ライフサイエンスコーパス: articular

1 Among all the patients, 56% had extra-articular (65% in paediatric patients) and 44% had intra

2 Intra-articular administered triamcinolone acetonide (TAA) is

3 radiographic knee osteoarthritis, the intra-articular administration of 100 mug of sprifermin every

4 In mice intra-articular administration of gremlin-1 antibody or chondr

5 Moreover, intra-articular administration of lentiviral vector encoding Y

6 ates osteoarthritis development, while intra-articular administration of recombinant gremlin-1 exacer

7 re the third most frequent EIMs, preceded by articular and dermatological ones.

8 d the CD4(+) T-cell DNA methylome of 68 poly-articular and extended oligo-articular JIA patients, bef

9 are divided by location into osseous, intra-articular and extra-articular lesions.

10 While chondrocyte apoptosis rates in articular and growth plate cartilage were similar betwee

11 s are available and can be effective on both articular and intestinal involvement.

12 The articular and neural contributors to TMJ pain, imaging m

13 In both articular and pulmonary manifestations, TNF is a signifi

14 l accounting for differential effects, intra-articular and topical therapies were superior to oral tr

15 istopathologic evaluation confirmed osseous, articular, and neurovascular invasion in 8.6%, 2.9%, and

16 Intra-articular anti-VEGF antibodies suppress OA progression,

17 Collectively, our data suggest that intra-articular BMNC could increase synovial macrophage counts

18 y (3), medial circumflex femoral artery (2), articular branch of descending genicular artery (1), per

19 has been focused on the intervening tissue, articular calcified cartilage (ACC) and its role in the

20 ated numbers of hypertrophic chondrocytes in articular calcified cartilage.

21 Articular cartilage (AC) and intervertebral discs are ca

22 This study investigated articular cartilage (AC) homeostasis and different signa

23 therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries.

24 Articular cartilage (AC) lacks the ability to self-repai

25 xpression level of ADAM12 protein in the KBD articular cartilage (average positive chondrocyte rate =

26 rate = 47.59 +/- 7.79%) compared to healthy articular cartilage (average positive chondrocyte rate =

27 evated ratio of calcified cartilage to total articular cartilage (CC/TAC), and synovial hyperplasia w

28 ture, ultrastructure and function of hyaline articular cartilage (HAC) and subchondral bone (SCB), an

29 abnormalities or morphologic defects in the articular cartilage (mean age, 54 years +/- 5; 51% women

30 development of synthetic composite gel-based articular cartilage analog suggests new avenues to explo

31 ctures include a skeletal element lined with articular cartilage and a synovial cavity, and we demons

32 ition as it progresses to destruction of the articular cartilage and ankylosis of the joints.

33 ure of osteoarthritis is the gradual loss of articular cartilage and bone deformation, resulting in t

34 characterised by progressive destruction of articular cartilage and chondrocyte cell death.

35 oint motion via adsorption to the surface of articular cartilage and its lubricating properties in so

36 ubricin) is secreted by cells that reside in articular cartilage and line the synovial joint.

37 duced joint pathology, including thinning of articular cartilage and loss of proteoglycans in the car

38 collagen network and proteoglycan content in articular cartilage and meniscal matrix.

39 Injuries to articular cartilage and menisci can lead to cartilage de

40 ence was found in morphological thickness of articular cartilage and menisci in early osteoarthritis

41 T1 and T2 relaxation time values of articular cartilage and menisci were significantly highe

42 nologies that are being developed for use in articular cartilage and meniscus repair and regeneration

43 lay unique aggressive behavior, invading the articular cartilage and promoting inflammation.

44 potential in amelioration of degeneration of articular cartilage and subchondral bone microarchitectu

45 erestingly, IL-3 reduces the degeneration of articular cartilage and subchondral bone microarchitectu

46 OA) is a progressive degenerative disease of articular cartilage and surrounding tissues, and is asso

47 We found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selecti

48 r findings suggest that Gdf5 upregulation in articular cartilage and synovium is a generic response t

49 Current literature suggests that articular cartilage and transient cartilage originate fr

50 ochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, w

51 dent of joint loading forces responsible for articular cartilage anisotropy.

