K(ox)) and maximum reactivation rat

13 in the agonist-bound state increased agonist apparent affinity 15-fold, and slowed both deactivation

14 he mGluR7/7 homodimer revealed it to have an apparent affinity ~4000-fold lower than other mGluRs and

15 mbrane-proximal, and V1/V2 MAbs with similar apparent affinities, although the T/F Envs bound with hi

16 The apparent affinities and other thermodynamic parameters d

17 to a heteromeric complex increases glutamate apparent affinity and also enables receptor activation b

18 domain of the channel showed reduced proton apparent affinity and biphasic proton activation curves.

19 is more effective than Unc45b with a higher apparent affinity and greater extent of folding.

20 The results demonstrated that both the apparent affinity and intrinsic affinity of the Abs stud

21 ot related to an avidity-related increase in apparent affinity and points instead to a crucial role o

22 , has a dramatically different effect on the apparent affinity and transport rate for N-acetylneurami

23 phosphatase (AP) and examined the impact on apparent affinity and utility.

24 al AChR to which it bound with sub-nanomolar apparent affinity, and detected the presence of fetal AC

25 nds Cu(+), Ag(+), and ATP with the same high apparent affinities as the wild-type CopA.

26 , 2-O-, or 6-O-sulfates bind with equivalent apparent affinity as a disulfated DS tetrasaccharide.

27 larger interaction energy than the measured apparent affinity between the tetraloop and the free rec

28 nctions, however, are influenced not only by apparent affinities but also by alternate factors, inclu

29 II binds to beta1b and beta2a with a similar apparent affinity but does not bind to beta3 or beta4.

30 )1.1 or K(v)1.6 subunit with 100-fold higher apparent affinity compared with homomeric K(v)1.2 channe

31 The apparent affinity constant of Con A binding to mannose w

32 The apparent affinity constants determined using surface pla

33 MAbs to virions and allowed determination of apparent affinity constants in solution.

34 t's results showed a correlation between the apparent affinity constants measured for the NIP and MIP

35 The apparent affinity constants of lactose binding with ECL

36 Apparent affinity constants of Sc(3+) with membrane tran

37 for each glycan-lectin pair, from which the apparent affinity constants were obtained.

38 es revealed that these derivatives differ in apparent affinities depending on the modification type b

39 or resistance to E, can be correlated to the apparent affinities determined by in vivo multicopy supp

40 IR-AB1/IgY interaction allows an increase in apparent affinity due to avidity effects when the recept

41 in the absence of phospholipids with a high apparent affinity (EC50 of approximately 1.3-2.3 microM)

42 Their apparent affinity, epitope complementarity, and epitope

43 vivo to all three T antigens with different apparent affinities estimated as 1:7:100 (large T antige

44 nd that TAAR4 is exquisitely sensitive, with apparent affinities for a preferred ligand, phenylethyla

45 Furthermore, the apparent affinities for ATP and vanadate were WT-like in

46 for an epitope peptide as WT 4E10 but lower apparent affinities for both viral membrane mimetic lipo

47 The tetracaine analogues described here have apparent affinities for CNGA1 channels that vary over ne

48 The isozymes were found to share similar apparent affinities for cofactors.

49 immunosorbent assay technology to assess the apparent affinities for each isotype and IgG subclass of

50 Variants also exhibited lower apparent affinities for Env(+) virions and failed to sig

51 on additional membrane sites and had altered apparent affinities for factor X.

52 ltose uptake than the wild type and enhanced apparent affinities for maltose.

53 wed modest to significant decreases in their apparent affinities for Na(+) o and/or H(+) i.

54 Apparent affinities for substrates were unaffected by th

55 through a mechanism that does not alter the apparent affinities for the cosubstrates glutamate or so

56 e quantified the mutational effects based on apparent affinities for the respective inactivated state

57 void interference), the L subunit had a high apparent affinity for 3-phosphoglycerate and substrates

58 Apparent affinity for [(3)H]MeTRH was increased 8-fold i

59 gle strand DNA or single strand RNA, yet the apparent affinity for a DNA activator is 11-fold higher

60 The loop 2 mutants altered the apparent affinity for actin (K(ATPase)) without altering

61 al kinetic differences explain the increased apparent affinity for activation by cytosolic Ca2+ and t

62 Intriguingly, the apparent affinity for activation of TPC1 by its ligand N

63 C and D345C channels by MTSET reduced proton apparent affinity for activation.

64 more than 10,000-fold without affecting the apparent affinity for ADP-Glc and glycogen binding.

