ライフサイエンスコーパス: approach to

1 We apply machine learning approaches to a comprehensive vascular plant database fo

2 Here, we present a general approach to access solid-state CNT mimic structures via

3 ydride catalysis as a convenient and general approach to access these substructures.

4 highlights the value of multiple measurement approaches to accurately estimate facility-scale methane

5 sformation algorithm to provide an effective approach to achieving 3D sub-diffraction-limit informati

6 disparities research requires a multifaceted approach to address genetic, biological, socioeconomic,

7 al control of myosin isoforms is a promising approach to address metastatic disease, one that may be

8 We developed a new approach to address this challenge, combining long-range

9 We advocate a new global approach to address this conservation gap, which must en

10 Focusing on neuroscience, we discuss approaches to address some of the factors that currently

11 lmonary siRNA delivery and successful recent approaches to advance this field forward.

12 dulating this draining may offer therapeutic approaches to alleviate SAH severity.

13 We propose an approach to allow one to increase the sensitivity of the

14 We used an in vivo local gene delivery approach to alter CaM function by directly injecting ade

15 ad or inhibition of Na/Ca(mito) may be a new approach to ameliorate metabolic dysregulation in heart

16 oach are presented, and an extension of this approach to an instrumented fleet of mobile monitoring v

17 We compare diverse approaches to analyse the effect of MDD and AD on human

18 By using a multicolor flow cytometry approach to analyze and characterize differential cell s

19 Furthermore, we have used different approaches to analyze the differences between the parent

20 nce of breast MRI compared with more complex approaches to apparent diffusion coefficient measurement

21 hism (SNP) markers generated using the 2bRAD approach to assess fine-scale genetic structure across t

22 x population models, we used a retrospective approach to assess the contributions of age-structure an

23 t G-CSFR blockade as a promising therapeutic approach to attenuate renal IRI.

24 ty of using this deletion in the L-IGR as an approach to attenuate TCRV, and potentially other mammar

25 infection in various organisms and highlight approaches to better understand QS during human infectio

26 e the human brain, and the potential of such approaches to better understand the genetic basis of hum

27 srupting K-Ras PM interaction is a tractable approach to block oncogenic K-Ras activity.

28 Here, we used this approach to build a set of 10 versatile yeast-based repo

29 study, we integrate a number of experimental approaches to build a model that provides insights into

30 as liposomes, is one of the major bottom-up approaches to building minimal cells.

31 Antiangiogenesis is a promising approach to cancer therapy but is limited by the lack of

32 This study describes a metal-free approach to catalyzing the reduction of O(2) into H(2)O(

33 s limited evidence on scalable and effective approaches to change dietary intake, given the large pro

34 This new approach to charting thylakoid topology lays the foundat

35 soform-selective HDAC inhibition is a viable approach to circumvent off-target effects.

36 etic therapy and immunotherapy an attractive approach to circumvent the limitations of immunotherapy

37 xamine intergroup mixing by applying a novel approach to classify the active and non-active researche

38 With a tailored architecture and an ensemble approach to CNN parameter interpretation, we show that o

39 irected immunotherapy, providing a promising approach to combinatorial immunotherapy for cancer.

40 This systematic review used the GRADE approach to compile evidence to inform the European Acad

41 Current state-of-the-art approaches to computational protein design (CPD) aim to

42 omplexity of capsids and would provide a new approach to construct highly sophisticated supramolecula

43 ling of olefins and amines would be an ideal approach to construct these motifs.

44 ndividual electronic environment is a viable approach to control phase-transfer ability and enantiose

45 or DMEK surgery may therefore be a promising approach to counteract global donor shortage.

