ライフサイエンスコーパス: arousal

1 seline sleep, pre-arousal, arousal, and post-arousal).

2 pontaneous and anesthetic-induced changes in arousal.

3 QCA (in rats) on sleep/wake architecture and arousal.

4 hanisms, such as spontaneous fluctuations of arousal.

5 lated pathological disturbances of sleep and arousal.

6 swallows were overwhelmingly associated with arousal.

7 choice biases was reduced under high phasic arousal.

8 erpins afferent signalling of cardiovascular arousal.

9 y enhanced cognitive processing and cortical arousal.

10 sure, and rumination significantly modulated arousal.

11 C1 neuron ablation had no effect on arousal.

12 is exquisitely sensitive to fluctuations in arousal.

13 contribute predominantly to hypoxia-induced arousal.

14 spiration signal as indicator of sympathetic arousal.

15 o components: genital arousal and subjective arousal.

16 y active in states of low motor activity and arousal.

17 ecreased genital arousal have low subjective arousal.

18 lucidate mechanisms in the vPAG that promote arousal.

19 , the majority of boutons were suppressed by arousal.

20 tical sensory processing strongly depends on arousal.

21 evated child arousal by decreasing their own arousal.

22 lation modestly increased the probability of arousal.

23 o as "fluctuation") increases with decreased arousal.

24 al system, visual responses are modulated by arousal.

25 s, and an independent biosignal of emotional arousal.

26 ing that task-related activity is related to arousal.

27 duals in late hibernation and four days post-arousal.

28 mpathetic activity during negative emotional arousal.

29 ral process of torpor entry, maintenance and arousal.

30 ay a critical role in cognitive function and arousal.

31 out sleep to induce frequent auditory-evoked arousals.

32 asymptomatic) were followed by awakenings or arousals.

33 sion of protein degradation in muscle during arousals.

34 mponent of non-rapid eye-movement sleep (NR) arousals.

35 ts induction of translation during interbout arousals.

36 sleep-wake disturbances (46%), and impaired arousal (37%) had the highest prevalence and were never

37 that are involved in the basic mechanisms of arousal(6), and we therefore hypothesized that it may se

38 Here we propose an arousal-action circuit for sleep-wake control in which w

39 cholamine levels, and rescued stress-induced arousal along with challenge-induced behaviors, which to

40 e imaging methods, two new studies show that arousal already sculpts visual information as it first e

41 n which wakefulness is supported by separate arousal and action neurons, while REM and NREM sleep neu

42 es of a subset of neurons in regulating both arousal and anesthesia.

43 x (RR) is frequently used to assess level of arousal and applied to animal models of a range of neuro

44 behaving male mice increase as a function of arousal and are largest during sustained locomotion peri

45 Behavioral states such as arousal and attention have profound effects on sensory p

46 tes a critical source of neuromodulation for arousal and attention.

47 the contents of consciousness distinct from arousal and awareness of those contents.

48 firing are correlated with global levels of arousal and behavioural flexibility, whilst phasic LC re

49 ons, which are hypoxia activated and produce arousal and blood pressure increases when directly stimu

50 n high frequency gamma power, a correlate of arousal and cognition enhancement, without altering dura

51 mediates relationships between pupil-linked arousal and cognition.

52 ns in gCBF evoke enhanced levels of cortical arousal and cognitive processing, similar to those occur

53 s play a critical role in the maintenance of arousal and contribute to the regulation of multiple hom

54 eneral principle of interplay between phasic arousal and decision-making.

55 human participants to study the link between arousal and endogenous responses in visual cortex.

56 embodies multiple cognitive factors, such as arousal and fatigue, but it is unclear how these factors

57 ymptomatology, including the role of reduced arousal and increased contextual processing during traum

58 In the visual thalamus and cortex, arousal and locomotion are associated with changes in th

59 d four states with different levels of brain arousal and motor activity: locomotion, nonlocomotor mov

60 ental status, loss of consciousness, or poor arousal and responsiveness.