65 The apparent affinity for aspartate binding depended on the

66 While Sky1p has a low apparent affinity for ATP compared to other protein kina

67 by F6P compared to that of WT but increased apparent affinity for ATP in the presence of F6P.

68 The dissociation step showed an apparent affinity for ATP that was very weak (K(1/2),ATP

69 ns (NBDs) as the mutation does not alter the apparent affinity for ATP, and the mutant channels respo

70 We have tested this apparent affinity for betaproteobacteria by examining th

71 al time, we observe that PAR(2) has a higher apparent affinity for both beta-arrestins than does NK1R

72 meric channels that exhibited an increase in apparent affinity for both cAMP and cGMP compared with w

73 e activity was related to an increase in the apparent affinity for Ca(2+) and an increase in the phos

74 ulin-activated enzyme without increasing the apparent affinity for Ca(2+).

75 decreased by approximately 30% although the apparent affinity for Ca2+ was unchanged in heterozygous

76 linked dimer and has a significantly higher apparent affinity for calcium than the wild-type recepto

77 citrate and succinate but larger changes in apparent affinity for cations and substrate specificity

78 The apparent affinity for CCCP decreased in a linear manner

79 hannels (CNGCs) such that they have a higher apparent affinity for cGMP during the subjective night.

80 hannels (CNGCs) such that they have a higher apparent affinity for cGMP during the subjective night.

81 oncentration from 200 to 10 mM decreased the apparent affinity for d-galactose without altering the m

82 m) and etomidate (100 mum) and for increased apparent affinity for direct gating by the IV anesthetic

83 rating phenotype as determined by the cells' apparent affinity for dissolved inorganic carbon.

84 rNav1.2a (G1079C), which results in a higher apparent affinity for externally applied PaurTx3 and Pro

85 to have a approximately 15-fold decrease in apparent affinity for F6P compared to that of WT while A

86 s of 4% PS, and 3 mutants also had decreased apparent affinity for factor X.

87 le, metalloelastase (MMP-12) displays higher apparent affinity for fEln-100, while MMP-2 displays fas

88 ly open the channel of mutant G219F, and the apparent affinity for GABA was increased, and desensitiz

89 d-point of the inhibition being close to its apparent affinity for GDP-bound FtsZ.

90 mutants had 1 or 2 orders of magnitude lower apparent affinity for Glc-1-P compared with the wild typ

91 determinations of ADP-Glc PPases having high apparent affinity for glucose 1-phosphate.

92 luK2(E738D) mutation lowers the steady state apparent affinity for glutamate by 9000-fold in comparis

93 exhibit slowed kinetics and a shift in their apparent affinity for glutamate.

94 for proline and leucine and a low millimolar apparent affinity for glutamine.

95 at is similar to that in *Talpha is that the apparent affinity for guanine nucleotides is decreased i

96 in a functionally bivalent manner, with the apparent affinity for IgA1 related to the number of expo

97 In addition, the apparent affinity for Ins(3,4,5)P(3) is affected by the

98 oximately 10 ms; 4), InsP3R2 has the highest apparent affinity for InsP(3) (0.10 microM), followed by

99 The apparent affinity for K(+) activation of the ATPase acti

100 Trp38, causes decreased quenching, decreased apparent affinity for L-fucose, and significant inhibiti

101 tPh-L130W/T352A exhibited an ~15-fold higher apparent affinity for l-glutamate than the wild type tra

102 An even larger increase of the apparent affinity for l-glutamate, around 130-fold highe

103 g yielded less than a 4-fold decrease in the apparent affinity for melibiose at saturating Na(+) or L

104 syt VII, which we show has a relatively high apparent affinity for metals.

105 In general, taxane derivatives with higher apparent affinity for microtubules induced tubulin assem

106 entration from 20 to 0.5 mM reduced both the apparent affinity for Na(+) and the maximum quench at sa

107 Pase, and while TM5 showed modest changes in apparent affinity for Na(+), TM4, TM6, and TMAll display

108 tive transport and efflux, and decreased the apparent affinity for Na(+).

109 which upon binding estrogen shows increased apparent affinity for nuclear components (tight nuclear

110 In the absence of Mg(2+), SUR1 increases the apparent affinity for nucleotide inhibition at Kir6.2 by

111 , however, TgPhyA had a significantly higher apparent affinity for O(2).