46 y, we have previously employed computational approaches to deduce global dynamics of thin filament co

47 We consequently present an approach to define gene interaction networks underlying

48 omains, thus highlighting the ability of our approach to deliver insights into chromatin organization

49 tes (ADCs) developed as a targeted treatment approach to deliver toxins directly to cancer cells are

50 , we apply a high-resolution, pressure-based approach to describe how two fishes, bluegill sunfish (L

51 t (DEB) theory offers a mechanistic modeling approach to describe the entire life history of a single

52 rovide an initial example of a computational approach to design bicyclic peptides to target specific

53 The current approach to designing drug combinations includes in vitr

54 the heterostructure, thereby providing a new approach to designing oxide heterostructures for novel i

55 The principles of image-based approaches to detecting oral cancer are placed within th

56 This study describes a new approach to determine individual particle acidity and is

57 Here, we used quantitative kinetic approaches to determine the transient kinetics of recogn

58 to describe an innovative multidisciplinary approach to develop an efficient, inexpensive, and easy-

59 clinical presentations and used a 3-pronged approach to develop management recommendations based on

60 In this study, we used computational approaches to develop a structural model of SERCA-PLB in

61 e 2019 (COVID-19) requires an evidence-based approach to developing and deploying comprehensive clini

62 physiology of airway inflammation, different approaches to diagnose and target epithelial barrier def

63 earchers to consider sex and gender in their approach to diagnosis, prevention, and treatment of dise

64 However, existing machine learning approaches to diagnosis are purely associative, identify

65 provide recommendations on how to adapt the approach to different model systems.

66 dopsis Here, we employed a CRISPR/Cas9-based approach to disrupt a subset of cytokinin histidine kina

67 mediates CD95 signaling, we applied genetic approaches to dissect the roles of caspase-8 in cell dea

68 Overall, this systematic approach to drug repurposing lays the groundwork to stre

69 roviding an efficient and broadly applicable approach to early fragment development.

70 te pH, and it used experimental and modeling approaches to elucidate such impacts in flow-electrode c

71 ecimens directly from pigs thus providing an approach to emerging pathogen detection that appeals to

72 Importantly, this work demonstrates a facile approach to employ two-dimensional aromatic compounds as

73 the interaction between LMA and electrolyte, approaches to enable operation of LMA in practical condi

74 f of concept for the repurposing of existing approaches to enable rapidly scalable epidemiologic data

75 ugh their phenolic moiety represents a novel approach to enediyne ADC creation, while the pharmacolog

76 Moreover, a general approach to engender endogenous patient-specific cellula

77 Drug repurposing signifies an appealing approach to enhance the activity of current antifungal d

78 Regenerative medicine approaches to enhancing beta cell growth and survival re

79 This novel approach to EPR spectral analysis provides insight into

80 We apply the approach to Escherichia coli by successively adapting it

81 iscern, calling for additional complementary approaches to establish functionality.

82 esults suggest the feasibility of using this approach to estimate E/E (m).Supplemental material is av

83 c and dynamic global warming potential (GWP) approaches to estimate the global warming impacts from m

84 nt, and transcriptome-wide association study approaches to evaluate whether genome-wide association s

85 s highlighted potential problems with common approaches to evaluating and interpreting bifactor model

86 We then describe more valid approaches to evaluating bifactor models and highlight 3

87 We applied this approach to examine how a fungal pathogen affected the a

88 nority variants, and support the use of this approach to examine the impacts of minority HIV variants

89 A powerful approach to examine the personalized biology of liver ca

90 Here we describe an active learning approach to explore a combinatorial space of ~4,000,000

91 the present study, we used a RiboTag/RNA-Seq approach to explore the timing of maternal mRNA translat

92 delivery, from internal genetic engineering approaches to external encapsulation and modification, a

93 we developed a supramolecular-synthon-driven approach to fabricate Borromean linked organic polymer.

94 A novel benchtop approach to fabricate xurography-enabled thermally trans

95 dance, highlighting the applicability of our approach to facilitate image-based pooled CRISPR screens

96 e versatility of the enzyme, providing a new approach to facilitate novel applications.

