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1 les measured to date and are more basic than arginine.
2 ting that protection from colitis requires l-arginine.
3 , augment the ISCs function in response to L-arginine.
4 inverse of FBF reserve to N(G)-monomethyl-L-arginine.
5 cellular programming requires extracellular arginine.
6 from 0.723 and 0.640 to 0.734 and 0.643 for arginine.
7 ecific helix of the vWF A1 domain, via three arginines.
9 ) with moderate certainty; for air stimulus, arginine (2.22; 1.45-2.99), potassium + hydroxyapatite (
10 that PRMT5 catalyzes methylation of YBX1 at arginine 205 (YBX1-R205me2), an event that is critical f
14 ) catalyzes symmetric dimethylation (SDM) of arginine, a posttranslational modification involved in o
21 herefore aimed to develop a method to detect arginine and determine its delta(15)N value (delta(15)N(
22 m sized fluorescent capsules based on poly-L-arginine and dextran sulfate for targeting the kidney vi
23 ation, we converted each of these lysines to arginine and found that replacing two of these residues,
24 ; 10(7) copies per cell)(6,7) and their high arginine and lysine content has led to the hypothesis th
25 terized protein methylation events encompass arginine and lysine N-methylation, and only a few cases
26 chets/d) of either a formula enriched with l-arginine and omega-3 (n-3) fatty and ribonucleic acids (
28 erturbation in metabolic pathways related to arginine and proline metabolism as well as TCA cycle was
29 as low as 50 nM, can covalently transacylate arginine and serine residues in GSTP and cross-link them
30 bind in the open state to positively charged arginines and lysines between the intracellular ends of
33 20 amino acids, three of them-leucine (Leu), arginine (Arg), and serine (Ser)-are encoded by six diff
35 and simultaneously cross-linking to another arginine (Arg45) located across the carbohydrate-binding
36 unds bind galectin-8N by engaging its unique arginine (Arg59) and simultaneously cross-linking to ano
39 tains amlodipine, indapamide and perindopril arginine as active ingredients which might have induced
40 ium Pseudomonas putida KT2440, identifying L-arginine as the main one causing a significant increase
44 rains, except for replacement of lysine with arginine at 378th position of the cryptic epitope of a S
45 tation found, P542R (proline was replaced by arginine at aminoacid 542), affects the location of the
47 upported a critical role for substitution of arginine at position 207 (S207R) in mediating resistance
48 cancer, with small molecule inhibitors of an arginine-binding pocket of WDR5 (the 'WIN' site) showing
49 pathways (eg, branched chain amino acids and arginine biosynthesis) and virulence genes (eg, beta-tox
50 (100 and 300 mg/dL) followed by intravenous arginine bolus before and after 72-h glucose infusion.
51 60% (second clamp step) and by 62% following arginine (both P < 0.005) following 72-h glucose infusio
52 thine side chains were further modified into arginine by an abiotic chemical reaction, improving both
53 ide (NO(-)) is a member of RNS produced from arginine by inducible Nitric Oxide Synthase (iNOS) enzym
54 ed nominally significant increases in plasma arginine, citrulline, and glycine, with decreases in tot
56 eology, we demonstrate that droplets of poly-arginine coassembled with mono/polynucleotides have appr
59 he peak of C. rodentium infection, increased arginine concentration in the colon correlated with down
60 een shown to co-precipitate with the C9orf72 arginine-containing dipeptide repeat proteins (R-DPRs),
61 as five arginines were analyzed, only three arginines could bind simultaneously with major-groove gu
62 ether with its postsynthesis modification to arginine, could have been the earliest basic amino acids
63 nt3a in the Paneth cell niche by exogenous L-arginine couples ISCs function and favours a model in wh
67 s also reduced by citrullination by peptidyl arginine deiminase 4, or digestion by serine proteases.
