ライフサイエンスコーパス: apurinic

1 The damaged sites studied include apurinic and apyrimidinic a basic sites, thymine glycol

2 However, apyrimidinic/apurinic (AP) endonuclease-deficient cells (xth nfo stra

3 by adenine DNA glycosylase, MYH, creating an apurinic (AP) site.

4 clease III (Exo III) removes apyrimidinic or apurinic (AP) sites and 3'-phosphate termini in single-s

5 or 4 h, and the levels of stable adducts and apurinic (AP) sites in the DNA were determined.

6 s DNA damage arises frequently, particularly apurinic (AP) sites.

7 uracil-DNA glycosylase to remove uracil, and apurinic/apryimidinic endonuclease to nick the abasic si

8 ificities of two major human SN-BER enzymes, apurinic/aprymidinic endonuclease 1 (APE) and DNA polyme

9 In contrast, DNA glycosylases, apurinic/aprymidinic endonuclease 1 and flap endonucleas

10 e multistep repair process of damaged bases, apurinic-apyrimidic (AP) endonucleases play an essential

11 er proteins from the BER pathway, such as an apurinic-apyrimidinic (AP) endonuclease, as turnover-enh

12 T, the mismatch repair enzyme MUTYH, and the apurinic-apyrimidinic endonuclease APEX2.

13 Aberrant expression of apurinic-apyrimidinic endonuclease-1 (APEX1) has been re

14 onuclease that is related in sequence to the apurinic-apyrimidinic endonucleases that participate in

15 e HSV-1 DNA polymerase (Pol) (UL30) exhibits apurinic/apyrimidinic (AP) and 5'-deoxyribose phosphate

16 For example, it is capable of cleaving apurinic/apyrimidinic (AP) DNA via a beta-elimination re

17 oving damaged or mismatched bases, producing apurinic/apyrimidinic (AP) DNA.

18 Apurinic/apyrimidinic (AP) endonuclease (APE) is a multi

19 The mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) is a mult

20 Human apurinic/apyrimidinic (AP) endonuclease (hAPE) initiates

21 Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is a ce

22 The overexpression of human apurinic/apyrimidinic (AP) endonuclease 1 (APE1/Ref-1),

23 ses TDG and 8-oxoG DNA glycosylase 1 (OGG1), apurinic/apyrimidinic (AP) endonuclease 1, DNA polymeras

24 A base excision repair protein, Apurinic/apyrimidinic (AP) endonuclease 2 (APE2, APN2, o

25 y and is responsible for >/=95% of the total apurinic/apyrimidinic (AP) endonuclease activity in huma

26 Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mamm

27 nstituted with uracil-DNA glycosylase (UDG), apurinic/apyrimidinic (AP) endonuclease and DNA ligase I

28 Ape1 is the major human apurinic/apyrimidinic (AP) endonuclease and initiates re

29 Apurinic/apyrimidinic (AP) endonuclease and polymerase g

30 Apurinic/apyrimidinic (AP) endonuclease Ape1 is a key en

31 HAP1, also known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells.

32 Apn1 is the major apurinic/apyrimidinic (AP) endonuclease in yeast.

33 We have identified and characterised two apurinic/apyrimidinic (AP) endonuclease paralogues in th

34 ammalian adenine-DNA glycosylase activity by apurinic/apyrimidinic (AP) endonuclease using murine hom

35 on during abasic site repair and between the apurinic/apyrimidinic (AP) endonuclease, Ape1, and the 8

36 purified recombinant CSB and the major human apurinic/apyrimidinic (AP) endonuclease, APE1, physicall

37 e, we report overexpression of the S. mutans apurinic/apyrimidinic (AP) endonuclease, Smx, in Escheri

38 Apurinic/apyrimidinic (AP) endonuclease-deficient cells

39 ir activity that was restored by addition of apurinic/apyrimidinic (AP) endonuclease.