97 rial variational autoencoder), a data-driven approach to fulfill the task of dimensionality reduction

98 n centromeres in the RH pools suggests a new approach to functional dissection of these chromosomal e

99 Here, we applied a systems biology approach to gain deeper insights into the PCSK6 role in

100 c atypical forms of diabetes is an important approach to gaining insight and suggest that an insulin

101 oximity-enabled reactive therapeutics (PERx) approach to generate covalent protein drugs.

102 used natural product and synthetic chemistry approaches to generate libraries of compounds, with some

103 , we have applied different machine learning approaches to generate models for predicting different c

104 We here apply comparative genomic approaches to generate the first genome-wide estimates o

105 his paper, we derived and compared different approaches to generating predictive polygenic risk score

106 Approaches to genetically engineer high HbF include de n

107 e, inexpensive, and environmentally friendly approach to graphene ink that is suitable for screen pri

108 age patient." This personalized or precision approach to health care involves correctly diagnosing an

109 COVID-19 has exposed the limits of this approach to health.

110 s, the latter permitting a radiation chimera approach to help identify the CCL17 responding cell type

111 iew ongoing challenges and discuss potential approaches to help advance the promotion of women in the

112 This work demonstrates a powerful new approach to hit-finding.

113 -blood ratios provides a clinically feasible approach to human imaging.

114 Here, we use a combinatorial screening approach to identify a bis-benzodioxolylindolinone (azof

115 Objective: To develop an approach to identify additional AF-related genes by inte

116 We therefore designed a systematic approach to identify amino acid residues crucial for the

117 ty selection as an alternative computational approach to identify an optimal signature for short-term

118 sociation studies (GWAS) provide an unbiased approach to identify loci influencing serum uric acid.

119 We further employed a machine learning approach to identify novel associations.

120 We describe a genome-wide approach to identify potential candidates for such inter

121 hromatin accessibility mapping is a powerful approach to identify potential regulatory elements.

122 Here, we developed a machine-learning approach to identify small molecules that broadly correc

123 beta(6)-BP PET/CT is a promising noninvasive approach to identify the presence and potentially monito

124 tructural biology with high-throughput iCLIP approaches to identify a regulatory mechanism for U2AF2

125 We then applied network and clustering approaches to identify bronchiolitis endotypes.

126 TS can inspire novel functional metagenomics approaches to identify natural biocatalysts for novel ch

127 ur findings underscore the value of targeted approaches to identify organisms utilizing key nutrients

128 exercise using expert opinion and consensus approaches to identify the species that are likely to pr

129 tructure of BaCuAs using a molecular orbital approach to illustrate the structural origins of the two

130 geting agents and constitutes a personalized approach to immunotherapy, particularly in combination w

131 Urine-based hrHPV testing may be a promising approach to improve cervical cancer screening coverage,

132 film in organic solar cells (OSCs) is a key approach to improve device efficiencies.

133 on remains a key goal for crop research; one approach to improve N nutrition is identifying plant-int

134 iciency and provides a prospective technical approach to improve the charge density, which could push

135 the dentate gyrus is a potential adjunctive approach to improve therapeutic efficacy of SSRI antidep

136 -aging and present senolytics as a potential approach to improve transplant outcomes and availability

137 fy people at risk for AKI and to develop new approaches to improve AKI outcomes.

138 dentifying more efficient, targeted recovery approaches to improve athletic performance.

139 A practical and standardized approach to incorporating intravascular imaging with per

140 Therefore, in this paper, we present a new approach to increase the resolving power of a drift time

141 early viral clearance and the development of approaches to induce clearance will be important for can

142 en immunosuppressive drugs and antimicrobial approaches to infection control.

143 composition (DDD), an operator approximation approach to infer a continuous distribution map between

144 study revealed the potential of a structural approach to inform clinical efforts in targeting KRAS-G1

145 induced SHP2 degradation is a very effective approach to inhibit the function of SHP2.

146 w, we use a layer-specific and cell-specific approach to integrate physiological accounts of this mot

147 yet this atom is rarely found in Nature and approaches to integrate fluorometabolites into the bioch

148 Here, we used an alternative approach to interpret the functional significance of non

149 ural time-series modeling is a promising new approach to interrupted time-series studies.

