ライフサイエンスコーパス: arsenal

1 loping future improvements in our antifungal arsenal.

2 this critical gap in the synthetic chemist's arsenal.

3 found a place in the routine cancer-fighting arsenal.

4 their preeminently elaborate photoreceptive arsenal.

5 g means for enhancing our current antibiotic arsenal.

6 o evade the effects of the oncologist's drug arsenal.

7 m that enhance the immunologist's analytical arsenal.

8 ally telesurgery) a standard tool in the MIS arsenal.

9 istance that has emerged to the current drug arsenal.

10 added to the tobacco prevention and control arsenal.

11 ction of viral therapeutics to its medicinal arsenal.

12 proteins in T. gondii's host cell-modifying arsenal.

13 ical agents have been added to the treatment arsenal.

14 ded a primary weapon in the medical research arsenal.

15 s will decide their place in the therapeutic arsenal.

16 oming an important weapon in our therapeutic arsenal.

17 erved to foster the role of NO in the immune arsenal.

18 ideal application for SBRT in the treatment arsenal.

19 and highly predictive tool in the chemist's arsenal.

20 active oxygen species is a key part of their arsenal.

21 s have become part of the approved treatment arsenal.

22 ailable bond disconnections in the synthetic arsenal.

23 growing threat to the utility of our current arsenal.

24 nisms used to generate such complex chemical arsenals.

25 ding insects include in their antihemostatic arsenal a potent thrombin inhibitor, the flexible and cy

26 as emerged as a promising alternative in the arsenal against cancer by harnessing the power of the im

27 Radionuclide therapy remains a promising arsenal against cancer.

28 pathway is a powerful tool in the host cell arsenal against cytosolic pathogens.

29 new antibacterial drugs is evident, and the arsenal against infectious diseases needs to be improved

30 signaling are essential constituents of the arsenal against MCMV infections, validated the forward g

31 al anti-inflammatory use will strengthen our arsenal against ocular surface disease.

32 allows P. aeruginosa to direct its effector arsenal against the cell types most damaging to its surv

33 l need to improve the tools available in our arsenal against this disease, both in terms of treatment

34 but recent work suggests that this antiviral arsenal also includes the cellular DNA damage response m

35 : specific effectors of the direct antiviral arsenal and host factors that indirectly dampened the ov

36 ause PI-9 can protect CTL from its own fatal arsenal and potentially enhance the vitality of CTL, we

37 The limited therapeutic arsenal and the increase in reports of fungal resistance

38 Hiroshima and the status of today's nuclear arsenals and dangers.

39 e recent literature on the status of nuclear arsenals and the risk of nuclear war.

40 potent virulence factor in the P. aeruginosa arsenal, and also elevated expression of the Type VI (T6

41 ovel strategies for enhancing our antibiotic arsenal are needed.

42 antibodies occupy an increasing niche in the arsenal available to treat cancer.

43 The formation of the cutaneous immune arsenal begins before birth and evolves throughout our l

44 PADS Arsenal can also visualize the dynamic variation informa

45 Although PMNs possess a potent antimicrobial arsenal comprising both oxidative and non-oxidative kill

46 e therapeutic efficacies of our current drug arsenal could be significantly improved with an active d

47 conflict using <1% of the worldwide nuclear arsenal could have adverse consequences for global food

48 quefaciens does not reflect the vast genetic arsenal devoted to the formation of such compounds.

49 ved from the antitubercular chemotherapeutic arsenal due to toxic side effects.

50 are an important component of the molecular arsenal employed by hosts against bacteria.

51 an important component of the antiapoptosis arsenal encoded by the E3 transcription unit of subgroup

52 ivery pathway and provided evidence that its arsenal extends beyond known effector proteins.

53 or each stress and elucidated a new response arsenal for adapting to radical environments.

54 dified Metarhizium spp represent a major new arsenal for combating insect pests and insect-borne dise

55 l arm surgeons with a powerful and versatile arsenal for intraoperative NIR imaging in real time.

56 s (EBMT) are a new addition to the treatment arsenal for obesity.