52 Here, by using self-assembled articular cartilage as a model to examine the effects of

53 uciate ligament (ACL) remnants compared with articular cartilage at the cellular and tissue level.

54 nlike the well-defined zonal organization of articular cartilage attributed to postnatal biomechanica

55 escribe physiological benchmarks for healthy articular cartilage behavior during walking and provide

56 sion to show that chondrocytes isolated from articular cartilage biopsies of patients and subjected t

57 Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence sug

58 hyaluronan, anchored at the outer surface of articular cartilage by lubricin molecules, complexes wit

59 arthritis and its hallmark is degradation of articular cartilage by proteolytic enzymes leading to lo

60 t, similar to transient cartilage, embryonic articular cartilage cells also originate from the prolif

61 ignificantly greater agent uptake of CA4+ in articular cartilage compared to that of similar anionic

62 Growth plate and articular cartilage constitute a single anatomical entit

63 rocyte catabolism, not death, contributes to articular cartilage damage following injury.

64 tion of lentiviral Wnt7a strongly attenuated articular cartilage damage induced by destabilization of

65 , in spite of the protection from structural articular cartilage damage, the postnatal growth plates

66 he progeny of these cells reconstitute adult articular cartilage de novo, entirely substituting fetal

67 The development of morphologic articular cartilage defects (Whole-Organ MR Imaging Scor

68 termine the incidence with which morphologic articular cartilage defects develop over 48 months in ca

69 e the potential to therapeutically attenuate articular cartilage degeneration as part of OA.

70 uated hedgehog-induced or surgically induced articular cartilage degeneration in mouse models of OA.

71 ith losartan both delayed the progression of articular cartilage degeneration induced by DMM compared

72 gery in Cre-negative control mice, including articular cartilage degradation and subchondral sclerosi

73 As a result, this study suggests articular cartilage derived-CPSC can be used as a novel

74 r chondrocytes and synoviocytes, stimulating articular cartilage destruction.

75 ession to direct interzone progeny fates and articular cartilage development and disease.

76 We conclude that Phd2 is a key regulator of articular cartilage development that acts by inhibiting

77 Bovine full-depth articular cartilage explants were loaded to 2.5 MPa (phy

78 To simulate osteoarthritis in vitro, human articular cartilage explants were placed in culture and

79 e was little histological evidence of mature articular cartilage formation in all animals.

80 We characterized undamaged and damaged articular cartilage from 22 participants having hip repl

81 Finally, mouse articular cartilage from Sirt1(-/-) presented increased

82 Articular cartilage from young, old and OA knees was use

83 years it has become increasingly clear that articular cartilage harbours a viable pool of progenitor

84 Articular cartilage has little regenerative capacity.

85 Characterization of articular cartilage homeostasis and the mechanism of sup

86 hACs and the importance of NGF signaling in articular cartilage homeostasis.

87 wing chondrocyte progenitors, which form the articular cartilage in juvenile mice.

88 growth and differentiation of transient and articular cartilage in juxtaposed domains.

89 drocyte differentiation, and degeneration of articular cartilage in osteoarthritis (OA).

90 chronic disease characterized by the loss of articular cartilage in synovial joints through a process

91 d extensive synovial hypertrophy and loss of articular cartilage in the knees.

92 as a frictional behaviour resembling that of articular cartilage in the major joints.

93 Mechanical loading on articular cartilage induces various mechanical stresses

94 Articular cartilage injury can result in chondrocyte los

95 Articular cartilage is a load-bearing tissue found in an

96 Mammalian articular cartilage is an avascular tissue with poor cap

97 Articular cartilage is exposed to a gradient of oxygen l

98 The articular cartilage is exquisitely sensitive to mechanic

99 but the exact targets of NGF action on human articular cartilage is unknown.