150 Here, we take a multifaceted approach to investigate whether tagging leads to short-t

151 ur findings, we applied systems pharmacology approaches to investigate the crosstalk between AD and p

152 computational, analytical, and experimental approaches to investigate the potential mechanical vulne

153 Applying our approach to knockout mice revealed that Piezo2 different

154 findings motivate an exploration of creative approaches to KT transport as the impact of this pandemi

155 Here, we describe an approach to large-scale nuclear architecture in metazoan

156 One approach to learning action-oriented models is to learn

157 Regularized SIs offer an effective approach to leverage HTP data that is routinely generate

158 eduction in cost of photovoltaic energy, new approaches to limit module temperature increase in natur

159 ining persistent adherence to PrEP and novel approaches to making PrEP services accessible, simplifie

160 obtained in this study potentially open new approaches to malaria diagnosis and surveillance.

161 ing the cornea for therapy presents a unique approach to managing such infections since both direct m

162 study was to understand experiences with and approaches to managing asthma, of which little is known

163 Evaluating for non-pharmacologic approaches to managing symptoms and asthma-related cough

164 We used the integrative approach to map the relative abundance of thousands of p

165 Next-generation sequencing approaches to map RNA-DNA hybrids, a component of R-loop

166 This supports the ability of this biomimetic approach to match the needs of cell-specific targeting,

167 Genome Initiative, we present an integrated approach to materials discovery and qualification to ins

168 Combinatorial approaches to materials discovery offer promising potent

169 t, optimization, and applications of optical approaches to measure the spatial and temporal profiles

170 The current approach to measuring hand hygiene (HH) relies on human

171 ical services to individuals is not a viable approach to meeting the mental health needs of a populat

172 We then compare this approach to methods in the literature.

173 The conventional pharmacological approach to mild asthma has long relied on reliever ther

174 Here, we present a new game theoretical approach to model complex coevolutionary processes and a

175 Machine learning approaches to modeling of epidemiologic data are becomin

176 we applied state-of-the-art systems biology approaches to models of liver regeneration, pharmacologi

177 Here, we present an approach to modulate extruded inks at the point of print

178 quiescence will be key for developing novel approaches to modulate protective and pathological T cel

179 assays (IDAs) offer a unique and innovative approach to molecular sensing.

180 tumour cohort and develop a machine learning approach to molecularly classify and characterize tumour

181 We report a new approach to monitor drug release from nanocarriers via a

182 COVID-19 risk and enable an evidenced-based approach to national social isolation policies.

183 This study provides an unbiased evolutionary approach to non-invasively delineate clonal dynamics and

184 odrugs (HAPs) present a conceptually elegant approach to not only overcome, but better yet, exploit i

185 Model approaches to nuclear architecture have traditionally ig

186 has resisted conventional structural-biology approaches, to obtain atomic models of multiple protein

187 Generalized recommendations about which approach to offer elective AAA patients should not be ba

188 ngs for COVID-19 vaccine development and our approach to optimizing for safety and efficacy.

189 tional and deep learning-assisted analytical approaches to overcome longstanding challenges in natura

190 Here we report a new approach to oxidation catalysts for total oxidation of h

191 by moving away from the 'one-size-fits-all' approach to patient care.

192 al sensory and motor capabilities, analogous approaches to peripheral nerves and peripheral myelin ha

193 The stepwise approach to pharmacological treatment in adult asthma ma

194 Applying synthetic signaling approaches to plants offers the promise of mitigating th

195 What does a formal approach to population health science teach us about COV

196 We developed a preliminary approach to predict 135 adverse events using post-market

197 We used a landmarking approach to predict death within 120 days after treatmen

198 Identifying approaches to preserve mitochondrial function, adipose t

199 ispecific CAR presents a promising treatment approach to prevent antigen escape in CAR-T cell therapy