57 in the expansion of the current antimalarial arsenal for the elimination of this disease.

58 ensive programmes that deliver an integrated arsenal for tuberculosis control might continue to strug

59 s emerged as a novel tool in our therapeutic arsenals for fighting cancer.

60 it is unknown to what extent the diverse Ig arsenal generated by somatic recombination and diversifi

61 This arsenal has been expanded by the recent discovery of the

62 tic resistance and formidable immune evasion arsenal have emphasized the need for more effective anti

63 heterogeneity reflects the parasite invasion arsenal in the field.

64 rrently, clinicians have a limited treatment arsenal in the repair of peri-implant defects.

65 The initial version of PADS Arsenal integrates 18 distinctive categories of defense

66 A component of this arsenal is a set of proteins, termed restriction factors

67 Overall, PADS Arsenal is a state-of-the-art open comprehensive resourc

68 Our current antibacterial arsenal is composed of growth-inhibiting agents that tar

69 infection while ensuring that our antibiotic arsenal is deployed as efficiently as possible.

70 drug development; as a result the antifungal arsenal is exceedingly limited.

71 ainst parasitic nematode infections, but the arsenal is limited and resistance threatens sustained ef

72 population of the world, but the therapeutic arsenal is limited.

73 0 warheads that remain in superpower-nuclear arsenals, many still on hair-trigger alert.

74 DS constitutes a unique tool in the software arsenal now available to evolutionary biologists.

75 The results expand our arsenal of AC inhibitors, thereby facilitating the use o

76 These findings reveal a new arsenal of actionable therapeutic targets to drive clini

77 We anticipate that Perseus's arsenal of algorithms and its intuitive usability will e

78 l also enable bench biologists to perform an arsenal of analysis using cutting-edge methods in a fami

79 nd therefore is an important addition to the arsenal of analytical techniques used in carbohydrate re

80 through the uptake and removal of Li via an arsenal of analytical techniques.

81 ed UGMDR offers an important addition to the arsenal of analytical tools for identifying nonlinear mu

82 t PIN1 inhibitors are still missing from the arsenal of anti-cancer drugs.

83 sm-based rationale to the use of our current arsenal of anti-cancer drugs.

84 fection, bacteria have evolved an impressive arsenal of anti-phage systems.

85 a novel and adaptable method for building an arsenal of antibacterials potentially capable of targeti

86 r decades medicinal chemists replenished the arsenal of antibiotics by semisynthetic and to a lesser

87 sistant bacteria compounded by the depleting arsenal of antibiotics has accelerated efforts toward de

88 Today's arsenal of antibiotics is ineffective against some emerg

89 tuents will be an invaluable addition to the arsenal of anticancer therapeutics.

90 o the emergence of resistance to our limited arsenal of antifungal agents, necessitating the developm

91 Here, we describe our current arsenal of antifungals and elaborate on the resistance m

92 at AMN could be an important addition to our arsenal of antifungals for the treatment of invasive fun

93 be the foundation for the discovery of a new arsenal of antimalarials.

94 Among the host's arsenal of antimicrobial factors, the type 1 interferons

95 Bacteria exploit an arsenal of antimicrobial peptides and proteins to compet

96 module and the drug mechanism to expand the arsenal of antitumor therapy.

97 l pathogens for which we have a very limited arsenal of antiviral agents.

98 us promises to be a valuable addition to the arsenal of approaches for tackling the NMR sampling prob

99 A new arsenal of approaches, including single-molecule fluores

100 eported herein is a new entry in the growing arsenal of arylmethyl ether protecting groups.

101 ET will be a valuable addition to the narrow arsenal of automatic gene prediction tools.

102 Although the arsenal of bacterial effectors and their cellular target

103 Our study explored the potential arsenal of beneficial molecules contained in wine from b

104 s and efflux pumps, along with an increasing arsenal of beta-lactamases.