61 neurodegenerative disease-related changes in arousal and sleep.

62 l in women comprises two components: genital arousal and subjective arousal.

63 ich posits an inverse-U relationship between arousal and task performance, suggests that there is a s

64 esthetized macaques and effectively restored arousal and wake-like neural processing.

65 en reward-related brain regions that mediate arousal and wakefulness as well as the effect of opioids

66 al injury and are not associated with sexual arousal and without suicidal intent.

67 glia and, most likely, convey information on arousal and/or stressful stimuli to neuronal circuits th

68 ory stimulation degraded sleep with frequent arousals and increased next-day vigilance lapses versus

69 ly linked to the intense, prolonged cortical arousals and marked tachycardia.

70 C1 neuron stimulation produced robust arousals and similar increases in breathing frequency an

71 in a torpor and during torpor re-entry after arousal) and summer active animals using next generation

72 to drive prolonged sleep (with resistance to arousal) and to promote survival after infection.

73 within the mushroom body (MB) implicated in arousal, and a structure outside the MB implicated in in

74 xual arousal problems have decreased genital arousal, and only some women with decreased genital arou

75 d time windows (baseline sleep, pre-arousal, arousal, and post-arousal).

76 ticipants' task was to rate both valence and arousal, and subsequently to categorize the target perso

77 For the High ED group, physiological arousal, and tactile sensitivity (d') were increased whe

78 itioned threat responses including autonomic arousal, anxiety, and freezing behavior, while thalamic

79 Thereafter, loop gain and measures of arousal, apnea severity and upper airway collapsibility

80 ing with theoretical claims that valence and arousal are building blocks of subjective experience.

81 ective arousal; for others, the two types of arousal are desynchronous.

82 These markers of brain arousal are in line with the established effects of inva

83 r 3-second time windows (baseline sleep, pre-arousal, arousal, and post-arousal).

84 c burst index increased significantly before arousals as compared to baseline and postarousal, irresp

85 vent boundaries, elicit a burst of autonomic arousal, as indexed by pupil dilation.

86 corrugator supercilii muscle, and autonomic arousal, as indexed by skin conductance, while viewing p

87 rious functions such as visceral activities, arousal, attention, and locomotion, but the specific rol

88 ippocampal activity does not reflect general arousal/attention but instead reflects what we term "att

89 their worries and reinterpret their anxious arousal before their tests.

90 eliably induces pupillary and EEG markers of arousal beyond the effects of somatosensory stimulation,

91 that POA Tac1 neurons can potently reinforce arousal both against endogenous and drug-induced unconsc

92 eurons may have dual role for both sleep and arousal/brief wake activation.

93 eurons may have dual role for both sleep and arousal/brief wake control.

94 neurons receive inputs related to autonomic arousal, but distinct subpopulations of those neurons ca

95 tate is controlled by behavioral demands and arousal by asymmetrically modulating the slow response f

96 as high, parents responded to elevated child arousal by decreasing their own arousal.

97 nt-to-moment fluctuations in waking state or arousal can account for much of this variability.

98 Arousal can also be detrimental to health by interruptin

99 Thus, arousal can shape tuning via modulation of indirect chan

100 Our state of arousal can significantly affect our ability to make opt

101 Pupillometry, a noninvasive measure of arousal, complements human functional MRI (fMRI) to dete

102 sleep stages, including brief awakenings and arousals, constitute a challenge to the current homeosta

103 n deficits that emerge most robustly in high arousal contexts.

104 ss the 2 cultures than levels of valence and arousal, contrasting with theoretical claims that valenc

105 ortical and hippocampal LFPs preceding micro-arousals could be part of the regulatory processes in sl

106 e present study support the possibility that arousal-dependent modulation of breathing involves recru

107 ions, but the synaptic mechanisms underlying arousal-dependent modulation of cortical processing are

108 Arousal duration and tachycardia increased in parallel a

109 PBel(CGRP) neurons) are critical for causing arousal during hypercapnia.

110 opment, and the role played by physiological arousal during their interactions.

