ライフサイエンスコーパス: appetitive

1 a particular type of procedure (aversive or appetitive).

2 d link distinct memory systems (aversive and appetitive).

3 Appetitive aggression and relapse to aggression seeking

4 the behavioral procedures developed to probe appetitive aggression in mouse models, spanning from Pav

5 One form, appetitive aggression, exhibits symptomatology that mimi

6 rsal midline thalamus, in the arbitration of appetitive and aversive behavior during motivational con

7 rior PVT alone, disrupts arbitration between appetitive and aversive behaviors when they are in confl

8 area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays

9 r such training, the CS controls conflicting appetitive and aversive behaviors.

10 To address this question, we trained rats on appetitive and aversive conditioning in different contex

11 elease conveys a learning signal during both appetitive and aversive conditions.

12 ts indicate that after a mix experience with appetitive and aversive consequences, parallel memories

13 idance but suppress inappropriate actions in appetitive and aversive contexts.

14 ay be necessary for memory retention in both appetitive and aversive domains.

15 We use the optoPAD to induce appetitive and aversive effects on feeding by activating

16 ical for amygdala-dependent learning of both appetitive and aversive emotional memories.

17 opamine is thought to regulate learning from appetitive and aversive events.

18 This effect on appetitive and aversive goal-directed behaviour is likel

19 allel memories are established in a way that appetitive and aversive information is stored to be retr

20 arn about and integrate different sources of appetitive and aversive information.

21 al substantia nigra (SNL) that contribute to appetitive and aversive learning in mice.

22 rabs, taking advantage of two well-described appetitive and aversive learning paradigms and combining

23 ation of this US ensemble can also reinforce appetitive and aversive learning when paired with differ

24 t learning task, which simultaneously probes appetitive and aversive learning.

25 We discuss how such an interplay between appetitive and aversive memories might be implemented in

26 We found that crabs build separate appetitive and aversive memories that compete during ret

27 s, M4/6 output is required for expression of appetitive and aversive memory performance.

28 Moreover, appetitive and aversive olfactory conditioning bidirecti

29 e patterns coding for the predicted value of appetitive and aversive outcomes are similar, indicating

30 Amisulpride reduced both appetitive and aversive PEs, while memantine diminished

31 the phasic DA increases and decreases during appetitive and aversive PEs.

32 nin, neuromodulators traditionally linked to appetitive and aversive processes, are also involved in

33 s often depend upon the relative strength of appetitive and aversive sensory stimuli, the relative se

34 ural circuits mediating the effects of OT in appetitive and aversive social contexts.

35 evidence that oxytocin plays a role in both appetitive and aversive social learning.

36 l have been implicated in promoting opposing appetitive and aversive states, respectively.

37 CeA->SNL neural responses to appetitive and aversive stimuli were modulated by expect

38 ior in response to optogenetically delivered appetitive and aversive stimuli.

39 ructure linked to emotion, predict impending appetitive and aversive stimuli.

40 s in the cortex, expose the innate nature of appetitive and aversive taste responses, and illustrate

41 Our work reveals independent processing of appetitive and aversive tastes, suggesting that flies an

42 form a sensory discrimination task involving appetitive and aversive visual cues.

43 s in the behavioral adaptations seen in both appetitive and aversive-cue-mediated responding, but the

44 ioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contri

45 ns before food availability promotes intense appetitive and consummatory behaviors that persist for t

46 H) is a neuroanatomical region essential for appetitive and consummatory behaviors, but whether indiv

47 rgic (Vgat-expressing) neurons enhances both appetitive and consummatory behaviors, whereas genetic a

48 echanistic congruence and divergence between appetitive and consummatory phases of aggression.

49 vity in TH-immunoreactive (TH-ir) neurons to appetitive and consummatory sexual and aggressive behavi

50 ed TH-Fos colocalization in association with appetitive and consummatory sexual behavior expression,

51 vidence for catecholaminergic involvement in appetitive and consummatory sexual behaviors and consumm

52 neurons in the LH have been shown to mediate appetitive and feeding-related behaviors.