68 efficacy of arginine deprivation (pegylated arginine deiminase) and chemotherapy (cisplatin), offeri
69 iR-1291 effectively enhanced the efficacy of arginine deprivation (pegylated arginine deiminase) and
72 -1291 was effective to sensitize PC cells to arginine deprivation treatment and chemotherapy through
73 kably, fractional excretions of 6 lysine and arginine-derived glycation free adducts were higher in p
74 4 binding through mutation of the C-terminal arginine did not impact the ability of several high-risk
75 and nonribosomal interfaces with analysis of arginine dihedral angles and structural (suite) classifi
77 75% hemoglobin-SS) were randomized to 1 of 3 arginine doses: (1) 100 mg/kg IV 3 times/day (TID); (2)
78 ncreased at discharge in subjects from all 3 arginine-dosing schemes; greatest increase occurred with
79 t DNA, and why replacement of residue 848 by arginine during RAG domestication led to suppression of
80 in the M(pro)C domain-swapping hinge and an arginine elsewhere forms early during folding, modulates
83 d incorporation of key amino acids including arginine for nucleic acid complexation and cellular upta
84 of DyPs can be tuned to select aspartate or arginine for the rate enhancement of peroxide heterolysi
86 inine-guanine recognition, we found that the arginine fork geometry was more consistent with the expe
88 stence of a recurrent structural motif, the "arginine fork", that codifies arginine readout of cognat
89 he results revealed four distinct classes of arginine forks that we have defined using a rigorous but
90 These findings prompted us to search for arginine forks within experimental protein-RNA structure
91 effect of Arg1 deletion was reduced by an l-arginine-free diet, but rescued by simultaneous deletion
92 l activity for a T3SS effector and show that arginine-GlcNAcylation, once thought to be restricted to
93 investigations show that TNPO1 recognizes an arginine-glycine(-glycine) (RG/RGG)-rich region, whereas
94 matrix (ECM) proteins, and reveal tripeptide Arginine-Glycine-Aspartate (RGD) domains that bind and s
96 Gylated surface decorated with two different arginine-glycine-aspartic acid (RGD) peptides: one is cy
97 S with the high-affinity amino acid sequence arginine-glycine-aspartic acid-phenylalanine-cysteine (R
98 cretory responses from a glucose-potentiated arginine (GPA) test, insulin sensitivity from a hyperins
99 ptide repeat proteins (R-DPRs), poly-glycine arginine (GR) and poly-proline arginine (PR), and are pr
100 applied to existing structures with unusual arginine-guanine recognition, we found that the arginine
103 n of ASS1 protein levels, miR-1291 perturbed arginine homeostasis and preferably sensitized ASS1-abun
106 tatic interaction between positively charged arginine in extracellular loop 2 (K210) and a negatively
108 timulation or intraperitoneal injection of l-arginine in mice with deletion of interleukin (IL)12B, N
109 le of the distal heme residues aspartate and arginine in the heterolysis of peroxide to form the cata
111 n 2 (VSD2) and that each of the three gating arginines in VSD2 reduces the activation threshold.
112 imethylarginine (ADMA) and N(G)-monomethyl-l-arginine, in tumor-bearing mice compared with control mi
113 , respectively, and 4) increased fasting and arginine-induced glucagon levels compared with control s
114 secretion in response to glucose-potentiated arginine-induced insulin secretion (GPAIS) challenge in
115 in the pancreas of mice with cerulean- or L-arginine-induced pancreatitis, and in an oncogenic Kras
117 vironmental) and endogenous (biosynthetic) L-arginine influence biofilm formation by P. putida throug
118 xes have unveiled new details, including (i) arginine interactions with the phosphate backbone and th
120 es virulence gene expression in C. rodentium Arginine is an important modulator of the host immune re
122 sporins such as cefotaxime, either lysine or arginine is sufficient for hydrolysis of ampicillin.
123 ifically after the basic residues lysine and arginine, is the predominant enzyme used for proteome di
124 We showed that TbUnc119 binds to a flagellar arginine kinase TbAK3 in a myristoylation-dependent mann
125 ea moiety constructed from N(omega)-methyl-l-arginine (l-NMA) by the multi-domain metalloenzyme SznF.