111 amics and to explain the occurrence of brief arousals during sleep.

112 We assessed the intra-arousal dynamics of spikes and their relationship with t

113 ant to the diagnosis and treatment of sexual arousal dysfunction.

114 d be affected by emotion via the attentional/arousal effect according to the attentional gate model.

115 ns in mediating stress hormone and emotional arousal effects on memory consolidation.

116 C in regulating stress hormone and emotional arousal effects on memory.

117 are associated with changes in fly sleep and arousal, emphasizing the importance of lamination-mediat

118 For some women, genital arousal enhances subjective arousal; for others, the two

119 Whilst good indicators of arousal exist, clear indicators of emotional valence, pa

120 othalamic area (LH) is a vital controller of arousal, feeding, and metabolism [1, 2], which integrate

121 e women, genital arousal enhances subjective arousal; for others, the two types of arousal are desync

122 rtical layer specific effects during induced arousal from general anesthesia.

123 quencies of genes associated with regulating arousal from hibernation (GABARB1), breakdown of fats (c

124 5HT) neurons in the brainstem also prevented arousal from hypercapnia.

125 Cortical arousal from sleep is associated with autonomic activati

126 hing) and differ in their ability to produce arousal from sleep.

127 nced cardiac autonomic activity and cortical arousal from sleep.

128 nline neurofeedback to shift an individual's arousal from the right side of the Yerkes-Dodson curve t

129 of the brain circuitry that generates brief arousals from sleep in response to stimuli, which may in

130 Arousal had similar effects postsynaptically in collicul

131 ual system, locomotion (associated with high arousal) has previously been shown to enhance the sensor

132 , and only some women with decreased genital arousal have low subjective arousal.

133 sleep to wakefulness and produces sustained arousal, higher locomotor activity (LMA), and hypertherm

134 out which neural systems mediate these brief arousals, hindering the development of treatments that r

135 es using approaches avoiding novelty-induced arousal (i.e., gentle handling) suggest that sleep can p

136 forming decisions, our understanding of how arousal impacts these processes remains limited.

137 etween hip joint hypermobility and emotional arousal in domestic dogs, which parallel results found i

138 The neural basis of sexual arousal in humans is associated with sexual orientation

139 Hypercapnia and hypoxia produce arousal in mammals by activating central (pH-sensitive)

140 rainstem parabrachial neurons, which promote arousal in response to elevated blood carbon dioxide lev

141 curately calibrates and establishes level of arousal in rodents.

142 Sexual arousal in women comprises two components: genital arous

143 However, increased arousals in patients with sleep apnea and other disorder

144 4], but which BF cell types mediate cortical arousals in response to hypercarbia or other sensory sti

145 cessing with concurrent indices of autonomic arousal, in a cohort of patients representing all major

146 21% O(2) suppresses CO(2)-evoked locomotory arousal; in the other, CO(2) evokes arousal regardless o

147 oxia, but had a minimal effect on markers of arousal (including AHI), subjective sleepiness, or objec

148 logical marker that tracks states of reduced arousal, including different sleep stages as well as ane

149 A similar pre-arousal increase was observed for the spike index in NR

150 udies in monkeys and support the notion that arousal increases precision of neural activity.

151 ciated with fluctuations in tonic and phasic arousal, indicative of neuromodulators acting on multipl

152 ula positively correlates with physiological arousal induced by visual threats and that low-frequency

153 FC) negatively correlates with physiological arousal induced by visual threats.

154 of BF glutamatergic and cholinergic neurons, arousals induced by stimulation of BF-PV neurons were br

155 By contrast, a putative arousal-induced memory boosting effect was insensitive t

156 Changes in arousal influence cortical sensory representations, but

157 Yet factors that modify the arousal intensity and autonomic activity remain enigmati

158 ts basic role in the circadian regulation of arousal is conserved.