100 fering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage

101 nic disease characterized by degeneration of articular cartilage leading to pain and physical disabil

102 Chondrocytes were isolated from articular cartilage obtained during talonavicular joint

103 creased levels of hypertrophy markers in the articular cartilage of the cKO mice.

104 used towards the repair of focal defects in articular cartilage or broadly towards widespread biomed

105 However, structural changes of articular cartilage or menisci cannot be directly evalua

106 tion of the Phd2 gene in chondrocytes on the articular cartilage phenotype in mice.

107 Gdf5 expression was upregulated in articular cartilage post-DMM, and was increased in human

108 In this study we propose articular cartilage progenitor/stem cells (CPSC) as a va

109 at acts by inhibiting the differentiation of articular cartilage progenitors via modulating HIF-1alph

110 Articular cartilage quality was assessed by quantitative

111 Cell and tissue engineering approaches for articular cartilage regeneration increasingly focus on m

112 nstructs from MSCs for future transplantable articular cartilage regeneration therapies.

113 ls have emerged as a favourable approach for articular cartilage regeneration.

114 attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled an

115 and histologic sections of growth plate and articular cartilage revealed no significant abnormalitie

116 tes taken from paired intact versus degraded articular cartilage samples across 38 patients undergoin

117 Articular cartilage specimens from 8 subjects were colle

118 y investigated mechano-regulation of miRs in articular cartilage subjected to 'physiological' and 'no

119 tilage strands as building units to bioprint articular cartilage tissue.

120 Exposure of articular cartilage to excessive mechanical loading is d

121 It reduces the coefficient of friction of articular cartilage under boundary mode conditions (0.08

122 The degeneration of articular cartilage underscores the clinical pathology o

123 ion channel transduces mechanical loading of articular cartilage via the generation of intracellular

124 running show higher reductions of knee joint articular cartilage volume after 75 minutes of running.

125 We quantified knee joint articular cartilage volumes before and after the run usi

126 In the OA and OPOA groups, articular cartilage was degenerated and Osteoarthritis R

127 imaging in comparison with the incidence in articular cartilage without signal abnormalities at base

128 in irreversible, progressive destruction of articular cartilage(1).

129 res and CC/TAC (calcified cartilage to total articular cartilage), but increased SBP (subchondral bon

130 joints causes profound loss of volume in the articular cartilage, a clinical observation first descri

131 r the correct development and homeostasis of articular cartilage, as evidenced by the fact that aberr

132 findings show that RRV infection damages the articular cartilage, including a loss of proteoglycans w

133 nic joint pain resulting from degradation of articular cartilage, inflammation of the synovial lining

134 ntitative ultrasound grading of knee femoral articular cartilage, osteophytes and meniscal extrusion,

135 lesion scores in ankle-joint, knee-joint and articular cartilage, reduced pain perception.

136 ciated with chondrocyte hypertrophy in adult articular cartilage, the lack of which protects from car

137 Unlike appendicular articular cartilage, the TMJ has two distinct functions

138 is a novel adipokine that negatively impacts articular cartilage, triggering catabolic and inflammato

139 ty for assessment of pathological changes in articular cartilage.

140 nitor cells (CPC) derived from human OA knee articular cartilage.

141 t, thickness, and volume of the femoral head articular cartilage.

142 n upregulation of Runx2-Adamts5 signaling in articular cartilage.

143 icin (Prg4), the major boundary lubricant of articular cartilage.

144 is often associated with the degeneration of articular cartilage.

145 differentiation of MF-activated SSCs toward articular cartilage.

146 nd contribute to the growth and reshaping of articular cartilage.

147 nd organized cartilage resembling the native articular cartilage.

148 ntrast agent (CA4+) is described for imaging articular cartilage.

149 ches for application of miRNAs to regenerate articular cartilage.

150 NFkappaB and LCN2 in the pathophysiology of articular cartilage.

151 ing and the sGAG and collagen content of the articular cartilage.

152 II collagen, the major structural protein of articular cartilage.

153 ng, result in progressive damage and loss of articular cartilage.