200 The iBMW will provide an effective approach to prevent, evaluate and intervene in a fast, a

201 ms use a variety of semantic and statistical approaches to prioritize the typically long lists of gen

202 Here, we demonstrate an approach to produce ultrapure H(2) and O(2) from liquid-

203 This reliable approach to producing wafer-scale single-crystal hBN pav

204 ddress this issue, we used a high-throughput approach to profile the alphabeta TCR repertoires of hum

205 itical review and highlight several emerging approaches to promote tumor retention and limit systemic

206 We use a computational approach to propose a proof of concept model showing tha

207 Energy-efficient approaches to propylene/propane separation such as molec

208 Approaches to prostate cancer screening, diagnosis, surv

209 Thus, an effective conservation approach to protect different species is to preserve nat

210 alized this result by developing a numerical approach to PSC that can be applied to any computational

211 this variability using a spatially explicit approach to quantify regional-scale diversity through th

212 on monitoring (MRM)-based targeted proteomic approach to quantify systemically the changes in express

213 ess this problem, we describe a diversity of approaches to quantify intrinsic growth rates of plant p

214 This approach to quantifying reactivation risks will enable e

215 Synthetic chemistry enables a bottom-up approach to quantum information science, where atoms can

216 date statistical randomness as an unexplored approach to realize protein-like behaviour at the single

217 An attractive approach to reduce gene expression is via the use of ant

218 Utilizing a pharmacologic approach to reduce placental adenosine levels, we found

219 ctricity and using electric tugboats are two approaches to reduce pollution damages.

220 e have developed a transient-directing-group approach to reductive Heck hydroarylation of alkenyl ben

221 We evaluate transfer-like and multitask approaches to regularizing the high-dimensional classifi

222 leukin-2 (IL-2) represents a new therapeutic approach to regulate immune homeostasis to promote immun

223 We developed gplas, a new approach to reliably separate plasmid contigs into discr

224 help to identify and test novel therapeutic approaches to restore the impaired epithelial repair mec

225 To establish a stem cell-based approach to restoring TM function and normalizing IOP, h

226 perimental and molecular dynamics simulation approaches to reveal a detailed mechanism.

227 risk groups, necessitating an individualized approach to risk stratification.

228 We propose a sequential approach to sampling from the joint features population

229 An unbiased approach to SARS-CoV-2-induced immune dysregulation has

230 using a deconvolved, confocal line scanning approach to score the distribution of the tsO45 mutant o

231 Here we present iScore, a novel approach to scoring docked conformations that combines H

232 We used this approach to screen for phenotypic targets of the essenti

233 nalysis approaches provide rapid and modular approaches to screen for alterations in CT organization

234 toxicity assays and a variety of biophysical approaches to show that two molecules with tails made of

235 determining the cPRA per titer is a reliable approach to simplify complex antibody data and an ideal

236 ng toward electrical storage is a worthwhile approach to solar energy harvesting.

237 es that are testing the latest immunotherapy approaches to specifically target AML cells (antibodies,

238 f AV using this cap-assisted endoscopy (CAE) approach to standard forward-viewing endoscopy (FVE).

239 We introduce a novel approach to statistically assess the non-linear interact

240 Approaches to stereocontrol that invoke thermodynamic co

241 Diet adherence scores for the Dietary Approaches to Stop Hypertension (DASH) and Alternate Med

242 n (AHA) diet recommendations and the Dietary Approaches to Stop Hypertension (DASH) with the risk of

243 We use this approach to study chromatin architecture at high spatial

244 eus and a novel experimental and theoretical approach to study electrically coupled networks.