53 ic and cognitive information to control both appetitive and ingestive behavior.

54 ptin receptor (LepRb) signaling also reduces appetitive and motivational aspects of feeding, and that

55 the lateral hypothalamus (LH) in regulating appetitive and reward-related behaviors has been evident

56 e drugs, aggression can be highly rewarding (appetitive) and continually pursued despite short- and l

57 erest for their roles in motor coordination, appetitive, and aversive behavior, as well as neuropsych

58 ior cingulate cortex (sgACC, area 25) blunts appetitive anticipatory, but not consummatory, arousal,

59 ecifically on neuronal ensembles that encode appetitive associations.

60 sequentially to consolidate the learning of appetitive associations.

61 ect of the somatostatin analog octreotide on appetitive behavior among patients after ES.

62 ral hypothalamus (LHA) integrates reward and appetitive behavior and is composed of many overlapping

63 The NAcc mediates appetitive behavior and is critically modulated by dopam

64 ormones are linked to mechanisms that govern appetitive behavior and its suppression.

65 nship through which the central clock drives appetitive behavior and metabolic homeostasis and the pa

66 sed behavior and reveals mechanisms by which appetitive behavior can go awry.

67 ditioned reflexes discussed by Pavlov or the appetitive behavior discussed by Craig; they have only u

68 supports a multitude of functions related to appetitive behavior in humans and animals, and it has be

69 ce of neural systems-level information about appetitive behavior that could be used in responsive neu

70 ormone response is associated with increased appetitive behavior toward a sweet-fat stimulus among pa

71 Performance levels and lipping intensity (an appetitive behavior) both showed that the monkeys' motiv

72 g trait anxiety, contextual fear memory, and appetitive behavior, and is known to be sensitive to str

73 e within a distributed network that controls appetitive behavior, and neuromodulation of the VS has d

74 may be a reinforcer that elicits conditioned appetitive behavior, but its reinforcing properties stro

75 ion can be quite variable between studies of appetitive behavior, even within the same species.

76 es associated with hedonic taste evaluation, appetitive behavior, oromotor coordination, and inhibito

77 Although compelling within the framework of appetitive behavior, the view that illicit drugs hijack

78 A measure of appetitive behavior, this task requires subjects to unde

79 ry effects cannot be explained by changes in appetitive behavior.

80 via MOR, within the CeA promote this form of appetitive behavior.

81 cortex (IL) in the environmental control of appetitive behavior.

82 s capable of supporting distinct theories of appetitive behavior.

83 epresentations of space to promote effective appetitive behavior.

84 Interestingly, appetitive behavioral responses of wild type flies to he

85 Importantly, loss of appetitive behavioral responses to fatty acids in IR25a

86 ts in the amygdala that promote and suppress appetitive behaviors analogous to the direct and indirec

87 inct populations of CeA neurons that mediate appetitive behaviors and dissect the BLA-to-CeA circuit

88 e been studied extensively, CeA circuits for appetitive behaviors and their relationship to threat-re

89 the causal role for CeA circuits underlying appetitive behaviors is poorly understood.

90 on a range of conditioned and unconditioned appetitive behaviors known to depend on mesolimbic DA ac

91 rimary role for these neurons in controlling appetitive behaviors such as foraging that promote the d

92 variety of physiologic functions, including appetitive behaviors, cognitive functions and metabolism

93 rrive in the CeA eliciting both aversive and appetitive behaviors, our understanding of the anatomy o

94 dopamine (DA) is phasically released during appetitive behaviors, though there is substantive disagr

95 Silencing neuronal activity reduces appetitive behaviors, whereas inducible activation resul

96 ) CeA neurons define a pathway for promoting appetitive behaviors, while R-spondin 2(+) BLA pyramidal

97 viors and dissect the BLA-to-CeA circuit for appetitive behaviors.

98 signaling and examined several aversive and appetitive behaviors.

99 mprise a network likely involved in approach/appetitive behaviors.

100 CeA neurons define a pathway for suppressing appetitive behaviors.

101 een proposed to be selectively active during appetitive behaviors.

102 o produce different conditioned defensive or appetitive behaviors.