112 ing several at position 223, that reduce the apparent affinity for oseltamivir in vitro.

113 ion neurons from Pirt knock-out mice have an apparent affinity for PIP2 indistinguishable from that o

114 2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low mill

115 oup interactions control Ca(2+) sensitivity, apparent affinity for RetGC, and maximal level of cyclas

116 ing in the hydrophobic core and lowers RD3's apparent affinity for RetGC1.

117 iminates DksA function without affecting its apparent affinity for RNAP.

118 ents also revealed that PLB has a 50% higher apparent affinity for SERCA1a relative to SERCA2a.

119 The apparent affinity for sildenafil increased from the nano

120 voltage dependence, indicating an increased apparent affinity for sodium.

121 in impaired transport activity and a reduced apparent affinity for sodium.

122 oltage-dependence indicative of an increased apparent affinity for sodium.

123 ant determinant of functional differences in apparent affinity for substrate and cations.

124 This chimera has similar apparent affinity for succinate and sodium as the wild-t

125 That is, the apparent affinity for sugar and driver cation Na(+) exhi

126 The S subunit had a typical low apparent affinity for the activator 3-phosphoglycerate,

127 fect the specific activity but did alter the apparent affinity for the activator 3-phosphoglycerate,

128 sponding active conformation potentiates the apparent affinity for the agonist, effectively equating

129 Modification at N1 of cGMP reduces the apparent affinity for the channel; however, when combine

130 RQ(102), and (119)RSVL(122), reduced the RD3 apparent affinity for the cyclase 180-700-fold.

131 epolarized synaptosomes correlated well with apparent affinity for the inactivated state of sodium ch

132 MP-PNP is not disrupted by the mutation, the apparent affinity for the nucleotide is decreased by 4-f

133 te with PtdIns(4,5)P(2) for binding, but the apparent affinity for the soluble inositol phosphate is

134 pen conformation, which mostly increases the apparent affinity for the substrates (i.e. by a reductio

135 Similarly, a 30-150-fold decrease in the apparent affinity for verapamil and cyclic peptide inhib

136 TRPM3 activator, CIM0216, whose potency and apparent affinity greatly exceeds that of the canonical

137 olar concentrations of Tb(3+), indicating an apparent affinity >100-fold higher than Ca(2+).

138 in MAbs 6D8 and 13F6 bind with the strongest apparent affinity, helping to explain their effectivenes

139 SYY (i) decreased both Na(o)(+) and Na(i)(+) apparent affinities in the absence of K(o)(+), and (ii)

140 -molecule inhibitor of ASICs with a reported apparent affinity in the low micromolar range, making it

141 in a concentration-dependent manner, with an apparent affinity in the low nanomolar range.

142 T(20)) single-stranded flanking region, with apparent affinity in the micromolar range.

143 nhibits ClC-ec1 activity reversibly, with an apparent affinity in the micromolar range.

144 ichiometry in the presence of Ca(2+) with an apparent affinity in the micromolar range.

145 nds the five oriC-proximal RBMs with similar apparent affinity in units of two and four.

146 chanism of En-dependent repression, and that apparent affinity in vitro is an unreliable predictor of

147 microM; in the presence of membranes, these apparent affinities increase by up to sevenfold.

148 PF1 binds to single-stranded NAs (ssNA) with apparent affinity increasing with substrate length and w

149 ATP analogs bind MRP1 with reduced apparent affinity, inducing a partially closed conformat

150 omain of the alpha1 ILD near M3 altered GABA apparent affinity; interestingly, alpha1(K312E) exhibite

151 ith an IC50 in the high picomolar range, the apparent affinity is higher than known high affinity BK

152 The apparent affinity ( K(a)) of the GBP for the GP is then

153 E1, and hMATE2-K transport mIBG with similar apparent affinities (K (m) of 19.5 +/- 6.9, 17.2 +/- 2.8

154 , simple phenolics and cyanogens with higher apparent affinities (K(m)) and specificities (k(cat)/K(m

155 The apparent affinities (K(m)) for ADP were similar for both

156 ve binding of two MsrA to each CaMox with an apparent affinity (K = 70 +/- 10 nM) that is 3 orders of

157 esence of Rng3p in ATPase assays doubles the apparent affinity (K(ATPase)) of both native Myo2 and re

158 The effect of bulk-phase pH on the apparent affinity (K(d)(app)) of purified wild-type lact

159 In general, substrates have lower apparent affinities (K0.5) for hSGLT3 than hSGLT1 (D-glu

160 It is activated by Cu2+ with high apparent affinity (K1/2 = 0.28 microm) and partially by

161 at 190-HARE and 315-HARE bind HA with higher apparent affinity (Kd approximately 10-20 nM) than chond

162 or diversifying the ion-release dynamics and apparent affinity (Km ) at opposite sides of the membran

163 ximal velocity (Vmax) without any changes in apparent affinity (Km) for the substrate Na+ .