154 hythm and caused progressive degeneration of articular cartilage.

155 g new insights into the impact of hypoxia in articular cartilage.

156 to determine the viscoelastic properties of articular cartilage.

157 E3 ubiquitin ligases abundantly expressed in articular cartilage.

158 esponsible for the remarkable lubrication of articular cartilage; but alone, these molecules cannot e

159 Strategies to deplete these pathogenic intra-articular cell subpopulations could be a therapeutic opt

160 though the off-label administration of intra-articular cell therapies (such as platelet-rich plasma a

161 the interaction between degeneration, intra-articular chemical factors, and pain has further restric

162 IOX2, a specific inhibitor of PHD2, promoted articular chondrocyte differentiation.

163 However, the specific role of Runx2 in articular chondrocyte function and in OA development in

164 distinct synovial cell types and 7 distinct articular chondrocyte phenotypes from matched tissues.

165 Using RNA sequencing we identified a human articular chondrocyte repertoire of lncRNAs from normal

166 ubtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and demonstrate its role as

167 ultures of mesenchymal stem cells (MSCs) and articular chondrocytes (ACs) in PLL-loaded hydrogels.

168 Monolayer cultured primary bovine articular chondrocytes (BACs) were subjected to cyclic t

169 a role in the calcification process of human articular chondrocytes (hACs).

170 primary cells with known TRPV4 expression - articular chondrocytes and astrocytes.

171 They were transfected into CH-8 articular chondrocytes and HEK293 cells.

172 i-induced catabolic gene expression in human articular chondrocytes and is sufficient to attenuate MM

173 It stimulates catabolic events in articular chondrocytes and prevents chondrogenic precurs

174 n, reduce levels of phosphorylated VEGFR2 in articular chondrocytes and synovial cells and reduce lev

175 nction induces matrix-degrading proteases in articular chondrocytes and synoviocytes, stimulating art

176 so required for postnatal differentiation of articular chondrocytes and the timely ossification of bo

177 Articular chondrocytes are distinct in producing lower l

178 We found that lysis of articular chondrocytes by PBMC or polyclonal NK cells wa

179 lic events and stimulated anabolic events in articular chondrocytes cultured in an inflammatory envir

180 Analysis of primary cultures of TMJ articular chondrocytes from wild-type and Ddr2(slie/slie

181 rkA signaling were examined in human healthy articular chondrocytes maintained under conditions suppo

182 apoptosis, which were not as evident in the articular chondrocytes of the same animals.

183 Healthy articular chondrocytes release ACVs into conditioned med

184 50 mM) inhibits Hedgehog signaling in bovine articular chondrocytes such that the induction of GLI1 a

185 e results show that susceptibility of normal articular chondrocytes to lysis by NK cells is modulated

186 Furthermore, articular chondrocytes treated with OA derived extracell

187 nockdown of Hif-1alpha expression in primary articular chondrocytes using lentiviral vectors containi

188 ther with HMWHA inhibits catabolic events in articular chondrocytes via the inhibition of p38 mitogen

189 medium from IL-1beta and P15-1-treated human articular chondrocytes was less inhibitory for chondroge

190 Human OA articular chondrocytes were examined for miR-146b expres

191 Treatment of primary articular chondrocytes, in vitro, with IOX2, a specific

192 ontribution of growth plate chondrocytes and articular chondrocytes, not only for long bone growth, b

193 oforms 1 and 8 were highly expressed only in articular chondrocytes, suggesting their splice-specific

194 Upon ectopic expression in primary human articular chondrocytes, Wnt7a inhibited IL-1beta-induced

195 l-mediated cytotoxicity against normal human articular chondrocytes.

196 ial cells divide more slowly than underlying articular chondrocytes.

197 development of methods to direct vectors to articular chondrocytes.

198 n interleukin-1beta (IL-1beta)-treated human articular chondrocytes.

199 le of NGF-TrkA signaling in calcification of articular chondrocytes.