40 /lyases (NEIL1, Nei, Fpg, Nth, and NTH1) and apurinic/apyrimidinic (AP) endonucleases (Apn1, APE1, an

41 s/intermediates, organisms are equipped with apurinic/apyrimidinic (AP) endonucleases and 3'-nuclease

42 In Saccharomyces cerevisiae, the apurinic/apyrimidinic (AP) endonucleases Apn1 and Apn2 a

43 organisms, uracil residues are eliminated by apurinic/apyrimidinic (AP) endonucleases in the nucleoti

44 Here we report that the apurinic/apyrimidinic (AP) endonucleases--Escherichia co

45 g a plasmid DNA that carries a site-specific apurinic/apyrimidinic (AP) lesion as template, we have f

46 Duplex DNA containing an apurinic/apyrimidinic (AP) lesion undergoes cleavage sig

47 Drosophila S3 also possesses an apurinic/apyrimidinic (AP) lyase activity in which the e

48 A subset of glycosylases has an associated apurinic/apyrimidinic (AP) lyase activity that further p

49 ntrinsic 5' deoxyribosephosphate (5'dRP) and apurinic/apyrimidinic (AP) lyase activity, and showed th

50 oli Nth, possessing both DNA glycosylase and apurinic/apyrimidinic (AP) lyase activity.

51 ir (BER) pathway, initiated by N-glycosylase apurinic/apyrimidinic (AP) lyase proteins.

52 ndonuclease III (hNth1) is a DNA glycosylase/apurinic/apyrimidinic (AP) lyase that initiates base exc

53 an DNA is initiated by the DNA N-glycosylase/apurinic/apyrimidinic (AP) lyase, human NTH1 (hNTH1), th

54 ase (mOGG1), the two major DNA N-glycosylase/apurinic/apyrimidinic (AP) lyases involved in the repair

55 p are S. cerevisiae N-glycosylase-associated apurinic/apyrimidinic (AP) lyases that recognize a wide

56 o DNA duplexes each containing two synthetic apurinic/apyrimidinic (AP) residues, positioned on oppos

57 rted a G or less frequently an A opposite an apurinic/apyrimidinic (AP) site but was unable to extend

58 Genome-wide mapping of occurrence of Apurinic/apyrimidinic (AP) site damage, binding of BER p

59 donuclease (APE1), an enzyme that cleaves an apurinic/apyrimidinic (AP) site from double stranded DNA

60 A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP en

61 The apurinic/apyrimidinic (AP) site is a common lesion of DN

62 An apurinic/apyrimidinic (AP) site is one of the most abund

63 ically insert a dCMP opposite a DNA template apurinic/apyrimidinic (AP) site or a uracil residue.

64 least two DNA repair lyase active sites for apurinic/apyrimidinic (AP) site processing, one within t

65 e have used a substrate containing a reduced apurinic/apyrimidinic (AP) site resistant to beta-elimin

66 st common DNA lesions arising in cells is an apurinic/apyrimidinic (AP) site resulting from base loss

67 U base created by the deaminase, forming an apurinic/apyrimidinic (AP) site that initiates the DNA r

68 The formation of apurinic/apyrimidinic (AP) site-derived crosslinks, at l

69 er, Iduna facilitates DNA repair by reducing apurinic/apyrimidinic (AP) sites after MNNG exposure and

70 The mammalian AP-endonuclease (APE1) repairs apurinic/apyrimidinic (AP) sites and strand breaks with

71 m deoxyribose, resulting in the formation of apurinic/apyrimidinic (AP) sites and strand breaks.

72 Apurinic/apyrimidinic (AP) sites are alkali labile lesio

73 Apurinic/apyrimidinic (AP) sites are common DNA lesions

74 Apurinic/apyrimidinic (AP) sites are common mutagenic an

75 Apurinic/apyrimidinic (AP) sites are constantly formed i

76 Apurinic/apyrimidinic (AP) sites are continuously genera

77 Non-coding apurinic/apyrimidinic (AP) sites are generated at high f

78 Apurinic/apyrimidinic (AP) sites are ubiquitous DNA lesi

79 ouble-stranded DNA treated with PAP contains apurinic/apyrimidinic (AP) sites due to the removal of a

80 In growing cells, apurinic/apyrimidinic (AP) sites generated spontaneously

81 rimidinic endonuclease 1 (APE1) to cleave at apurinic/apyrimidinic (AP) sites in a collection of tand

82 Non-coding apurinic/apyrimidinic (AP) sites in DNA are continually

83 in with a major role in initiating repair of apurinic/apyrimidinic (AP) sites in DNA by catalyzing hy

84 Mammalian cells repair apurinic/apyrimidinic (AP) sites in DNA by two distinct

85 Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneous

86 unctional human Ape1 protein is to incise at apurinic/apyrimidinic (AP) sites in DNA via site-specifi

87 s for removal of endogenous base lesions and apurinic/apyrimidinic (AP) sites in DNA.