126 oxide synthase inhibitor N(G) -monomethyl-l-arginine (l-NMMA, 5 mg kg(-1) bolus & subsequent 50 mug
128 astingly, increasing positive charge through arginine leads to enhanced condensation, speckle enlarge
130 e C9orf72 complex is negatively regulated by arginine, lysine, and histidine, the amino acids that PQ
131 veals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and
132 ) is an inborn error of cationic amino acid (arginine, lysine, ornithine) transport caused by biallel
133 hydrophobicity scheme nor one augmented with arginine/lysine-aromatic cation-pai interactions consist
134 a single active site, where it then uses an arginine/lysine-mediated hydrogen-bonding network to rep
138 rescued by simultaneous deletion of other l-arginine-metabolizing enzymes, such as Arg2 or Nos2, dem
140 nd mechanism of action of Mb on N(G)-Nitro-L-arginine Methyl Ester (L-NAME) and Deoxycorticosterone A
141 xide (NO) synthase inhibitor l-N (G)-nitro-l-arginine methyl ester, while iontophoresis of the NO don
145 uate the effect of type I PRMT inhibition on arginine methylation in normal human peripheral blood mo
149 ts highlight a novel role for PRMT7-mediated arginine methylation of RBP substrates, suggesting a reg
151 T1), a key enzyme that catalyzes the protein arginine methylation process, particularly the isoform e
152 gluconeogenesis, enhancing its activity via arginine methylation, while no effects of PRMT1V1 were o
156 ere, we identify that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Pontin c
166 showed that the Arabidopsis thaliana protein arginine methyltransferase AtPRMT3 regulates pre-rRNA pr
171 es aimed at blocking the activity of protein arginine methyltransferases (PRMTs), which catalyze the
172 found that a small molecule inhibitor of the arginine methyltransferases CARM1 and PRMT6 was able to
175 ride, PP-O, PP-R, pentalsamonin, puractin-A, arginine-monascorubrin, purpurquinone-A, ankaflavin, pur
177 Using this strategy we probed several lethal arginine mutants and found that they retain appreciable
178 maging animal models, we showed that protein arginine N-methyltransferase 6 (PRMT6) regulates aerobic
182 t the beneficial effects of spermidine, or l-arginine, on gut immunity by promoting Treg cell develop
186 supplementation of the media with lysine and arginine or suboptimal temperature appears to delay bloc
188 =6.1x10(-67)), nitric oxide bioavailability (arginine/ornithine + citrulline, +29%; P=2.8x10(-169)),
190 udy, we assessed whether kisspeptin (Kp) and arginine-phenylalanine (RF)-amide related peptide-3 (RFR
192 ids-processing enzymes, a positively charged arginine plays a key role by assisting with transition s
194 poly-glycine arginine (GR) and poly-proline arginine (PR), and are protective in genetic modifier sc
196 catalyze the formation of various methylated arginine products on a wide variety of cellular substrat
197 nalysis revealed up-regulated AA metabolism, arginine/proline metabolism, and branched-chain AA (BCAA
198 his increase in the concentration of colonic arginine promotes virulence gene expression in C. rodent
201 do not readily interact with WT FUS, whereas arginine (R) mutants form mixed condensates with WT FUS.