103 Ac to likely account for CRF facilitation of appetitive behaviors.SIGNIFICANCE STATEMENT Although the

104 iting food-rewarded, but not money-rewarded, appetitive behaviour, suggesting that obesity is associa

105 tivity among these structures contributes to appetitive behaviours, how projection-specific prefronta

106 utritious content of food, guiding essential appetitive behaviours, preventing the ingestion of toxic

107 mygdala is necessary for innate aversive and appetitive behaviours.

108 and aversive PEs, while memantine diminished appetitive, but not aversive PEs.

109 octopamine-OAMB pathways jointly facilitate appetitive, but not aversive, learning.

110 ecific reward, first exhibiting increases in appetitive calls (50 kHz), then exhibiting increases in

111 sa by suggesting disturbances in subcortical appetitive circuits.

112 and used these quantities as two concurrent appetitive components, driving choices.

113 reviously shown to potentiate responding for appetitive conditioned reinforcers (CRfs), also regulate

114 Elevating cAMP to equivalent levels as appetitive conditioning also produced plasticity, sugges

115 for defining the functional neuroanatomy of appetitive conditioning and identify specific brain regi

116 e trace conditioning procedure, but impaired appetitive conditioning at a 2 s trace interval.

117 Olfactory appetitive conditioning enhanced MB odor responses, mimi

118 However, in mice, appetitive conditioning generally requires intensive tra

119 Flies fed after appetitive conditioning needed increased sleep for memor

120 Findings from appetitive conditioning studies have shown that basal am

121 After appetitive conditioning to 1-hexanol, the representation

122 nt protein (GFP) in activated neurons, after appetitive conditioning with sucrose and extinction lear

123 and response-outcome conditioning (a form of appetitive conditioning).

124 Using either of two procedures, aversive or appetitive conditioning, animals were trained to detect

125 block of M4/6 neurons in naive flies mimics appetitive conditioning, being sufficient to convert odo

126 /+ flies perform poorly in both aversive and appetitive conditioning, while individual heterozygous r

127 indicating enhanced conditioned approach and appetitive conditioning.

128 s for each set of MB neurons in aversive and appetitive conditioning.

129 mally associated with competing aversive and appetitive consequences and that interaction between con

130 nals of the amygdala thus appear to modulate appetitive consumption decisions, and may be useful to i

131 avoid a threat but suppress movements in an appetitive context.

132 ubcortical sites that can drive aversive and appetitive CRs.

133 A) regulates conditioned responses evoked by appetitive CS, but less is known about how the BLA contr

134 neurons displayed increased activity during appetitive (CS-R) versus aversive (CS-S) conditioned sti

135 d CR or not, to show that cells activated by appetitive CSs mainly encode behavioural output, not CS

136 6162 on consummatory (binge-like eating) and appetitive (cue-controlled seeking) behavior motivated b

137 itically opposes the motivating influence of appetitive cues.

138 S has demonstrated therapeutic potential for appetitive disorders.

139 dulates striatal dopamine (DA) and regulates appetitive drive and reinforcement learning.

140 in life among individuals who are born with appetitive drive for overconsumption.

141 Appetitive drive is influenced by coordinated interactio

142 ude functionally opposed PFC-->hypothalamus 'appetitive driver' and PFC-->striatum 'appetitive limite

143 ty to obesity was partially mediated by the "appetitive" eating behavior traits (uncontrolled and emo

144 r an essential circuit underlying the highly appetitive effects of sugar.

145 acquire prediction signals in the absence of appetitive experience and update them when the value of

146 inly studied by focusing on pure aversive or appetitive experiences.

147 tic mechanisms beyond fear extinction (e.g., appetitive extinction, hippocampal-dependent learning).

148 thalamus (LH) GABAergic neurons induced both appetitive (food-seeking) and consummatory (eating) beha

149 ecisions about expending physical effort for appetitive foods.

150 n why high intensity sensory experiences are appetitive for some individuals, but not for others, and

151 Conversely, on a cued appetitive go/no-go task, both IL and PL inactivation im

152 comes, including achievement of movement and appetitive goals.