88 thod to detect traces of aldehyde-containing apurinic/apyrimidinic (AP) sites in nucleic acids has be

89 hality of the PARP inhibitor is dependent on apurinic/apyrimidinic (AP) sites in the DNA and the pres

90 on product, deoxyinosine, and the numbers of apurinic/apyrimidinic (AP) sites were identical in DNA i

91 otide damage, including base loss (abasic or apurinic/apyrimidinic (AP) sites).

92 Apurinic/apyrimidinic (AP) sites, or abasic sites, which

93 Apurinic/apyrimidinic (AP) sites, the most frequently fo

94 uct of ROS damage to DNA is the formation of apurinic/apyrimidinic (AP) sites, which without removal

95 in the base excision repair of premutagenic apurinic/apyrimidinic (AP) sites.

96 endonuclease IV (endo IV), which recognizes apurinic/apyrimidinic (AP) sites.

97 he major and minor grooves of DNA containing apurinic/apyrimidinic (AP) sites.

98 DNA such as phosphoglycolates and abasic or apurinic/apyrimidinic (AP) sites.

99 damage they produce [e.g., 8-oxo-guanine and apurinic/apyrimidinic (AP) sites] have been linked to th

100 toxic double strand breaks (DSB) and abasic (apurinic/apyrimidinic (AP)) sites in DNA.

101 Abasic [apurinic/apyrimidinic (AP)] sites are common, noncoding

102 We investigated whether apurinic/apyrimidinic (AP/abasic) sites were more freque

103 that Ape1, an enzyme required for processing apurinic/apyrimidinic (known as abasic) sites, is also i

104 nical fold, such as a G4, to be displayed to apurinic/apyrimidinic 1 (APE1) and stalling on the fold

105 of the HSV-1 DNA polymerase (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase

106 polymerase catalytic subunit (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase

107 ROCKI interacted with APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1) to form a

108 Apurinic/apyrimidinic endonuclease (AP endo) is a key en

109 Apurinic/apyrimidinic endonuclease (AP endo) is a key en

110 The endonucleolytic activity of human apurinic/apyrimidinic endonuclease (AP endo) is a major

111 Apurinic/apyrimidinic endonuclease (AP endo) is believed

112 Apurinic/apyrimidinic endonuclease (APE) efficiently nic

113 A identified 12 property-based motifs in the apurinic/apyrimidinic endonuclease (APE) family of DNA-r

114 NG; the resulting abasic sites are nicked by apurinic/apyrimidinic endonuclease (APE).

115 ated by uracil DNA glycosylases-2 (UNG2) and apurinic/apyrimidinic endonuclease (APE).

116 We showed that human apurinic/apyrimidinic endonuclease (APE-1) has exonuclea

117 lanoma cell lines accumulated high levels of apurinic/apyrimidinic endonuclease (APE-1/Ref-1, redox e

118 Surprisingly, this enzyme was found to be apurinic/apyrimidinic endonuclease (APE1) (), a well cha

119 Human apurinic/apyrimidinic endonuclease (APE1) is an essentia

120 It is known that apurinic/apyrimidinic endonuclease (APE1) plays a crucia

121 Human DNA apurinic/apyrimidinic endonuclease (APE1) plays a key ro

122 Human apurinic/apyrimidinic endonuclease (Ape1) plays an impor

123 hMYH is associated in vivo with apurinic/apyrimidinic endonuclease (APE1), proliferating

124 aired by 8-oxoguanine glycosylase (OGG1) and apurinic/apyrimidinic endonuclease (APE1), respectively.