164 This apparent affinity matches that for its canonical dsDNA l

165 To test the idea that increasing apparent affinity might enhance neutralizing activity, w

166 We obtained excellent agreement in the apparent affinities obtained across platforms and within

167 transports uracil, adenine, and guanine with apparent affinities of 16.4, 0.4, and 6.3 muM, respectiv

168 subunits (GDP-Galpha(s) and Gbetagamma) with apparent affinities of 270 +/- 21 and 190 +/- 7 nM, resp

169 scence emission spectrum of dansyl-CaM, with apparent affinities of 87 +/- 23 nm and 1.70 +/- 0.16 mi

170 d isotypes, immunoglobulin G subclasses, and apparent affinities of anti-FVIII autoantibodies to asse

171 with the biochemical data, we found that the apparent affinities of Ca(2+) activating and inhibitory

172 We show that the apparent affinities of DksA and GreB for RNAP are simila

173 Whereas the apparent affinities of DksA for RNAP core and holoenzyme

174 ey also reveal complex relationships between apparent affinities of drugs for radioligand binding and

175 We present a unique data set of apparent affinities of FVIII-specific antibodies found i

176 spectively) are consistent with the reported apparent affinities of hGal-3 for serum GPs and their N-

177 Divergent apparent affinities of Kv7.2-7.4 channels for PIP2 may u

178 We find that the apparent affinities of P-gp for anticancer drugs actinom

179 Measuring the apparent affinities of the agonists for the mG(s)-couple

180 Further, the apparent affinities of the membrane-displayed scFvs were

181 Fast decay amplitude data indicated an apparent affinity of 0.9 microM for the closed-state alp

182 binds three Ca2+ ions at saturation with an apparent affinity of 2 microm and Hill coefficient of 1.

183 The increased valency enhances the apparent affinity of 2G12 for Man(4) up to a limit which

184 tides ATP and cAMP block the channel with an apparent affinity of 3 and 42 microM, respectively (-80

185 e reversibly inhibits ASCT2 function with an apparent affinity of 30 muM.

186 els also suggest that binding occurs with an apparent affinity of 7 muM.

187 We hypothesized that the reduction in apparent affinity of 8-Br-cGMP for cGKI in AHR might be

188 on, high-affinity AXL decoy receptor with an apparent affinity of 93 femtomolar to GAS6.

189 The apparent affinity of acto-heavy meromyosin (acto-HMM) fo

190 r function and is a major determinant of the apparent affinity of agonists.

191 ired in a major transport mechanism, with an apparent affinity of approximately 0.9 mm K(+)(Rb(+)).

192 that Zn(2+) inhibits these currents, with an apparent affinity of approximately 50 microM.

193 The apparent affinity of ASCT2 for extracellular Na(+) was d

194 These same mutations lower the apparent affinity of Ba2+ by approximately 10(3)- or app

195 One consequence of this effect is that the apparent affinity of baclofen is strongly reduced during

196 Micromolar Ca increased the apparent affinity of CaM binding and slowed CaM dissocia

197 phosphorylation at Thr286 is to increase the apparent affinity of CaMKII for calmodulin, a phenomenon

198 g to the CNBD of HCN2 channels decreases the apparent affinity of cAMP for the CNBD.

199 gly, these mutations selectively enhance the apparent affinity of CARD11 for Bcl10, but not for other

200 e active at night in cones, and increase the apparent affinity of CNGCs for cGMP.

201 vo and in vitro, primarily by increasing the apparent affinity of DksA for RNA polymerase (RNAP).

202 r RNAP core and holoenzyme are the same, the apparent affinity of DksA for RNAP decreases almost 10-f

203 ding site with alanine (N128A) increases the apparent affinity of dTC by approximately 10-fold.

204 al rate of translocation (k(trans)), and the apparent affinity of EF-G for the pretranslocation compl

205 Under neutral pH conditions, the apparent affinity of Fcepsilon for the dimeric fusion pr

206 These data suggest that proton alters the apparent affinity of GABA receptors for agonist.

207 submaximal GABA responses by increasing the apparent affinity of GABA(A)Rs for GABA.