153 avioural cycle reducing the establishment of appetitive habitual engagement.

154 ergy expenditure, macronutrient utilization, appetitive hormones, sleep, and circadian phase during d

155 requirements for Esr1(+) neurons in both the appetitive (investigative) and the consummatory phases o

156 nts controlling aversive learning (heel) vs. appetitive learning (medial tip).

157 sensory information to determine feeding and appetitive learning behaviors.

158 a1R-cAMP pathway processes both aversive and appetitive learning in distinct neural sites of the olfa

159 ns of the D(1) receptor dDA1 in aversive and appetitive learning, and the alpha1 adrenergic-like rece

160 acts with dumb (dDA1 mutant) in aversive and appetitive learning, but it interacts with oamb only in

161 DA1 signals together drive both aversive and appetitive learning, whereas the octopamine-Octbeta1R an

162 Octbeta1R in the projection neurons mediates appetitive learning.

163 uits is oppositely regulated by aversive and appetitive learning.

164 rning, and pairing odor with food results in appetitive learning.

165 the alpha1 adrenergic-like receptor OAMB in appetitive learning.

166 ine and octopamine signaling to aversive and appetitive learning.

167 what extent this interaction is involved in appetitive learning.

168 learning, but it interacts with oamb only in appetitive learning.

169 dopamine signaling in the VLS to facilitate appetitive learning.SIGNIFICANCE STATEMENT Acute stress

170 -like receptor Octbeta1R drives aversive and appetitive learning: Octbeta1R in the mushroom body alph

171 is acutely required during aversive, but not appetitive, learning.

172 amus 'appetitive driver' and PFC-->striatum 'appetitive limiter' projections.

173 partite cross-circuit motif supports spatial appetitive memory and associated NAc assemblies, being i

174 ard inhibition is required for expression of appetitive memory at all times.

175 mposing MVP2 activity promotes inappropriate appetitive memory expression in food-satiated flies.

176 ovide the inhibitory control of satiety over appetitive memory expression.

177 ially activating these neurons also promotes appetitive memory performance in sated flies, indicating

178 te or reduce an aversive memory, or write an appetitive memory, depending on when it is activated rel

179 evidence that the intrinsic excitability of appetitive memory-encoding ensembles is regulated differ

180 a passive (Pavlovian) conditioning task with appetitive (monetary gain) and aversive (monetary loss a

181 in volunteers as they performed a concurrent appetitive (money) and aversive (effort) learning task.

182 eus accumbens (NAc) can cause either intense appetitive motivation (i.e., 'desire') or intense defens

183 ablished roles in aversive reinforcement and appetitive motivation [5, 6].

184 e did not gain more weight or show increased appetitive motivation compared with wild-type mice in a

185 While our understanding of appetitive motivation has benefited immensely from the u

186 In major depressive disorder (MDD) appetitive motivation is impaired, evident in a reduced

187 2R generates a reward deficiency and altered appetitive motivation that induces compulsive eating and

188 Aversive learning and appetitive motivation therefore toggle alternate modes o

189 ine and assessed both energy expenditure and appetitive motivation under conditions of diet-induced o

190 ioral inhibition) and approach (a measure of appetitive motivation) at 7 y.

191 lity of NAc DNQX microinjections to generate appetitive motivation, and similarly reversed ability of

192 ontostriatal neurocircuitry in orchestrating appetitive motivation, we hypothesized that inhibitory t

193 ssociative learning has been well studied in appetitive motivation, where the value of different food

194 risk-taking were not secondary to changes in appetitive motivation.

195 aggressive behaviors, from their monomorphic appetitive/motivational to their dimorphic consummatory

196 Thus, the satiating and appetitive nature of PVH(MC4R)-->LPBN neurons supports t

197 nial magnetic stimulation (TMS) would reduce appetitive neuromodulation in a manner similar to MDD.

198 arisons revealed a TBS-induced inhibition of appetitive neuromodulation, manifest in a diminished sta

199 In final experiment using an appetitive object discrimination task, we showed normal

200 In contrast, novel appetitive odor learning is sensitive to inactivation of

201 int aversive odors in the presence of strong appetitive odors.