125 man heat shock protein 70 (HSP70) with human apurinic/apyrimidinic endonuclease (HAP1) was demonstrat

126 hMYH and apurinic/apyrimidinic endonuclease (hAPE1) co-migrate wi

127 d DNA repair enzyme, Redox effector factor-1/apurinic/apyrimidinic endonuclease (Ref-1/Ape), facilita

128 e PQS, adopting a G-quadruplex fold in which apurinic/apyrimidinic endonuclease 1 (APE1) binds, but i

129 The apurinic/apyrimidinic endonuclease 1 (APE1) functions ar

130 Although it is presumed that the apurinic/apyrimidinic endonuclease 1 (APE1) generates DN

131 For both processes, a central role for apurinic/apyrimidinic endonuclease 1 (APE1) has been dem

132 Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifu

133 Apurinic/apyrimidinic endonuclease 1 (APE1) is an essent

134 Human apurinic/apyrimidinic endonuclease 1 (APE1) is an import

135 Apurinic/apyrimidinic endonuclease 1 (APE1) is the main

136 Apurinic/apyrimidinic endonuclease 1 (APE1) plays a cent

137 We have also found that apurinic/apyrimidinic endonuclease 1 (APE1) stimulates l

138 This presents AP to apurinic/apyrimidinic endonuclease 1 (APE1) that poorly

139 bstrates, we determined the ability of human apurinic/apyrimidinic endonuclease 1 (APE1) to cleave at

140 We found that the nuclear apurinic/apyrimidinic endonuclease 1 (APE1), a core enzy

141 Apurinic/apyrimidinic endonuclease 1 (APE1), a member of

142 athway (LP-BER), including DNA glycosylases, apurinic/apyrimidinic endonuclease 1 (APE1), DNA polymer

143 The essential base excision repair protein, apurinic/apyrimidinic endonuclease 1 (APE1), plays an im

144 xes formed by DNA polymerase beta (Polbeta), apurinic/apyrimidinic endonuclease 1 (APE1), poly(ADP-ri

145 ehyde-3-phosphate dehydrogenase (GAPDH) with apurinic/apyrimidinic endonuclease 1 (Ape1), the major o

146 our canonical undamaged bases and stimulated apurinic/apyrimidinic endonuclease 1 (APE1)-mediated DNA

147 residue by uracil DNA glycosylase (UDG) and apurinic/apyrimidinic endonuclease 1 (APE1).

148 ase in mammalian base excision repair (BER), apurinic/apyrimidinic endonuclease 1 (APE1).

149 of the essential base-excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1)/redox effect

150 A glycosylases and the downstream processing apurinic/apyrimidinic endonuclease 1 (APE1)] can be test

151 ased expression of critical DNA repair genes apurinic/apyrimidinic endonuclease 1 (Apex1) and DNA pol

152 Apurinic/apyrimidinic endonuclease 1 (APEX1) participate

153 her proteins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA proces

154 Recent findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism.

155 molecular mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes

156 ves N-glycosidic bonds on RNA and that human apurinic/apyrimidinic endonuclease 1 incises RNA abasic

157 Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enz

158 We also show that endonuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the

159 We also show that apurinic/apyrimidinic endonuclease 1 participates in RNA

160 BER intermediate, the DNA is channeled from apurinic/apyrimidinic endonuclease 1 to DNA polymerase b

161 the characterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other

162 Apurinic/apyrimidinic endonuclease 1, a key enzyme in re

163 red to the reactive geometry observed in the apurinic/apyrimidinic endonuclease 1, explaining the dep

164 nds with selected DNA glycosylases and human apurinic/apyrimidinic endonuclease 1.

165 The apurinic/apyrimidinic endonuclease 1/redox effector fact

166 nes potentiate radiotherapy, we investigated apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE

167 ficient for the base excision repair enzyme, apurinic/apyrimidinic endonuclease 2 (APE2) protein deve

168 The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participa

169 ncodes APE2, a nuclease related to APE1, the apurinic/apyrimidinic endonuclease acting in base excisi

170 e IV family of DNA repair enzymes, including apurinic/apyrimidinic endonuclease activity and repair a

171 correlated with an increase in mitochondrial apurinic/apyrimidinic endonuclease activity in both H2O2

172 p53 did not influence mitochondrial apurinic/apyrimidinic endonuclease activity measured by

173 cised abasic residues, which result from the apurinic/apyrimidinic endonuclease activity of Ape1.