203 metry, we find that substitution of the FLVR arginine R377A does not cause a significant loss of phos
204 actions unique to the closed complex between arginines R55/R57 of eIF2alpha with mRNA, including the
205 al motif, the "arginine fork", that codifies arginine readout of cognate backbone and guanine nucleob
206 NrfA, and site-directed mutagenesis of this arginine reduced enzymatic activity to <3% of the WT lev
207 th all five intracellular lysines altered to arginines remains deubiquitinated and shows augmented tr
208 through mutation of the conserved C-terminal arginine rendered both HPV16 and HPV18 E7 unable to repr
210 al cap of THIK-1 showed that mutation of the arginine residue at position 92, which is in the linker
215 strom resolution revealed the presence of an arginine residue in the region otherwise occupied by cal
217 ral spectroscopy assays, we identified three arginine residues (Arg-97, Arg-277, and Arg-303) that ar
218 ified with hydroimidazolone modifications of arginine residues and products of their hydrolysis) by b
219 5) catalyzes the symmetric di-methylation of arginine residues in histones H3 and H4, marks that are
225 e measured the contributions of tyrosine and arginine residues to phase separation experimentally thr
229 ronment because of the low expression of the arginine resynthesis enzymes argininosuccinate synthase
231 d in cultured cells expressing either of two arginine-rich dipeptide repeats (R-DPRs), poly(GR) and p
232 ve splicing is pronounced in the serine- and arginine-rich intrinsically disordered domain; these dom
238 h nominally significant increases in NAD(+), arginine, saturated long chain free fatty acids, diacylg
241 e show that in the presence of arginine, the arginine sensor ArgR, identified through this screen, di
242 ent degradation of Cactin, a coiled-coil and arginine-serine-rich domain-containing protein that regu
245 between the incorporated nucleotide and the arginine side chain are broken, but the templating base
246 the methylation status and symmetry of each arginine side chain even in highly repetitive RGG amino
248 ial in the inner leaflet, ordered lysine and arginine side chains in the membrane interfacial regions
249 one MGO-glycation by protecting the reactive arginine sites, as well as by converting already-glycate
250 ism by which METTL2 identifies specific tRNA arginine species for m3C formation as well as the biolog
251 In addition, we show that a methionine-to-arginine substitution at residue 58 impairs Orf6 binding
252 in an SLC30A8 exon, encoding a tryptophan-to-arginine substitution that decreases SLC30A8 function, w
253 nalysis of the LLI sequence with alanine and arginine substitutions showed that its overall hydrophob
255 acute C-peptide and proinsulin responses to arginine that were positively correlated with peak MMTT
257 n which these lysine residues are mutated to arginine, the inhibitory effect of RGFP966 on expansions
259 issue of Blood, Morris et al have shown that arginine therapy can improve mitochondrial function and
262 n domain then rearranges the triply modified arginine to N(delta)-hydroxy-N(omega)-methyl-N(omega)-ni
263 ructure reveals that cGAS uses two conserved arginines to anchor to the nucleosome acidic patch.
264 f nutritional glucose and amino acids (e.g., arginine) to drive the synthesis of critical macromolecu
265 ementation of spermidine, or its precursor l-arginine, to assess the frequency and total numbers of r
271 take of glycation free adducts by lysine and arginine transporter proteins in patients with early GFR
273 rate that mutations in a neuronally enriched arginine tRNA, n-Tr20, increased seizure threshold and a
275 DALRD3 protein in the targeting of distinct arginine tRNAs for m3C modification and suggest a crucia
276 he NTD forms insoluble aggregates through an arginine/tyrosine-rich sequence reminiscent of low-compl
278 rofiling of mutant cells highlighted purine, arginine/urea cycle and glutamate metabolisms as the mos
282 ) concentration of the "social" neuropeptide arginine vasopressin (AVP) is significantly lower in ped
284 sed that a self-assembling lipidized peptide arginine vasopressin (AVP) receptor agonist, that had no
286 sotocin or isotocin, homologues of mammalian arginine vasopressin and oxytocin that are broadly impli
287 al hemorrhage studies, adjunct 1-deamino-8-D-arginine vasopressin showed no benefit in limiting hemat
288 sses of peptidergic neurons in the SCN: AVP (arginine vasopressin) and VIP (vasoactive intestinal pol
289 , but the latter conferred responsiveness to arginine-vasopressin (an inhibitory PKC-dependent respon
290 s RXFP3-mediated inhibition of oxytocin- and arginine-vasopressin-synthesizing paraventricular nucleu
292 neurons express galanin and the nonapeptides arginine-vasotocin or isotocin, homologues of mammalian
295 idine, phenylalanine, lysine, tryptophan and arginine were the monitored AAs in wort and finished bee
297 itrulline (co-product of NO synthesis from L-arginine), which were affected by NOS inhibitors confirm
299 ing in GluA2 subunits replacing glutamine to arginine, with the percent inhibition being lower and IC
300 requires a distinct sequence and spacing of arginines within a specific beta2-beta3 hairpin loop tha