208 nodiscs was significantly different, and the apparent affinity of Galphaq and Gbeta(1)gamma(1) to act

209 Rac membrane cycling reveals that the lower apparent affinity of GDI for RacGTP compared to RacGDP c

210 In the presence of Mg2+, the apparent affinity of Glu-297 3Dpol for 2'-deoxyribonucle

211 In contrast to GreB, the apparent affinity of GreA for RNAP was weaker than that

212 olesterol depletion dramatically reduced the apparent affinity of homomeric CNGA2 channels for cAMP b

213 ormation between Hsp90 and p23 increased the apparent affinity of Hsp90 for AMP-PNP and completely in

214 the N terminal NxNNWHW motif, modulates the apparent affinity of Hsp90 for nucleotide substrates.

215 The apparent affinity of K114 for fibril binding is 20-30 nM

216 model for Kap translocation, we measured the apparent affinity of Kap95p to FG Nups representing thre

217 The apparent affinity of LMWH for the factor IXa-PL complex

218 h leucine and the lrp-1 mutation reduced the apparent affinity of Lrp binding to ilvIH DNA (contains

219 flecting specific structural preference, the apparent affinity of mincle for ligands with hydrophobic

220 ta3 reduced and increased, respectively, the apparent affinity of Mn(2+) to the integrin.

221 A reduced apparent affinity of N (6)-Phe-cAMP toward the variants

222 Accordingly, the apparent affinity of NMIIB S1 for actin in the presence

223 profile (i.e. a progressive decrease in the apparent affinity of oxotremorine-M).

224 the intramolecular binding motif reduces the apparent affinity of p53 for MdmX by a factor of 400.

225 RGS13 reduced the apparent affinity of pCREB for both the CRE and CBP.

226 CBD1, resulted in a drastic decrease in the apparent affinity of peak exchange current for regulator

227 oss of PLB-PLB FRET due to a decrease in the apparent affinity of PLB oligomerization.

228 e, heteroligation demonstrably increases the apparent affinity of polyreactive antibodies to HIV.

229 sor." Mutations in these two areas shift the apparent affinity of protons toward a more acidic range

230 ilter binding assays, we determined that the apparent affinity of Prp22 is approximately 20-fold grea

231 of 49 C-terminal residues did not affect the apparent affinity of RD3 for RetGC.

232 ions in the region of 70- to 165-fold in the apparent affinity of receptors for glucose in which Glu1

233 y in membrane-based assays by increasing the apparent affinity of RGS4 for Gialpha and Goalpha, sugge

234 BTS weakens the apparent affinity of S1.ADP for actin, increasing the K(

235 i) release in conjunction with the decreased apparent affinity of S1.ADP.P(i) and S1.ADP for actin.

236 tion of SERCA2a is manifested as a decreased apparent affinity of SERCA2a for Ca(2+).

237 We also determined the apparent affinity of SOX2 and NANOG for their consensus

238 The apparent affinity of substrate-free EAAC1 for Na(+) was

239 ncentrations, subunit conformations, and the apparent affinity of subunits for polymer ends.

240 The apparent affinity of the Abs ranged from nearly 10(-10)

241 d substitutions that significantly alter the apparent affinity of the active site for beta-lactams an

242 that describe the specificity, isotype, and apparent affinity of the antibodies secreted from large

243 l-DTPA were hyperbolic, but in each case the apparent affinity of the antibody for the chelator-metal

244 F256V, I765A, and Y837A reduce not only the apparent affinity of the ATPase for TG but also the maxi

245 cket (Phe342) was replaced with alanine, the apparent affinity of the blocker was increased approxima

246 mainly due to an >200-fold reduction in the apparent affinity of the Ca2+-inhibitory site; 6), the a

247 ite to tyrosine (F226Y) has no effect on the apparent affinity of the competitive antagonist d-tubocu

248 It is found that the apparent affinity of the complex is significantly greate

249 828A, R834A, and R837A mutations reduced the apparent affinity of the enzyme for both Na(+) and K(+)

250 ac sarcoplasmic reticulum, by decreasing the apparent affinity of the enzyme for Ca(2+).

251 decrease of approximately >or=10-fold in the apparent affinity of the enzyme for sodium (Km(app)(Na+)

252 This is due largely to the high apparent affinity of the enzyme for this DNA substrate,

253 f CaMKII and a significant increase (22%) in apparent affinity of the enzyme.