202 tificial activation of dNPF neurons inhibits appetitive olfactory learning by modulating the sugar re

203 acetyl with the absence of food, but not for appetitive olfactory learning in response to butanone.

204 allowed us to determine their necessity for appetitive olfactory learning.

205 gar components to form parallel aversive and appetitive olfactory memories, with distinct kinetics, t

206 tectable for the retrieval of an established appetitive olfactory memory.

207 We recently developed a mouse model of appetitive operant aggression and reported that adult ma

208 ic understanding of the circuitry modulating appetitive operant aggression is limited.

209 behaviors by promoting learned responses to appetitive or aversive cues in distinct, intermingled se

210 lifera) associate environmental stimuli with appetitive or aversive experiences, forming preferences

211 d valence is typically determined by whether appetitive or aversive interneuron populations are activ

212 of responses to stimuli that predict salient appetitive or aversive outcomes.

213 e genetically determined to elicit an innate appetitive or aversive response, ensuring that animals c

214 In naive rats, no significant differences in appetitive or aversive taste reactivity (TR) to sucrose

215 nate behavioral responses that can be either appetitive or aversive, depending on an animal's age, pr

216 that preferentially encode aspects of either appetitive or consummatory behaviors, but rarely both.

217 simultaneously prevents generation of either appetitive or defensive motivated behaviors.

218 press local neuronal firing, generate either appetitive or defensive motivation, depending on site an

219 neuronal inhibition is necessary to generate appetitive or defensive motivations, using local optogen

220 e is suppressed by a new association with an appetitive or neutral outcome.

221 ritious and harmful foods, triggering either appetitive or rejective behaviors.

222 taste groups, including sodium, electrolyte, appetitive, or bitter cells.

223 ific conditioned inhibitors for two distinct appetitive outcomes.

224 that stimuli predict the absence of specific appetitive outcomes; however, the neural substrates unde

225 s CS control over behavior by enhancing both appetitive Pavlovian conditioning and instrumental pursu

226 Accordingly, studies using appetitive Pavlovian conditioning confirm that environme

227 omedial prefrontal neurons in mice during an appetitive Pavlovian conditioning task.

228 ressful experience influenced learning in an appetitive pavlovian conditioning task.

229 Next, all rats learned an appetitive Pavlovian discrimination and voltammetric rec

230 n patients and healthy controls completed an appetitive Pavlovian-instrumental transfer procedure.

231 Brain histamine is released during the appetitive phase to provide a high level of arousal in a

232 s in preventing pain were consistent with an appetitive prediction error in both groups.

233 ting pain, modulation was consistent with an appetitive prediction error.

234 ine has a well established role in reporting appetitive prediction errors that are widely considered

235 vanced age, the extent to which aging alters appetitive processes coordinated by the OFC and the amyg

236 ormalize memory formation across the day for appetitive processes.

237 hypoactivation of brain regions involved in appetitive processing, with subjective intensities of cr

238 code within regions involved in sensory and appetitive properties of taste.

239 gesia.SIGNIFICANCE STATEMENT In aversive and appetitive reinforcement learning, learned effects show

240 ange after association of an input odor with appetitive reinforcement.

241 diction that losartan augments learning from appetitive relative to aversive outcomes.

242 rug-associated cues and the consummatory and appetitive responding driven by cocaine, we have develop

243 ssion determination of both consummatory and appetitive responding for reinforcers.

244 t underwent reward conditioning exhibited an appetitive response in an optogenetic place preference t

245 crucial to turn a defensive response into an appetitive response.

246 ic acid, whereas starved flies show a robust appetitive response.

247 ignaling negatively modulates mu-OR-mediated appetitive responses at the level of the AcbSh.

248 muli associated with pain termination elicit appetitive responses like startle attenuation.

249 uctose versus glucose on brain, hormone, and appetitive responses to food cues and food-approach beha

250 Many of the brain regions implicated in appetitive responses to food have also been implicated i

251 rturbation engenders disorganized, impulsive appetitive responses.

