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2 that the effect is attributable to a single appended 3'-end residue, is dependent upon its single-st
3 inoids reveal that, on a per atom basis, the appended 6pi electron heterocycles of porphyrinoids conf
4 nsferase recognition motif that allows us to append a bioorthogonal azide or alkyne moiety and use th
8 eavage; 3) modification of the C terminus by appending a C-terminal tag altered the pattern of proces
9 to a well-defined octahedral protein cage by appending a C4-symmetric coiled-coil domain to the prote
11 e potency of CD4-Ig is markedly increased by appending a coreceptor-mimetic sulfopeptide to its C ter
12 e (TM) and cytoplasmic tail (CT) domains and appending a glycosylphosphatidylinositol (GPI) anchor si
17 e followed by GPI-phospholipase D digestion, appending a trimeric coiled-coil (GCNt) domain (sF(GCNt)
18 esultant OH and NH(2) groups as a handle for appending a variety of substituents by means of several
25 o which a meso-tetraphenylporphyrin has been appended and which self-assembles to fibrils, platelets
26 e the adaptive properties of this system, we appended another DNA sequence to Dk2, which, once amplif
28 probe 5 has been designed and synthesized by appending anthracene and benzhydryl moieties through a p
29 , we report a Pd(II)-catalysed protocol that appends arene feedstocks to tertiary alkylamines via C(s
31 orientation of the aryl chromophore and the appended arsenic chelate: the fluorescence is rotamer-re
39 Diol sensors are often based on fluorophore-appended boronic acids, but these severely lack discrimi
44 hains for degradation in a direct manner, by appending C-terminal poly-alanine tails that act as degr
46 racterization of a triazole linked quinoline appended calix[4]arene conjugate, L, and its fluorescenc
48 aled 3426 glycosides containing 344 distinct appended carbohydrates and highlights a range of unique
51 reactive moieties is adjusted solely by the appended chiral scaffold through outer-sphere interactio
52 utility of CHaMPs, we used this approach to append cholesterol to biologically active peptide exendi
57 composed of nanoswitch 1 and the anthracene-appended crown ether 2 is infallibly driven by chemical
58 r H-bonded 1D ensemble was used to order the appended crown ethers in such a way that they roughly st
59 stallography) of PAHs containing one or more appended dienes with the ortho-quinodimethane (o-QDM) st
60 ater-compatible using poly (ethylene glycol)-appended dihydrolipoic acid (DHLA-PEG), where a fraction
62 In this regard, the self-assembly of dye-appended DNA sequences into programmed photonic architec
68 provides structural information on flexibly appended domains, characteristic of nearly all MSC const
69 RSs expanded by acquiring novel noncatalytic appended domains, which are absent from bacteria and man
70 ny eukaryotic tRNA synthetases have acquired appended domains, whose origin, structure and function a
73 induced electron-transfer reactions with the appended dyes, but ineffective electronic energy transfe
74 locyanine ligand, which can be suppressed by appending electron-donating amino substituents to the ph
75 ine unit and can be tuned by over 70-fold by appending electron-withdrawing substituents to the pheny
76 ile the most selective compound is a glucose-appended enantiomer, its cellular entry is not mainly gl
78 atin-derived and 3,3'-disubstituted oxindole-appended epoxy-acrylate undergoing Cp(2)Ti(III)Cl-mediat
79 tion and a [3 + 2] cycloaddition strategy to append five membered isoxazole and isoxazolone as new ph
81 and monitoring the change in emission of an appended fluorophore, we exploit a series of host-fluoro
82 ethylphenylboronic acid-based receptors with appended fluorophores are commonly used as molecular sen
83 ole in the modulation of the fluorescence of appended fluorophores in the protic-solvent-inserted for
91 rthermore, this offers a modular approach to append functionality to biopharmaceuticals by noncovalen
92 using pyrimidine-pyrazolyl pharmacophore to append HDAC recognition cap and hydroxamic acid as a zin
93 terface of the ETS domain and stabilizing an appended helical inhibitory module against allostericall
94 120 CD4bs cavity (pocket-filling; PF2) or by appending heterologous trimerization motifs to soluble E
95 iii) that pilin subunits with a C-terminally appended hexa-histidine (6His) tag are still assembled i
96 er-forming organic nanoarchitecture, peptide-appended hybrid[4]arene (PAH[4]), as a new class of arti
101 idate the importance of this alpha3-helix by appending it to the RRM of the unrelated U1A protein and
102 ulating a base-metal center via a covalently appended Lewis acidic support is viable for promoting se
103 llow face-to-face pi-pi interactions between appended linear aromatic segments to be strong enough fo
107 ation from the crystal structures of diamine-appended metal-organic frameworks exhibiting two-step co
110 enerate secondary metabolites by iteratively appending monomers to a growing serial oligomer chain.