174 P excision by a mechanism independent of its apurinic/apyrimidinic endonuclease activity.

175 ion of the transcription regulator FoxD3 and apurinic/apyrimidinic endonuclease and the presence of c

176 The major mammalian apurinic/apyrimidinic endonuclease Ape1 is a multifuncti

177 cruiting the base excision repair-associated apurinic/apyrimidinic endonuclease APE1, independent of

178 tagenic DNA damage is initiated by the major apurinic/apyrimidinic endonuclease Ape1, which specifica

179 thetic abasic site; this site was incised by apurinic/apyrimidinic endonuclease creating a nick with

180 ion repair ung and mutY glycosylase and xthA apurinic/apyrimidinic endonuclease genes in H. pylori, m

181 ation damage and the additional depletion of apurinic/apyrimidinic endonuclease I (APE1) confers hype

182 hosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth musc

183 In addition to its primary activity as an apurinic/apyrimidinic endonuclease in BER, Ape1 also pos

184 Apurinic/apyrimidinic endonuclease is a key enzyme in th

185 Inhibition of apurinic/apyrimidinic endonuclease may therefore be a re

186 onents (two endonuclease III homologs and an apurinic/apyrimidinic endonuclease) that might account f

187 viral uracil DNA glycosylase (UL2), cellular apurinic/apyrimidinic endonuclease, and DNA ligase IIIal

188 enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically,

189 P0/AP3, a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary

190 major base excision repair proteins, such as apurinic/apyrimidinic endonuclease, DNA polymerase beta,

191 ified human enzymes: uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta,

192 specific DNA glycosylase, strand scission by apurinic/apyrimidinic endonuclease, DNA resynthesis and

193 Apurinic/apyrimidinic endonuclease-1 (APE-1) regulates t

194 Human apurinic/apyrimidinic endonuclease-1 (APE-1), a key enzy

195 Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox facto

196 ry, we found that recombinant purified human apurinic/apyrimidinic endonuclease-1 (APE1) and APE1 fro

197 Apurinic/apyrimidinic endonuclease-1 (APE1) is a multifu

198 Apurinic/apyrimidinic endonuclease-1 (APE1) is an essent

199 Apurinic/apyrimidinic endonuclease-1/redox effector fact

200 We recently reported that the expression of apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE

201 ligase III, poly(ADP-ribose) polymerase, and apurinic/apyrimidinic endonuclease.

202 lap endonuclease-1, DNA polymerase beta, and apurinic/apyrimidinic endonuclease.

203 Apurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/

204 The dual-function protein apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/

205 Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/

206 The apurinic/apyrimidinic endonucleases (APE) contain severa

207 onuclease IV belongs to a class of important apurinic/apyrimidinic endonucleases involved in DNA repa

208 G) yields abasic sites, which are excised by apurinic/apyrimidinic endonucleases, eventually generati

209 am intermediates by the specific activity of apurinic/apyrimidinic endonucleases.

210 DNA and stimulated both the glycosylase and apurinic/apyrimidinic lyase activities of OGG1.

211 nctional enzyme that has DNA glycosylase and apurinic/apyrimidinic lyase activities.

212 However, MutY(Dr) exhibits limited apurinic/apyrimidinic lyase activity and can form only w

213 introduces a single strand break through its apurinic/apyrimidinic lyase activity to initiate base ex

214 ucture also suggest a role for Glu161 in the apurinic/apyrimidinic lyase chemistry.