105 The extensive arsenal of bioactive molecules secreted by mesenchymal s

106 To replenish the clinicians' diminishing arsenal of bioactive molecules, a promising strategy aim

107 Evolution has provided ticks with an arsenal of bioactive saliva molecules that counteract ho

108 At the time of this writing, the arsenal of biophysical methods for such measurements is

109 ave become one of the primary weapons in the arsenal of biophysicists, and have revolutionized the ne

110 tical need to expand our currently available arsenal of broad-spectrum antibiotics.

111 f new potential targets will ensure that the arsenal of cancer therapies continues to expand.

112 reveal a genetic architecture that boasts an arsenal of candidate virulence factors to rival that of

113 t-activated catalysts in conjunction with an arsenal of carbon-radical precursors, an array of triflu

114 Compared with the enormous arsenal of catalysts used to produce organic compounds,

115 In the current arsenal of catalytic dihalogenation technologies, the di

116 are equivalent to portions of the regulatory arsenal of Ci.

117 can be recovered and the availability of an arsenal of classical and emerging methods for manipulati

118 hy has become a major diagnostic tool in the arsenal of clinical cardiology for real-time imaging of

119 d by the experimental methodologies from the arsenal of combinatorial chemistry.

120 taphylococcus aureus possesses an impressive arsenal of complement evasion proteins that help the bac

121 t AR signaling and resistance to the current arsenal of conventional and next generation AR-directed

122 These novel nanoparticles may extend the arsenal of currently available nanoparticle MR contrast

123 oster cancer development despite wielding an arsenal of cytotoxic agents.

124 striction-modification module, expanding the arsenal of defence systems known to be at the disposal o

125 also enhance our understanding of the known arsenal of defence systems.

126 s activated and olive massively releases the arsenal of defense.

127 o combat these invaders, bacteria possess an arsenal of defenses, such as CRISPR-Cas adaptive immunit

128 Poison frogs have a diverse arsenal of defensive alkaloids that target the nervous s

129 of sedentary phytonematodes suggests that an arsenal of different secreted parasitism proteins from t

130 ver the decades, what we have in our current arsenal of drugs for this potentially devastating diseas

131 Despite an increasing arsenal of effective treatments, there are mounting chal

132 Natural killer cells employ a diverse arsenal of effector mechanisms to target intracellular p

133 t with the host cell, it delivers a distinct arsenal of effector proteins directly into the cytoplasm

134 An arsenal of effector proteins is injected by bacterial pa

135 etes infect their hosts, they employ a large arsenal of effector proteins to establish a successful i

136 The reported arsenal of effectors is likely to expand since genomic a

137 and cell types due, in part, to the diverse arsenal of effectors it secretes into the host cell.

138 ever-growing threat because of the shrinking arsenal of efficacious antibiotics.

139 Cells possess an arsenal of enzymatic tools capable of remodeling and rep

140 ned beetle genome encodes a uniquely diverse arsenal of enzymes that can degrade the main polysacchar

141 king it an ideal candidate for expanding the arsenal of enzymes used in precise genome editing.

142 ibitors, which could complement the existing arsenal of epigenetic drugs that are currently limited t

143 At the same time, an expanding arsenal of experimental tools can constrain models and d

144 pathogen Ustilago maydis encodes a different arsenal of extracellular hydrolases with more copies of

145 M. globosa shares a similar arsenal of extracellular hydrolases with the phylogeneti

146 To expand the arsenal of fluorescent cytidine analogues for the detect

147 ters encoding different proteins with a vast arsenal of functions, including carbohydrate binding, tr

148 eby filling an important void in the current arsenal of gene-therapy vectors.

149 A wider arsenal of genes related to oxidative stress, cellular r

150 with reduced cost have led to unraveling the arsenal of genes utilized by the colonic Bacteroidetes t

151 e model species Drosophila, which has a rich arsenal of genetic tools.

152 o the availability of a large and increasing arsenal of genetically modified mouse strains and molecu

153 This greatly extends the arsenal of graphene materials and their potential for a

154 asive S. aureus strains secrete an extensive arsenal of hemolysins, immunomodulators, and exoenzymes

155 he overall reaction sequence complements the arsenal of Horner-Wadsworth-Emmons-type coupling reactio

156 ges in nutrient availability and to evade an arsenal of host defenses.