159 dition, the spike index increased during the arousal itself in neocortical channels, and was strongly

160 states of local desynchronization and global arousal jointly optimise sensory processing and performa

161 Furthermore, the arousal level corresponding to optimal visual detection

162 al axonal boutons were robustly modulated by arousal level in a manner that varied across stimulus di

163 However, when the overall arousal level of the dyad was high, parents responded to

164 sic selected on the basis of its valence and arousal levels and for traditional Chinese music.

165 relevant to the task, lead to an increase in arousal levels as reflected by the pupillary response.

166 insights about the mechanisms driving global arousal levels, and it provides new possibilities for re

167 as generally best at a range of intermediate arousal levels, but worst during high arousal with locom

168 EM) sleep is also associated with diminished arousal levels, it is characterized by a desynchronized,

169 ith propofol are prominent states of reduced arousal linked to the occurrence of synchronized oscilla

170 ojections to brainstem regions that regulate arousal (locus ceruleus, CGRP(+) parabrachial neurons).

171 Cardiovascular arousal may facilitate inhibition to mitigate risks of i

172 additional increase in the spike rate during arousals may result from a sleep-wake boundary instabili

173 facilitate CO(2) elevation, and faulty CO(2) arousal mechanisms could, at least in part, contribute t

174 ng and a persistent internal state of social arousal mediated by pCd neurons.

175 relationship between genital and subjective arousal might not be relevant to the diagnosis and treat

176 Our results uncover the existence of an arousal-modulated thalamo-corticothalamic loop that link

177 These results indicate that arousal modulates activity at every stage of the mouse v

178 tinal axons in the optic tract revealed that arousal modulates the firing of some retinal ganglion ce

179 Thalamic arousal network dysfunction may contribute to morbidity

180 Here, we evaluate thalamic arousal network functional connectivity in TLE and exami

181 otransmitter GABA and inhibit octopaminergic arousal neurons.

182 Dysregulated arousal often accompanies neurodevelopmental disorders s

183 citatory input cannot explain the effects of arousal on the broadness of frequency-tuned output.

184 hether feedback serves a more global role in arousal or attention.

185 No other parameter such as arousal or stress could account for the transient and re

186 oms were largely associated with poor sexual arousal, orgasmic dysfunction, sexual distress, and sexu

187 holinergic, noradrenergic, and glutamatergic arousal pathways.

188 xual-identified men's genital and subjective arousal patterns were more bisexual than were those who

189 t bisexual feelings tend to produce bisexual arousal patterns.

190 ion of visual context to affect (valence and arousal) perception.

191 The arousal potential of the C1 neurons is far greater than

192 e shown that not all women who report sexual arousal problems have decreased genital arousal, and onl

193 on of BF-PV neurons increased the latency to arousal produced by exposure to hypercarbia or auditory

194 e wide-ranging inputs and innervate multiple arousal-promoting and motor-control circuits through ext

195 rough the coordinated activation of multiple arousal-promoting circuits.

196 s that tVNS elevates noradrenaline and other arousal-promoting neuromodulatory signaling, and mimics

197 ) has been proposed to stimulate subcortical arousal-promoting nuclei, though previous studies yielde

198 Consistent with the potent arousal-promoting property of the LH(GABA) -> VLPO pathw

199 rons may limit wakefulness by inhibiting the arousal-promoting VTA glutamatergic and/or dopaminergic

200 orrelated with the slow wave component of NR arousals (r = 0.99, p < 0.0001).

201 On a behavioral level, stronger arousal reactions were associated with better attention.

202 We find that RR is an unreliable metric for arousal/recovery of consciousness.

203 comotory arousal; in the other, CO(2) evokes arousal regardless of previous O(2) experience.