200 Intra-articular collagenase in the rat facet joint was investi

201 whereas 3-T MR imaging with or without intra-articular contrast material appears to improve diagnosti

202 iority of 3-T imaging, with or without intra-articular contrast material compared with 1.5-T imaging,

203 with 1.5-T MR imaging with or without intra-articular contrast material.

204 ed with 1.5-T imaging, with or without intra-articular contrast material.

205 Intra-articular corticosteroid (IACS) injections are frequentl

206 Intra-articular corticosteroid (IACS) injections are often use

207 Clinical Question: Are intra-articular corticosteroids associated with improvement in

208 Intra-articular corticosteroids could reduce cartilage damage

209 Bottom Line: Intra-articular corticosteroids may be associated with moderat

210 c autoimmune disease that causes progressive articular damage, functional loss, and comorbidity.

211 ets for therapeutic interventions that limit articular degeneration.

212 es provide a reproducible platform for intra-articular delivery of therapeutics.

213 together propogate chronic inflammation and articular destruction.

214 lung disease (which can predate the onset of articular disease by many years) probably originates fro

215 is (RA) is articular disease; however, extra-articular disease can also occur.

216 anifestation of rheumatoid arthritis (RA) is articular disease; however, extra-articular disease can

217 Conceptualizing worsening of TMJ intra-articular disorders as 4 stages and characterizing impac

218 Intra-articular drug delivery has a number of advantages over

219 tors when evaluating nanoparticles for intra-articular drug delivery.

220 , IL-36beta and IL-36gamma) are found in the articular environment during arthritis and often correla

221 The posterior articular facet of the coracoid greatly expands anterove

222 g and so-called 'remote' (non-immune and non-articular) factors.

223 d lubricin has been observed following intra-articular fracture in humans and horses and in human lat

224 ars or older with an acute, displaced, extra-articular fracture of the distal tibia from April 2013 t

225 ars or older with an acute, displaced, extra-articular fracture of the distal tibia, neither nail fix

226 sified as juxta-articular haemangioma, intra-articular haemangioma or an intermediate type of hemangi

227 They are classified as juxta-articular haemangioma, intra-articular haemangioma or an

228 Local intra-articular (IA) injections of drugs suffer from rapid cle

229 This result was associated with decreased articular IL-12/23p40 and IFN-gamma levels.

230 hree key EVD sequelae (ocular, auditory, and articular) in this cohort of EVD survivors.

231 agents revealed which immune pathways drive articular inflammation and related comorbidities.

232 of animal models captures features of intra-articular inflammation, joint overloading, and tissue da

233 Intra-articular injection in an adjuvant-induced rat model of

234 To determine the effects of intra-articular injection of 40 mg of triamcinolone acetonide

235 Intra-articular injection of a senolytic molecule that selecti

236 Intra-articular injection of AAT or GSN protected cartilage in

237 s determined histologically 48 h after intra-articular injection of AAT or GSN.

238 Moreover, intra-articular injection of adeno-associated virus carrying H

239 odel of post-traumatic osteoarthritis; intra-articular injection of adenosine nanoparticles prevented

240 imental osteoarthritis was elicited by intra-articular injection of collagenase in wild type and Cxcr

241 Adenosine replacement by intra-articular injection of liposomal suspensions containing

242 athology were studied in models of OA (intra-articular injection of monosodium iodoacetate in rats an

243 tory MK2-inhibiting (MK2i) peptide for intra-articular injection to halt inflammation that contribute

244 roinflammatory cytokine IL-6, and, via intra-articular injection, are successfully delivered into the

245 Moreover, after intra-articular injection, NFAT5-deficient macrophages were mo

246 Intra-articular injections are the most direct route for admin

247 st-line treatments and oral NSAIDs and intra-articular injections for persistent pain.

248 ants were randomized to 1 of 5 groups: intra-articular injections of 100 mug of sprifermin administer

249 nfirmed these findings in vivo through intra-articular injections of lubricin in a rat OA model where

250 the chondrocytes inaccessible, even to intra-articular injections.