157 l agent of Legionnaires' disease, employs an arsenal of hundreds of Dot/Icm-translocated effector pro

158 This exploits the full arsenal of imaging statistics to discover and replicate

159 me organization, origins to bat CoVs, and an arsenal of immune antagonists.

160 skin's physical barrier is reinforced by an arsenal of immune cells that actively patrol the tissue

161 coccus aureus expresses a highly diversified arsenal of immune evasion proteins, many of which target

162 another mechanism to the already formidable arsenal of immunoevasion tactics used by solid tumors.

163 The established arsenal of immunomodulatory proteins encoded by viruses

164 osyltransferase is a valuable addition to an arsenal of immunoreactive proteins which could be incorp

165 y different phyla have evolved an impressive arsenal of light manipulation strategies that rely on th

166 changing the TCR affinity will allow a large arsenal of low-avidity T cells previously thought to be

167 to be tested in conjunction with the growing arsenal of markers for human plasmacytoid dendritic cell

168 D4(+) T-cell functions that indicate a large arsenal of mechanisms by which CD4(+) T cells act to com

169 yed as a model system in combination with an arsenal of mechanistic techniques, including (13)C kinet

170 Living organisms use a sophisticated arsenal of membrane receptors, channels, and pumps to co

171 These findings enrich the available arsenal of metal-catalyzed spirocyclization methods base

172 addressed by tapping into the ever expanding arsenal of methods to manipulate ions in the gas phase o

173 y become a valuable addition to the existing arsenal of methods used to monitor duplex DNA interactio

174 d through direct observation using the large arsenal of molecular tools available for Arabidopsis.

175 ged as an important weapon in the pathogenic arsenal of multiple intracellular protozoan parasites.

176 Together, our study provides an arsenal of multivalent immunogens for HIV-1 vaccine deve

177 We detail the arsenal of nanocarriers and molecules available for sele

178 Recent advances in immunology and a growing arsenal of new drugs are bringing the focus of tolerance

179 the bacteroids are kept under control by an arsenal of nodule-specific cysteine-rich (NCR) peptides,

180 ill be a valuable complement to the existing arsenal of nucleophiles in Pd-catalyzed allylic substitu

181 ill be a valuable complement to the existing arsenal of nucleophiles with applications in allylic sub

182 new CRY2-based approaches expand the growing arsenal of optogenetic strategies to probe cellular func

183 terfere with complement by producing a small arsenal of outer-surface lipoproteins that bind host com

184 n, and (3) ExoY contributes to the virulence arsenal of P aeruginosa through the subversion of endoth

185 lusive capacity to elicit disease through an arsenal of pathogen-specific "virulence factors." This n

186 re represents a valuable new addition to the arsenal of pharmacological tools competent to investigat

187 tween cell senescence and CKD may expand the arsenal of pharmacotherapy to include the judicious use

188 ructing plant biomass by the secretion of an arsenal of plant cell wall-degrading enzymes, by remodel

189 Among the arsenal of plant-derived compounds activated upon attack

190 iew, we discuss differences between the CWDE arsenal of plant-pathogenic and non-plant-pathogenic fun

191 The arsenal of pneumococcal adhesins interacts with a multit

192 as Nup98, may be an additional weapon in the arsenal of poliovirus and perhaps other picornaviruses t

193 vasion strategy, which is predicated upon an arsenal of potent inhibitory proteins.

194 VSV is one oncolytic virus out of an arsenal of potential candidates shown to provide selecti

195 been a very promising recent addition to our arsenal of potentially useful drugs for epigenetic thera

196 32b enriches the arsenal of promising lead compounds that may therefore a

197 Advances in synthetic biology have led to an arsenal of proof-of-principle bacterial circuits that ca

198 d potato (Solanum tuberosum), has evolved an arsenal of protease inhibitors to overcome the action of

199 The release of their formidable arsenal of proteases and other toxic intracellular conte

200 CMV encodes a diverse arsenal of proteins focused on altering and/or mimicking

201 creens reveal that the host cells express an arsenal of proteins that inhibit replication of plus-str

202 The human genome encodes an arsenal of proteins that protect us against deadly virus

203 ms a complex array of functions using a vast arsenal of proteins, ion channels, pumps, motors, signal

204 The DhMRE genome encodes an arsenal of putative regulatory proteins with eukaryotic-

205 fills one of the last remaining gaps in the arsenal of radical cyclizations.