215 Moreover, in vitro assays revealed that apurinic/apyrimidinic nuclease 1 provides nearly maximum

216 Thus, under our assay conditions, apurinic/apyrimidinic nuclease 1-mediated stimulation or

217 Abasic (apurinic/apyrimidinic or AP) sites are a frequent type o

218 The unrepaired apurinic/apyrimidinic site (AP site) in mitochondrial DN

219 g BER, Ape1 recruits pol beta to the incised apurinic/apyrimidinic site and stimulates 5'-dRP excisio

220 esulting abasic site is further processed by apurinic/apyrimidinic site endonuclease 1 (APE1) to crea

221 istry of the T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase (T4-pdg) has been explo

222 kDa protein, T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase.

223 1 but enhances resection by BLM-DNA2, and an apurinic/apyrimidinic site stimulates resection by BLM-D

224 ly six times more tightly toward its product apurinic/apyrimidinic site than the substrate, whereas f

225 droxypropanodeoxyguanosine adduct and (2) an apurinic/apyrimidinic site, and the initiation of repair

226 diester backbone in DNA on the 5' side of an apurinic/apyrimidinic site, was monitored by FCCS using

227 tic mobility of a DNA fragment containing an apurinic/apyrimidinic site.

228 rences of MPG binding affinity toward Hx and apurinic/apyrimidinic sites and thus is essential for th

229 e to generate single-strand breaks (SSBs) at apurinic/apyrimidinic sites do not form DSBs immediately

230 The Ape1 protein initiates the repair of apurinic/apyrimidinic sites during mammalian base excisi

231 repair enzyme that initiates the removal of apurinic/apyrimidinic sites from DNA, excises 3' replica

232 We further demonstrate that most apurinic/apyrimidinic sites in highly transcribed DNA ar

233 Here we show that the accumulation of apurinic/apyrimidinic sites is greatly enhanced in highl

234 ing of MutY with GO mispaired with T, G, and apurinic/apyrimidinic sites may be involved in the regul

235 ely, its ability to be covalently trapped to apurinic/apyrimidinic sites within duplex DNA under redu

236 DNA damage, as determined by the level of apurinic/apyrimidinic sites, also decreased significantl

237 bundance of oxidative DNA adducts, mutagenic apurinic/apyrimidinic sites, and expression of base exci

238 y, all of which fail to seal SSBs induced at apurinic/apyrimidinic sites, exhibit strongly elevated l

239 zyme is product-inhibited by both uracil and apurinic/apyrimidinic sites.

240 not fully prevent processing of 8-oxo-G and apurinic/apyrimidinic sites.

241 n complex with adenine that the abasic site (apurinic/apyrimidinic) lyase activity is alternatively r

242 DNA N-glycosylase/AP (apurinic/apyrimidinic) lyase enzymes of the endonuclease

243 from DNA and then nicks the nascent abasic (apurinic/apyrimidinic) site by beta-elimination.

244 Abasic (apurinic/apyrimidinic) sites are among the most abundant

245 ma) is active in base excision repair of AP (apurinic/apyrimidinic) sites in DNA.

246 Furthermore, mtTGendo has an associated apurinic/apyrimidinic-lyase activity.

247 Abasic (apurinic/apyrimidinic; AP) sites are generated in vivo t

248 n (Ugi)-sensitive uracil-DNA glycosylase, an apurinic/apyrimidiniclyase, and a 3'-phosphodiesterase.

249 at the mitochondrial 8-oxodG DNA glycosylase/apurinic DNA lyase activity is the mitochondrial isoform

250 with 8-oxoguanine (8-oxodG) DNA glycosylase/apurinic DNA lyase activity.

251 racil DNA glycosylase (UDG) and apyrimidinic/apurinic endonuclease (APE) digest G:U mismatches to com

252 C1), poly(ADP-ribose) polymerase (PARP), and apurinic endonuclease (Ape) proteins.

253 n uracil DNA glycosylase (UDG), apyrimidinic/apurinic endonuclease (APE), and DNA polymerase beta (po

254 e determined that the DNA glycosylase hNTH1, apurinic endonuclease (APE), and DNA polymerase beta (Po

255 zinc-containing DNA-repair proteins p53 and apurinic endonuclease (APE).