113 utaminyl-tRNA synthetase (GlnRS) contains an appended N-terminal domain (NTD) whose precise function
116 shown that the quenched emission of thiourea-appended naphthalimides can be restored by metal binding
117 We have prepared a new class of boronic acid-appended naphthyl-pyridinium receptor compounds as chemo
118 ansfer dynamics from photoexcited QDs to the appended NDI ligands is explored as a function of both s
119 his redox-economical approach can be used to append nearly any kind of cargo onto serine, generating
120 oligonucleotides spin-labelled with triazole-appended nitroxides at the 2' position offers a robust a
121 non-traditional applications is the need to append nucleic-acid barcodes to entities of interest.
122 ore domain is not pressure-sensitive and the appending of Piezo Repeat-A did not restore pressure-dep
124 e can tailor the type of biomolecular probes appended on individual TDNs for the detection of specifi
125 ferent acyl and carbamoyl moieties (R7) were appended on the 7-amino group, as well as a para-methoxy
126 nduces an upfield shift of the fluorine atom appended on the arylimido group, the extent of which is
127 tinct (19)F NMR shifts of the fluorine atoms appended on the ligand that defines a chiral environment
128 sents two lipoic acids (higher coordination) appended onto a single end-functionalized PEG, and (ii)
135 analysis of truncation products reveals that appending other extensions to the ATPase domain is suffi
137 ocycle threading by a dye conjugate with two appended PEG2000 chains is only three times slower than
138 erves a dual function, not only encoding the appended peptide but also directing the PTR by decoding
139 extracellular matrix material by genetically appending peptide domains to the amyloid protein CsgA, t
140 ated by a flash-quench sequence oxidizes the appended phenol and the proton is transferred to the hyd
141 ecificity of this method are well-suited for appending piperidine motifs to natural product and compl
142 form illustrate how type A CBMs target their appended plant cell wall-degrading enzymes to a diversit
143 oramine C contains a large macrocycle and an appended polyamine component and was shown to be both an
144 r between the 15-membered carbocycle and the appended polyamine showed improved antimigration propert
146 process of transglycosylation, the quencher-appended polyprenol is released and the fluorescence of
147 in-conjugating enzymes and ubiquitin ligases append polyubiquitin chains onto misfolded protein subst
149 d Dy(3+) DOTA-tetraamide complexes with four appended primary amine groups are measured as a function
152 ared published reports with their respective appended protocols with regard to primary end points, no
155 present the use of fluorinated boronic acid-appended pyridinium salts in combination with (19)F NMR
156 We have generated two persistent pyridyl-appended radical cations: 10-(pyrid-2-yl)-10H-phenothiaz
157 th the AuNPs surface thereby facilitated the appended recognition block a better upright conformation
159 2) reduction by a d(0) Zr(IV) center with an appended redox-active Co(-I) site serving as an electron
160 cting group strategy during the synthesis to append residues from Abeta(1-14) to the parent macrocycl
161 the ATP5G1 mitochondrial targeting sequence appended restored viability on Krebs cycle substrates an
162 cesses can be achieved both with and without appended ring systems and stereogenic centers, (3) that
163 synthetic protocol to obtain oligosaccharide-appended salicylaldehydes, key intermediates for the syn
164 ligonucleotide recognition occurs through an appended SAVED domain that is an unexpected fusion of tw
165 We developed a series of ionic head groups-appended self-assembled monolayers with C2, C6, C8, and
166 stfusion structures of sF(GCNt) and non-GCNt-appended sF could be revealed by electron microscopy and
168 Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more effective
169 acid groups and the single amine group on an appended side chain of GdL(1) and forms a ternary comple
170 ity of main chain hydroxyaldehyde, while the appended side-chain-protected 3,4-dihydroxypentanoic aci
171 chemical and biological sciences, since, by appending small molecules into proteins surfaces, fundam
174 ibited by them after subtle changes to their appended substituents, are becoming increasingly importa
177 e feasibility of nucleophilic addition to an appended sulfoxide as a means to form a bond to aryl(het
182 onetheless, the affinity of the FERM for the appended tail was similar to its affinity for binding to
184 for corrective mitochondrial-encoded tRNAs, appending the 3'-UTR localization sequence was essential
185 their high-symmetry nuclear positions, thus appending the basic understanding of related phenomena w
187 in Grx3 abrogated Mzm1 interaction; however, appending the C-terminal 30 residues of Rip1 to the Rip1
192 ulations show that when a daughter branch is appended, the buckling resistance of a filament changes
193 n a Tat-derived cell-penetrating peptide was appended, the resulting molecule (FabRev1-Tat) was stron
195 n of this domain precludes prionogenesis and appending this domain to reporter proteins can confer pr
198 ting of a cyclic polymerizable group that is appended to a drug through a cleavable linker is achieve
201 mediated cleavage of a commonly used HIS tag appended to a protein, we generate with high yield and p
202 etrasaccharyl triazole cluster can be easily appended to a range of acetylene-functionalized peptides
203 with a carbohydrate-binding "lectin" domain appended to a receptor-destroying sialate-O-acetylestera
205 r Staphylococcus pyogenes sortase A), can be appended to a variety of probes such as fluorophores, bi
208 t-shaped ssDNA binding claw that is flexibly appended to an APE2 endonuclease/exonuclease/phosphatase
214 ici Phylogenetic analysis showed that CBM32s appended to chitosanases are highly conserved across dif
215 is the presence of an unusual acetal moiety appended to daunosamine, which is hydrolyzed during acid
216 cells, a cyclic cell-penetrating peptide is appended to DNA-encoded libraries for delivery across th
218 The classic 4-azido-3-iodo-phenyl group was appended to either the C-1 or C-5 position of the parent
220 1 subtype B and G pol genetic sequences were appended to global reference data sets to identify count
221 Carbohydrate-binding modules (CBMs) are appended to glycoside hydrolases and can contribute to t
223 idue domain mediates antiviral activity when appended to heterologous proteins, and we provide geneti
224 ich exclusively hydroxylates C5 of norvaline appended to its carrier protein but can either chlorinat
227 nhance neutralization of other isolates when appended to most classes of bNAbs, with one exception.