206 This work increases the arsenal of reactions and strategies available for the sy

207 ponse, selection favors hosts with a broader arsenal of recognition molecules, thus favoring diploid

208 20C to be another tool that is unique in the arsenal of S. pneumoniae and that it may implement the e

209 MRSA possesses an arsenal of secreted host-damaging virulence factors that

210 Fungi and bacteria compete with an arsenal of secreted molecules for their ecological niche

211 ure comparison and classification, given the arsenal of sequence comparison tools developed by comput

212 nd provide global control over Streptomyces' arsenal of signaling and antagonistic compounds.

213 h-throughput dPCR provides a new tool in the arsenal of single-cell analysis methods, with a unique c

214 Our results revealed a substantial arsenal of small molecules induced by microbial interact

215 Pathogenic bacteria are endowed with an arsenal of specialized enzymes to convert nutrient compo

216 ion pressures, driving evolution of a robust arsenal of starvation survival defenses.

217 By exploiting an arsenal of state-of-the-art imaging and genetic manipula

218 A whole arsenal of statistical tools can be used to deal with in

219 Microbial pathogens possess an arsenal of strategies to invade their hosts, evade immun

220 and provides a novel addition to the growing arsenal of structurally diverse irreversible ligands tha

221 ealing alternative to the currently employed arsenal of surface modification methods consisting mainl

222 Compared with the well equipped arsenal of surface modification methods for flat surface

223 sitions of the thiazole ring, broadening the arsenal of synthetic methods to obtain such scaffolds.

224 the last 10 years from the rapidly expanding arsenal of system-wide genomic methodologies.

225 and development efforts have created a large arsenal of targeted and chemotherapeutic drugs for preci

226 h work is focused upon the development of an arsenal of targeted therapies, towards oncogenic driver

227 rin and its potential impurities adds to the arsenal of techniques available for the rapid identifica

228 ing technology to add to the ever increasing arsenal of techniques available to the modern day chemis

229 sothermal titration calorimetry (ITC) to our arsenal of techniques for characterizing adsorption mech

230 expression and covalent modification to the arsenal of techniques for characterizing the dynamic, im

231 Here, we review the current arsenal of techniques used to query chromosome structure

232 Despite the arsenal of technologies employed to control foodborne no

233 the validity of our approach and expands the arsenal of the crystallization chaperone toolkit, which

234 partment has emerged as the frontline in the arsenal of the host's antiviral defenses.

235 ish them as essential tools in the technical arsenal of the modern biochemist.

236 abel-free detection differs greatly from the arsenal of the so-called traditional 7TM techniques comm

237 A growing arsenal of therapeutic agents is under development to in

238 nderlying mechanisms, demands a multifaceted arsenal of therapeutic strategies.

239 ide new opportunities to augment the limited arsenal of therapeutics against influenza.

240 hus offering opportunities for improving the arsenal of therapeutics for this extremely deadly diseas

241 In this review, we outline the existing arsenal of therapies available for AMD and discuss the a

242 The current arsenal of tools and methods for the continuous monitori

243 transposition is a valuable addition to the arsenal of tools available for molecular biology and gen

244 re, glycerotoxin is a unique addition to the arsenal of tools available to unravel the mechanism cont

245 An arsenal of tools for designing DNA circuits to implement

246 stained effort has resulted in an impressive arsenal of tools for determining the static structures.

247 s suggests that MAb 201 may be useful in the arsenal of tools to combat SARS.