251 ed to a dramatic and progressive loss of TMJ articular integrity and osteoarthritis-like changes.

252 It was substantial for articular invasion (kappa = 0.794).

253 staging systems and analysis of osseous and articular invasion were performed.

254 For articular invasion, sensitivity was 80% (both readers);

255 lome of 68 poly-articular and extended oligo-articular JIA patients, before and after anti-TNF therap

256 Osteoarthritis (OA) is a chronic disease of articular joints that leads to degeneration of both cart

257 degeneration of the cartilaginous tissue in articular joints, severely impairs mobility in many peop

258 rventions, and thereby improve the health of articular joints.

259 In vivo, articular knockdown of miR-132 in murine arthritis model

260 tion into osseous, intra-articular and extra-articular lesions.

261 autologous nature, and potential to generate articular-like cartilage rather than fibrocartilage.

262 ial lung disease (ILD) is a well-known extra-articular manifestation of rheumatoid arthritis (RA).

263 ases that have variable presentations, extra-articular manifestations and clinical outcomes, and that

264 Extra-articular manifestations occur in many patients and can

265 Using i.p. and intra-articular mouse models of gout-like inflammation, we fou

266 ependently associated with LNJSA, age, intra-articular nonarthroplasty prosthesis, and number of surg

267 lage cells are capable of differentiating as articular or transient cartilage, depending on exposure

268 spect to sex, age, and cutaneous, abdominal, articular, or renal involvement.

269 nodes (differential model) showed that intra-articular placebo (effect size, 0.29 [95% credible inter

270 e neural arch for 21 of 57 patients, and the articular process for 18 of 57 patients.

271 ere was a positive correlation between intra-articular PTX3 and IL-1beta levels.

272 Although the pathophysiology of articular RA has been extensively investigated, the mech

273 A hypothetical, intra-articular, regenerative medicine-based treatment techniq

274 articular triamcinolone, compared with intra-articular saline, resulted in significantly greater cart

275 Of the potential extra-articular sites implicated in disease initiation, mucosa

276 Thus, abnormal peri-articular skeletal development and modeling, rather than

277 Models of TMJ intra-articular status other than ours (normal structure --> D

278 TMJ intra-articular status was determined by 3 blinded, calibrated

279 model estimated the association of TMJ intra-articular status with the latent measure TMD impact as a

280 was unresponsive to physiotherapy and intra-articular steroid injections.

281 g a tight-junction-mediated shield for intra-articular structures.

282 omous expression of diphtheria toxin to kill articular surface chondrocytes in mice and determined th

283 Lesions to the articular surface, which are thought to progress to OA,

284 have revealed chondrocyte progenitors at the articular surface.

285 , such as prominent rims around the anterior articular surfaces of cervical centra and bifurcated ant

286 the trapezial and proximal first metacarpal articular surfaces of Neanderthals (Homo neanderthalensi

287 riacanthosaurid allosauroids), flat anterior articular surfaces of the cervical centra (also present

288 Biological resurfacing of entire articular surfaces represents an important but challengi

289 eal joints, normal human metatarsophalangeal articular tissue and human OA tibial plateau tissues mea

290 ation; however, for the past 20 years, intra-articular treatment options for the management of knee o

291 Furthermore, intra-articular treatment with RvD1 diminishes the progression

292 We also show that intra-articular treatment with the Wnt inhibitor sclerostin su

293 A number of promising intra-articular treatments are currently in clinical developme

294 Intra-articular triamcinolone (n = 70) or saline (n = 70) ever

295 Intra-articular triamcinolone resulted in significantly greate

296 cebo-controlled, double-blind trial of intra-articular triamcinolone vs saline for symptomatic knee o

297 omatic knee osteoarthritis, 2 years of intra-articular triamcinolone, compared with intra-articular s

298 We report a new case of osteo-articular tuberculosis localized to the xiphisternum, a

299 tiotemporally precise manner, reducing intra-articular vector spread and possible loss of the therape

300 referentially expressed and activated in the articular zone of TMJs but not knee joints.