256 he essential base excision DNA repair enzyme apurinic endonuclease 1 (Ape1) in response to sodium ars

257 the role of a critical histidine residue of apurinic endonuclease 1 (Ape1), a human DNA repair enzym

258 ity and increased mRNA and protein levels of apurinic endonuclease 1 (APE1).

259 and the apurinic endonuclease redox factor 1/apurinic endonuclease 1 (REF1/APE1), in human breast car

260 The multifunctional enzyme apurinic endonuclease 1/redox enhancing factor 1 (Ape1/r

261 BRCA2-deficient cells require the apurinic endonuclease activity and the PCNA-binding doma

262 cate that RECQL4 specifically stimulates the apurinic endonuclease activity of APE1, the DNA strand d

263 s confirmed by digestion of plasmid DNA with apurinic endonuclease IV, followed by primer extension a

264 se (OGG1), the DNA glycosylase NTH1, and the apurinic endonuclease redox factor 1/apurinic endonuclea

265 limiting enzyme of DNA base excision repair, apurinic endonuclease-1 (Ape1), which is also known as r

266 he more "modern" non-LTR lineages possess an apurinic endonuclease-like domain and generally lack sit

267 ity, genetic inactivation of all known yeast apurinic endonucleases does not increase the sensitivity

268 7 bp apart, even in the absence of the major apurinic endonucleases.

269 Exo III's apurinic endonucleolytic activity differentially process

270 The resultant apurinic lesion is subject to error-prone repair, consis

271 ough most non-LTR retrotransposons encode an apurinic-like endonuclease upstream of a common reverse

272 ir enzyme human 8-oxoguanine DNA glycosylase/apurinic lyase (hOGG1) downstream of the mitochondrial t

273 of recombinant 8-oxoguanine DNA glycosylase/apurinic lyase (OGG1) in mtDNA repair, we constructed an

274 removes the faulty base and an apyrimidinic/apurinic lyase activity that introduces a single-strand

275 Glycosylase/apurinic lyase activity was reduced in Rad9(-/-) mouse E

276 stimulates its glycosylase and apyrimidinic/apurinic lyase enzymatic activities.

277 phosphodiester bond 5 ' to a baseless sugar (apurinic or apyrimidinic site).

278 ei enzymes unliganded or bound to an abasic (apurinic or apyrimidinic) site, until now there was no s

279 s that contain 8-oxoG:A, 8-oxoG:cytosine, or apurinic product analog sites.

280 In the apurinic simulations (i.e., when a pyrimidine is opposit

281 erted naturally to two secondary lesions, an apurinic site and an AFB(1)-formamidopyrimidine (AFB(1)-

282 adenine DNA glycosylase, and APE1, the major apurinic site endonuclease; and (b) the prevalence of mi

283 ng important for synthetic oligonucleotides, apurinic site formation in cellular DNA is a common occu

284 he latter are likely to have arisen from the apurinic site generated from the Gua-N7 adduct.

285 diation-induced (6-4) photoproduct and to an apurinic site in DNA.

286 Appearance of the apurinic site in the self-depurinating stem-loop was con

287 The resulting apurinic site is further processed by the other members

288 sidue, leading to DNA strand scission at the apurinic site.

289 usly crystallized bound to DNA containing an apurinic site.

290 If apurinic sites accumulate, they are mutagenic and cytoto

291 tains genetic fidelity through the repair of apurinic sites and regulates transcription through redox

292 es, but not fibroblasts, carried spontaneous apurinic sites and TG sequence lesions more frequent tha

293 Because apurinic sites are subject to error-prone repair, leadin

294 op-mediated depurination leading to flexible apurinic sites may therefore serve some important biolog

295 on found to rival the stimulatory effects of apurinic sites on the DNA scission activity of eukaryoti

296 , whereas other DNA modifications, including apurinic sites, 8-oxoguanine, 8-oxoadenine and cholester

297 nvert 8-oxo-7,8-dihydroguanine (8-oxoGua) to apurinic sites, subsequently measured as DNA breaks usin

298 byproduct of serial elimination reactions at apurinic sites.

299 " genomic damage is endogenous generation of apurinic sites.

300 Three major features distinguished the apurinic structure ( = 0.095) from that of wild-type ( =