248 Fragment-based approaches have added to the arsenal of tools used to identify novel developable lead

249 d flow to the field of optics, with its full arsenal of tools, opens the door to the investigation of

250 The pediatric dermatologist's arsenal of topical anesthetic preparations is increasing

251 Clinically, a large arsenal of topoisomerase inhibitors has been used to sup

252 g white blood cell in humans, and contain an arsenal of toxic substances that kill and degrade microb

253 obe Clostridium perfringens produces a large arsenal of toxins that are responsible for histotoxic an

254 re currently under development to add to our arsenal of treatment strategies in this devastating dise

255 The arsenal of treatments for most cancers fit broadly into

256 efficacious and tolerable than the available arsenal of treatments.

257 Bacteremia isolates exhibit an arsenal of VFs that distinguishes them from rectal isola

258 Its ability to persist likely is due to its arsenal of viral immunoevasion proteins.

259 thin its genome that temporally regulate its arsenal of virulence determinants throughout its virulen

260 The arsenal of virulence factors deployed by streptococci in

261 Its arsenal of virulence factors includes a secreted hemaggl

262 pathogenicity of P. aeruginosa is due to the arsenal of virulence factors produced by the pathogen an

263 This bacterium deploys an arsenal of virulence factors that act in concert to prom

264 Its genome encodes an arsenal of virulence factors that allow it, when require

265 um Porphyromonas gingivalis, produces a vast arsenal of virulence factors that compromise human defen

266 erial pathogens have evolved a sophisticated arsenal of virulence factors to modulate host cell biolo

267 Group A Streptococcus (GAS) has acquired an arsenal of virulence factors, promoting life-threatening

268 g biofilm formation and the production of an arsenal of virulence factors.

269 S. aureus adapts the expression of its broad arsenal of virulence genes to promote different types of

270 icts can point to possible weaknesses in the arsenal of viruses and may lead to the rational design o

271 ect to continuous damage and the cell has an arsenal of ways of responding to such injury.

272 The abundance and diversity of this potent arsenal of weapons are clear.

273 and how do microorganisms respond to such an arsenal of weapons?

274 y metabolism and defending themselves via an arsenal of xenobiotic metabolizing enzymes.

275 his powerful and practical route adds to the arsenals of chemists and biologists interested in the sy

276 Xanthomonas, and Ralstonia spp. harbor large arsenals of effectors.

277 Plants possess large arsenals of immune receptors capable of recognizing all

278 n particular, cytomegaloviruses encode large arsenals of molecules that seek to subvert T cell and na

279 us with many microorganisms possessing large arsenals of predicted multidrug efflux transporters.

280 tome and chordate invertebrates harbor large arsenals of recognition receptors primarily encoding LRR

281 Venoms are complex biochemical arsenals, often containing hundreds to thousands of uniq

282 the infectious necrotroph of its pathogenic arsenal or attenuates its effect, restricting further in

283 esent only a portion of the virulence factor arsenal possessed by P. aeruginosa.

284 PADS Arsenal provides various ways to retrieve defense system

285 Thus, intratumor heterogeneity is like an arsenal, providing a variety of weapons for self-defense

286 Among the current arsenal, SM fluorescence techniques have capabilities of

287 In addition to expanding the anti-HIV arsenal, small-molecule inhibitors against untargeted HI

288 re extended and sophisticated methodological arsenal than is the case currently.

289 ication machine and a component of the viral arsenal that hijacks cellular components and counteracts

290 ly reinforcing components of the immunologic arsenal that the host mobilizes to defend itself against

291 However, in this arsenal the supplies are constantly changing, as cancer

292 ases that can be treated with a limited drug arsenal; the development of new molecules is therefore a

293 learning approaches to expand our antibiotic arsenal through the discovery of structurally distinct a

294 ne analysis pipeline is integrated into PADS Arsenal to facilitate annotation and evolutionary analys

295 (2) could be an important new therapy in the arsenal to fight metastatic breast cancer.

296 eutics that continue to add to our medicinal arsenal today.

297 ) are recent compounds in the antiretroviral arsenal used against HIV.

298 e invention and diversification of molecular arsenals, which, in turn, promote the cellular co-option

299 pigenomic testing into the clinical research arsenal will greatly facilitate our understanding of the

300 s allow researchers to equip their technical arsenal with an interchangeable patch-clamp/ERG system.