245 risk assessment models and presents a novel approach to study sublethal effects of pollutants on fis

246 H MRS study is the first to use a multivoxel approach to study the AWM of BD youth.

247 We also apply this approach to study the causal pathway from smoking to ove

248 y DEHP and emphasize the value of multiomics approaches to study microbiome-host interactions followi

249 eme brings multiple opportunities to rethink approaches to sustaining long-term critical research in

250 Current approaches to synthesize pai-conjugated polymers (CPs) a

251 In summary, we introduce a novel statistical approach to systematically evaluate deleterious DNMs in

252 oyed a genome-wide CRISPR knockout screening approach to systemically identify the genetic factors in

253 A One Health approach to tackle zoonotic cryptosporidiosis looking at

254 nal deletions in mice as well as CRISPR/Cas9 approaches to target CTNND1 in Xenopus, we identified a

255 o define its roles in disease processes, and approaches to target Siglecs for treatment of human dise

256 nd extensively characterized a head-specific approach to TBI in Drosophila, a powerful genetic system

257 We used an immunoassay approach to test samples for the presence of several pro

258 colleagues take on an intensive experimental approach to test whether one potential stressor-limited

259 Population genomics offers innovative approaches to test hypotheses related to the source and

260 We apply our approach to the actin cross-linker alpha-actinin-4 and s

261 tion of pathogenesis and outline a practical approach to the evaluation of patients with suspected au

262 Here an alternative approach to the existing selective reverse INEPT FESTA (

263 As a proof of principle, we applied this approach to the malaria-causing parasite Plasmodium falc

264 multidisciplinary field that requires a team approach to the management of cardiovascular disease dur

265 We suggest that a transdiagnostic approach to the spectrum of frontotemporal lobar degener

266 tical and subcortical regions as a promising approach to the study of neuropsychiatric symptoms such

267 ronment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC(

268 ting of epigenetic modulators offers a novel approach to the treatment of multiple diseases.

269 An efficient synthetic approach to the tricyclic 1,7a-dihydro-1,3a-ethano-inden

270 o the current emphasis on precision medicine approaches to the blockade of pathways involved in aller

271 transform synthetic biology by enabling new approaches to the model-driven design of synthetic gene

272 of awareness and highlight the need for new approaches to the neuroscience of consciousness.

273 a synthesis of how to apply macroecological approaches to the study of ecoimmunology (i.e. macroimmu

274 te block of the channels involved as a novel approach to therapy.

275 As a complementary approach to these classic genetic methods, we describe a

276 to inspire the consideration of lectin-based approaches to thwart infection by present and future vir

277 yperthyroid Conditions, Goiter, Adjuncts and Approaches to Thyroidectomy, Laryngology, Familial Thyro

278 ry domain, we used a genetic sparse labeling approach to track SGNs and found no differences compared

279 Kirigami structures provide a promising approach to transform flat films into 3D complex structu

280 Immunotherapy has emerged as a promising approach to treat cancer, however, its efficacy in highl

281 omising the immune response, providing a new approach to treat diseases associated with endothelial d

282 axonal protective, SARM1 inhibitors a viable approach to treat multiple neurodegenerative disorders.

283 Thus, development of nonantibiotic-based approaches to treat chronic disease is a priority.

284 s to manipulate habenular activity may yield approaches to treat nicotine addiction.

285 We utilized a novel personalized approach to treating APOE4 susceptible mice by administe

286 is emerging as a safe and effective targeted approach to treating many types of cancer.

287 er outcomes and may point to a new metabolic approach to treating some cancers.

288 Non-pharmacological approaches to treatment have proven less effective than

289 We apply this approach to two real data applications to highlight the

290 etastable pores and illustrates a systematic approach to uncover the mechanisms of diverse cellular m

291 recent progress made using systems genetics approaches to uncover novel mechanisms and molecular bas

292 Graph theory approaches to understanding decision-making in single ce

293 n biology and medicine has motivated diverse approaches to understanding their detailed genetic bases

294 that multiomics data analysis is a powerful approach to unravel the functional mechanisms underlying

295 riptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network i

296 sing a process based, integrative, modelling approach to upscale from existing observations, we estim

297 In this study, we propose a simple approach to use network edges as features, based on two

298 This approach to visualizing glomerular filtration function w

299 Here, we introduce a full-field approach to wave imaging based on the concept of the dis

300 can be used for a precision-guided treatment approach to WM.