254 ed from the intact antibody only in that the apparent affinity of the Fab was generally lower for a g

255 y complex, but HFE binding to TfR lowers the apparent affinity of the Fe-Tf/TfR interaction.

256 DH2 were found to be a dramatic reduction in apparent affinity of the holoenzyme for NAD(+) and a con

257 The higher apparent affinity of the immobilized aptamer may result

258 CTT may produce this effect by reducing the apparent affinity of the interaction between beta-cateni

259 ered Cdc25C protein partner and enhances the apparent affinity of the interaction.

260 istent with a multivalent interaction: 1) an apparent affinity of the multivalent ligand for the M2 r

261 However, the apparent affinity of the nonconserved mutants for GABA w

262 e p5 (as in Jdp5) dramatically increases the apparent affinity of the p5 moiety for DnaK in the prese

263 re of the regulatory complex and reduced the apparent affinity of the PLM-NKA interaction.

264 as continuous-time random walks decrease the apparent affinity of the reaction, locally slowed-down B

265 ee scenarios have distinctive effects on the apparent affinity of the reaction.

266 the estimated channel opening rate or on the apparent affinity of the receptor for GABA.

267 r importance in defining the specificity and apparent affinity of the receptor for germinants.

268 The two mutations increased the apparent affinity of the regulatory Ca2+ binding sites o

269 ons included 2-fold or less increases in the apparent affinity of the thin filament regulatory Ca(2+)

270 We determined the apparent affinity of the wild-type and the mutant RetGC-

271 193A, gammaH200A, and gammaH202A reduced the apparent affinity of the Zn(2+) activating site, gammaH2

272 The apparent affinity of these derivatives for GMPCPP-stabil

273 Rather, hyperpolarization increases the apparent affinity of TPC1 for NAADP by 10 nm/mV.

274 R activation, G (alphaq) binding reduces the apparent affinity of TRPM8 for PI(4,5)P(2) and thus sens

275 We demonstrate that Dcs1 improves the apparent affinity of Xrn1 for RNA and that Xrn1 and Dcs1

276 eplacement of Thr with Ala or Cys lowers the apparent affinity ofK+, Rb+, and Cs+ for tetramer stabil

277 The latter is thought to decrease antibody apparent affinity or avidity, thereby interfering with n

278 This apparent affinity reduction could result from direct com

279 ed to disrupt these contacts reduced agonist apparent affinity, speeded up receptor deactivation and

280 O-sulfate, an analog that binds with greater apparent affinity than cholesterol.

281 ars to interact with the spores with greater apparent affinity than does taurocholate.

282 r (reduced V(max(app))), with 50-fold higher apparent affinity than LMWH.

283 clathrin binds the beta2 chain with a higher apparent affinity than PIPKIgamma661.

284 III inhibitors have an up to 100-fold higher apparent affinity than that of antibodies found in patie

285 ied to inside-out patches, with differential apparent affinities that correlate with their maximal Po

286 is and diazepam to manipulate GABAA receptor apparent affinity, the decrease in arcuate miniature pos

287 (BZD efficacy) without altering BZD binding apparent affinity, three residues whose mutation altered

288 ing to free RNAP below detection limits, the apparent affinity to Mg2+ in transcription complexes for

289 he Slp-4 C2A domain binds with low nanomolar apparent affinity to PIP(2) in lipid vesicles that also

290 ing a closed conformation that decreases the apparent affinity to protons and also slows the rise and

291 (2+), both sTnC and xxsTnC bind with similar apparent affinity to sTnC-extracted thin filaments.

292 ly dephosphorylates CMP, although with lower apparent affinity; UMP and the purine nucleotides are po

293 mibefradil block of Na(+) channels in which apparent affinity was enhanced when channels were recrui

294 This 5-fold increase in apparent affinity was not species-specific since bovine

295 However, the apparent affinities were rather weak (VX-950, K(D)* of 3

296 inward currents activated by L-Arg with low apparent affinity were measured in whole-cell voltage-cl

297 apamil from the outside, with an increase in apparent affinity when the drug was applied from the ins

298 riant FlhBs had similar kinetic profiles and apparent affinities, which ranged between 1 and 10.5 mic

299 ersus 20-fold) and interacted with an higher apparent affinity with its target guanylate cyclase.

300 in relatively small changes in the substrate apparent affinities, yet at several of these positions,