252 ective cue values, as expressed in Pavlovian appetitive responses.

253 n to gastrointestinal hormone, glycemic, and appetitive responses.

254 l-weight and obese participants performed an appetitive reversal learning task in which they had to l

255 attenuation of reward prediction signals to appetitive reward in the striatum.

256 of the ventral striatum (VS) and amygdala to appetitive RL, we tested rhesus macaques with VS or amyg

257 These findings reveal a novel appetitive role for LepRb signaling in the mNTS, a brain

258 n outcome-specific conditioned inhibition in appetitive settings.

259 Appetitive short-term memory (STM), which in wild-type (

260 In appetitive situations, rats produce 50 kHz USVs, whereas

261 y from the dH, vH, and NAc of rats during an appetitive spatial task and focused on hippocampal sharp

262 of the hippocampus and VTA as rats performed appetitive spatial tasks and subsequently slept.

263 pulsive action in a high-arousal, high-drive appetitive state, and that PFC-based opioid systems enac

264 e orexin homeostatically control arousal and appetitive states, while neurons in the suprachiasmatic

265 alue correlates perfectly with salience when appetitive stimuli are investigated in isolation.

266 a neurons, MORs also moderate motivation for appetitive stimuli within forebrain circuits that drive

267 imals must be able to recognize aversive and appetitive stimuli within the environment and subsequent

268 drive orienting and approach behavior toward appetitive stimuli, we explored the role of three geneti

269 e attractive male cues compared to nonsocial appetitive stimuli.

270 tarts to drop within a second of exposure to appetitive stimuli.

271 ferentially to auditory cues associated with appetitive sucrose versus aversive quinine, indicating t

272 el role for the clock circuit in stabilizing appetitive sucrose/odor memory across the day.

273 from aversion to attraction by enhancing the appetitive sugar pathway as well as suppressing the aver

274 ompare convergent feedback from aversive and appetitive systems, which enables the computation of int

275 proaches that examine learning mechanisms in appetitive tasks.

276 learning paradigm, wherein consumption of an appetitive tastant (e.g., saccharin) is paired to the ad

277 eurons modulate the threshold of response to appetitive tastants.

278 and assessed their necessity in aversive and appetitive taste learning.

279 IC or NBM during learning or retrieval of an appetitive taste memory on taste preference in male Spra

280 ral studies have established that Drosophila appetitive taste responses towards fatty acids are media

281 significantly attenuated fMRI activation by appetitive tastes in the midbrain and amygdala.

282 e progression of a social encounter from its appetitive through its consummatory phases, in a scalabl

283 IL) versus prelimbic regions of rat mPFC, in appetitive trace and locomotor activity (LMA) procedures

284 in medial prefrontal cortex (mPFC) impaired appetitive trace conditioning at a 2 s trace interval.

285 Aversive and appetitive trace conditioning procedures were used to ex

286 precentral gyrus were negatively related to appetitive traits (P < 0.05).

287 used to associate BOLD contrast values with appetitive traits and laboratory intake from meals for w

288 explore cross-sectional associations between appetitive traits and meal variables.

289 ve traits of infants, and how FRR relates to appetitive traits and obesity development.

290 FinnTwin12 study) to investigate whether two appetitive traits mediate the associations between known

291 rk has examined the relation between FRR and appetitive traits of infants, and how FRR relates to app

292 ween the brain response to the PS and either appetitive traits or intake.

293 Individual differences in appetitive traits present in the first few weeks of life

294 esity may partly exert their effects through appetitive traits reflecting lack of control over eating

295 R) and low satiety responsiveness (SR) are 2 appetitive traits that have been associated longitudinal

296 odium depletion to reversibly manipulate the appetitive value of a hypertonic sodium solution while m

297 , by imaging calcium dynamics in response to appetitive versus aversive events in conditioning paradi

298 e discrimination task with auditory cues for appetitive versus aversive outcomes.

299 ion with particular conditions, notably with appetitive versus aversive stimuli or positive versus ne

300 the study of the mechanisms that control the appetitive versus the consummatory (attack) phases of ag