204 us add causal support for the involvement of arousal-regulating systems in the state of general anest

205 and function oppositely to regulate multiple arousal-related behaviors including sex, sleep and spont

206 y neglected class of PVT neurons that convey arousal-related information to corticothalamic neurons o

207 Arousal-related modulation also varied with a bouton's p

208 originate from several canonical stress- and arousal-related network nodes.

209 ured pupil dilation, a noninvasive marker of arousal-related norepinephrine (NE) release, while concu

210 er (DAT) has been implicated in a variety of arousal-related processes including the regulation of mo

211 Here, we show that this arousal-related suppression in decision bias acts on bot

212 ic varies along three dimensions (formality, arousal, religiosity), more within societies than across

213 tomically complex brain region implicated in arousal, reproduction, energy balance, and memory proces

214 -conditioned stimuli reinstated the acquired arousal response, as reflected in pupil and EEG alpha-be

215 unclear how sleep influences the associated arousal response.

216 Arousal responses linked to locus coeruleus noradrenergi

217 C1 neurons orchestrate cardiorespiratory and arousal responses to somatic stresses, whereas RTN selec

218 We visually marked sleep stages, arousals, seizures, and epileptic bursts in 36 patients

219 The continuously measured arousal signal from the thermal facial imagery was moder

220 ns located in multiple brain regions mediate arousal, sleep drive, and homeostasis (reviewed in [3, 5

221 established as a key regulator of behavioral arousal, sleep, and wakefulness and has been an area of

222 function are associated with disruptions in arousal, sleep/wake architecture, and cognition.

223 nally, we demonstrate a dissociation between arousal-specific amygdala responding and triggered valen

224 Like upward FRH, downward FRH was gated by arousal state but in the opposite direction: it occurred

225 both connecting and disconnecting their own arousal state from that of the child contingent on conte

226 To understand how arousal state impacts cerebral hemodynamics and neurovas

227 n of distinct visual information channels by arousal state occurs at very early stages of visual proc

228 The arousal state of the brain covaries with the motor state

229 ess to sleep, and from moment to moment, the arousal state of the brain is a powerful internal contex

230 ty that are not easily explained by expected arousal state or physiological artefacts.

231 nals in the cortex are strongly modulated by arousal state, and changes during sleep are substantiall

232 e under constant illumination reflects brain arousal state, and dilates in response to novel informat

233 nd an inability to develop stress-associated arousal state.

234 spatial phase offsets of grid cells predict arousal-state-independent spike rate correlations.

235 d by noradrenergic tone fluctuations between arousal states and emphasize the need to understand the

236 This observation implies that reduced arousal states are not necessarily only defined by synch

237 lcium imaging in awake mouse thalamus across arousal states associated with different pupil sizes.

238 oting monoamine implicated in stress-related arousal states, is synthesized in histidine decarboxylas

239 ternal influences, including attentional and arousal states, motor activity and neuromodulatory input

240 achycardia conserved across wake, sleep, and arousal states.

241 ral stability of more prolonged pupil-linked arousal states.

242 intake (reduced or absent and mistimed), and arousal stimuli (increased and mistimed).

243 Under normal conditions, CO(2) is a potent arousal stimulus.

244 in the control of diverse processes such as arousal, stress, emotional memory and motivation, in mic

245 However, we show that arousal strongly modulates a slow tone-evoked suppressio

246 temporal lobe epilepsy (TLE) on subcortical arousal structures remain incompletely understood.

247 holds that desynchronization reflects global arousal, such as task engagement.

248 rrelated with the magnitude of physiological arousal, suggesting that visual scanning behavior is dir

249 ease in interictal epileptic activity before arousals suggests its participation in sleep disruption.

250 nic optogenetic manipulation of an ascending arousal system bidirectionally tunes cortical broadband

251 hat the constraints imposed by the ascending arousal system constrain low-dimensional modes of inform

252 actor (CRF), that render the locus coeruleus arousal system of females more vulnerable to stress and

253 ole-brain network topology and the ascending arousal system with information processing dynamics, and

254 ves inputs from many nuclei of the ascending arousal system, including the brainstem parabrachial neu

255 re nuanced relationship between pupil-linked arousal systems and cognitive expectations.