230 as internal redox references were covalently appended to representative electrophores in order to cou
232 ealkylation on a dibenzylamino group that is appended to the 6-position of a pyridyl donor of a tripo
233 cts the endonuclease and helicase domains is appended to the adeno-associated virus type 5 (AAV5) hel
234 n, and a cleavable bidentate directing group appended to the alkene to control the regioselectivity a
237 tion, nature of the solubilizing side-chains appended to the backbones, and extent of structural orde
239 nized by a carbohydrate-binding module (CBM) appended to the C terminus of the nucleotide-binding dom
240 ne activity and that moieties that have been appended to the C7 position of different quinolone scaff
242 ates C4 of its native substrate, l-threonine appended to the carrier protein, SyrB1, but hydroxylates
246 TP using yeast PaP, and the short DNA strand appended to the end of the RNA by PaP acts as the initia
248 ns of the tetraalkylammonium ionized species appended to the ferrocene, such as bis(trifluoromethanes
250 ions to just one of the many hydroxyl groups appended to the ion channel-forming natural product amph
251 ed of 2,2-dimethyl-1,3-diaminopropane (dmpn) appended to the Mg(2+) sites lining the channels of Mg2(
256 ts demonstrate that variation of the R group appended to the phosphorus atom informs the lipophilicit
257 tive interaction with chemical functionality appended to the previously developed I-BET151 scaffold.
260 n enantiopure beta-epoxyaldehyde that can be appended to the rest of the skipped polyene core by Witt
261 hanges in (a) the number of polyamine chains appended to the ring system, (b) the polyamine sequence,
263 energy migration occurs between yellow dyes appended to the same nanoparticle and, at higher loading
264 Decyl and oligo(ethylene glycol) chains were appended to the same poly(methacrylate) backbone to gene
265 receptor or IL-9 receptor, in which JAK1 is appended to the specific chain, and JAK3 is appended to
266 ween azide and cyclooctyne functional groups appended to the termini of the split aptamer fragments.
267 ron center is coordinatively unsaturated and appended to the trinuclear core through three bridging p
269 esentation of yellow-shifted pHluorin (YpH), appended to the vesicle lumen domain of Sb2, and perform
273 of cruzain, composed of a dipeptide scaffold appended to vinyl heterocycles meant to provide replacem
274 erent susceptibility of exposed individuals, appending tools for predicting risk of disease progressi
277 amine functionalities, and the use of an NBD-appended urea-monomer as a binary hydrogen-bond donor ta
278 ent a detailed investigation of nine diamine-appended variants of the metal-organic framework Mg2(dob
279 were synthesized with aromatic substitutions appended via a carboxamide linker to the 5-position of t
282 s were assembled with up to six boronic acid-appended viologens (BBVs): 4,4'-o-BBV, 3,3'-o-BBV, 3,4'-
283 , we present ten principles that clarify and append what these concepts are and are not, explain how
287 -trisubstituted imidazole scaffold which are appended with aliphatic linkers that enable coupling to
288 free and target-bound states of LUMP fusions appended with capture sequences of up to 20 kDa are used
290 These spatial data, accrued over time and appended with detailed cohort information, will offer an
291 a strain promoted click reaction between DNA appended with dibenzylcyclooctyne and azide-functionaliz
292 bacterium uses diverse GH5 catalytic domains appended with different CBMs, including novel forms of C
293 ed of a branched oligopeptide tree structure appended with glycosidic groups at its multiple N-termin
296 kel complexes supported by terphenyl ligands appended with phenoxy and imine donors were synthesized.
299 in biocompatible systems, tridecafullerenes appended with up to 360 1,2-mannobiosides have been synt
300 mplementary monomer comprising a BB(4+) ring appended with viologen (V(2+)) and 1,5-dioxynaphthalene