256 C1 stimulation strongly stimulates ascending arousal systems and sighs, consistent with their postula

257 The brain's arousal systems are activated during such decisions.

258 in humans, we found that evoked responses of arousal systems during decisions are reported by rapid d

259 or idiosyncratic cognitive processing in how arousal systems respond to new inputs and, via our compl

260 pressin (AVP) gene, exhibit lower behavioral arousal than their heterozygous (Het) littermates in the

261 rformance, suggests that there is a state of arousal that is optimal for behavioral performance in a

262 or broad affective features (e.g., valence, arousal) that they made individuals feel.

263 d be implicated in CO(2) and hypoxia-induced arousal: the retrotrapezoid nucleus (RTN), a CO(2)-respo

264 causes an increase in loop gain (LG) and the arousal threshold (AT) during non-rapid eye movement (NR

265 ted that the hypnotic zolpidem increases the arousal threshold and genioglossus responsiveness in peo

266 nd pneumotachograph to measure OSA severity, arousal threshold and upper airway muscle responsiveness

267 show that zolpidem increases the respiratory arousal threshold by ~15%, an effect size which was insu

268 Arousal threshold increased by 15 +/- 5% with zolpidem t

269 A decreased respiratory arousal threshold is one of the main contributors to obs

270 ineteen people with OSA with low-to-moderate arousal threshold received 10 mg zolpidem or placebo acc

271 However, despite increases in arousal threshold without any change in pharyngeal muscl

272 a drug capable of increasing the respiratory arousal threshold without impairing pharyngeal muscle ac

273 respiratory event duration, a marker for low arousal threshold, predicts mortality in men and women.

274 moreceptive negative feedback loop gain, and arousal threshold.

275 ght, with night sleep associated with higher arousal thresholds compared to day sleep.

276 One such feature may be deficiency of arousal to CO(2).

277 epressant effects, fails to reverse elevated arousal to distal threat contrary to the beneficial effe

278 g cardiovascular and behavioral anticipatory arousal to high-value food reward.

279 Conversely, inactivation enhanced the arousal to high-value reward cues while dampening the ac

280 CB ablation impaired arousal to hypoxia and, to a lesser extent, hypercapnia.

281 Patterns of physiological (genital) arousal to male and female erotic stimuli can provide co

282 cs can co-opt the neural circuits regulating arousal to produce unconsciousness.

283 itivity of the PBel(CGRP) neurons that cause arousal to rising levels of blood CO(2).

284 abrachial neurons in the BF impairs cortical arousals to hypercarbia [4], but which BF cell types med

285 he complex micro-architecture of sleep-stage/arousal transitions arises from intrinsic non-equilibriu

286 sm essential for spontaneous sleep-stage and arousal transitions that lays the bases for a novel, non

287 -architecture of spontaneous sleep-stage and arousal transitions within a novel, non-homeostatic para

288 Arousal typically reduced their visual responses and sel

289 d the role of BF parvalbumin (PV) neurons in arousal using optogenetic techniques in mice.

290 Arousals vary considerably in their frequency, intensity

291 rpersonal discrimination predicted increased arousal via EDA.

292 a explicit signals and subtle reflections of arousal visible in the face.

293 Arousal was modulated on a trial-by-trial basis using fe

294 t for representing affect (e.g., valence and arousal), we propose that the default mode network (DMN)

295 in accord with known circadian variation in arousal, we hypothesised that GS fluctuation would be lo

296 renergic-linked behaviors of sociability and arousal were altered in chronically infected animals, wi

297 ED group, sensitivity (d') and physiological arousal were higher in the control conditions.

298 pupil and EEG markers related to heightened arousal were identified.

299 ypoxia and hypercapnia during sleep produces arousal, which helps restore breathing and normalizes bl

300 ediate arousal levels, but worst during high arousal with locomotion.